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The map label for this gene is trxA [H]

Identifier: 18309721

GI number: 18309721

Start: 916103

End: 916420

Strand: Direct

Name: trxA [H]

Synonym: CPE0739

Alternate gene names: 18309721

Gene position: 916103-916420 (Clockwise)

Preceding gene: 18309718

Following gene: 18309722

Centisome position: 30.22

GC content: 26.73

Gene sequence:

>318_bases
ATGGTAAAACATATAAATCAAGATGAATTTGAAAAGGAAGTAATAAATGAAGAAGGAGTAGTTGTTGTTGTTGATTTCTT
TGCAACTTGGTGTGGCCCTTGTAAAATGCTAGCACCAGTTTTGGATGAAGTACAAGATGAAATGAAGAATGTAAAAATAG
TTAAAATAGATATAGATGAAAATTCAGATAAGGCTTCTGAATATGGAGTTAAAAATATACCAACAATAAAAATATTTAAA
AATGGAGAAGAGATTACTACAAATGTAGGATTTGTACCTAAAAATTTATTAAAAGAGATGATAGAAAAAACTTTATAA

Upstream 100 bases:

>100_bases
GCCTAATTGTTAAAAAATTATATGTTGATAGAATTAAGCTAGAGATTAAAGAGATTCTGTTTTAGAGATGAAATATGAAT
TTAAAAATGGAGGTATGAAA

Downstream 100 bases:

>100_bases
TTACTTATTAAGTTATATAAATATTTATTTTGGATAGTCTTTTAGATATTAAGATATTTTTATCTGTTTAGTAGAAACTA
CTTTGAAATATGGTATATAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 105; Mature: 105

Protein sequence:

>105_residues
MVKHINQDEFEKEVINEEGVVVVVDFFATWCGPCKMLAPVLDEVQDEMKNVKIVKIDIDENSDKASEYGVKNIPTIKIFK
NGEEITTNVGFVPKNLLKEMIEKTL

Sequences:

>Translated_105_residues
MVKHINQDEFEKEVINEEGVVVVVDFFATWCGPCKMLAPVLDEVQDEMKNVKIVKIDIDENSDKASEYGVKNIPTIKIFK
NGEEITTNVGFVPKNLLKEMIEKTL
>Mature_105_residues
MVKHINQDEFEKEVINEEGVVVVVDFFATWCGPCKMLAPVLDEVQDEMKNVKIVKIDIDENSDKASEYGVKNIPTIKIFK
NGEEITTNVGFVPKNLLKEMIEKTL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI50592994, Length=91, Percent_Identity=40.6593406593407, Blast_Score=75, Evalue=9e-15,
Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=40.625, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI21361657, Length=91, Percent_Identity=36.2637362637363, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI20070125, Length=66, Percent_Identity=42.4242424242424, Blast_Score=68, Evalue=1e-12,
Organism=Homo sapiens, GI5031973, Length=87, Percent_Identity=41.3793103448276, Blast_Score=66, Evalue=5e-12,
Organism=Homo sapiens, GI38505222, Length=78, Percent_Identity=46.1538461538462, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=44.6601941747573, Blast_Score=107, Evalue=2e-25,
Organism=Escherichia coli, GI1788936, Length=113, Percent_Identity=35.3982300884956, Blast_Score=80, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71980562, Length=96, Percent_Identity=37.5, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71980565, Length=97, Percent_Identity=36.0824742268041, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=99, Percent_Identity=39.3939393939394, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=100, Percent_Identity=35, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=65, Percent_Identity=32.3076923076923, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=104, Percent_Identity=31.7307692307692, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=61, Percent_Identity=39.344262295082, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=76, Percent_Identity=44.7368421052632, Blast_Score=81, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=39.3258426966292, Blast_Score=79, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=75, Percent_Identity=42.6666666666667, Blast_Score=69, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24639826, Length=96, Percent_Identity=39.5833333333333, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17648013, Length=92, Percent_Identity=39.1304347826087, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583090, Length=92, Percent_Identity=39.1304347826087, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=37, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664269, Length=89, Percent_Identity=38.2022471910112, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21358065, Length=85, Percent_Identity=41.1764705882353, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24658597, Length=80, Percent_Identity=33.75, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921434, Length=84, Percent_Identity=40.4761904761905, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639068, Length=94, Percent_Identity=32.9787234042553, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11943; Mature: 11943

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKHINQDEFEKEVINEEGVVVVVDFFATWCGPCKMLAPVLDEVQDEMKNVKIVKIDIDE
CCCCCCHHHHHHHHCCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHCEEEEEEECCC
NSDKASEYGVKNIPTIKIFKNGEEITTNVGFVPKNLLKEMIEKTL
CCCCHHHCCCCCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVKHINQDEFEKEVINEEGVVVVVDFFATWCGPCKMLAPVLDEVQDEMKNVKIVKIDIDE
CCCCCCHHHHHHHHCCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHCEEEEEEECCC
NSDKASEYGVKNIPTIKIFKNGEEITTNVGFVPKNLLKEMIEKTL
CCCCHHHCCCCCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]