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The map label for this gene is trpS

Identifier: 18309615

GI number: 18309615

Start: 794912

End: 795910

Strand: Direct

Name: trpS

Synonym: CPE0633

Alternate gene names: 18309615

Gene position: 794912-795910 (Clockwise)

Preceding gene: 18309611

Following gene: 18309616

Centisome position: 26.22

GC content: 31.03

Gene sequence:

>999_bases
ATGGAAGATAAGAAAAAAATTATTTTTAGTGGAATAAAGCCATCAGGTGATTTAACATTAGGAAATTACTTAGGCGCTAT
AAAAAACTGGACTAAATTACAAGAAGAATATGATTGTTATTTCTGCGTTGTTGATTTACATGCCATAACAGTAAAACAAT
TACCAGCAGATTTAAGAAGAAGAACTTTAGAAGTTTTAGCTATATATATAGCATCAGGAATAAATCCAGAGGAAAATACA
TTATTTATCCAATCACATGTACCAGCTCATTCAGAAGCTTCATGGCTTTTAACATGTAATTCATATATGGGTGAATTAAG
CAGAATGACTCAGTATAAAGATAAATCAAAGAAAATGGGAGATTCAATAGGGGCAGGATTATTTAATTATCCAGTTCTTA
TGGCAGCTGACATACTTTTATATAATGCAGATCTTGTTCCAGTGGGAAAAGACCAAATGCAACATTTAGAGCTTGCTAGA
GATATTGGTACTAGATTTAACAATTCTTATAGCAAAACATTCACTATACCAGAGGGATATGTTCCAAAAGAGGGAGCAAA
AATAATGGATTTACAAGATCCAAGCAAAAAGATGTCTAAGTCAGATGCTAATCCAAATGGTTTCATATTAATAATGGATG
AACCTAATGTTATAAGAAAGAAAATTTCAAGAGCTGTAACAGATAGTATAGGTATTGTAAATTATACTGATGAACAGCCA
GGAGTTAAGAATTTAATAAATATTCTTTGTGCAATAAAAGGATATACTCCTGATGAAGTTGTAAAAATGTATGATGGCAA
AGGATATGCTGAATTTAAAAATGATGTAGCGGAAGCTATAGTTGAAGAGTTAGCTCCAGTTCAAGAAAAGGTTAAAGCTT
TATTAGGAGATAAAAAAGCTTTAGAGGAAATATACAAAAAGGGTGCAGAAAAAGCAAATTATGCTGCAATGAAAACTCTT
AGAAAAATGCAAAAGAAAATAGGATTAATCCCAAGATAG

Upstream 100 bases:

>100_bases
AAAGAAAATAGCTATTTAAGAAATAAAGAGATTAATTAAATTTTTATAAAGGAGGTGTATCTGATACTTCATTTGATTTT
TAGAAGCATCAGAAAAACTA

Downstream 100 bases:

>100_bases
GAATTAAAACTCTAAAATAGAAAATTCATCATATATAGCTTAAAGATTATTGAATTTCATGAAGAATTTTTATTGTTTTT
TACATGAATTTATCTAAATC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MEDKKKIIFSGIKPSGDLTLGNYLGAIKNWTKLQEEYDCYFCVVDLHAITVKQLPADLRRRTLEVLAIYIASGINPEENT
LFIQSHVPAHSEASWLLTCNSYMGELSRMTQYKDKSKKMGDSIGAGLFNYPVLMAADILLYNADLVPVGKDQMQHLELAR
DIGTRFNNSYSKTFTIPEGYVPKEGAKIMDLQDPSKKMSKSDANPNGFILIMDEPNVIRKKISRAVTDSIGIVNYTDEQP
GVKNLINILCAIKGYTPDEVVKMYDGKGYAEFKNDVAEAIVEELAPVQEKVKALLGDKKALEEIYKKGAEKANYAAMKTL
RKMQKKIGLIPR

Sequences:

>Translated_332_residues
MEDKKKIIFSGIKPSGDLTLGNYLGAIKNWTKLQEEYDCYFCVVDLHAITVKQLPADLRRRTLEVLAIYIASGINPEENT
LFIQSHVPAHSEASWLLTCNSYMGELSRMTQYKDKSKKMGDSIGAGLFNYPVLMAADILLYNADLVPVGKDQMQHLELAR
DIGTRFNNSYSKTFTIPEGYVPKEGAKIMDLQDPSKKMSKSDANPNGFILIMDEPNVIRKKISRAVTDSIGIVNYTDEQP
GVKNLINILCAIKGYTPDEVVKMYDGKGYAEFKNDVAEAIVEELAPVQEKVKALLGDKKALEEIYKKGAEKANYAAMKTL
RKMQKKIGLIPR
>Mature_332_residues
MEDKKKIIFSGIKPSGDLTLGNYLGAIKNWTKLQEEYDCYFCVVDLHAITVKQLPADLRRRTLEVLAIYIASGINPEENT
LFIQSHVPAHSEASWLLTCNSYMGELSRMTQYKDKSKKMGDSIGAGLFNYPVLMAADILLYNADLVPVGKDQMQHLELAR
DIGTRFNNSYSKTFTIPEGYVPKEGAKIMDLQDPSKKMSKSDANPNGFILIMDEPNVIRKKISRAVTDSIGIVNYTDEQP
GVKNLINILCAIKGYTPDEVVKMYDGKGYAEFKNDVAEAIVEELAPVQEKVKALLGDKKALEEIYKKGAEKANYAAMKTL
RKMQKKIGLIPR

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=331, Percent_Identity=41.9939577039275, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI41352700, Length=179, Percent_Identity=49.7206703910614, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1789786, Length=331, Percent_Identity=49.8489425981873, Blast_Score=355, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI71982800, Length=333, Percent_Identity=36.3363363363363, Blast_Score=200, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71982793, Length=333, Percent_Identity=36.3363363363363, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320474, Length=343, Percent_Identity=40.8163265306122, Blast_Score=233, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24666151, Length=325, Percent_Identity=39.6923076923077, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_CLOPE (Q8XMQ5)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_561549.1
- ProteinModelPortal:   Q8XMQ5
- SMR:   Q8XMQ5
- GeneID:   988891
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE0633
- NMPDR:   fig|195102.1.peg.696
- HOGENOM:   HBG293263
- OMA:   NKPGVSN
- PhylomeDB:   Q8XMQ5
- ProtClustDB:   PRK00927
- BioCyc:   CPER195102:CPE0633-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 37159; Mature: 37159

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS00962 RIBOSOMAL_S2_1

Important sites: BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDKKKIIFSGIKPSGDLTLGNYLGAIKNWTKLQEEYDCYFCVVDLHAITVKQLPADLRR
CCCCCCEEEECCCCCCCEEHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHH
RTLEVLAIYIASGINPEENTLFIQSHVPAHSEASWLLTCNSYMGELSRMTQYKDKSKKMG
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
DSIGAGLFNYPVLMAADILLYNADLVPVGKDQMQHLELARDIGTRFNNSYSKTFTIPEGY
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
VPKEGAKIMDLQDPSKKMSKSDANPNGFILIMDEPNVIRKKISRAVTDSIGIVNYTDEQP
CCCCCCEEECCCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCC
GVKNLINILCAIKGYTPDEVVKMYDGKGYAEFKNDVAEAIVEELAPVQEKVKALLGDKKA
CHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LEEIYKKGAEKANYAAMKTLRKMQKKIGLIPR
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEDKKKIIFSGIKPSGDLTLGNYLGAIKNWTKLQEEYDCYFCVVDLHAITVKQLPADLRR
CCCCCCEEEECCCCCCCEEHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHH
RTLEVLAIYIASGINPEENTLFIQSHVPAHSEASWLLTCNSYMGELSRMTQYKDKSKKMG
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
DSIGAGLFNYPVLMAADILLYNADLVPVGKDQMQHLELARDIGTRFNNSYSKTFTIPEGY
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
VPKEGAKIMDLQDPSKKMSKSDANPNGFILIMDEPNVIRKKISRAVTDSIGIVNYTDEQP
CCCCCCEEECCCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCC
GVKNLINILCAIKGYTPDEVVKMYDGKGYAEFKNDVAEAIVEELAPVQEKVKALLGDKKA
CHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LEEIYKKGAEKANYAAMKTLRKMQKKIGLIPR
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842