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The map label for this gene is betA [H]

Identifier: 17548062

GI number: 17548062

Start: 3605487

End: 3607121

Strand: Reverse

Name: betA [H]

Synonym: RSc3345

Alternate gene names: 17548062

Gene position: 3607121-3605487 (Counterclockwise)

Preceding gene: 17548063

Following gene: 17548061

Centisome position: 97.06

GC content: 70.46

Gene sequence:

>1635_bases
ATGGAGACCTACGACTACATCATCATCGGCGCGGGCTCGGCGGGCTGCGTCCTGGCCAATCGCCTGACGCTGGATCCGGA
GGTGTCGGTGCTGCTGCTGGAGGCCGGCGGCAAGGACGACTATCACTGGATCCACATCCCCGTCGGCTACCTGTATTGCA
TCGGCAACCCGCGCACTGACTGGCTGTATCGCACGCAGGCCGAGCCGGGCCTGAACGGCCGTTCGCTGGGGTATCCGCGC
GGCCGCGTGCTGGGCGGCTGCTCGTCGATCAACGGGATGATCTACATGCGCGGCCAGCGCGAGGACTACGACGGCTGGGC
GGCGTTGACCGGTGACGATTCGTGGAGGTGGGACGCGGTGCTGCCGTTCTTCAAGGCCTCGGAGCATTACCACGGCGGTG
CCGACGCCTGGCACGGCGCCGGCGGCGAATGGCGGGTGGAGCCGCAGCGGCTGCACTGGCAGATCCTGGAGAGCTTCATC
GAGGCGGCGGTGCAGGCCGGCATTCCGCGCACGGAGGATTTCAACCGCGGCGACAACTTCGGCGTGGGCTACTTCGAGGT
CAACCAGAAGCGTGGCATCCGCTGGAACACGGCCAAGGGGTTCCTGCGGCCGGCGTCGCAGCGGCCGAACCTGACCATCG
TGACCGGGGCGCAGGTGCGGGCGCTGACTTTCGACGGCAGGCGCTGCACGGGCGTGACGTATCGCGGTGCGGGGCAGGAC
TACGCGGCGGCCGCGCGCGAAGAGGTCGTGCTGTCGGCGGGCGCGGTCAACTCGCCGCAGTTGCTGGAGCTGTCGGGCAT
CGGGCAGCCGCAGCGGCTGCAGGCACTGGGTATCGCCGTGCGCTGCGCGCTGCCCGGCGTCGGCGAGAACCTGCAGGACC
ACCTGCAACTGCGCAGCGTGATCAAGGTGCACGGCGTGCCGACGCTCAATACGCGCGCCGCCAGCTGGTGGGGCAAGGCC
ATGATCGGCATGCAGTACGCCTTCAACCGGAGCGGGCCGATGAGCATGGCGCCGTCGCAACTGGGCGCGTTCGCCCGGTC
CGATCCGTCCGTGGCGCGGCCGGATGTGGAGTACCACGTGCAGCCGCTGTCGCTCGACAAGTTCGGCGATCCGCTGCACG
CCTTCAATGCGTTCACGGCCAGCGTCTGCAACCTGCGGCCGACCTCGCGCGGCACGGTGCATCTCGCCTCGGCCGATCCG
TTCGCCGCGCCGGTCATCGCGCCCAACTATCTGTCGACGGACGCCGACCGCAAGGTCGCCGCCGCTTCGCTGCGCCTGAC
GCGCCGCATCGTGTCGCAGCCGGCGCTGGCCAGGTACCGGCCGGAGGAATATCTGCCCGGCGCGGCGCTCCAGACCGACG
AAGACCTCGCGCGCGCCGCCGGCGATATCGGCACGACCATCTTCCACCCGGTCGGCACCTGCCGCATGGGCCGGGCGGAC
GACGCCGGCGCGGTGGTCGACGCGCAGCTGCGGGTACGCGGCATCGAGGGCCTGCGCGTGGTCGACGCATCCGTCATGCC
GACCATCACCTCCGGCAACACCAACTCGCCGACCATCATGATCGCGGAGAAGGCCGGCGAGATGATCCGCGCGGCGCGGC
GGGCCCGTGCGCGGGGCGAGGCCGTGCCGGCCTGA

Upstream 100 bases:

>100_bases
GGGACGATGCGGGCGTGGCTGGCCGGGCGGATCTGAGCCCGGGGGGGCCGGGCCACCGGCGATCGGACAAGAACAAAACA
CCCAAGAGCAGGCAGGAGAC

Downstream 100 bases:

>100_bases
CGGGTTTCGACACGGCCGTGACATGACGGCCGTGTCATATGGATGGGCCCTCGGCGAGGCCCCGATACGTAACTCTACGT
AAGCCCTTCGGCGGGCCGCA

Product: choline dehydrogenase lipoprotein oxidoreductase

Products: betaine aldehyde; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
METYDYIIIGAGSAGCVLANRLTLDPEVSVLLLEAGGKDDYHWIHIPVGYLYCIGNPRTDWLYRTQAEPGLNGRSLGYPR
GRVLGGCSSINGMIYMRGQREDYDGWAALTGDDSWRWDAVLPFFKASEHYHGGADAWHGAGGEWRVEPQRLHWQILESFI
EAAVQAGIPRTEDFNRGDNFGVGYFEVNQKRGIRWNTAKGFLRPASQRPNLTIVTGAQVRALTFDGRRCTGVTYRGAGQD
YAAAAREEVVLSAGAVNSPQLLELSGIGQPQRLQALGIAVRCALPGVGENLQDHLQLRSVIKVHGVPTLNTRAASWWGKA
MIGMQYAFNRSGPMSMAPSQLGAFARSDPSVARPDVEYHVQPLSLDKFGDPLHAFNAFTASVCNLRPTSRGTVHLASADP
FAAPVIAPNYLSTDADRKVAAASLRLTRRIVSQPALARYRPEEYLPGAALQTDEDLARAAGDIGTTIFHPVGTCRMGRAD
DAGAVVDAQLRVRGIEGLRVVDASVMPTITSGNTNSPTIMIAEKAGEMIRAARRARARGEAVPA

Sequences:

>Translated_544_residues
METYDYIIIGAGSAGCVLANRLTLDPEVSVLLLEAGGKDDYHWIHIPVGYLYCIGNPRTDWLYRTQAEPGLNGRSLGYPR
GRVLGGCSSINGMIYMRGQREDYDGWAALTGDDSWRWDAVLPFFKASEHYHGGADAWHGAGGEWRVEPQRLHWQILESFI
EAAVQAGIPRTEDFNRGDNFGVGYFEVNQKRGIRWNTAKGFLRPASQRPNLTIVTGAQVRALTFDGRRCTGVTYRGAGQD
YAAAAREEVVLSAGAVNSPQLLELSGIGQPQRLQALGIAVRCALPGVGENLQDHLQLRSVIKVHGVPTLNTRAASWWGKA
MIGMQYAFNRSGPMSMAPSQLGAFARSDPSVARPDVEYHVQPLSLDKFGDPLHAFNAFTASVCNLRPTSRGTVHLASADP
FAAPVIAPNYLSTDADRKVAAASLRLTRRIVSQPALARYRPEEYLPGAALQTDEDLARAAGDIGTTIFHPVGTCRMGRAD
DAGAVVDAQLRVRGIEGLRVVDASVMPTITSGNTNSPTIMIAEKAGEMIRAARRARARGEAVPA
>Mature_544_residues
METYDYIIIGAGSAGCVLANRLTLDPEVSVLLLEAGGKDDYHWIHIPVGYLYCIGNPRTDWLYRTQAEPGLNGRSLGYPR
GRVLGGCSSINGMIYMRGQREDYDGWAALTGDDSWRWDAVLPFFKASEHYHGGADAWHGAGGEWRVEPQRLHWQILESFI
EAAVQAGIPRTEDFNRGDNFGVGYFEVNQKRGIRWNTAKGFLRPASQRPNLTIVTGAQVRALTFDGRRCTGVTYRGAGQD
YAAAAREEVVLSAGAVNSPQLLELSGIGQPQRLQALGIAVRCALPGVGENLQDHLQLRSVIKVHGVPTLNTRAASWWGKA
MIGMQYAFNRSGPMSMAPSQLGAFARSDPSVARPDVEYHVQPLSLDKFGDPLHAFNAFTASVCNLRPTSRGTVHLASADP
FAAPVIAPNYLSTDADRKVAAASLRLTRRIVSQPALARYRPEEYLPGAALQTDEDLARAAGDIGTTIFHPVGTCRMGRAD
DAGAVVDAQLRVRGIEGLRVVDASVMPTITSGNTNSPTIMIAEKAGEMIRAARRARARGEAVPA

Specific function: Converts aliphatic medium-chain-length alcohols into aldehydes. May be linked to the electron transfer chain [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=536, Percent_Identity=42.5373134328358, Blast_Score=407, Evalue=1e-113,
Organism=Escherichia coli, GI1786503, Length=534, Percent_Identity=41.7602996254682, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17532301, Length=549, Percent_Identity=35.1548269581056, Blast_Score=337, Evalue=8e-93,
Organism=Drosophila melanogaster, GI24642055, Length=585, Percent_Identity=37.6068376068376, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24642042, Length=565, Percent_Identity=35.7522123893805, Blast_Score=308, Evalue=9e-84,
Organism=Drosophila melanogaster, GI45551458, Length=577, Percent_Identity=35.7019064124783, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI45549471, Length=577, Percent_Identity=35.7019064124783, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24642059, Length=573, Percent_Identity=36.9982547993019, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24642048, Length=574, Percent_Identity=35.7142857142857, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24642035, Length=573, Percent_Identity=34.0314136125654, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24650267, Length=571, Percent_Identity=35.7267950963222, Blast_Score=279, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24642051, Length=577, Percent_Identity=32.7556325823224, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24642039, Length=568, Percent_Identity=34.8591549295775, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI17137792, Length=570, Percent_Identity=34.0350877192982, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24642037, Length=578, Percent_Identity=32.6989619377163, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI18859995, Length=564, Percent_Identity=33.6879432624113, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI18859993, Length=570, Percent_Identity=31.4035087719298, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24642057, Length=589, Percent_Identity=30.3904923599321, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24645930, Length=575, Percent_Identity=28, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1

Molecular weight: Translated: 58980; Mature: 58980

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METYDYIIIGAGSAGCVLANRLTLDPEVSVLLLEAGGKDDYHWIHIPVGYLYCIGNPRTD
CCCEEEEEEECCCCCEEEEEEEEECCCCEEEEEECCCCCCEEEEEEEEEEEEECCCCCCC
WLYRTQAEPGLNGRSLGYPRGRVLGGCSSINGMIYMRGQREDYDGWAALTGDDSWRWDAV
EEEEECCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEE
LPFFKASEHYHGGADAWHGAGGEWRVEPQRLHWQILESFIEAAVQAGIPRTEDFNRGDNF
CHHHHCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GVGYFEVNQKRGIRWNTAKGFLRPASQRPNLTIVTGAQVRALTFDGRRCTGVTYRGAGQD
CEEEEEECCCCCCEEECCCCCCCCCCCCCCEEEEECCEEEEEEECCCEEECEEECCCCCH
YAAAAREEVVLSAGAVNSPQLLELSGIGQPQRLQALGIAVRCALPGVGENLQDHLQLRSV
HHHHHHHHEEEECCCCCCCCEEEECCCCCCHHHHHHEEEEEEECCCCCCCHHHHHHHHHH
IKVHGVPTLNTRAASWWGKAMIGMQYAFNRSGPMSMAPSQLGAFARSDPSVARPDVEYHV
HHHCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEE
QPLSLDKFGDPLHAFNAFTASVCNLRPTSRGTVHLASADPFAAPVIAPNYLSTDADRKVA
EEECHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEECCCCCCCCCCHHHH
AASLRLTRRIVSQPALARYRPEEYLPGAALQTDEDLARAAGDIGTTIFHPVGTCRMGRAD
HHHHHHHHHHHCCCHHHHCCCHHHCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCC
DAGAVVDAQLRVRGIEGLRVVDASVMPTITSGNTNSPTIMIAEKAGEMIRAARRARARGE
CCCCEEEEEEEEECCCCEEEECCCCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHCCC
AVPA
CCCC
>Mature Secondary Structure
METYDYIIIGAGSAGCVLANRLTLDPEVSVLLLEAGGKDDYHWIHIPVGYLYCIGNPRTD
CCCEEEEEEECCCCCEEEEEEEEECCCCEEEEEECCCCCCEEEEEEEEEEEEECCCCCCC
WLYRTQAEPGLNGRSLGYPRGRVLGGCSSINGMIYMRGQREDYDGWAALTGDDSWRWDAV
EEEEECCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEE
LPFFKASEHYHGGADAWHGAGGEWRVEPQRLHWQILESFIEAAVQAGIPRTEDFNRGDNF
CHHHHCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GVGYFEVNQKRGIRWNTAKGFLRPASQRPNLTIVTGAQVRALTFDGRRCTGVTYRGAGQD
CEEEEEECCCCCCEEECCCCCCCCCCCCCCEEEEECCEEEEEEECCCEEECEEECCCCCH
YAAAAREEVVLSAGAVNSPQLLELSGIGQPQRLQALGIAVRCALPGVGENLQDHLQLRSV
HHHHHHHHEEEECCCCCCCCEEEECCCCCCHHHHHHEEEEEEECCCCCCCHHHHHHHHHH
IKVHGVPTLNTRAASWWGKAMIGMQYAFNRSGPMSMAPSQLGAFARSDPSVARPDVEYHV
HHHCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEE
QPLSLDKFGDPLHAFNAFTASVCNLRPTSRGTVHLASADPFAAPVIAPNYLSTDADRKVA
EEECHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEECCCCCCCCCCHHHH
AASLRLTRRIVSQPALARYRPEEYLPGAALQTDEDLARAAGDIGTTIFHPVGTCRMGRAD
HHHHHHHHHHHCCCHHHHCCCHHHCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCC
DAGAVVDAQLRVRGIEGLRVVDASVMPTITSGNTNSPTIMIAEKAGEMIRAARRARARGE
CCCCEEEEEEEEECCCCEEEECCCCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHCCC
AVPA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: choline; acceptor

Specific reaction: choline + acceptor = betaine aldehyde + reduced acceptor

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11390693 [H]