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The map label for this gene is pncB [H]

Identifier: 18310189

GI number: 18310189

Start: 1413167

End: 1414639

Strand: Direct

Name: pncB [H]

Synonym: CPE1207

Alternate gene names: 18310189

Gene position: 1413167-1414639 (Clockwise)

Preceding gene: 18310184

Following gene: 18310192

Centisome position: 46.62

GC content: 30.41

Gene sequence:

>1473_bases
ATGGATTATAAGTTTGATGTAAAAAACCCTAGAAATCTTACAATGCTAGTTGATTTCTATGAACTTACTATGGCAAATGG
ATATTTTAAAAATGGCATAGAAAATAAAATTGCCTATTTTGATATGTATTTTAGAAGGGTACCTGATGGTGGCGGCTATT
GTATAATGGCTGGTGTTGAGCAATTAATTGAATACCTATCAAATCTAAACTTTTCAGAAGATGATATAGCCTATTTAAGA
TCAAAGGAATTATTTTGTGATGAATTCTTAGACTTTTTAATAAATTTCAAGTTTACTTGTGATGTTTGGGCAATTCCAGA
AGGAAATCCTGTCTTCCCAAATGAACCTTTAGTTATTGTTAAAGGTCCTGTAATACAAGCACAGTTTGTAGAAACTATGA
TACTTCTTACTATAAATCACCAAACACTTATAGCTACTAAGGCTAATAGAATATGTAGAGCAGCTAAGGATAAGACTGTA
ATGGAATTTGGTTCTAGAAGAGCTCAAGGATATGATGGAGCTATTTATGGAGCAAGAGCTGCTGCCATAGGTGGTTGTGA
TTCTACAGCATGTACAATAGCTGATCAAATGTTTGATATACCCGCTATAGGAACTATGGCTCATAGTTGGATTCAACTTT
TTGGAGACGAATATGAAGCCTTTAAGGCCTGGGCAGTGGCATATCCTGATAACTGTACATTATTAATAGATACTTATAAC
GTTTTAAAGTCTGGTGTTCCTAATGCTATTAAGGTATTTGATGAGGTTTTAAAACCTTTAGGAAAAAGACCAAAAGGAAT
AAGAATAGATAGTGGTGATATAACTTATCTATCTAAAAAATGTAGACAGATGTTAGATGAAGCTGGATATCCAGATTGTA
AAATAATAGTTTCAAATTCTCTAGATGAATATATAATAAGAGATGTATTAAGCCAAGGAGCTTCAATAGATGCCTTTGGA
GTTGGAGAAAGACTTATAACAGCTAGATCAGAACCTGTTTTTGGTGGAGTTTATAAATTAGTTGCAGTAGAAGACGAAGA
AGGTAATATAATTCCTAGAATAAAGATAAGTGAAAATGAAGAAAAAATAACAAACCCTGGATTTAAGAGAATAATAAGAA
TATTTGATAATAATACTCATACAGCCTTAGCTGATTTAATTCTTTTAAATGATGAAGAAATAGATACTAATAAACCATTA
GAGATTTTTGATCCTATTCATGTATGGAAAAGAAAAACATTAACTAATTATTACGTTAAAGATTTACTAGTTAAAATATT
TGAAGATGGAAAAGTATGCTACAAAAATCCAACAGTAATGGAAATTAGAGATTATGCTCAAAAAGAGTGTGAAAAACTTT
GGCCAGAAATTTTAAGATTTGAAAATCCTCATACTTATTATGTGGATTTATCAAATGGTTTATGGAATTTAAAACATAAT
TTACTTCATAGATATTCTAGCATATATAAATAG

Upstream 100 bases:

>100_bases
CTCTAGTAAACCATAATATTTATTAACATATATATTGTAATAATTCTAACTACTGGTTACAATAGTTATTGATAACTTAT
GAAAAGGAGATAATTTTTAT

Downstream 100 bases:

>100_bases
CACTTATATTTTTAAAAAATAAGAGACGCTTCATTAATGTGAAGCGTCTCTTATTAATTTACTTGACTTAAAACTAGATT
TGATTTTTCATAATCATCCT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MDYKFDVKNPRNLTMLVDFYELTMANGYFKNGIENKIAYFDMYFRRVPDGGGYCIMAGVEQLIEYLSNLNFSEDDIAYLR
SKELFCDEFLDFLINFKFTCDVWAIPEGNPVFPNEPLVIVKGPVIQAQFVETMILLTINHQTLIATKANRICRAAKDKTV
MEFGSRRAQGYDGAIYGARAAAIGGCDSTACTIADQMFDIPAIGTMAHSWIQLFGDEYEAFKAWAVAYPDNCTLLIDTYN
VLKSGVPNAIKVFDEVLKPLGKRPKGIRIDSGDITYLSKKCRQMLDEAGYPDCKIIVSNSLDEYIIRDVLSQGASIDAFG
VGERLITARSEPVFGGVYKLVAVEDEEGNIIPRIKISENEEKITNPGFKRIIRIFDNNTHTALADLILLNDEEIDTNKPL
EIFDPIHVWKRKTLTNYYVKDLLVKIFEDGKVCYKNPTVMEIRDYAQKECEKLWPEILRFENPHTYYVDLSNGLWNLKHN
LLHRYSSIYK

Sequences:

>Translated_490_residues
MDYKFDVKNPRNLTMLVDFYELTMANGYFKNGIENKIAYFDMYFRRVPDGGGYCIMAGVEQLIEYLSNLNFSEDDIAYLR
SKELFCDEFLDFLINFKFTCDVWAIPEGNPVFPNEPLVIVKGPVIQAQFVETMILLTINHQTLIATKANRICRAAKDKTV
MEFGSRRAQGYDGAIYGARAAAIGGCDSTACTIADQMFDIPAIGTMAHSWIQLFGDEYEAFKAWAVAYPDNCTLLIDTYN
VLKSGVPNAIKVFDEVLKPLGKRPKGIRIDSGDITYLSKKCRQMLDEAGYPDCKIIVSNSLDEYIIRDVLSQGASIDAFG
VGERLITARSEPVFGGVYKLVAVEDEEGNIIPRIKISENEEKITNPGFKRIIRIFDNNTHTALADLILLNDEEIDTNKPL
EIFDPIHVWKRKTLTNYYVKDLLVKIFEDGKVCYKNPTVMEIRDYAQKECEKLWPEILRFENPHTYYVDLSNGLWNLKHN
LLHRYSSIYK
>Mature_490_residues
MDYKFDVKNPRNLTMLVDFYELTMANGYFKNGIENKIAYFDMYFRRVPDGGGYCIMAGVEQLIEYLSNLNFSEDDIAYLR
SKELFCDEFLDFLINFKFTCDVWAIPEGNPVFPNEPLVIVKGPVIQAQFVETMILLTINHQTLIATKANRICRAAKDKTV
MEFGSRRAQGYDGAIYGARAAAIGGCDSTACTIADQMFDIPAIGTMAHSWIQLFGDEYEAFKAWAVAYPDNCTLLIDTYN
VLKSGVPNAIKVFDEVLKPLGKRPKGIRIDSGDITYLSKKCRQMLDEAGYPDCKIIVSNSLDEYIIRDVLSQGASIDAFG
VGERLITARSEPVFGGVYKLVAVEDEEGNIIPRIKISENEEKITNPGFKRIIRIFDNNTHTALADLILLNDEEIDTNKPL
EIFDPIHVWKRKTLTNYYVKDLLVKIFEDGKVCYKNPTVMEIRDYAQKECEKLWPEILRFENPHTYYVDLSNGLWNLKHN
LLHRYSSIYK

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=526, Percent_Identity=30.6083650190114, Blast_Score=250, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71997947, Length=532, Percent_Identity=33.2706766917293, Blast_Score=271, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI71997952, Length=532, Percent_Identity=33.2706766917293, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71997955, Length=209, Percent_Identity=37.3205741626794, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24581587, Length=523, Percent_Identity=31.1663479923518, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI161076680, Length=276, Percent_Identity=31.5217391304348, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24581595, Length=276, Percent_Identity=31.5217391304348, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28574709, Length=276, Percent_Identity=31.5217391304348, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24581593, Length=276, Percent_Identity=31.5217391304348, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24581591, Length=276, Percent_Identity=31.5217391304348, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55930; Mature: 55930

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKFDVKNPRNLTMLVDFYELTMANGYFKNGIENKIAYFDMYFRRVPDGGGYCIMAGVE
CCCEECCCCCCCEEEEEEHHHHHHCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEHHHHH
QLIEYLSNLNFSEDDIAYLRSKELFCDEFLDFLINFKFTCDVWAIPEGNPVFPNEPLVIV
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCEEEE
KGPVIQAQFVETMILLTINHQTLIATKANRICRAAKDKTVMEFGSRRAQGYDGAIYGARA
ECCCCHHHHHCEEEEEEECCCEEEEEHHHHHHHHHCCHHHHHHCCHHCCCCCCCEECCHH
AAIGGCDSTACTIADQMFDIPAIGTMAHSWIQLFGDEYEAFKAWAVAYPDNCTLLIDTYN
HCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHEEEEEECCCCCEEEEECHH
VLKSGVPNAIKVFDEVLKPLGKRPKGIRIDSGDITYLSKKCRQMLDEAGYPDCKIIVSNS
HHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCC
LDEYIIRDVLSQGASIDAFGVGERLITARSEPVFGGVYKLVAVEDEEGNIIPRIKISENE
HHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCC
EKITNPGFKRIIRIFDNNTHTALADLILLNDEEIDTNKPLEIFDPIHVWKRKTLTNYYVK
HHCCCHHHHHHHHHHCCCCHHHHHEEEEECCCCCCCCCCCCHHCHHHHHHHHHHHHHHHH
DLLVKIFEDGKVCYKNPTVMEIRDYAQKECEKLWPEILRFENPHTYYVDLSNGLWNLKHN
HHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHH
LLHRYSSIYK
HHHHHHHHCC
>Mature Secondary Structure
MDYKFDVKNPRNLTMLVDFYELTMANGYFKNGIENKIAYFDMYFRRVPDGGGYCIMAGVE
CCCEECCCCCCCEEEEEEHHHHHHCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEHHHHH
QLIEYLSNLNFSEDDIAYLRSKELFCDEFLDFLINFKFTCDVWAIPEGNPVFPNEPLVIV
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCEEEE
KGPVIQAQFVETMILLTINHQTLIATKANRICRAAKDKTVMEFGSRRAQGYDGAIYGARA
ECCCCHHHHHCEEEEEEECCCEEEEEHHHHHHHHHCCHHHHHHCCHHCCCCCCCEECCHH
AAIGGCDSTACTIADQMFDIPAIGTMAHSWIQLFGDEYEAFKAWAVAYPDNCTLLIDTYN
HCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHEEEEEECCCCCEEEEECHH
VLKSGVPNAIKVFDEVLKPLGKRPKGIRIDSGDITYLSKKCRQMLDEAGYPDCKIIVSNS
HHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCC
LDEYIIRDVLSQGASIDAFGVGERLITARSEPVFGGVYKLVAVEDEEGNIIPRIKISENE
HHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCC
EKITNPGFKRIIRIFDNNTHTALADLILLNDEEIDTNKPLEIFDPIHVWKRKTLTNYYVK
HHCCCHHHHHHHHHHCCCCHHHHHEEEEECCCCCCCCCCCCHHCHHHHHHHHHHHHHHHH
DLLVKIFEDGKVCYKNPTVMEIRDYAQKECEKLWPEILRFENPHTYYVDLSNGLWNLKHN
HHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHH
LLHRYSSIYK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]