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The map label for this gene is rnr [H]

Identifier: 18310278

GI number: 18310278

Start: 1530963

End: 1533218

Strand: Reverse

Name: rnr [H]

Synonym: CPE1296

Alternate gene names: 18310278

Gene position: 1533218-1530963 (Counterclockwise)

Preceding gene: 18310279

Following gene: 18310277

Centisome position: 50.58

GC content: 31.47

Gene sequence:

>2256_bases
ATGAAAATAAAAGATATAATTTTAGGTCTTATGAAAGAAGAAGCATATAGACCAATGACAATGTTAGAATTATCAAAGAT
ATTTAACATAAATAAAGCTGAATATAAACAATTTAAAAAAGTCTTTAAGGCCTTAGAAGCAGAGGGCTTAATAGCAAGAG
ATGAGGAAGATAGATTTGGCCTAATAGACAAAGTAGGTTTAATACCTGGAAAAATCCAAATACATCAAAAAGGCTTTGGT
TTCTTAATACCAGATGAAGAAGGTGTAACAGATGTATTTATACCTAAGAATGCTTTAAATGGGGCTATGAACGGAGATAG
AGTATTAGGTAAGGTTGTAAAGGAAAGTCAAGAAGGTAAAAGATGTGAAGGTGAAATAGTAAGAATAACTGAGAGAGTTA
ATACAAAGGTAATAGGAATATATGAAGATAATAAGAGTTTTGGATTTGTACTTCCACAGGATCAAAGAATTCAAAATGAT
ATATTCATATCTAAGAAGGATAGAAATGGAGCTAAAAAAGGCAATGTAGTTGTTGTTGAAATAACTAAGTGGCCAGATGG
TAGAAGAAAGAATCCAGAAGGAGTAGTAGTAGAAATACTAGGAAACAGAGGAGATTTAGGCTTAGATATTATAACTGTAA
TTAAGAAATATGCTCTTCCAGAAGAATTCCCTCCACAAGTTTTAGCCTTTGCAGAAGAAATTTCAGAGGAAATCCCAGAG
TCAGAAATTAAGAGAAGAACAGACTTAAGAGATGTAAAAATGGTTACTATAGATGGTGAAGATGCTAAGGACTTAGATGA
CGCTGTATCTATAGAAAGACTTCCAAATGGAAACTATAAATTAGGAGTTCACATTGCAGACGTAACTCACTATGTAAAAG
AAAACAATCCTTTAGATAAAGAGGCCTTTAAAAGAGCTACTTCTGTTTATTTAGTTGATAGAGTTATTCCTATGCTTCCT
AAAAAGTTATCAAATGGAATATGTTCATTAAATCCACAGGTAGACAGACTTGCCTTAACTTGCTTTATGGAAATAGATCA
TAAAGGAAATGTGGTTAACCATTCAATACATGAAAGTGTAATTAAAACTAATGAGAGAATGACATACACTGATGTAACTA
AGATTTTAAGAGATAATGACCAAGAGTTAATTGAAAGATATAAGGATTTAGTAGATGACTTTAAGGCTATGGAAGAGTTA
TGTAAAATATTAAATAAGAGAAGAATGGGAAGAGGAGCTATTGACTTTGAATTTGCAGAGAGCAAAATAATCTTAGATGA
AAAAGGAAAGCCAATAGATATAAAACCATATGAAAGAGCTATAGCAAACAGAATCATAGAAGAATTTATGCTAGTATGTA
ATGAAACTATAGCAGAATATATGAATAAGGCTGAAATACCATTTGTATATAGAATACATGAGGAGCCAGATAATGAAAAG
CTTCAAAGATTTAAAAACTTTGCATATAGCTTAGGATATTCATTTAACTTTGGAGAACTTATTGAACCTAGAGATTTACA
AAAGGTTGTTGAGGAAGTTAAGGGTAAAAATGAAGAGATGGTAATAAACACATTACTTTTAAGAAGTATGATGCAAGCTA
GATATTCTCCAGACTGTGCAGGTCACTTTGGATTAGCAGCTGAATACTACTGTCACTTTACTTCACCAATTAGAAGATAT
CCAGACTTACAAATTCATAGAATAATAAAAGAATATATAAATAAAAAGATTGATCCTAAGAGAGCTAAGAGACTTTTAAG
CATTGTTGATTCTGCATCTAAGCAATCTTCAGAAATGGAAAGAATAGCTCAAGAAGCTGAAAGAGAAACAAATGATCTTA
AGAAAGCTGAATATATGAAAGATAGAATTGGAGAAATATTTGATGGTATTATTTCTTCAGTTACTGGATTTGGAGCCTTT
GTTGAACTTCCAAATACTGTAGAAGGTCTTGTTCATGTAACAAGCTTTAGAGATGATTATTACATCTATGATGAAGAAAA
CCTTCAATTAATAGGTGAAAGAACTAAGAAGGTTTATAAACTTGGAGAAAAGGTTAAGGTTCTTTGCTCAAGAGTAGAAA
TGGATACTAGAGAAGTTTATTTTGAAATAGTTGAGGATAAGTATACTATTGAGGAAAAGGAAGCTGAAACTGAAAAGAGA
GAGAATTTACTTGATGAAGTAAAAAAAGAGCTTGAAGCAGAGGGAAAGGTTGAAATAATAGAGCCAAGAGAAGAAACTGC
TGAGGAAGAGCTTTAA

Upstream 100 bases:

>100_bases
ATAATTAGGTGAATTAATCCATTAGAATTTAAGAGAAACAGGCTTTGAACTAAAATATAAAAGTTGCATTTAAATCTATA
TATAGAACGGAGGAAAAAGC

Downstream 100 bases:

>100_bases
AAAGTTAAAAATAAAACTTACAAACATATTTCGAGAATTACTAGATTTCGCTAAGAATTTATAATCATTACTACGAAGAT
ATTACTAAAGCTTCGAAACT

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 751; Mature: 751

Protein sequence:

>751_residues
MKIKDIILGLMKEEAYRPMTMLELSKIFNINKAEYKQFKKVFKALEAEGLIARDEEDRFGLIDKVGLIPGKIQIHQKGFG
FLIPDEEGVTDVFIPKNALNGAMNGDRVLGKVVKESQEGKRCEGEIVRITERVNTKVIGIYEDNKSFGFVLPQDQRIQND
IFISKKDRNGAKKGNVVVVEITKWPDGRRKNPEGVVVEILGNRGDLGLDIITVIKKYALPEEFPPQVLAFAEEISEEIPE
SEIKRRTDLRDVKMVTIDGEDAKDLDDAVSIERLPNGNYKLGVHIADVTHYVKENNPLDKEAFKRATSVYLVDRVIPMLP
KKLSNGICSLNPQVDRLALTCFMEIDHKGNVVNHSIHESVIKTNERMTYTDVTKILRDNDQELIERYKDLVDDFKAMEEL
CKILNKRRMGRGAIDFEFAESKIILDEKGKPIDIKPYERAIANRIIEEFMLVCNETIAEYMNKAEIPFVYRIHEEPDNEK
LQRFKNFAYSLGYSFNFGELIEPRDLQKVVEEVKGKNEEMVINTLLLRSMMQARYSPDCAGHFGLAAEYYCHFTSPIRRY
PDLQIHRIIKEYINKKIDPKRAKRLLSIVDSASKQSSEMERIAQEAERETNDLKKAEYMKDRIGEIFDGIISSVTGFGAF
VELPNTVEGLVHVTSFRDDYYIYDEENLQLIGERTKKVYKLGEKVKVLCSRVEMDTREVYFEIVEDKYTIEEKEAETEKR
ENLLDEVKKELEAEGKVEIIEPREETAEEEL

Sequences:

