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The map label for this gene is gutA [H]

Identifier: 18309751

GI number: 18309751

Start: 949815

End: 951179

Strand: Direct

Name: gutA [H]

Synonym: CPE0769

Alternate gene names: 18309751

Gene position: 949815-951179 (Clockwise)

Preceding gene: 18309750

Following gene: 18309753

Centisome position: 31.33

GC content: 29.01

Gene sequence:

>1365_bases
TTGGATACATTAATAAATAAAAAAGTAGAAAAAAGTGATGATGTTTCTATAAAAACTTTAATTACTTATAGTATGGGAAG
TTTAGGAAACAATATGATATACGCATTGATTAGTTCCTACCTTTTAATATTTTTAACAGATAGTTTTAAAGTAGGGGCAG
CTGCCATAGGAACCTTATTTTTGGTGGCAAGAATTATAGATGCAATAACAGACCCTATAATGGGGGTTATAGTTGATAAT
ACTAATACTAAAATCGGAAAGAGTAGACCCTATTTATTTATCGTTCCTATTTTCATGGGAATAGCAACAATTATGTGTTT
TTCAGCACCAGATTTAAGTTATAGTGGTAAAATAATATGGATATACATAGCATATATTTTCTGGGGAATATCCTTTACTG
CAATGGATATACCATATTGGTCATTATCTGCCAATATTACAAGATCTTCATCAGGAAAAACTAAGATTGTTACATCAGCA
AGAACAGTAGCCTATGTAGGTAATTTTATAATTTTAACTTCAACAATTCCTCTTGTATCAATAATTGGAAACTGGCAAAC
TGTGGCCATAATATATGTTTGCTTTGCTACTATATTTACTTGGGTTACAGCCTTTGGAATTAGAGAAATTAAGGATAATG
TGGCAAAGAAAAAGGAAAAGCAAGGGTTTAAACAATTTATAAATCTATTAAAGACAAATAAGCCTTTAAGAATAGTTTTA
TTATCAATGTTAGTTTTAGAATTAAGTGGATCAATAAAAAATACAATATCTATATATTATGTAAAGTATAATTTTAATGC
GGAAATGATGATTCCAGTAGTTAGTTCAGTTGGTATGGGAGCTAGTATATTAGGTGGAATAATGTCACCATTTTTAACAA
AAAAATTAGGAAAAAGAAATACAGCTCTTTTAGGATTATTAGCTGGTGCTGCAGGATCATTTTTAGTATTTTTATTATCC
TATTCTTCATTACCTTTAATGATAGTTATAAACTTCATAAGTGGAATTTTTGATGGAGCAGGTTATATTACTTTAACATC
AATGGTTGCAGATTGTGTTGAGTATGGTGAGTGGAAAACTGGAAAAAGATCAGAAGGAATGATATTCTCTTTAAATATAT
TTAAAAGTAAGATTGCTAGTGCTATTGGAGGATCCTTATGTGGATATATCTTAGCGTATATTGGTTATACAGCAAATGAA
AGTCAATCTGCTTTTACATTAAACGGAATTCATTTAATACAGACTTTAGTTCCATGTGCAATTGTAATAATAAGCTTTAT
TTTATTAAGAAGATATAATTTATCTGAGGCAGAATATGAAGCTATAGTTGATGACTTGAAAAATGGTGTTACAAGAATAG
GTTAA

Upstream 100 bases:

>100_bases
GCAATAATATAAACGAAGATTAAGAAATCGATTTCTTTTTTGAAGGTTTAATTAAACGGGTATTTATAAGATTTTATTAT
TTAAATATAGAGGTGATGGT

Downstream 100 bases:

>100_bases
CATTAATATGAAAAGTATTAGGGCTAATTTAGATATTAATTCTAAATTAAGTGAAATTAATATAGTAATTATATTAAAAG
TCTAATTAAGACTTTAGAAA

Product: sugar transport protein

Products: Proton [Cytoplasm]; Glucuronides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MDTLINKKVEKSDDVSIKTLITYSMGSLGNNMIYALISSYLLIFLTDSFKVGAAAIGTLFLVARIIDAITDPIMGVIVDN
TNTKIGKSRPYLFIVPIFMGIATIMCFSAPDLSYSGKIIWIYIAYIFWGISFTAMDIPYWSLSANITRSSSGKTKIVTSA
RTVAYVGNFIILTSTIPLVSIIGNWQTVAIIYVCFATIFTWVTAFGIREIKDNVAKKKEKQGFKQFINLLKTNKPLRIVL
LSMLVLELSGSIKNTISIYYVKYNFNAEMMIPVVSSVGMGASILGGIMSPFLTKKLGKRNTALLGLLAGAAGSFLVFLLS
YSSLPLMIVINFISGIFDGAGYITLTSMVADCVEYGEWKTGKRSEGMIFSLNIFKSKIASAIGGSLCGYILAYIGYTANE
SQSAFTLNGIHLIQTLVPCAIVIISFILLRRYNLSEAEYEAIVDDLKNGVTRIG

Sequences:

