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The map label for this gene is sdaA2 [H]

Identifier: 17548013

GI number: 17548013

Start: 3550647

End: 3552023

Strand: Direct

Name: sdaA2 [H]

Synonym: RSc3296

Alternate gene names: 17548013

Gene position: 3550647-3552023 (Clockwise)

Preceding gene: 17548012

Following gene: 17548014

Centisome position: 95.54

GC content: 69.35

Gene sequence:

>1377_bases
ATGGCTGTTTCTGTTTTCGACCTCTTCAAGATCGGCATCGGCCCGTCCAGCTCGCACACGGTCGGCCCGATGCGCGCCGC
GCTGATGTTCGCCTCCGGCCTGGAGGCCGATGGCCTGATGCCGCAAATCGCCAGCGTGCGCGTCGAACTGTATGGCTCGC
TCGGCGCCACCGGCAAGGGCCACGGCACCGACCGCGGCGTCATCCTCGGCCTGATGGGCGAGGCGCCCGACACCATCGAT
CCCGACACCATCGACGCCAAGCTGGCCGCGCTGCGCCAGTCGCAATCGCTGTCGCTGCTGGGCCACCACGCGGTGCGCTT
CACCGAGAAGGAGCACATTGCCTTCTACCGCCGCGAGGCCATGGCCGAGCATCCCAACGGCATGAAGTTCCACGCCTTCG
ACGCGGCCGGCGAGCGGCTGCGTGAGGCGCGCTACCTGTCGGTGGGCGGCGGCTTCGTCGTCACAGCGGGCGCGCCCAAC
ACGCAGGTCCTGAGCGCGCACGACCAGCTGCCCCACCCGTTTCGCAGCGGCCGCGAACTGCTGGCGATGTGCGAATCGAC
GGGCAAGTCCATCGCCCGGCTGATGCTCGAAAACGAACTGACCTGGCGCAGCGAGGCCGAAGTGCGCGCCGGCCTGCTCA
ACATCTGGCACGTGATGCAGGCCTGCGTGGCGCGCGGCTGCCGCACCGAGGGCGAGCTGCCCGGGCCCTTCCACGTGCGC
CGCCGCGCCGCCGAGCTATACACGCGGCTGACCGGCCAGGCCGAGCGCACGCTGTCCGACCCGCTGTCGGTCATCGACTG
GGTCAACCTGTACGCCATCGCCGTCAACGAAGAGAACGCCGCGGGTGGGCGCGTGGTCACGGCCCCCACCAACGGCGCGG
CCGGCATCATCCCCGCCGTGCTGCACTACTACGACCGCTTCGTGCCCGGCGCCAATGACAACGGCGTGGTCGATTTCCTG
CTGACCGCCGGCGCGATCGGCATGCTCTACAAGATGAACGCCTCCATCTCCGGCGCCGAGGTCGGCTGCCAGGGCGAAGT
GGGCGTGGCCTGCTCGATGGCCGCGGGCGCGCTGGCCGCCGTGCTGGGCGGCACGCCCGCGCAGGCCGAGAACGCCGCCG
AGATCGGCATGGAGCACAACCTCGGGCTGACCTGCGACCCGGTCGGCGGGCTGGTGCAGATCCCGTGCATCGAGCGCAAC
GCGATGGCCTCCGTGAAAGCCGTCAATGCGGCGCGCATGGCGCTGCGCGGCGACGGCACGCACTATGTCTCGCTCGACTC
CGTCATCAAAACGATGCGGGAGACGGGGGCGGACATGAAGACCAAATACAAGGAGACGGCCCGGGGGGGATTGGCGGTGA
ATATCGTCGAGTGTTGA

Upstream 100 bases:

>100_bases
ACGGCCGCCTCGTACCCCGGGGCGGCCGTTTTCATCTGAGAACCCCGTGCGCGGGCGGCCACAAGCCCACCCGCGCCACC
ACGCCTGCGGAGCCCCACCC

Downstream 100 bases:

>100_bases
GGGCGGGCTTTTACGGTTCGTTTTTTTGCTGGTTGGTTCTTCTTTTTTGGGTGCATTCCGGGTTTCGTCCCCTGGCGGGG
CTGGGCTTGGTGGTCCATCC

Product: L-serine dehydratase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFASGLEADGLMPQIASVRVELYGSLGATGKGHGTDRGVILGLMGEAPDTID
PDTIDAKLAALRQSQSLSLLGHHAVRFTEKEHIAFYRREAMAEHPNGMKFHAFDAAGERLREARYLSVGGGFVVTAGAPN
TQVLSAHDQLPHPFRSGRELLAMCESTGKSIARLMLENELTWRSEAEVRAGLLNIWHVMQACVARGCRTEGELPGPFHVR
RRAAELYTRLTGQAERTLSDPLSVIDWVNLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYDRFVPGANDNGVVDFL
LTAGAIGMLYKMNASISGAEVGCQGEVGVACSMAAGALAAVLGGTPAQAENAAEIGMEHNLGLTCDPVGGLVQIPCIERN
AMASVKAVNAARMALRGDGTHYVSLDSVIKTMRETGADMKTKYKETARGGLAVNIVEC

Sequences:

>Translated_458_residues
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFASGLEADGLMPQIASVRVELYGSLGATGKGHGTDRGVILGLMGEAPDTID
PDTIDAKLAALRQSQSLSLLGHHAVRFTEKEHIAFYRREAMAEHPNGMKFHAFDAAGERLREARYLSVGGGFVVTAGAPN
TQVLSAHDQLPHPFRSGRELLAMCESTGKSIARLMLENELTWRSEAEVRAGLLNIWHVMQACVARGCRTEGELPGPFHVR
RRAAELYTRLTGQAERTLSDPLSVIDWVNLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYDRFVPGANDNGVVDFL
LTAGAIGMLYKMNASISGAEVGCQGEVGVACSMAAGALAAVLGGTPAQAENAAEIGMEHNLGLTCDPVGGLVQIPCIERN
AMASVKAVNAARMALRGDGTHYVSLDSVIKTMRETGADMKTKYKETARGGLAVNIVEC
>Mature_457_residues
AVSVFDLFKIGIGPSSSHTVGPMRAALMFASGLEADGLMPQIASVRVELYGSLGATGKGHGTDRGVILGLMGEAPDTIDP
DTIDAKLAALRQSQSLSLLGHHAVRFTEKEHIAFYRREAMAEHPNGMKFHAFDAAGERLREARYLSVGGGFVVTAGAPNT
QVLSAHDQLPHPFRSGRELLAMCESTGKSIARLMLENELTWRSEAEVRAGLLNIWHVMQACVARGCRTEGELPGPFHVRR
RAAELYTRLTGQAERTLSDPLSVIDWVNLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYDRFVPGANDNGVVDFLL
TAGAIGMLYKMNASISGAEVGCQGEVGVACSMAAGALAAVLGGTPAQAENAAEIGMEHNLGLTCDPVGGLVQIPCIERNA
MASVKAVNAARMALRGDGTHYVSLDSVIKTMRETGADMKTKYKETARGGLAVNIVEC

Specific function: Deaminates Also Threonine, Particularly When It Is Present In High Concentration. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1789161, Length=458, Percent_Identity=55.0218340611354, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1788116, Length=457, Percent_Identity=54.0481400437637, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI48994925, Length=458, Percent_Identity=55.4585152838428, Blast_Score=479, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48438; Mature: 48307

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFASGLEADGLMPQIASVRVELYGSLGATGKG
CEEEHEEHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCCCCCC
HGTDRGVILGLMGEAPDTIDPDTIDAKLAALRQSQSLSLLGHHAVRFTEKEHIAFYRREA
CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHEECCHHHHHHHHHHH
MAEHPNGMKFHAFDAAGERLREARYLSVGGGFVVTAGAPNTQVLSAHDQLPHPFRSGREL
HHCCCCCCEEEEEHHHHHHHHHCEEEEECCCEEEECCCCCCEEEECCCCCCCCHHHHHHH
LAMCESTGKSIARLMLENELTWRSEAEVRAGLLNIWHVMQACVARGCRTEGELPGPFHVR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
RRAAELYTRLTGQAERTLSDPLSVIDWVNLYAIAVNEENAAGGRVVTAPTNGAAGIIPAV
HHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEECCCCCCCHHHHHH
LHYYDRFVPGANDNGVVDFLLTAGAIGMLYKMNASISGAEVGCQGEVGVACSMAAGALAA
HHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
VLGGTPAQAENAAEIGMEHNLGLTCDPVGGLVQIPCIERNAMASVKAVNAARMALRGDGT
HHCCCCCCCCCHHHCCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHHHHHHHEEECCCC
HYVSLDSVIKTMRETGADMKTKYKETARGGLAVNIVEC
EEEEHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure 
AVSVFDLFKIGIGPSSSHTVGPMRAALMFASGLEADGLMPQIASVRVELYGSLGATGKG
EEEHEEHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCCCCCC
HGTDRGVILGLMGEAPDTIDPDTIDAKLAALRQSQSLSLLGHHAVRFTEKEHIAFYRREA
CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHEECCHHHHHHHHHHH
MAEHPNGMKFHAFDAAGERLREARYLSVGGGFVVTAGAPNTQVLSAHDQLPHPFRSGREL
HHCCCCCCEEEEEHHHHHHHHHCEEEEECCCEEEECCCCCCEEEECCCCCCCCHHHHHHH
LAMCESTGKSIARLMLENELTWRSEAEVRAGLLNIWHVMQACVARGCRTEGELPGPFHVR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
RRAAELYTRLTGQAERTLSDPLSVIDWVNLYAIAVNEENAAGGRVVTAPTNGAAGIIPAV
HHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEECCCCCCCHHHHHH
LHYYDRFVPGANDNGVVDFLLTAGAIGMLYKMNASISGAEVGCQGEVGVACSMAAGALAA
HHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
VLGGTPAQAENAAEIGMEHNLGLTCDPVGGLVQIPCIERNAMASVKAVNAARMALRGDGT
HHCCCCCCCCCHHHCCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHHHHHHHEEECCCC
HYVSLDSVIKTMRETGADMKTKYKETARGGLAVNIVEC
EEEEHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]