>Translated_751_residues
MKIKDIILGLMKEEAYRPMTMLELSKIFNINKAEYKQFKKVFKALEAEGLIARDEEDRFGLIDKVGLIPGKIQIHQKGFG
FLIPDEEGVTDVFIPKNALNGAMNGDRVLGKVVKESQEGKRCEGEIVRITERVNTKVIGIYEDNKSFGFVLPQDQRIQND
IFISKKDRNGAKKGNVVVVEITKWPDGRRKNPEGVVVEILGNRGDLGLDIITVIKKYALPEEFPPQVLAFAEEISEEIPE
SEIKRRTDLRDVKMVTIDGEDAKDLDDAVSIERLPNGNYKLGVHIADVTHYVKENNPLDKEAFKRATSVYLVDRVIPMLP
KKLSNGICSLNPQVDRLALTCFMEIDHKGNVVNHSIHESVIKTNERMTYTDVTKILRDNDQELIERYKDLVDDFKAMEEL
CKILNKRRMGRGAIDFEFAESKIILDEKGKPIDIKPYERAIANRIIEEFMLVCNETIAEYMNKAEIPFVYRIHEEPDNEK
LQRFKNFAYSLGYSFNFGELIEPRDLQKVVEEVKGKNEEMVINTLLLRSMMQARYSPDCAGHFGLAAEYYCHFTSPIRRY
PDLQIHRIIKEYINKKIDPKRAKRLLSIVDSASKQSSEMERIAQEAERETNDLKKAEYMKDRIGEIFDGIISSVTGFGAF
VELPNTVEGLVHVTSFRDDYYIYDEENLQLIGERTKKVYKLGEKVKVLCSRVEMDTREVYFEIVEDKYTIEEKEAETEKR
ENLLDEVKKELEAEGKVEIIEPREETAEEEL
>Mature_751_residues
MKIKDIILGLMKEEAYRPMTMLELSKIFNINKAEYKQFKKVFKALEAEGLIARDEEDRFGLIDKVGLIPGKIQIHQKGFG
FLIPDEEGVTDVFIPKNALNGAMNGDRVLGKVVKESQEGKRCEGEIVRITERVNTKVIGIYEDNKSFGFVLPQDQRIQND
IFISKKDRNGAKKGNVVVVEITKWPDGRRKNPEGVVVEILGNRGDLGLDIITVIKKYALPEEFPPQVLAFAEEISEEIPE
SEIKRRTDLRDVKMVTIDGEDAKDLDDAVSIERLPNGNYKLGVHIADVTHYVKENNPLDKEAFKRATSVYLVDRVIPMLP
KKLSNGICSLNPQVDRLALTCFMEIDHKGNVVNHSIHESVIKTNERMTYTDVTKILRDNDQELIERYKDLVDDFKAMEEL
CKILNKRRMGRGAIDFEFAESKIILDEKGKPIDIKPYERAIANRIIEEFMLVCNETIAEYMNKAEIPFVYRIHEEPDNEK
LQRFKNFAYSLGYSFNFGELIEPRDLQKVVEEVKGKNEEMVINTLLLRSMMQARYSPDCAGHFGLAAEYYCHFTSPIRRY
PDLQIHRIIKEYINKKIDPKRAKRLLSIVDSASKQSSEMERIAQEAERETNDLKKAEYMKDRIGEIFDGIISSVTGFGAF
VELPNTVEGLVHVTSFRDDYYIYDEENLQLIGERTKKVYKLGEKVKVLCSRVEMDTREVYFEIVEDKYTIEEKEAETEKR
ENLLDEVKKELEAEGKVEIIEPREETAEEEL

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=440, Percent_Identity=32.7272727272727, Blast_Score=219, Evalue=7e-57,
Organism=Homo sapiens, GI190014623, Length=440, Percent_Identity=32.7272727272727, Blast_Score=219, Evalue=9e-57,
Organism=Homo sapiens, GI134288890, Length=479, Percent_Identity=27.9749478079332, Blast_Score=189, Evalue=1e-47,
Organism=Homo sapiens, GI219521928, Length=638, Percent_Identity=27.742946708464, Blast_Score=186, Evalue=1e-46,
Organism=Homo sapiens, GI19115966, Length=638, Percent_Identity=27.742946708464, Blast_Score=185, Evalue=2e-46,
Organism=Homo sapiens, GI156105695, Length=514, Percent_Identity=23.5408560311284, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI156105693, Length=217, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI87082383, Length=697, Percent_Identity=37.8766140602582, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1787542, Length=647, Percent_Identity=25.9659969088099, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI212645896, Length=509, Percent_Identity=28.4872298624754, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17553506, Length=525, Percent_Identity=26.8571428571429, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324552, Length=616, Percent_Identity=29.0584415584416, Blast_Score=191, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6320499, Length=430, Percent_Identity=24.8837209302326, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323943, Length=432, Percent_Identity=24.537037037037, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24649634, Length=469, Percent_Identity=34.3283582089552, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24654592, Length=437, Percent_Identity=29.7482837528604, Blast_Score=186, Evalue=7e-47,
Organism=Drosophila melanogaster, GI19922976, Length=437, Percent_Identity=29.7482837528604, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24654597, Length=437, Percent_Identity=29.7482837528604, Blast_Score=185, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 86589; Mature: 86589

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKDIILGLMKEEAYRPMTMLELSKIFNINKAEYKQFKKVFKALEAEGLIARDEEDRFG
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCC
LIDKVGLIPGKIQIHQKGFGFLIPDEEGVTDVFIPKNALNGAMNGDRVLGKVVKESQEGK
CHHHHCCCCCEEEEEECCCEEECCCCCCCEEEEECHHHHCCCCCHHHHHHHHHHHCCCCC
RCEGEIVRITERVNTKVIGIYEDNKSFGFVLPQDQRIQNDIFISKKDRNGAKKGNVVVVE
CCCCHHEEEEECCCCEEEEEEECCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCEEEEE
ITKWPDGRRKNPEGVVVEILGNRGDLGLDIITVIKKYALPEEFPPQVLAFAEEISEEIPE
EEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCH
SEIKRRTDLRDVKMVTIDGEDAKDLDDAVSIERLPNGNYKLGVHIADVTHYVKENNPLDK
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEHHHHHHHHCCCCCCH
EAFKRATSVYLVDRVIPMLPKKLSNGICSLNPQVDRLALTCFMEIDHKGNVVNHSIHESV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEHEEEECCCCCCCHHHHHHHH
IKTNERMTYTDVTKILRDNDQELIERYKDLVDDFKAMEELCKILNKRRMGRGAIDFEFAE
HHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
SKIILDEKGKPIDIKPYERAIANRIIEEFMLVCNETIAEYMNKAEIPFVYRIHEEPDNEK
CEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LQRFKNFAYSLGYSFNFGELIEPRDLQKVVEEVKGKNEEMVINTLLLRSMMQARYSPDCA
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
GHFGLAAEYYCHFTSPIRRYPDLQIHRIIKEYINKKIDPKRAKRLLSIVDSASKQSSEME
CCCCCHHHHHEEECCHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
RIAQEAERETNDLKKAEYMKDRIGEIFDGIISSVTGFGAFVELPNTVEGLVHVTSFRDDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCHHHHHEEHEEECCCE
YIYDEENLQLIGERTKKVYKLGEKVKVLCSRVEMDTREVYFEIVEDKYTIEEKEAETEKR
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHH
ENLLDEVKKELEAEGKVEIIEPREETAEEEL
HHHHHHHHHHHCCCCCEEEECCCHHHHCCCC
>Mature Secondary Structure
MKIKDIILGLMKEEAYRPMTMLELSKIFNINKAEYKQFKKVFKALEAEGLIARDEEDRFG
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCC
LIDKVGLIPGKIQIHQKGFGFLIPDEEGVTDVFIPKNALNGAMNGDRVLGKVVKESQEGK
CHHHHCCCCCEEEEEECCCEEECCCCCCCEEEEECHHHHCCCCCHHHHHHHHHHHCCCCC
RCEGEIVRITERVNTKVIGIYEDNKSFGFVLPQDQRIQNDIFISKKDRNGAKKGNVVVVE
CCCCHHEEEEECCCCEEEEEEECCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCEEEEE
ITKWPDGRRKNPEGVVVEILGNRGDLGLDIITVIKKYALPEEFPPQVLAFAEEISEEIPE
EEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCH
SEIKRRTDLRDVKMVTIDGEDAKDLDDAVSIERLPNGNYKLGVHIADVTHYVKENNPLDK
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEHHHHHHHHCCCCCCH
EAFKRATSVYLVDRVIPMLPKKLSNGICSLNPQVDRLALTCFMEIDHKGNVVNHSIHESV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEHEEEECCCCCCCHHHHHHHH
IKTNERMTYTDVTKILRDNDQELIERYKDLVDDFKAMEELCKILNKRRMGRGAIDFEFAE
HHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
SKIILDEKGKPIDIKPYERAIANRIIEEFMLVCNETIAEYMNKAEIPFVYRIHEEPDNEK
CEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LQRFKNFAYSLGYSFNFGELIEPRDLQKVVEEVKGKNEEMVINTLLLRSMMQARYSPDCA
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
GHFGLAAEYYCHFTSPIRRYPDLQIHRIIKEYINKKIDPKRAKRLLSIVDSASKQSSEME
CCCCCHHHHHEEECCHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
RIAQEAERETNDLKKAEYMKDRIGEIFDGIISSVTGFGAFVELPNTVEGLVHVTSFRDDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCHHHHHEEHEEECCCE
YIYDEENLQLIGERTKKVYKLGEKVKVLCSRVEMDTREVYFEIVEDKYTIEEKEAETEKR
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHH
ENLLDEVKKELEAEGKVEIIEPREETAEEEL
HHHHHHHHHHHCCCCCEEEECCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]