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The map label for this gene is pepQ [H]

Identifier: 18309854

GI number: 18309854

Start: 1072648

End: 1074423

Strand: Direct

Name: pepQ [H]

Synonym: CPE0872

Alternate gene names: 18309854

Gene position: 1072648-1074423 (Clockwise)

Preceding gene: 18309851

Following gene: 18309855

Centisome position: 35.38

GC content: 31.08

Gene sequence:

>1776_bases
ATGAAGGTGACTGAAAGATTAGAAAAATTAAGAAAAATTATGAAGGATAAAGGAATTGATTATTATATAATTCCTAGTGA
AGATGCTCACCAAAGTGAGTATGTGTGCGAACATTACAGGGGCAGGGCATATATGTCAGGTTTTACAGGGTCAGCAGGAA
CTTTACTTGTCGGTTTAGAAAATGGGATTTTGTGGACTGACGGTAGATATTTCATACAAGCTTTAGATGAGTTAAAGGGT
TCTGGAATTGAAATGTTTAAAATGAGAATTCCAGGATGGCCAAGCTTATTAGAATGGCTTAAAGAAAATGCAAAGGCAGG
AGAAACTATTGCTTTTGATGGAAAGGTATTTTCAGTAGGAGAATATAAAGATTTTAAAAAATTAGAAGAAGAAAATAATA
TTAATATAAAAATAGATGAGGACCTTTTAGATGAGGTTTGGAAAGAGAGACCATCTCTTCCTAAGGAAAAGGCATTTTTA
CATGAAGTTAAGTACTGTGGAAAAAGTGCGAGAGAAAAATTAAGAGAAGTTAGAGAGGAAATGAAAAAGCTAGGCGCTAA
TAATTATATTATAGCTTCTTTAGATGATATAGCTTGGCTTTATAATATTAGAGGAAATGATGTTAAATGCAATCCTGTAG
TTTTAAGCTATGCCTTAGTTAAAGAAAATGAAGCATATCTTTATGTAGATAAATCAAAGTTCACTTCTAAAATGGAGGAA
GAACTTTTAAATGAAGGGGTTACTTTAAAATCATATGATGAAATAGGAAATGCTATTAGTAATTTAGAAGGGAAGATTTT
AATTGATCCAAATAAGATAAGTGCTTATTTATACGAGTGCATTAAGGATAAAAATAATATTGTGGAATTTGGAAACATAA
CAACTAAGTTTAAGGCTATTAAGAATGAAGTTGAATTAGATAACTTAAGAAAGTGTCAAGTAAGAGATGGAGTAGCCATG
GTTAAGTTTATGAAATGGCTTAAGGATAACATTGGAAAGATAGAAATAAGTGAAATATCAGCTTCAGATAAGTTAGAAGA
ACTTAGAAGTTTAGATAAGTTATTTAAAGGAATTAGTTTTGAAACCATAGCAGGGCATAAAGAACATGGTGCTATGATGC
ATTATTCAGCAACTAAAGAGAGTGATTACACTTTAGAACCAAGAGGATTTTTATTAATAGATTCAGGTGGACAATACTTA
GATGGAACTACAGATATAACAAGAACTTTTGTTTTAGGAGAATTAACTGAGGAAGAGAGAAAAGATTATACTTTAGTTTT
AAAAGGACATATAGGACTTATGAGAGCTAAATTCTTAAAGGGAGCTACTGGATCAGCCCTTGATATAAAAGCTAGAGAGC
CATTATGGAATGAAGGAATTGATTATAAATGTGGAACAGGTCATGGAGTTGGATTTTTCTTAAATGTTCATGAAGGACCA
CAAAGCATAAGCCCAGTACCAAATAAGGTTGCCTTAGAGCCAGGAATGATCATAACTAATGAACCTGGAGTTTATAGAGA
AGGAAAACATGGAATAAGAACAGAGAATACAATGGTAGTTGTTAAAGATACTTATTCAGAAGAGTTTGGAGAATTTTATA
AGTTTGATACTATTTCACTTTGTCCAATAGACTTAGCAGGATTAGATATAAGTTTAATAAATGAAGAGGAAAAGGCTTGG
CTAAATAATTATCATAAAAAGGTTTATTATTTATTATCACCATATTTAGATGAAGAGGAAAAAGAATTCTTAAAGAATGA
AACAAGAGCAATATAA

Upstream 100 bases:

>100_bases
AATATTTTTATGTTACTATTATTGAAAGCAGAAAATTAAATTGAGGTTTGAAAAGTTAAATCAAATTACAATTTAGATTA
AAAAATAGGGGGCTATAATT

Downstream 100 bases:

>100_bases
GTAAGTTCTGTAGGGCTGTATCAAAATATAACAAATAAAAGTTATTTTGATACATGCCCTATTTTAACTTTTAGTTAATA
TGTAGTTATAGATAATAGGG

Product: metallopeptidase, M24 family

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MKVTERLEKLRKIMKDKGIDYYIIPSEDAHQSEYVCEHYRGRAYMSGFTGSAGTLLVGLENGILWTDGRYFIQALDELKG
SGIEMFKMRIPGWPSLLEWLKENAKAGETIAFDGKVFSVGEYKDFKKLEEENNINIKIDEDLLDEVWKERPSLPKEKAFL
HEVKYCGKSAREKLREVREEMKKLGANNYIIASLDDIAWLYNIRGNDVKCNPVVLSYALVKENEAYLYVDKSKFTSKMEE
ELLNEGVTLKSYDEIGNAISNLEGKILIDPNKISAYLYECIKDKNNIVEFGNITTKFKAIKNEVELDNLRKCQVRDGVAM
VKFMKWLKDNIGKIEISEISASDKLEELRSLDKLFKGISFETIAGHKEHGAMMHYSATKESDYTLEPRGFLLIDSGGQYL
DGTTDITRTFVLGELTEEERKDYTLVLKGHIGLMRAKFLKGATGSALDIKAREPLWNEGIDYKCGTGHGVGFFLNVHEGP
QSISPVPNKVALEPGMIITNEPGVYREGKHGIRTENTMVVVKDTYSEEFGEFYKFDTISLCPIDLAGLDISLINEEEKAW
LNNYHKKVYYLLSPYLDEEEKEFLKNETRAI

Sequences:

>Translated_591_residues
MKVTERLEKLRKIMKDKGIDYYIIPSEDAHQSEYVCEHYRGRAYMSGFTGSAGTLLVGLENGILWTDGRYFIQALDELKG
SGIEMFKMRIPGWPSLLEWLKENAKAGETIAFDGKVFSVGEYKDFKKLEEENNINIKIDEDLLDEVWKERPSLPKEKAFL
HEVKYCGKSAREKLREVREEMKKLGANNYIIASLDDIAWLYNIRGNDVKCNPVVLSYALVKENEAYLYVDKSKFTSKMEE
ELLNEGVTLKSYDEIGNAISNLEGKILIDPNKISAYLYECIKDKNNIVEFGNITTKFKAIKNEVELDNLRKCQVRDGVAM
VKFMKWLKDNIGKIEISEISASDKLEELRSLDKLFKGISFETIAGHKEHGAMMHYSATKESDYTLEPRGFLLIDSGGQYL
DGTTDITRTFVLGELTEEERKDYTLVLKGHIGLMRAKFLKGATGSALDIKAREPLWNEGIDYKCGTGHGVGFFLNVHEGP
QSISPVPNKVALEPGMIITNEPGVYREGKHGIRTENTMVVVKDTYSEEFGEFYKFDTISLCPIDLAGLDISLINEEEKAW
LNNYHKKVYYLLSPYLDEEEKEFLKNETRAI
>Mature_591_residues
MKVTERLEKLRKIMKDKGIDYYIIPSEDAHQSEYVCEHYRGRAYMSGFTGSAGTLLVGLENGILWTDGRYFIQALDELKG
SGIEMFKMRIPGWPSLLEWLKENAKAGETIAFDGKVFSVGEYKDFKKLEEENNINIKIDEDLLDEVWKERPSLPKEKAFL
HEVKYCGKSAREKLREVREEMKKLGANNYIIASLDDIAWLYNIRGNDVKCNPVVLSYALVKENEAYLYVDKSKFTSKMEE
ELLNEGVTLKSYDEIGNAISNLEGKILIDPNKISAYLYECIKDKNNIVEFGNITTKFKAIKNEVELDNLRKCQVRDGVAM
VKFMKWLKDNIGKIEISEISASDKLEELRSLDKLFKGISFETIAGHKEHGAMMHYSATKESDYTLEPRGFLLIDSGGQYL
DGTTDITRTFVLGELTEEERKDYTLVLKGHIGLMRAKFLKGATGSALDIKAREPLWNEGIDYKCGTGHGVGFFLNVHEGP
QSISPVPNKVALEPGMIITNEPGVYREGKHGIRTENTMVVVKDTYSEEFGEFYKFDTISLCPIDLAGLDISLINEEEKAW
LNNYHKKVYYLLSPYLDEEEKEFLKNETRAI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=617, Percent_Identity=36.4667747163695, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI264681565, Length=617, Percent_Identity=34.8460291734198, Blast_Score=342, Evalue=8e-94,
Organism=Homo sapiens, GI93141226, Length=607, Percent_Identity=32.6194398682043, Blast_Score=341, Evalue=1e-93,
Organism=Escherichia coli, GI1788728, Length=169, Percent_Identity=31.9526627218935, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17509539, Length=592, Percent_Identity=35.6418918918919, Blast_Score=352, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI25149105, Length=592, Percent_Identity=28.5472972972973, Blast_Score=239, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322999, Length=655, Percent_Identity=34.0458015267176, Blast_Score=339, Evalue=9e-94,
Organism=Drosophila melanogaster, GI17137632, Length=612, Percent_Identity=37.5816993464052, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI161078230, Length=586, Percent_Identity=29.3515358361775, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI21357287, Length=586, Percent_Identity=29.3515358361775, Blast_Score=260, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 67446; Mature: 67446

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTERLEKLRKIMKDKGIDYYIIPSEDAHQSEYVCEHYRGRAYMSGFTGSAGTLLVGLE
CCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCCEEECCCCCCCCEEEEEEC
NGILWTDGRYFIQALDELKGSGIEMFKMRIPGWPSLLEWLKENAKAGETIAFDGKVFSVG
CCEEEECCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEECCEEEEEC
EYKDFKKLEEENNINIKIDEDLLDEVWKERPSLPKEKAFLHEVKYCGKSAREKLREVREE
CCHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHH
MKKLGANNYIIASLDDIAWLYNIRGNDVKCNPVVLSYALVKENEAYLYVDKSKFTSKMEE
HHHCCCCCEEEEEECCEEEEEEECCCCEECCCEEEEEEEEECCCEEEEEEHHHHHHHHHH
ELLNEGVTLKSYDEIGNAISNLEGKILIDPNKISAYLYECIKDKNNIVEFGNITTKFKAI
HHHHCCCCEECHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEEEECCCHHHHHHH
KNEVELDNLRKCQVRDGVAMVKFMKWLKDNIGKIEISEISASDKLEELRSLDKLFKGISF
HHHCCCCCCHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCE
ETIAGHKEHGAMMHYSATKESDYTLEPRGFLLIDSGGQYLDGTTDITRTFVLGELTEEER
EEECCCCCCCCEEEEECCCCCCCEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
KDYTLVLKGHIGLMRAKFLKGATGSALDIKAREPLWNEGIDYKCGTGHGVGFFLNVHEGP
CCEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEECCCCCCEEEEEEECCCC
QSISPVPNKVALEPGMIITNEPGVYREGKHGIRTENTMVVVKDTYSEEFGEFYKFDTISL
CCCCCCCCCEEECCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCEEE
CPIDLAGLDISLINEEEKAWLNNYHKKVYYLLSPYLDEEEKEFLKNETRAI
CCEEECCCEEEEECCHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVTERLEKLRKIMKDKGIDYYIIPSEDAHQSEYVCEHYRGRAYMSGFTGSAGTLLVGLE
CCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCCEEECCCCCCCCEEEEEEC
NGILWTDGRYFIQALDELKGSGIEMFKMRIPGWPSLLEWLKENAKAGETIAFDGKVFSVG
CCEEEECCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEECCEEEEEC
EYKDFKKLEEENNINIKIDEDLLDEVWKERPSLPKEKAFLHEVKYCGKSAREKLREVREE
CCHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHH
MKKLGANNYIIASLDDIAWLYNIRGNDVKCNPVVLSYALVKENEAYLYVDKSKFTSKMEE
HHHCCCCCEEEEEECCEEEEEEECCCCEECCCEEEEEEEEECCCEEEEEEHHHHHHHHHH
ELLNEGVTLKSYDEIGNAISNLEGKILIDPNKISAYLYECIKDKNNIVEFGNITTKFKAI
HHHHCCCCEECHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEEEECCCHHHHHHH
KNEVELDNLRKCQVRDGVAMVKFMKWLKDNIGKIEISEISASDKLEELRSLDKLFKGISF
HHHCCCCCCHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCE
ETIAGHKEHGAMMHYSATKESDYTLEPRGFLLIDSGGQYLDGTTDITRTFVLGELTEEER
EEECCCCCCCCEEEEECCCCCCCEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
KDYTLVLKGHIGLMRAKFLKGATGSALDIKAREPLWNEGIDYKCGTGHGVGFFLNVHEGP
CCEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEECCCCCCEEEEEEECCCC
QSISPVPNKVALEPGMIITNEPGVYREGKHGIRTENTMVVVKDTYSEEFGEFYKFDTISL
CCCCCCCCCEEECCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCEEE
CPIDLAGLDISLINEEEKAWLNNYHKKVYYLLSPYLDEEEKEFLKNETRAI
CCEEECCCEEEEECCHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]