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The map label for this gene is fnr [H]

Identifier: 18309758

GI number: 18309758

Start: 959551

End: 960252

Strand: Direct

Name: fnr [H]

Synonym: CPE0776

Alternate gene names: 18309758

Gene position: 959551-960252 (Clockwise)

Preceding gene: 18309757

Following gene: 18309760

Centisome position: 31.65

GC content: 27.21

Gene sequence:

>702_bases
ATGGAAAAAACATGTACATGTGGATCATGTAAAGAACCTTGTGCTAAAAATATATCTATTTTTTCAACATTATCCACTGA
GGAGTTGTTGAAAATAGTTAATATGACTGAACATAAAAGTTTTAAAGAAAATGATGTTTTATGTAGAGAAGGGGAAAAAT
CAGATAAGCTTTTCTTAATTAGAGAAGGCAGGGTAAAGATATGCAAAATAACTAAAGAGGGAAAAGAACAGATAGTTTAC
GTATTATCTAAAGGTGATTTCTTTGGAGAAAATAATCTTTTTACTAGTAATAATATTAGCAACTTTTCAGCTTATGCAAT
AACAGATGCAAAGTTATGTATTTTAAAAAAGGAGAATTTAGAAAAAATACTCATAAAAAATCCAGAGATATCATTAAAAA
TAATACAAGAGATGGCAGATAGAATAAATTCTGCTGAAAATTTAGCACAAACATTAGCTACTAGAGATGTGGAAGCAAGA
TTAGCCACTGTATTAATAGAATTTATGAATAAGTATGGTCAAAAAAAGGAAGAAGGAATATACATAAATTTACCTCTTAA
TAGAGAACAAATAGCAAATTACTGTGGTATAACAAGAGAAACTGTAAGTAGAAGACTTTCAAAATTTGATAAATTAGGAA
TAATAAAATTACAGGGAAATAAAGGGCTTATTATTAAGGATAAGAAGCTTTATTTAGTTTAG

Upstream 100 bases:

>100_bases
GAAACTATTTTATGTTTCTTTTTTTATTAAATGTTAAGTTTTATAGTAGAATATTAAATAAAGAAAAAGGATAAATAAAA
TAGTAAGGAGGAAGATAGAA

Downstream 100 bases:

>100_bases
CTGAATAGTTAAAAGGGGATTATATATTAATAGGTTGAAAATTTTTAACAAGGCTATATTTTTAAGTCAGATTTGATTTT
ATACTCACTTAATGATTTAG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MEKTCTCGSCKEPCAKNISIFSTLSTEELLKIVNMTEHKSFKENDVLCREGEKSDKLFLIREGRVKICKITKEGKEQIVY
VLSKGDFFGENNLFTSNNISNFSAYAITDAKLCILKKENLEKILIKNPEISLKIIQEMADRINSAENLAQTLATRDVEAR
LATVLIEFMNKYGQKKEEGIYINLPLNREQIANYCGITRETVSRRLSKFDKLGIIKLQGNKGLIIKDKKLYLV

Sequences:

>Translated_233_residues
MEKTCTCGSCKEPCAKNISIFSTLSTEELLKIVNMTEHKSFKENDVLCREGEKSDKLFLIREGRVKICKITKEGKEQIVY
VLSKGDFFGENNLFTSNNISNFSAYAITDAKLCILKKENLEKILIKNPEISLKIIQEMADRINSAENLAQTLATRDVEAR
LATVLIEFMNKYGQKKEEGIYINLPLNREQIANYCGITRETVSRRLSKFDKLGIIKLQGNKGLIIKDKKLYLV
>Mature_233_residues
MEKTCTCGSCKEPCAKNISIFSTLSTEELLKIVNMTEHKSFKENDVLCREGEKSDKLFLIREGRVKICKITKEGKEQIVY
VLSKGDFFGENNLFTSNNISNFSAYAITDAKLCILKKENLEKILIKNPEISLKIIQEMADRINSAENLAQTLATRDVEAR
LATVLIEFMNKYGQKKEEGIYINLPLNREQIANYCGITRETVSRRLSKFDKLGIIKLQGNKGLIIKDKKLYLV

Specific function: It is involved in the activation of genes necessary for anaerobic respiration [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=211, Percent_Identity=27.0142180094787, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789756, Length=183, Percent_Identity=27.8688524590164, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 26528; Mature: 26528

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTCTCGSCKEPCAKNISIFSTLSTEELLKIVNMTEHKSFKENDVLCREGEKSDKLFLI
CCCCCCCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEE
REGRVKICKITKEGKEQIVYVLSKGDFFGENNLFTSNNISNFSAYAITDAKLCILKKENL
ECCCEEEEEECCCCCEEEEEEEECCCCCCCCCEEECCCCCCEEEEEECCCEEEEEECCCC
EKILIKNPEISLKIIQEMADRINSAENLAQTLATRDVEARLATVLIEFMNKYGQKKEEGI
CEEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
YINLPLNREQIANYCGITRETVSRRLSKFDKLGIIKLQGNKGLIIKDKKLYLV
EEEECCCHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCCCEEEECCEEEEC
>Mature Secondary Structure
MEKTCTCGSCKEPCAKNISIFSTLSTEELLKIVNMTEHKSFKENDVLCREGEKSDKLFLI
CCCCCCCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEE
REGRVKICKITKEGKEQIVYVLSKGDFFGENNLFTSNNISNFSAYAITDAKLCILKKENL
ECCCEEEEEECCCCCEEEEEEEECCCCCCCCCEEECCCCCCEEEEEECCCEEEEEECCCC
EKILIKNPEISLKIIQEMADRINSAENLAQTLATRDVEARLATVLIEFMNKYGQKKEEGI
CEEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
YINLPLNREQIANYCGITRETVSRRLSKFDKLGIIKLQGNKGLIIKDKKLYLV
EEEECCCHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCCCEEEECCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8846791; 9384377 [H]