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The map label for this gene is purM [H]

Identifier: 18309666

GI number: 18309666

Start: 852104

End: 853105

Strand: Direct

Name: purM [H]

Synonym: CPE0684

Alternate gene names: 18309666

Gene position: 852104-853105 (Clockwise)

Preceding gene: 18309665

Following gene: 18309667

Centisome position: 28.11

GC content: 31.64

Gene sequence:

>1002_bases
ATGCTAACTTACAAAGAAGCAGGAGTAAATATTGAAGAAGGATATAGATCAGTAAAATTAATAAAAGAATATGCAAAAAA
AACAATGAGTGAATATGTATTAAATGGATTAGGATCTTTTGCTGGCATGATTGAACTTCCAGAGGGATATAAAAAACCAG
TTTTAGTTTCTGGAACAGATGGAGTGGGAACAAAACTTGATATTGCTTGTAAGAAAAGAAAGTTTGATACTGTTGGAATT
GACTGTGTTGCAATGTGTGTCAATGATATTTTATGTCATGGTGCTAAACCATTATTCTTCTTAGATTATATAGCTTGTGG
AAAACTTGAAGCTGAGGTTTCTTCTGATTTGGTAAAGGGAGTAGCTGAAGGATGTATTAAGTCTCAGTGCTCTTTAATTG
GAGGAGAAACTGCTGAAATGCCAGGTATGTATAAAGAAGGAGACTATGATATTGCTGGTTTTGCAGTAGGAATAGTAGAC
AAGGATAAAATAATAAATGGTAAAGATATAAAGAGTGGTGACAAGCTTATAGGAATTGCTTCTTCAGGAGTTCATTCAAA
TGGATATTCTCTTATAAGAAAGGTGTTTAAAAACTTAGATGAAGATTTTAATGGAAAAGCTATTTGGGAAGAATTATTAA
CTCCTACAAAGATTTATGTTAAACCTGTATTAAGTCTTTTAGAAAAATTTAATATTAAGGGTATGGCTCATGTAACTGGG
GGAGGATTTTATGAAAATCTTCCAAGAATGTTAAGTAAAGAAGGACTTAGTATAGTAATAAATAAAAATAGCTATGAGAT
TCCAGAAATATTTAAAAAGCTTATGGAACTTGGAGTTAAAGAAGAGGAAATGTATAACACTTTCAACATGGGTATAGGGT
TTGTTTTATGTGTTGAGGAAGATGAGGTTGAAGAAGTTTTAAAAGAACTTTCAAAGCAAGGAGAAAAAGCTTTTGAGATT
GGGTATATAAATGCTGGAGGTGAAGGAGTTTGTATAAAATAG

Upstream 100 bases:

>100_bases
AGGTAGAAGAAATTTCTGTGTAGGATGCTTTAGTGGGGTTTATCCAGTTGCAGCGCCTATGGAAGCTTTAGAGGATAATC
TTGAAAGGGTGGAGAATTAA

Downstream 100 bases:

>100_bases
CTGTATTAGCTTCTGGCAGTGGATCTAACCTTCAATCAATTTTAGATAATATAAATAATGGGAATATAAAGGGAGAAGTT
TCTTTGGTTATTGGAAGTAA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MLTYKEAGVNIEEGYRSVKLIKEYAKKTMSEYVLNGLGSFAGMIELPEGYKKPVLVSGTDGVGTKLDIACKKRKFDTVGI
DCVAMCVNDILCHGAKPLFFLDYIACGKLEAEVSSDLVKGVAEGCIKSQCSLIGGETAEMPGMYKEGDYDIAGFAVGIVD
KDKIINGKDIKSGDKLIGIASSGVHSNGYSLIRKVFKNLDEDFNGKAIWEELLTPTKIYVKPVLSLLEKFNIKGMAHVTG
GGFYENLPRMLSKEGLSIVINKNSYEIPEIFKKLMELGVKEEEMYNTFNMGIGFVLCVEEDEVEEVLKELSKQGEKAFEI
GYINAGGEGVCIK

Sequences:

>Translated_333_residues
MLTYKEAGVNIEEGYRSVKLIKEYAKKTMSEYVLNGLGSFAGMIELPEGYKKPVLVSGTDGVGTKLDIACKKRKFDTVGI
DCVAMCVNDILCHGAKPLFFLDYIACGKLEAEVSSDLVKGVAEGCIKSQCSLIGGETAEMPGMYKEGDYDIAGFAVGIVD
KDKIINGKDIKSGDKLIGIASSGVHSNGYSLIRKVFKNLDEDFNGKAIWEELLTPTKIYVKPVLSLLEKFNIKGMAHVTG
GGFYENLPRMLSKEGLSIVINKNSYEIPEIFKKLMELGVKEEEMYNTFNMGIGFVLCVEEDEVEEVLKELSKQGEKAFEI
GYINAGGEGVCIK
>Mature_333_residues
MLTYKEAGVNIEEGYRSVKLIKEYAKKTMSEYVLNGLGSFAGMIELPEGYKKPVLVSGTDGVGTKLDIACKKRKFDTVGI
DCVAMCVNDILCHGAKPLFFLDYIACGKLEAEVSSDLVKGVAEGCIKSQCSLIGGETAEMPGMYKEGDYDIAGFAVGIVD
KDKIINGKDIKSGDKLIGIASSGVHSNGYSLIRKVFKNLDEDFNGKAIWEELLTPTKIYVKPVLSLLEKFNIKGMAHVTG
GGFYENLPRMLSKEGLSIVINKNSYEIPEIFKKLMELGVKEEEMYNTFNMGIGFVLCVEEDEVEEVLKELSKQGEKAFEI
GYINAGGEGVCIK

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=339, Percent_Identity=47.1976401179941, Blast_Score=297, Evalue=7e-81,
Organism=Homo sapiens, GI209869995, Length=339, Percent_Identity=47.1976401179941, Blast_Score=297, Evalue=7e-81,
Organism=Homo sapiens, GI209869993, Length=339, Percent_Identity=47.1976401179941, Blast_Score=297, Evalue=7e-81,
Organism=Escherichia coli, GI1788845, Length=330, Percent_Identity=50.6060606060606, Blast_Score=342, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17567511, Length=345, Percent_Identity=42.8985507246377, Blast_Score=257, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6321203, Length=336, Percent_Identity=42.8571428571429, Blast_Score=278, Evalue=6e-76,
Organism=Drosophila melanogaster, GI24582400, Length=293, Percent_Identity=44.3686006825939, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36454; Mature: 36454

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYKEAGVNIEEGYRSVKLIKEYAKKTMSEYVLNGLGSFAGMIELPEGYKKPVLVSGTD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCEEEECCC
GVGTKLDIACKKRKFDTVGIDCVAMCVNDILCHGAKPLFFLDYIACGKLEAEVSSDLVKG
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
VAEGCIKSQCSLIGGETAEMPGMYKEGDYDIAGFAVGIVDKDKIINGKDIKSGDKLIGIA
HHHHHHHHHHHHCCCCCHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEE
SSGVHSNGYSLIRKVFKNLDEDFNGKAIWEELLTPTKIYVKPVLSLLEKFNIKGMAHVTG
CCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECC
GGFYENLPRMLSKEGLSIVINKNSYEIPEIFKKLMELGVKEEEMYNTFNMGIGFVLCVEE
CHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECH
DEVEEVLKELSKQGEKAFEIGYINAGGEGVCIK
HHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEC
>Mature Secondary Structure
MLTYKEAGVNIEEGYRSVKLIKEYAKKTMSEYVLNGLGSFAGMIELPEGYKKPVLVSGTD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCEEEECCC
GVGTKLDIACKKRKFDTVGIDCVAMCVNDILCHGAKPLFFLDYIACGKLEAEVSSDLVKG
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
VAEGCIKSQCSLIGGETAEMPGMYKEGDYDIAGFAVGIVDKDKIINGKDIKSGDKLIGIA
HHHHHHHHHHHHCCCCCHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEE
SSGVHSNGYSLIRKVFKNLDEDFNGKAIWEELLTPTKIYVKPVLSLLEKFNIKGMAHVTG
CCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECC
GGFYENLPRMLSKEGLSIVINKNSYEIPEIFKKLMELGVKEEEMYNTFNMGIGFVLCVEE
CHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECH
DEVEEVLKELSKQGEKAFEIGYINAGGEGVCIK
HHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA