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The map label for this gene is vgb [H]

Identifier: 17547874

GI number: 17547874

Start: 3408633

End: 3409811

Strand: Reverse

Name: vgb [H]

Synonym: RSc3155

Alternate gene names: 17547874

Gene position: 3409811-3408633 (Counterclockwise)

Preceding gene: 17547876

Following gene: 17547873

Centisome position: 91.75

GC content: 66.92

Gene sequence:

>1179_bases
ATGAAACGCCTGCTGTACCTGGCCGCGCCGGCCATCGTGGGCGCAGCCCTTCTCTGCCTGCCGGCCCCGTCCTCGGCTGC
CGCGAATGCGGTGGGCGCCAACGCCGTGATCGGCGAATTCGCGACGCCGTCCGCCGCCAGTTCGCCGCAGGGCGTGGATG
TCGCCGGCGACGGCAGCGTGTGGTACTCGGAAACCACGGCGGGAAAAATCGCCGTGCTGCGCCCGGATGGCTCTTCGGCC
GAATTCCCGGTGCCCAACGGGGGTCAGCCTTTCATCCTCAAGGTGGCGGATGACGGCGTCTGGTTTACCGACAGCGGGAC
GCGCGCCATCGGGCATCTGGACCCGGCCACCGGGACGGTCGAGACCTACGCAATTCCGTCCGGCGCATCGCCGTTCTTTA
TCCAGGTCGGCCCGGACGGCAGCAAATGGTTTACCGAGACCGCGGGCATCGGTCGCCTCTCGCCGAATGGCGAGTTCACC
GAGTGGACGGTGACGCTGGAGCATGCCGACGACAACATGGAACAGCTGAGCCTGGATCCCTGGGGCAATGTCTGGTTCGT
GGAGCGCAATTTCGATGGCATTGGCGCGGCCGGTACCAACAAGGTGCGCCGTCTCAATCCCTATTCGAACGTGATCAGCA
CCTACAGGGTGCCGACGCTGGGCGGCACGCCGTCGGGCGTGGTGGCCAATGCCAACGGGTCGGTCTGGGTGTCCGAGTAC
TACGCCAATGCGATCGCCTTGCTCAACCCCTTCGCCGCTCCGCACAGCGATGAGGTGGTGCAGCCCAACGCGCTGAAGGC
CGACAGCCGGACCGCATCGGTGTCGCCCATCCGGGCCGCGCGCACGACGGGCGCGAAGACGCAGGTCACCCCCAGCGCCC
ACGCGGTCAAGCCGTCCGTGACGCTGGGCTGGATCGAATATCCCCTCCCGAGCGCCAAGGCCGAGCCGGAAGACATGCGT
GTCGATCGGCATGGCCGCGTCTGGTTCGAGGCGGACGCCGGCTTCATCGGCCGCCTCGATCCCTTCGAGGCGCGCATCAC
GGAATACATGATCCCGTCGGCCAACAGCGGCTACTACAACATCGCGCTGGACCCGCGCTCCGGCTTGCTCTGGTTTACCG
AGGCCGGTGTCTTCGCGCCGGTGACGACCAAGATCGGCTATCTGGACACGCGGCACTGA

Upstream 100 bases:

>100_bases
CCAGCCGACACCCCCGGGACACGCTGCGATCATGTGTCTGGGGTGCGTCACTTCCCCCCCAATGGTGGTCGATTCCGAAC
GATTCACAAGGAGCCATGTG

Downstream 100 bases:

>100_bases
GCGCCGCCGATCCGGCCCGTTGATGTGTCGACGCTCCATGCCGGCAAGCCCCGGCATGGAGCGTTCGTGCGCCAGCGGTT
CGCATTCCCAACGCCTCGCG

Product: antibiotic hydrolase signal peptide protein

Products: NA

Alternate protein names: Streptogramin B lyase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKRLLYLAAPAIVGAALLCLPAPSSAAANAVGANAVIGEFATPSAASSPQGVDVAGDGSVWYSETTAGKIAVLRPDGSSA
EFPVPNGGQPFILKVADDGVWFTDSGTRAIGHLDPATGTVETYAIPSGASPFFIQVGPDGSKWFTETAGIGRLSPNGEFT
EWTVTLEHADDNMEQLSLDPWGNVWFVERNFDGIGAAGTNKVRRLNPYSNVISTYRVPTLGGTPSGVVANANGSVWVSEY
YANAIALLNPFAAPHSDEVVQPNALKADSRTASVSPIRAARTTGAKTQVTPSAHAVKPSVTLGWIEYPLPSAKAEPEDMR
VDRHGRVWFEADAGFIGRLDPFEARITEYMIPSANSGYYNIALDPRSGLLWFTEAGVFAPVTTKIGYLDTRH

Sequences:

>Translated_392_residues
MKRLLYLAAPAIVGAALLCLPAPSSAAANAVGANAVIGEFATPSAASSPQGVDVAGDGSVWYSETTAGKIAVLRPDGSSA
EFPVPNGGQPFILKVADDGVWFTDSGTRAIGHLDPATGTVETYAIPSGASPFFIQVGPDGSKWFTETAGIGRLSPNGEFT
EWTVTLEHADDNMEQLSLDPWGNVWFVERNFDGIGAAGTNKVRRLNPYSNVISTYRVPTLGGTPSGVVANANGSVWVSEY
YANAIALLNPFAAPHSDEVVQPNALKADSRTASVSPIRAARTTGAKTQVTPSAHAVKPSVTLGWIEYPLPSAKAEPEDMR
VDRHGRVWFEADAGFIGRLDPFEARITEYMIPSANSGYYNIALDPRSGLLWFTEAGVFAPVTTKIGYLDTRH
>Mature_392_residues
MKRLLYLAAPAIVGAALLCLPAPSSAAANAVGANAVIGEFATPSAASSPQGVDVAGDGSVWYSETTAGKIAVLRPDGSSA
EFPVPNGGQPFILKVADDGVWFTDSGTRAIGHLDPATGTVETYAIPSGASPFFIQVGPDGSKWFTETAGIGRLSPNGEFT
EWTVTLEHADDNMEQLSLDPWGNVWFVERNFDGIGAAGTNKVRRLNPYSNVISTYRVPTLGGTPSGVVANANGSVWVSEY
YANAIALLNPFAAPHSDEVVQPNALKADSRTASVSPIRAARTTGAKTQVTPSAHAVKPSVTLGWIEYPLPSAKAEPEDMR
VDRHGRVWFEADAGFIGRLDPFEARITEYMIPSANSGYYNIALDPRSGLLWFTEAGVFAPVTTKIGYLDTRH

Specific function: Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid [H]

COG id: COG4257

COG function: function code V; Streptogramin lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the vgb family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011217 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 41500; Mature: 41500

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLLYLAAPAIVGAALLCLPAPSSAAANAVGANAVIGEFATPSAASSPQGVDVAGDGSV
CCEEEEEHHHHHHCEEEEEECCCCCHHHHCCCCCCEEECCCCCCCCCCCCCEEEECCCCE
WYSETTAGKIAVLRPDGSSAEFPVPNGGQPFILKVADDGVWFTDSGTRAIGHLDPATGTV
EEEECCCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEECCCCEEEEECCCCCCCE
ETYAIPSGASPFFIQVGPDGSKWFTETAGIGRLSPNGEFTEWTVTLEHADDNMEQLSLDP
EEEEECCCCCEEEEEECCCCCCEEECCCCCCCCCCCCCEEEEEEEEEECCCCHHEEECCC
WGNVWFVERNFDGIGAAGTNKVRRLNPYSNVISTYRVPTLGGTPSGVVANANGSVWVSEY
CCCEEEEEECCCCCCCCCCCCEEEECCHHHHHHHEECCCCCCCCCCEEECCCCCEEEEHH
YANAIALLNPFAAPHSDEVVQPNALKADSRTASVSPIRAARTTGAKTQVTPSAHAVKPSV
HHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEECCCCCEECCCE
TLGWIEYPLPSAKAEPEDMRVDRHGRVWFEADAGFIGRLDPFEARITEYMIPSANSGYYN
EEEEEECCCCCCCCCHHHCEECCCCCEEEEECCCCCCCCCCHHHHHHHEECCCCCCCEEE
IALDPRSGLLWFTEAGVFAPVTTKIGYLDTRH
EEECCCCCEEEEECCCEEEEEEEEECEEECCC
>Mature Secondary Structure
MKRLLYLAAPAIVGAALLCLPAPSSAAANAVGANAVIGEFATPSAASSPQGVDVAGDGSV
CCEEEEEHHHHHHCEEEEEECCCCCHHHHCCCCCCEEECCCCCCCCCCCCCEEEECCCCE
WYSETTAGKIAVLRPDGSSAEFPVPNGGQPFILKVADDGVWFTDSGTRAIGHLDPATGTV
EEEECCCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEECCCCEEEEECCCCCCCE
ETYAIPSGASPFFIQVGPDGSKWFTETAGIGRLSPNGEFTEWTVTLEHADDNMEQLSLDP
EEEEECCCCCEEEEEECCCCCCEEECCCCCCCCCCCCCEEEEEEEEEECCCCHHEEECCC
WGNVWFVERNFDGIGAAGTNKVRRLNPYSNVISTYRVPTLGGTPSGVVANANGSVWVSEY
CCCEEEEEECCCCCCCCCCCCEEEECCHHHHHHHEECCCCCCCCCCEEECCCCCEEEEHH
YANAIALLNPFAAPHSDEVVQPNALKADSRTASVSPIRAARTTGAKTQVTPSAHAVKPSV
HHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEECCCCCEECCCE
TLGWIEYPLPSAKAEPEDMRVDRHGRVWFEADAGFIGRLDPFEARITEYMIPSANSGYYN
EEEEEECCCCCCCCCHHHCEECCCCCEEEEECCCCCCCCCCHHHHHHHEECCCCCCCEEE
IALDPRSGLLWFTEAGVFAPVTTKIGYLDTRH
EEECCCCCEEEEECCCEEEEEEEEECEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA