Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 18309577

GI number: 18309577

Start: 743070

End: 744470

Strand: Direct

Name: lysA [H]

Synonym: CPE0595

Alternate gene names: 18309577

Gene position: 743070-744470 (Clockwise)

Preceding gene: 18309576

Following gene: 18309578

Centisome position: 24.51

GC content: 30.84

Gene sequence:

>1401_bases
GTGTTCCTTTGCTGTTTTTATTTATTGGAATTAAATGCCAGGAGAGTCGGTAGCTTTGCATACTTTTATACTCTGCCACT
AAAAAAGTTTGTGGAGGGAAAAGATATGAAATTATTTGGATCAATGAAAGTAGAAGAAAATGAGTTATATGTTGGAGGAG
TAAAAGCAAGTGCTTTAAGCAAGGAATATGGAACTCCTTTATATGTTATTGATGAAGAGTTAGTGAGAAGCAATTGTAGA
AGATACTATAATGCTATGAAGTGTGAAGAAATAGGAAACAGAGTTACCTATGCAGGAAAGGCATTTATAAATATGTCCAT
GTGCAATTTAGTTAATGAAGAAAATTTATATTTAGATGTTGTTTCAGGTGGAGAGCTTTATACTGCTTATAAAGCAGGTT
TCCCATTAGAAAGAATATATTTCCATGGTAACAATAAATCTGATTATGAAATAGATTTAGGAGTAAGATTAGGAATTGGA
AGATTTATAGTTGATAATATTCATGAACTAGAAGTTCTTAATTCTATAGCTCAAGAATATGGAAGAGTTCAAAAAGTTTA
TTTGAGAATAACTCCTGGAGTAGAGGCCCATACCCATGAATATATAAAAACAGGTCAATTGGACTCAAAATTTGGATTCC
CTGTAATTGGTGATACAGTTTATGACGCTATTAAAAGAGCAATGGAATTAGAGTATATAGAACTTAATGGATTGCATTGT
CATATAGGTTCGCAAATATTTGACTTAGAACCTTTTGAAGATACAACAGAAATTATGCTAAATCTTATAAATGATATAAA
AGAAACCTTAGGATATGAAATAAAAGAATTAGACTTAGGTGGAGGATTTGGTATATATTACACTGAAGGAGATAAGCCAA
AAGAAATAGAAGAATATTGTTCAGTTATAATAAATAAAGCTGATGAAATATGCAGAAAGTTAAATATGAATGTTCCTATA
TTAAGTATAGAGCCAGGAAGAAGTATTGTAGGGAATGCAGGATTAACTCTTTATACTGTAGGAGCTATAAAAGAAATTCC
TAATATAAGAAAATATGTAAGTGTAGATGGTGGAATGAGTGATAATATAAGACCAGCCTTATACAGTGCAAATTATGAAT
CATTAATAGCTAACAGAGTTTTTGATAATTCTAAGGAGATAGTTACTGTGGCAGGAAAATGCTGTGAATCAGGGGATGTA
CTTTTAAATTCTATAGAGATGCCTAGAATGGAAACTGGAGATATATTAGCTATAATGTCTACAGGAGCATATGGACATTC
AATGGCTAATAATTATAATAGAATCCCTAAGGCGGCAGTTGTAAGTGTAAGTAATGGAATTTCAAAAGTTATGTGTAAAA
GAGAAACTTATGAAGATTTGCTTAGAAATGAATGTTTTTAA

Upstream 100 bases:

>100_bases
GATTAATATTTCTGGGTATATGTATAATATGCATATAACTGTCACTTTGAAAAAAGTGGAGTGCTACAAGGTACGCTAAG
TTGCGATTAAGGCAGCAAAG

Downstream 100 bases:

>100_bases
TTAATATAAAAGTTGTATGGTAAAAAAACTATACAACTTTTTTTATTAAAAGTATTTAGAATAATGTATTAAAGTATATA
ATAAAAGTGAAGGATAATAA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MFLCCFYLLELNARRVGSFAYFYTLPLKKFVEGKDMKLFGSMKVEENELYVGGVKASALSKEYGTPLYVIDEELVRSNCR
RYYNAMKCEEIGNRVTYAGKAFINMSMCNLVNEENLYLDVVSGGELYTAYKAGFPLERIYFHGNNKSDYEIDLGVRLGIG
RFIVDNIHELEVLNSIAQEYGRVQKVYLRITPGVEAHTHEYIKTGQLDSKFGFPVIGDTVYDAIKRAMELEYIELNGLHC
HIGSQIFDLEPFEDTTEIMLNLINDIKETLGYEIKELDLGGGFGIYYTEGDKPKEIEEYCSVIINKADEICRKLNMNVPI
LSIEPGRSIVGNAGLTLYTVGAIKEIPNIRKYVSVDGGMSDNIRPALYSANYESLIANRVFDNSKEIVTVAGKCCESGDV
LLNSIEMPRMETGDILAIMSTGAYGHSMANNYNRIPKAAVVSVSNGISKVMCKRETYEDLLRNECF

Sequences:

>Translated_466_residues
MFLCCFYLLELNARRVGSFAYFYTLPLKKFVEGKDMKLFGSMKVEENELYVGGVKASALSKEYGTPLYVIDEELVRSNCR
RYYNAMKCEEIGNRVTYAGKAFINMSMCNLVNEENLYLDVVSGGELYTAYKAGFPLERIYFHGNNKSDYEIDLGVRLGIG
RFIVDNIHELEVLNSIAQEYGRVQKVYLRITPGVEAHTHEYIKTGQLDSKFGFPVIGDTVYDAIKRAMELEYIELNGLHC
HIGSQIFDLEPFEDTTEIMLNLINDIKETLGYEIKELDLGGGFGIYYTEGDKPKEIEEYCSVIINKADEICRKLNMNVPI
LSIEPGRSIVGNAGLTLYTVGAIKEIPNIRKYVSVDGGMSDNIRPALYSANYESLIANRVFDNSKEIVTVAGKCCESGDV
LLNSIEMPRMETGDILAIMSTGAYGHSMANNYNRIPKAAVVSVSNGISKVMCKRETYEDLLRNECF
>Mature_466_residues
MFLCCFYLLELNARRVGSFAYFYTLPLKKFVEGKDMKLFGSMKVEENELYVGGVKASALSKEYGTPLYVIDEELVRSNCR
RYYNAMKCEEIGNRVTYAGKAFINMSMCNLVNEENLYLDVVSGGELYTAYKAGFPLERIYFHGNNKSDYEIDLGVRLGIG
RFIVDNIHELEVLNSIAQEYGRVQKVYLRITPGVEAHTHEYIKTGQLDSKFGFPVIGDTVYDAIKRAMELEYIELNGLHC
HIGSQIFDLEPFEDTTEIMLNLINDIKETLGYEIKELDLGGGFGIYYTEGDKPKEIEEYCSVIINKADEICRKLNMNVPI
LSIEPGRSIVGNAGLTLYTVGAIKEIPNIRKYVSVDGGMSDNIRPALYSANYESLIANRVFDNSKEIVTVAGKCCESGDV
LLNSIEMPRMETGDILAIMSTGAYGHSMANNYNRIPKAAVVSVSNGISKVMCKRETYEDLLRNECF

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=419, Percent_Identity=29.3556085918854, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 52441; Mature: 52441

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLCCFYLLELNARRVGSFAYFYTLPLKKFVEGKDMKLFGSMKVEENELYVGGVKASALS
CCEEEEEHHHHCCHHHCCEEEEEEECHHHHHCCCCEEEEECEEEECCEEEEECCCHHHHH
KEYGTPLYVIDEELVRSNCRRYYNAMKCEEIGNRVTYAGKAFINMSMCNLVNEENLYLDV
HHHCCEEEEECHHHHHHHHHHHHHHHHHHHHCCEEEECCHHEEEEHHHHHCCCCCEEEEE
VSGGELYTAYKAGFPLERIYFHGNNKSDYEIDLGVRLGIGRFIVDNIHELEVLNSIAQEY
ECCCCEEEEECCCCCEEEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
GRVQKVYLRITPGVEAHTHEYIKTGQLDSKFGFPVIGDTVYDAIKRAMELEYIELNGLHC
CCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHEEEEEEECCEEE
HIGSQIFDLEPFEDTTEIMLNLINDIKETLGYEIKELDLGGGFGIYYTEGDKPKEIEEYC
ECCCEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCCCHHHHHHH
SVIINKADEICRKLNMNVPILSIEPGRSIVGNAGLTLYTVGAIKEIPNIRKYVSVDGGMS
HHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCEEEEEEHHHHHCCCCHHEEEECCCCC
DNIRPALYSANYESLIANRVFDNSKEIVTVAGKCCESGDVLLNSIEMPRMETGDILAIMS
CCCCCEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCEEEEEE
TGAYGHSMANNYNRIPKAAVVSVSNGISKVMCKRETYEDLLRNECF
CCCCCHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFLCCFYLLELNARRVGSFAYFYTLPLKKFVEGKDMKLFGSMKVEENELYVGGVKASALS
CCEEEEEHHHHCCHHHCCEEEEEEECHHHHHCCCCEEEEECEEEECCEEEEECCCHHHHH
KEYGTPLYVIDEELVRSNCRRYYNAMKCEEIGNRVTYAGKAFINMSMCNLVNEENLYLDV
HHHCCEEEEECHHHHHHHHHHHHHHHHHHHHCCEEEECCHHEEEEHHHHHCCCCCEEEEE
VSGGELYTAYKAGFPLERIYFHGNNKSDYEIDLGVRLGIGRFIVDNIHELEVLNSIAQEY
ECCCCEEEEECCCCCEEEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
GRVQKVYLRITPGVEAHTHEYIKTGQLDSKFGFPVIGDTVYDAIKRAMELEYIELNGLHC
CCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHEEEEEEECCEEE
HIGSQIFDLEPFEDTTEIMLNLINDIKETLGYEIKELDLGGGFGIYYTEGDKPKEIEEYC
ECCCEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCCCHHHHHHH
SVIINKADEICRKLNMNVPILSIEPGRSIVGNAGLTLYTVGAIKEIPNIRKYVSVDGGMS
HHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCEEEEEEHHHHHCCCCHHEEEECCCCC
DNIRPALYSANYESLIANRVFDNSKEIVTVAGKCCESGDVLLNSIEMPRMETGDILAIMS
CCCCCEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCEEEEEE
TGAYGHSMANNYNRIPKAAVVSVSNGISKVMCKRETYEDLLRNECF
CCCCCHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]