>Translated_454_residues
MDTLINKKVEKSDDVSIKTLITYSMGSLGNNMIYALISSYLLIFLTDSFKVGAAAIGTLFLVARIIDAITDPIMGVIVDN
TNTKIGKSRPYLFIVPIFMGIATIMCFSAPDLSYSGKIIWIYIAYIFWGISFTAMDIPYWSLSANITRSSSGKTKIVTSA
RTVAYVGNFIILTSTIPLVSIIGNWQTVAIIYVCFATIFTWVTAFGIREIKDNVAKKKEKQGFKQFINLLKTNKPLRIVL
LSMLVLELSGSIKNTISIYYVKYNFNAEMMIPVVSSVGMGASILGGIMSPFLTKKLGKRNTALLGLLAGAAGSFLVFLLS
YSSLPLMIVINFISGIFDGAGYITLTSMVADCVEYGEWKTGKRSEGMIFSLNIFKSKIASAIGGSLCGYILAYIGYTANE
SQSAFTLNGIHLIQTLVPCAIVIISFILLRRYNLSEAEYEAIVDDLKNGVTRIG
>Mature_454_residues
MDTLINKKVEKSDDVSIKTLITYSMGSLGNNMIYALISSYLLIFLTDSFKVGAAAIGTLFLVARIIDAITDPIMGVIVDN
TNTKIGKSRPYLFIVPIFMGIATIMCFSAPDLSYSGKIIWIYIAYIFWGISFTAMDIPYWSLSANITRSSSGKTKIVTSA
RTVAYVGNFIILTSTIPLVSIIGNWQTVAIIYVCFATIFTWVTAFGIREIKDNVAKKKEKQGFKQFINLLKTNKPLRIVL
LSMLVLELSGSIKNTISIYYVKYNFNAEMMIPVVSSVGMGASILGGIMSPFLTKKLGKRNTALLGLLAGAAGSFLVFLLS
YSSLPLMIVINFISGIFDGAGYITLTSMVADCVEYGEWKTGKRSEGMIFSLNIFKSKIASAIGGSLCGYILAYIGYTANE
SQSAFTLNGIHLIQTLVPCAIVIISFILLRRYNLSEAEYEAIVDDLKNGVTRIG

Specific function: Probably involved in glucitol uptake [H]

COG id: COG2211

COG function: function code G; Na+/melibiose symporter and related transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:galactoside symporter (TC 2.A.2) family [H]

Homologues:

Organism=Escherichia coli, GI1787902, Length=460, Percent_Identity=30.4347826086957, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1786466, Length=449, Percent_Identity=28.9532293986637, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1790561, Length=429, Percent_Identity=27.972027972028, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87082306, Length=456, Percent_Identity=28.5087719298246, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI145693206, Length=445, Percent_Identity=25.1685393258427, Blast_Score=168, Evalue=8e-43,
Organism=Escherichia coli, GI48994989, Length=445, Percent_Identity=26.2921348314607, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001927
- InterPro:   IPR018043 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49662; Mature: 49662

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLINKKVEKSDDVSIKTLITYSMGSLGNNMIYALISSYLLIFLTDSFKVGAAAIGTLF
CCCHHCCCCCCCCCCEEEEEEEHHHHCCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHH
LVARIIDAITDPIMGVIVDNTNTKIGKSRPYLFIVPIFMGIATIMCFSAPDLSYSGKIIW
HHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCHH
IYIAYIFWGISFTAMDIPYWSLSANITRSSSGKTKIVTSARTVAYVGNFIILTSTIPLVS
HHHHHHHHCCHHEEEECCEEEEECCCEECCCCCEEEEEHHHHHHHHCCEEEEECHHHHHH
IIGNWQTVAIIYVCFATIFTWVTAFGIREIKDNVAKKKEKQGFKQFINLLKTNKPLRIVL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LSMLVLELSGSIKNTISIYYVKYNFNAEMMIPVVSSVGMGASILGGIMSPFLTKKLGKRN
HHHHHHHHCCCCCCEEEEEEEEEECCCEEEHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
TALLGLLAGAAGSFLVFLLSYSSLPLMIVINFISGIFDGAGYITLTSMVADCVEYGEWKT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
GKRSEGMIFSLNIFKSKIASAIGGSLCGYILAYIGYTANESQSAFTLNGIHLIQTLVPCA
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHH
IVIISFILLRRYNLSEAEYEAIVDDLKNGVTRIG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDTLINKKVEKSDDVSIKTLITYSMGSLGNNMIYALISSYLLIFLTDSFKVGAAAIGTLF
CCCHHCCCCCCCCCCEEEEEEEHHHHCCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHH
LVARIIDAITDPIMGVIVDNTNTKIGKSRPYLFIVPIFMGIATIMCFSAPDLSYSGKIIW
HHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCHH
IYIAYIFWGISFTAMDIPYWSLSANITRSSSGKTKIVTSARTVAYVGNFIILTSTIPLVS
HHHHHHHHCCHHEEEECCEEEEECCCEECCCCCEEEEEHHHHHHHHCCEEEEECHHHHHH
IIGNWQTVAIIYVCFATIFTWVTAFGIREIKDNVAKKKEKQGFKQFINLLKTNKPLRIVL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LSMLVLELSGSIKNTISIYYVKYNFNAEMMIPVVSSVGMGASILGGIMSPFLTKKLGKRN
HHHHHHHHCCCCCCEEEEEEEEEECCCEEEHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
TALLGLLAGAAGSFLVFLLSYSSLPLMIVINFISGIFDGAGYITLTSMVADCVEYGEWKT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
GKRSEGMIFSLNIFKSKIASAIGGSLCGYILAYIGYTANESQSAFTLNGIHLIQTLVPCA
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHH
IVIISFILLRRYNLSEAEYEAIVDDLKNGVTRIG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; Glucuronides [Periplasm] [C]

Specific reaction: Proton [Periplasm] + Glucuronides [Periplasm] = Proton [Cytoplasm] + Glucuronides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]