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The map label for this gene is uraA [H]

Identifier: 18310194

GI number: 18310194

Start: 1417936

End: 1419246

Strand: Reverse

Name: uraA [H]

Synonym: CPE1212

Alternate gene names: 18310194

Gene position: 1419246-1417936 (Counterclockwise)

Preceding gene: 18310195

Following gene: 18310193

Centisome position: 46.82

GC content: 31.05

Gene sequence:

>1311_bases
ATGGCACAACAAGTAATAAGCAAAGAGCAAGGAAGTATTAAAACATTAGGGATTTTCTCTTACTTTAAAAATGGAATTTT
AGGATTACAACATTTAGTTGCCATGTTTGGAGCTACAATACTAGTACCACTAGTAACAGGCTTAGATCCATCAGTAGCTT
TATTCACAGCAGGCATAGGTACTTTAATATTCCACTTATGTACTAAAGGAAAAGTTCCAGTATTTTTAGGATCATCCTTT
GCATTTATACCTGTAATACAAGTAATTGCAGCTAAATATGGAGATTTAAGATATGCACAAGGAGGTATATTCTTTGCAGG
ATTAGCTTATGTATTAATTTCTTTTGGAATAAAGAAAATAGGTGTAGATAAAATAAAAAGATTTTTACCTGCAAGGGTAG
TTGGTCCAATGATAATGGTTATAGGCTTAAATCTTATACCTAATGCCTTAGAAATGGCTGGGGTAAAATCTTTAATAGCT
GGAGAAACAGGAGCTATGACTTCAGTTTTAATAGCTTGTACTACATTAGGATTAGCATTAATAATAAGTAAGTTTGGAAA
GGGATTTTTTTCACAATTAGCAATAATAACAGCAGTTTGTGTAGGATATACTTTAAGTTTAATTTTAGGACAAGTTGATA
CAAGTTTAATTCAACAAAGTACAATGGTTGCAGTGCCAAACTTTACATTGCCAAAATTTGATTTTGGAGCAATAATGATA
ACTTTACCAGTTATTTTAGCGGTATCAATGGAGCATATAGGAGATATAACTACTAATGGACAAGTTGTAGGTAAAAACTT
TATAGAAGATCCAGGACTAAATAGAACAGTATTAGGAGATGGATTAGCAACTTTAGTTGCATCTTTATTAGGGGGACCAG
CTAATACTACTTACGGTGAAAATACAGGAGTTTTAGCTATAACTAAAAATTATAATCCATCAATTTTAAGATTAACAGCT
GTTTTTGCCATAATACTAAGCTTTATAGCTAAGTTTGGAGCGGTTATAAGAACAATTCCACAATCAGTAATGGGAGGAAT
AAGCTTAATGTTATTCTCTATGATTGCTTTAGTGGGAGTTAAAACTATAAAAAATGAAGGGGTTAAATTAAATAAAACTA
ACCTAATATTAATGGGATCAATAATTTTTGTAGGTTTATCAGGCTTATTTATGTCAGAGCCTATAGGAATTGAAATAAGT
GAAGCTGTAAGCATATCAGGCTTAAGCTTAGCAGCTTTAATAGGTGTTATTTTAAACTTAATAATCACTAAATTTGAATC
AGCAAAGAGTAGAAAAGAAGTAATTGCTTAA

Upstream 100 bases:

>100_bases
GGTAAGAAGTTTTATTTTTACCTTTTTAAATCAGTCCTGTGAGGCTGAAAAAAGGAGAAGCAGAGTTTTCTCCTTAAGAA
AAAATAAGGAGGCTTAAATT

Downstream 100 bases:

>100_bases
ATAAAAATAGCAAGTCATATATAAATGGCTTGCTATTTTTATTATTAAGTATGTAAAGTTTATATCTTAACTTCTTAATT
CATCATTTTAATAAAATAGA

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MAQQVISKEQGSIKTLGIFSYFKNGILGLQHLVAMFGATILVPLVTGLDPSVALFTAGIGTLIFHLCTKGKVPVFLGSSF
AFIPVIQVIAAKYGDLRYAQGGIFFAGLAYVLISFGIKKIGVDKIKRFLPARVVGPMIMVIGLNLIPNALEMAGVKSLIA
GETGAMTSVLIACTTLGLALIISKFGKGFFSQLAIITAVCVGYTLSLILGQVDTSLIQQSTMVAVPNFTLPKFDFGAIMI
TLPVILAVSMEHIGDITTNGQVVGKNFIEDPGLNRTVLGDGLATLVASLLGGPANTTYGENTGVLAITKNYNPSILRLTA
VFAIILSFIAKFGAVIRTIPQSVMGGISLMLFSMIALVGVKTIKNEGVKLNKTNLILMGSIIFVGLSGLFMSEPIGIEIS
EAVSISGLSLAALIGVILNLIITKFESAKSRKEVIA

Sequences:

>Translated_436_residues
MAQQVISKEQGSIKTLGIFSYFKNGILGLQHLVAMFGATILVPLVTGLDPSVALFTAGIGTLIFHLCTKGKVPVFLGSSF
AFIPVIQVIAAKYGDLRYAQGGIFFAGLAYVLISFGIKKIGVDKIKRFLPARVVGPMIMVIGLNLIPNALEMAGVKSLIA
GETGAMTSVLIACTTLGLALIISKFGKGFFSQLAIITAVCVGYTLSLILGQVDTSLIQQSTMVAVPNFTLPKFDFGAIMI
TLPVILAVSMEHIGDITTNGQVVGKNFIEDPGLNRTVLGDGLATLVASLLGGPANTTYGENTGVLAITKNYNPSILRLTA
VFAIILSFIAKFGAVIRTIPQSVMGGISLMLFSMIALVGVKTIKNEGVKLNKTNLILMGSIIFVGLSGLFMSEPIGIEIS
EAVSISGLSLAALIGVILNLIITKFESAKSRKEVIA
>Mature_435_residues
AQQVISKEQGSIKTLGIFSYFKNGILGLQHLVAMFGATILVPLVTGLDPSVALFTAGIGTLIFHLCTKGKVPVFLGSSFA
FIPVIQVIAAKYGDLRYAQGGIFFAGLAYVLISFGIKKIGVDKIKRFLPARVVGPMIMVIGLNLIPNALEMAGVKSLIAG
ETGAMTSVLIACTTLGLALIISKFGKGFFSQLAIITAVCVGYTLSLILGQVDTSLIQQSTMVAVPNFTLPKFDFGAIMIT
LPVILAVSMEHIGDITTNGQVVGKNFIEDPGLNRTVLGDGLATLVASLLGGPANTTYGENTGVLAITKNYNPSILRLTAV
FAIILSFIAKFGAVIRTIPQSVMGGISLMLFSMIALVGVKTIKNEGVKLNKTNLILMGSIIFVGLSGLFMSEPIGIEISE
AVSISGLSLAALIGVILNLIITKFESAKSRKEVIA

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=436, Percent_Identity=25.9174311926606, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI44680148, Length=435, Percent_Identity=24.5977011494253, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI40316845, Length=435, Percent_Identity=24.5977011494253, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI44680143, Length=440, Percent_Identity=25.4545454545455, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788843, Length=411, Percent_Identity=38.9294403892944, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI87081818, Length=392, Percent_Identity=36.2244897959184, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI87082181, Length=438, Percent_Identity=25.7990867579909, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87082178, Length=187, Percent_Identity=32.0855614973262, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790087, Length=424, Percent_Identity=25.4716981132075, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=213, Percent_Identity=27.2300469483568, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=227, Percent_Identity=25.5506607929515, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356175, Length=425, Percent_Identity=23.0588235294118, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45792; Mature: 45661

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQVISKEQGSIKTLGIFSYFKNGILGLQHLVAMFGATILVPLVTGLDPSVALFTAGIG
CCCHHHHCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TLIFHLCTKGKVPVFLGSSFAFIPVIQVIAAKYGDLRYAQGGIFFAGLAYVLISFGIKKI
HHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHC
GVDKIKRFLPARVVGPMIMVIGLNLIPNALEMAGVKSLIAGETGAMTSVLIACTTLGLAL
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IISKFGKGFFSQLAIITAVCVGYTLSLILGQVDTSLIQQSTMVAVPNFTLPKFDFGAIMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHH
TLPVILAVSMEHIGDITTNGQVVGKNFIEDPGLNRTVLGDGLATLVASLLGGPANTTYGE
HHHHHHHHHHHHHCCCCCCCEEECCHHCCCCCCCCCHHCCCHHHHHHHHHCCCCCCCCCC
NTGVLAITKNYNPSILRLTAVFAIILSFIAKFGAVIRTIPQSVMGGISLMLFSMIALVGV
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTIKNEGVKLNKTNLILMGSIIFVGLSGLFMSEPIGIEISEAVSISGLSLAALIGVILNL
HHHHCCCEEECCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHH
IITKFESAKSRKEVIA
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQQVISKEQGSIKTLGIFSYFKNGILGLQHLVAMFGATILVPLVTGLDPSVALFTAGIG
CCHHHHCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TLIFHLCTKGKVPVFLGSSFAFIPVIQVIAAKYGDLRYAQGGIFFAGLAYVLISFGIKKI
HHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHC
GVDKIKRFLPARVVGPMIMVIGLNLIPNALEMAGVKSLIAGETGAMTSVLIACTTLGLAL
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IISKFGKGFFSQLAIITAVCVGYTLSLILGQVDTSLIQQSTMVAVPNFTLPKFDFGAIMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHH
TLPVILAVSMEHIGDITTNGQVVGKNFIEDPGLNRTVLGDGLATLVASLLGGPANTTYGE
HHHHHHHHHHHHHCCCCCCCEEECCHHCCCCCCCCCHHCCCHHHHHHHHHCCCCCCCCCC
NTGVLAITKNYNPSILRLTAVFAIILSFIAKFGAVIRTIPQSVMGGISLMLFSMIALVGV
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTIKNEGVKLNKTNLILMGSIIFVGLSGLFMSEPIGIEISEAVSISGLSLAALIGVILNL
HHHHCCCEEECCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHH
IITKFESAKSRKEVIA
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]