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The map label for this gene is murA

Identifier: 17547672

GI number: 17547672

Start: 3182510

End: 3183775

Strand: Reverse

Name: murA

Synonym: RSc2953

Alternate gene names: 17547672

Gene position: 3183775-3182510 (Counterclockwise)

Preceding gene: 17547673

Following gene: 17547671

Centisome position: 85.67

GC content: 68.33

Gene sequence:

>1266_bases
ATGGACAAACTGCTGATCGAAGGCAATGGCCCGCTGTCGGGCGAAATCCGCGTTTCCGGCGCCAAGAATGCCGCGCTGCC
GATCATGTGCGCCGCGCTGCTGACGCCCGAGCCGTTCACGCTGCACAACGTGCCCAACCTGCAGGATGTGCGCACCATGC
TCAAGCTGCTGCGCCAGATGGGCGTGGAGGGCACGCAGGACGGCCATGACGTCACGCTCGATGCCGCCGCCATCGATGCG
CCGGAAGCGCCGTACGACCTGGTGAAGACCATGCGCGCGTCGATCCTTGTGCTGGGGCCGCTGCTGGCGCGCTTCGGCCA
CGCGCGCGTGTCGTTGCCGGGCGGCTGCGGCATCGGCGCGCGGCCGGTCGACCAGCACATCAAGGGCCTGCAGCAGATGG
GCGCCGAGATCGTCATCGAGCACGGCTACATCGAAGCCAAGCTCGCCGACGGCGCCAAGCGGCTGCACGGCGCGCGCATC
GTCACCGACATGGTGACCGTGACCGGCACCGAGAACCTGCTGATGGCCGCCGTGCTGGCCGACGGCGAGACCGTGCTGGA
AAACGCCGCGCGCGAGCCGGAGGTGACCGACCTCGCCAACCTGCTGGTGAAGATGGGCGCGCGCATCGACGGCATCGGCA
CCGACCGCCTGGTGGTGCAGGGCGTCGAAGCGCTCAGGGGTGCCGAGCACACCGTCATCGCCGACCGCATCGAGGCCGGC
ACGTTCCTGTGCGCGGTGGCCGCGGCCGGCGGCGACGTGACGCTGCGCGGCGTGCCGCCGGGCATTCTCGACGCGGTGCT
CGACAAGCTGCGCGAAGCCGGCGTGACGCTCACCATGGGCGACGACTGGATCCGCGTGCAGATGCACGGCCGCCCGAAGG
CGGTCAGCTTCCGCACCTCGGAATACCCAGCCTTCCCGACCGATATGCAGGCGCAGTTCATGATGCTGAACTGCATCGCC
GAAGGGGCTGCGCTGGTGACGGAGACGATCTTCGAGAACCGCTTCATGCACGTGCAGGAATTGAACCGCCTGGGCGCTAA
CATCATCACCGAAGGCAACACGGCGGCAGTCACGGGCGTGGAGCAGCTCTCGGGCGCGACCGTGATGGCGACCGACCTGC
GCGCCTCGGCCAGCCTGGTGATCGCCGGCCTGGTGGCGCAGGGCGAAACGCTGGTCGACCGCATCTATCACCTCGATCGT
GGCTACGACTGCATCGAGGACAAGCTGTCGGCGGTGGGCGCGAAGATCCGCCGCATCCAAGGTTAA

Upstream 100 bases:

>100_bases
AGACCCTGACATGGCCGAGCTCGATCCCACCCCGGCTGCCGCCGATACCGATTCCGACCCCGCGCTCGCCGAGCGCCCCG
TACGACGTGATGTCTCGCTC

Downstream 100 bases:

>100_bases
GAGGGCATAAGGGCCGCCATGAACGCTTTCCAGTCCGCCTCCGACCAGCTCACGCTGGCACTGTCGAAGGGGCGCATCTT
TGAAGAGACGCTGCCGCTGC

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDKLLIEGNGPLSGEIRVSGAKNAALPIMCAALLTPEPFTLHNVPNLQDVRTMLKLLRQMGVEGTQDGHDVTLDAAAIDA
PEAPYDLVKTMRASILVLGPLLARFGHARVSLPGGCGIGARPVDQHIKGLQQMGAEIVIEHGYIEAKLADGAKRLHGARI
VTDMVTVTGTENLLMAAVLADGETVLENAAREPEVTDLANLLVKMGARIDGIGTDRLVVQGVEALRGAEHTVIADRIEAG
TFLCAVAAAGGDVTLRGVPPGILDAVLDKLREAGVTLTMGDDWIRVQMHGRPKAVSFRTSEYPAFPTDMQAQFMMLNCIA
EGAALVTETIFENRFMHVQELNRLGANIITEGNTAAVTGVEQLSGATVMATDLRASASLVIAGLVAQGETLVDRIYHLDR
GYDCIEDKLSAVGAKIRRIQG

Sequences:

>Translated_421_residues
MDKLLIEGNGPLSGEIRVSGAKNAALPIMCAALLTPEPFTLHNVPNLQDVRTMLKLLRQMGVEGTQDGHDVTLDAAAIDA
PEAPYDLVKTMRASILVLGPLLARFGHARVSLPGGCGIGARPVDQHIKGLQQMGAEIVIEHGYIEAKLADGAKRLHGARI
VTDMVTVTGTENLLMAAVLADGETVLENAAREPEVTDLANLLVKMGARIDGIGTDRLVVQGVEALRGAEHTVIADRIEAG
TFLCAVAAAGGDVTLRGVPPGILDAVLDKLREAGVTLTMGDDWIRVQMHGRPKAVSFRTSEYPAFPTDMQAQFMMLNCIA
EGAALVTETIFENRFMHVQELNRLGANIITEGNTAAVTGVEQLSGATVMATDLRASASLVIAGLVAQGETLVDRIYHLDR
GYDCIEDKLSAVGAKIRRIQG
>Mature_421_residues
MDKLLIEGNGPLSGEIRVSGAKNAALPIMCAALLTPEPFTLHNVPNLQDVRTMLKLLRQMGVEGTQDGHDVTLDAAAIDA
PEAPYDLVKTMRASILVLGPLLARFGHARVSLPGGCGIGARPVDQHIKGLQQMGAEIVIEHGYIEAKLADGAKRLHGARI
VTDMVTVTGTENLLMAAVLADGETVLENAAREPEVTDLANLLVKMGARIDGIGTDRLVVQGVEALRGAEHTVIADRIEAG
TFLCAVAAAGGDVTLRGVPPGILDAVLDKLREAGVTLTMGDDWIRVQMHGRPKAVSFRTSEYPAFPTDMQAQFMMLNCIA
EGAALVTETIFENRFMHVQELNRLGANIITEGNTAAVTGVEQLSGATVMATDLRASASLVIAGLVAQGETLVDRIYHLDR
GYDCIEDKLSAVGAKIRRIQG

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=422, Percent_Identity=59.0047393364929, Blast_Score=491, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_RALSO (Q8XV78)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_521074.1
- ProteinModelPortal:   Q8XV78
- SMR:   Q8XV78
- GeneID:   1221807
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2953
- NMPDR:   fig|267608.1.peg.2953
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- BioCyc:   RSOL267608:RSC2953-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 44700; Mature: 44700

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLLIEGNGPLSGEIRVSGAKNAALPIMCAALLTPEPFTLHNVPNLQDVRTMLKLLRQM
CCCEEEECCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHH
GVEGTQDGHDVTLDAAAIDAPEAPYDLVKTMRASILVLGPLLARFGHARVSLPGGCGIGA
CCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
RPVDQHIKGLQQMGAEIVIEHGYIEAKLADGAKRLHGARIVTDMVTVTGTENLLMAAVLA
CCHHHHHHHHHHCCCEEEEECCEEEEEEHHHHHHHHCHHHEEHHEEECCCCHHEEHHHHC
DGETVLENAAREPEVTDLANLLVKMGARIDGIGTDRLVVQGVEALRGAEHTVIADRIEAG
CCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEHHHHCCC
TFLCAVAAAGGDVTLRGVPPGILDAVLDKLREAGVTLTMGDDWIRVQMHGRPKAVSFRTS
CEEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCEEEEECC
EYPAFPTDMQAQFMMLNCIAEGAALVTETIFENRFMHVQELNRLGANIITEGNTAAVTGV
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCEEEECH
EQLSGATVMATDLRASASLVIAGLVAQGETLVDRIYHLDRGYDCIEDKLSAVGAKIRRIQ
HHHCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
G
C
>Mature Secondary Structure
MDKLLIEGNGPLSGEIRVSGAKNAALPIMCAALLTPEPFTLHNVPNLQDVRTMLKLLRQM
CCCEEEECCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHH
GVEGTQDGHDVTLDAAAIDAPEAPYDLVKTMRASILVLGPLLARFGHARVSLPGGCGIGA
CCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
RPVDQHIKGLQQMGAEIVIEHGYIEAKLADGAKRLHGARIVTDMVTVTGTENLLMAAVLA
CCHHHHHHHHHHCCCEEEEECCEEEEEEHHHHHHHHCHHHEEHHEEECCCCHHEEHHHHC
DGETVLENAAREPEVTDLANLLVKMGARIDGIGTDRLVVQGVEALRGAEHTVIADRIEAG
CCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEHHHHCCC
TFLCAVAAAGGDVTLRGVPPGILDAVLDKLREAGVTLTMGDDWIRVQMHGRPKAVSFRTS
CEEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCEEEEECC
EYPAFPTDMQAQFMMLNCIAEGAALVTETIFENRFMHVQELNRLGANIITEGNTAAVTGV
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCEEEECH
EQLSGATVMATDLRASASLVIAGLVAQGETLVDRIYHLDRGYDCIEDKLSAVGAKIRRIQ
HHHCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852