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The map label for this gene is naoX [H]

Identifier: 18309716

GI number: 18309716

Start: 909869

End: 911569

Strand: Direct

Name: naoX [H]

Synonym: CPE0734

Alternate gene names: 18309716

Gene position: 909869-911569 (Clockwise)

Preceding gene: 18309714

Following gene: 18309717

Centisome position: 30.01

GC content: 31.98

Gene sequence:

>1701_bases
ATGAGTAAAAAGATAGTTATTGTTGGAGGAGTAGCAGGTGGAGCTTCAACAGCAGCAAGACTTAGAAGATTAGATGAAAA
TAATCAAATAATAATGTTTGAAAGAGGTCCTCACGTATCCTTTTCAAACTGTTGTCTACCATACTATTTAAGTGGAAAAG
TTGAAAATCATGAAGATTTAGTTCTTATGACTCCTGAAAAATTTTATAGCCAATATAGAATTGATGCGAGAGTTTATACA
GAAGTAGTATCAATTAATAGAAAAGCTAAAGAAGTAACAGTAAGAAATGTAGTAAGTGGACAAGAATATACTGAAAGCTA
TGACAAATTAGTTCTTTCACCAGGAGCAAAGGCTATAGTACCACCAATAAAAGGAATTGAAGATGTTAATGTATTTACAG
TTAGAAATGTTGTGGATATAGCAAAATTAGATTCTTTTATAAAGGATAATAATAGTAAGAACATATCAGTAATAGGTGGA
GGATTTATAGGAGTTGAAGTTGCAGAGAATTTACATGAAGCTGGATATAACGTAACTTTAATAGAAGCAATGGATCAAAT
AATGAAGCCATTTGATTATGATATGGTTCAAGTTTTACATAAAGAAATGTATGATAAGGGCGTAAATTTAATAGTTGGAG
ATAAAGTAAGCTCTTTTGAAAGTGGAAAAGTAGTATTAGAATCAGGAAAGAAAATAAATTCAGATGCAGTTGTTATGGCT
ATAGGAGTTGCACCAGAAACAGATTTAGCTAGGGAAGCTGGGTTAGAAATTGGACAAACTGGAGCAATAAAAGTTAATCA
AAATTATTTAACTAATGATAAGGATATCTATGCAGTTGGAGATGCTGTGGAAGTTTATAATTCATTAACAAACTCAATAT
CTAGATTACCATTAGCGGGACCCGCACAAAAACAAGCGAGAGCAGTAGCAGATCATATACATGGAAGACCATCAAGAAAT
AGTGGATATATAGGTTCATCCTGTGTTCAAATATTTCATTATAATGGAGCTTCAACAGGCTTAACAGAAGGTCAAATAAA
AGCTATGAATTTAAGCTTAAACTATGATGTTGTAAGGGTTATACCTCAAGACAAGGTAGGATTAATGCCAGGAAGTGAGC
CATTACACTTTAAATTAATATTTGAAGTTCCAACAGGAAGAATTTTAGGAGCACAAGCAATTGGTAAAGGAAATGCAGAT
AAGAGAGTTGATATAATAGCTACCTTAATAAAAATGGGTGGAACTGTAGAAGACTTAAAAGATTTAGAGCTTTGTTATGC
TCCTCCTTTCGGAACAGCTAAGGATGTAGTAAATCATGCTGCATTAGTTGCATCAAATCTTTTAGAAGGAACATTTAAAC
AAGTTTATGTACATGAAGTAAGGGATTTAGTTGAAAGCGGAGCATGTATAATAGACGTTAGAGAAGTAAGTGAATATGAA
GCAGGACATATAAAAGGAGCCAAAAATCTTCCTTTAAGTGAAATAAGAGATAGATTAGATGAAATACCAACTGATAGACC
AGTTTATTTACATTGTAGAAGTGCTCAAAGAAGTTATAATGCATGTTTAGCATTACAACATTTAGGATTTGATAACATTT
ATAATGTATCAGGTGGATTCATGGGAATAAGCTTCTATGAATACTATAATGATAAAGTTCAAGATAGAGAGCCTATAGTT
ACAGAATATAATTTTAATTAG

Upstream 100 bases:

>100_bases
ATGATACTATCAAGTAGAGGTAATTAAATTACACACATATTAGATAAAAATTTAACAAAGAGAATTTGTTTAGATATTCA
CTAAGAAAGGTGGAAATATA

Downstream 100 bases:

>100_bases
AGTAAATACATGGTGTTTTAATTAATTTTAAAACACCATAGTAAAAAATAATATTATTAAAAATAAAATAGTTTGTTAAT
TAACAAATTAATAGGGGGAA

Product: pyridine nucleotide-disulphide oxidoreductase family protein

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MSKKIVIVGGVAGGASTAARLRRLDENNQIIMFERGPHVSFSNCCLPYYLSGKVENHEDLVLMTPEKFYSQYRIDARVYT
EVVSINRKAKEVTVRNVVSGQEYTESYDKLVLSPGAKAIVPPIKGIEDVNVFTVRNVVDIAKLDSFIKDNNSKNISVIGG
GFIGVEVAENLHEAGYNVTLIEAMDQIMKPFDYDMVQVLHKEMYDKGVNLIVGDKVSSFESGKVVLESGKKINSDAVVMA
IGVAPETDLAREAGLEIGQTGAIKVNQNYLTNDKDIYAVGDAVEVYNSLTNSISRLPLAGPAQKQARAVADHIHGRPSRN
SGYIGSSCVQIFHYNGASTGLTEGQIKAMNLSLNYDVVRVIPQDKVGLMPGSEPLHFKLIFEVPTGRILGAQAIGKGNAD
KRVDIIATLIKMGGTVEDLKDLELCYAPPFGTAKDVVNHAALVASNLLEGTFKQVYVHEVRDLVESGACIIDVREVSEYE
AGHIKGAKNLPLSEIRDRLDEIPTDRPVYLHCRSAQRSYNACLALQHLGFDNIYNVSGGFMGISFYEYYNDKVQDREPIV
TEYNFN

Sequences:

>Translated_566_residues
MSKKIVIVGGVAGGASTAARLRRLDENNQIIMFERGPHVSFSNCCLPYYLSGKVENHEDLVLMTPEKFYSQYRIDARVYT
EVVSINRKAKEVTVRNVVSGQEYTESYDKLVLSPGAKAIVPPIKGIEDVNVFTVRNVVDIAKLDSFIKDNNSKNISVIGG
GFIGVEVAENLHEAGYNVTLIEAMDQIMKPFDYDMVQVLHKEMYDKGVNLIVGDKVSSFESGKVVLESGKKINSDAVVMA
IGVAPETDLAREAGLEIGQTGAIKVNQNYLTNDKDIYAVGDAVEVYNSLTNSISRLPLAGPAQKQARAVADHIHGRPSRN
SGYIGSSCVQIFHYNGASTGLTEGQIKAMNLSLNYDVVRVIPQDKVGLMPGSEPLHFKLIFEVPTGRILGAQAIGKGNAD
KRVDIIATLIKMGGTVEDLKDLELCYAPPFGTAKDVVNHAALVASNLLEGTFKQVYVHEVRDLVESGACIIDVREVSEYE
AGHIKGAKNLPLSEIRDRLDEIPTDRPVYLHCRSAQRSYNACLALQHLGFDNIYNVSGGFMGISFYEYYNDKVQDREPIV
TEYNFN
>Mature_565_residues
SKKIVIVGGVAGGASTAARLRRLDENNQIIMFERGPHVSFSNCCLPYYLSGKVENHEDLVLMTPEKFYSQYRIDARVYTE
VVSINRKAKEVTVRNVVSGQEYTESYDKLVLSPGAKAIVPPIKGIEDVNVFTVRNVVDIAKLDSFIKDNNSKNISVIGGG
FIGVEVAENLHEAGYNVTLIEAMDQIMKPFDYDMVQVLHKEMYDKGVNLIVGDKVSSFESGKVVLESGKKINSDAVVMAI
GVAPETDLAREAGLEIGQTGAIKVNQNYLTNDKDIYAVGDAVEVYNSLTNSISRLPLAGPAQKQARAVADHIHGRPSRNS
GYIGSSCVQIFHYNGASTGLTEGQIKAMNLSLNYDVVRVIPQDKVGLMPGSEPLHFKLIFEVPTGRILGAQAIGKGNADK
RVDIIATLIKMGGTVEDLKDLELCYAPPFGTAKDVVNHAALVASNLLEGTFKQVYVHEVRDLVESGACIIDVREVSEYEA
GHIKGAKNLPLSEIRDRLDEIPTDRPVYLHCRSAQRSYNACLALQHLGFDNIYNVSGGFMGISFYEYYNDKVQDREPIVT
EYNFN

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=322, Percent_Identity=28.2608695652174, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI65787454, Length=322, Percent_Identity=28.2608695652174, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI226437568, Length=322, Percent_Identity=28.2608695652174, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI1789065, Length=320, Percent_Identity=28.75, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789765, Length=327, Percent_Identity=28.1345565749235, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788892, Length=283, Percent_Identity=26.1484098939929, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786307, Length=329, Percent_Identity=26.7477203647416, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787352, Length=279, Percent_Identity=26.5232974910394, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI87082354, Length=386, Percent_Identity=25.6476683937824, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=292, Percent_Identity=28.4246575342466, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24585130, Length=291, Percent_Identity=23.0240549828179, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639257, Length=293, Percent_Identity=23.5494880546075, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281359715, Length=293, Percent_Identity=23.5494880546075, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281359713, Length=293, Percent_Identity=23.5494880546075, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24639250, Length=293, Percent_Identity=23.5494880546075, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI18543267, Length=293, Percent_Identity=23.5494880546075, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24639252, Length=293, Percent_Identity=23.5494880546075, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 62170; Mature: 62038

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKIVIVGGVAGGASTAARLRRLDENNQIIMFERGPHVSFSNCCLPYYLSGKVENHEDL
CCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCE
VLMTPEKFYSQYRIDARVYTEVVSINRKAKEVTVRNVVSGQEYTESYDKLVLSPGAKAIV
EEECCHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHEEECCCCCEEC
PPIKGIEDVNVFTVRNVVDIAKLDSFIKDNNSKNISVIGGGFIGVEVAENLHEAGYNVTL
CCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCEEHHHHHHHHHHCCCCEEH
IEAMDQIMKPFDYDMVQVLHKEMYDKGVNLIVGDKVSSFESGKVVLESGKKINSDAVVMA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEECCCEECCCEEEEE
IGVAPETDLAREAGLEIGQTGAIKVNQNYLTNDKDIYAVGDAVEVYNSLTNSISRLPLAG
EECCCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCC
PAQKQARAVADHIHGRPSRNSGYIGSSCVQIFHYNGASTGLTEGQIKAMNLSLNYDVVRV
CHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEEECCCCCCCCCCEEEEEEEEECCEEEEE
IPQDKVGLMPGSEPLHFKLIFEVPTGRILGAQAIGKGNADKRVDIIATLIKMGGTVEDLK
CCCCCCCCCCCCCCEEEEEEEECCCCCEECCHHCCCCCCCCHHHHHHHHHHHCCCHHHHH
DLELCYAPPFGTAKDVVNHAALVASNLLEGTFKQVYVHEVRDLVESGACIIDVREVSEYE
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCC
AGHIKGAKNLPLSEIRDRLDEIPTDRPVYLHCRSAQRSYNACLALQHLGFDNIYNVSGGF
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEECCCCE
MGISFYEYYNDKVQDREPIVTEYNFN
EEEEHHHHHCCCCCCCCCEEEECCCC
>Mature Secondary Structure 
SKKIVIVGGVAGGASTAARLRRLDENNQIIMFERGPHVSFSNCCLPYYLSGKVENHEDL
CCEEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCE
VLMTPEKFYSQYRIDARVYTEVVSINRKAKEVTVRNVVSGQEYTESYDKLVLSPGAKAIV
EEECCHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHEEECCCCCEEC
PPIKGIEDVNVFTVRNVVDIAKLDSFIKDNNSKNISVIGGGFIGVEVAENLHEAGYNVTL
CCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCEEHHHHHHHHHHCCCCEEH
IEAMDQIMKPFDYDMVQVLHKEMYDKGVNLIVGDKVSSFESGKVVLESGKKINSDAVVMA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEECCCEECCCEEEEE
IGVAPETDLAREAGLEIGQTGAIKVNQNYLTNDKDIYAVGDAVEVYNSLTNSISRLPLAG
EECCCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCC
PAQKQARAVADHIHGRPSRNSGYIGSSCVQIFHYNGASTGLTEGQIKAMNLSLNYDVVRV
CHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEEECCCCCCCCCCEEEEEEEEECCEEEEE
IPQDKVGLMPGSEPLHFKLIFEVPTGRILGAQAIGKGNADKRVDIIATLIKMGGTVEDLK
CCCCCCCCCCCCCCEEEEEEEECCCCCEECCHHCCCCCCCCHHHHHHHHHHHCCCHHHHH
DLELCYAPPFGTAKDVVNHAALVASNLLEGTFKQVYVHEVRDLVESGACIIDVREVSEYE
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCC
AGHIKGAKNLPLSEIRDRLDEIPTDRPVYLHCRSAQRSYNACLALQHLGFDNIYNVSGGF
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEECCCCE
MGISFYEYYNDKVQDREPIVTEYNFN
EEEEHHHHHCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA