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The map label for this gene is hisD

Identifier: 17547671

GI number: 17547671

Start: 3180466

End: 3181794

Strand: Reverse

Name: hisD

Synonym: RSc2952

Alternate gene names: 17547671

Gene position: 3181794-3180466 (Counterclockwise)

Preceding gene: 17547672

Following gene: 17547670

Centisome position: 85.61

GC content: 70.65

Gene sequence:

>1329_bases
ATGAGCCTGACCCTCCGCAAACTGGATTCGGCCGACGCCGGATTCGCGGCGCAACTGCGCCAGGTGCTCGCCTTCGAGGC
GAGCGAAGACGAAGCCATCGACCGCGCCGCCGCGCAGATCCTGGCCGACGTGAAGGTGCGCGGCGACGCCGCCGTGCTGG
AGACCACGCTGCGCTTCGACCGCGTCGAAGCCGACAGCGTGGCCGCGCTGGAGCTGTCGCCGGTGGTGCTGCAGGCCGCG
CTGGACGGCCTGGAGCCCACGCGCCGCGCCGCGCTGGAGGCCGCCGCCGCCCGCGTGCGCGCCTACCACGAGAAGCAGAA
GATCGAGTGCGGCACGCATAGCTGGGAGTACGCGGAAGCCGACGGCACCGTGCTCGGCCAGAAGGTCACGCCGCTCGACC
GCGTCGGCATCTACGTGCCGGGCGGCAAGGCGGCGTACCCGTCGTCGGTGCTGATGAACGCGATTCCGGCGCGTGTGGCC
GGCGTCAAGGAAATCATCATGGTGGTGCCCACGCCGGGCGGCGTGCGCAACGAACTGGTGCTGGCCGCGGCCTGCATCGC
CGGAGTGGACCGCGTGTTCACCATCGGCGGCGCGCAGGCGGTGGGCGCACTGGCCTATGGCACCGAGACCGTGCCCGCCG
TCGACAAGATCGTCGGCCCGGGCAACGCCTACGTGGCGGCGGCCAAGCGGCGCGTGTTCGGCACGGTCGGCATCGACATG
ATCGCCGGGCCGTCCGAGATCCTCGTCATCTGCGACGGCACCACCGATCCGGACTGGGTGGCGATGGACCTGTTCTCGCA
GGCCGAGCACGACGAGCTCGCGCAGTCGATCCTGCTGTGCCCGGACGCCGGCTTCATCGCCCAGGTGGAAGCCAGCATCC
GGCGCCAGCTCGACGACATGCCGCGCAAGGAGGTGATTGCCGCCTCGCTGTCGGGCCGCGGCGCGCTGATCCAGGTACGC
GACATGGACGAGGCGTGCGAGATCGCCAACGACATCGCGCCGGAGCACCTGGAGATCTCGGCCGAGAACCCGCGCCAGTG
GGCCGAGCGCATCCGCCATGCCGGCGCCATCTTCCTCGGCAAGTACACCAGTGAGTCGCTGGGCGACTACTGCGCGGGCC
CGAACCACGTGCTGCCGACCTCGCGCACGGCGCGCTTCTCGTCGCCGCTGGGCGTGTACGACTTCATCAAGCGCTCCAGC
CTGATCGAGGTGAGCGAGGCGGGCGCGCAGATGCTGGGCGAGATCGCCTCCGAACTGGCCTACGGCGAGGGGTTGCAGGC
GCATGCCCGCAGCGCTGAATACCGCCTGCAGCGCACCACCACCGAGTGA

Upstream 100 bases:

>100_bases
CGCTGAAGCTCAAGCGCGAACGGTTGGCGCCCATCCTCGACGCTTTCGAGCGCGCTTCGCGGCCGGCCGGTGCCGAGCCC
GAGCGCGTCGGAGAACCCGC

Downstream 100 bases:

>100_bases
TCCGATCCGCATGACCATGAACGCCAACGCACCTGTCCAGCCCTCTCTCGATGACCTGCTCGGCCGCATCGTGCGCGACG
ATGTGCGCGCGATGGGCGCG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSLTLRKLDSADAGFAAQLRQVLAFEASEDEAIDRAAAQILADVKVRGDAAVLETTLRFDRVEADSVAALELSPVVLQAA
LDGLEPTRRAALEAAAARVRAYHEKQKIECGTHSWEYAEADGTVLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVA
GVKEIIMVVPTPGGVRNELVLAAACIAGVDRVFTIGGAQAVGALAYGTETVPAVDKIVGPGNAYVAAAKRRVFGTVGIDM
IAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDAGFIAQVEASIRRQLDDMPRKEVIAASLSGRGALIQVR
DMDEACEIANDIAPEHLEISAENPRQWAERIRHAGAIFLGKYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSEAGAQMLGEIASELAYGEGLQAHARSAEYRLQRTTTE

Sequences:

>Translated_442_residues
MSLTLRKLDSADAGFAAQLRQVLAFEASEDEAIDRAAAQILADVKVRGDAAVLETTLRFDRVEADSVAALELSPVVLQAA
LDGLEPTRRAALEAAAARVRAYHEKQKIECGTHSWEYAEADGTVLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVA
GVKEIIMVVPTPGGVRNELVLAAACIAGVDRVFTIGGAQAVGALAYGTETVPAVDKIVGPGNAYVAAAKRRVFGTVGIDM
IAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDAGFIAQVEASIRRQLDDMPRKEVIAASLSGRGALIQVR
DMDEACEIANDIAPEHLEISAENPRQWAERIRHAGAIFLGKYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSEAGAQMLGEIASELAYGEGLQAHARSAEYRLQRTTTE
>Mature_441_residues
SLTLRKLDSADAGFAAQLRQVLAFEASEDEAIDRAAAQILADVKVRGDAAVLETTLRFDRVEADSVAALELSPVVLQAAL
DGLEPTRRAALEAAAARVRAYHEKQKIECGTHSWEYAEADGTVLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAG
VKEIIMVVPTPGGVRNELVLAAACIAGVDRVFTIGGAQAVGALAYGTETVPAVDKIVGPGNAYVAAAKRRVFGTVGIDMI
AGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDAGFIAQVEASIRRQLDDMPRKEVIAASLSGRGALIQVRD
MDEACEIANDIAPEHLEISAENPRQWAERIRHAGAIFLGKYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSL
IEVSEAGAQMLGEIASELAYGEGLQAHARSAEYRLQRTTTE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=427, Percent_Identity=41.92037470726, Blast_Score=289, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=413, Percent_Identity=36.0774818401937, Blast_Score=236, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_RALSO (Q8XV79)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_521073.1
- ProteinModelPortal:   Q8XV79
- SMR:   Q8XV79
- GeneID:   1221806
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2952
- NMPDR:   fig|267608.1.peg.2952
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   RSOL267608:RSC2952-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47039; Mature: 46908

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 335-335 ACT_SITE 336-336 BINDING 138-138 BINDING 199-199 BINDING 222-222 BINDING 245-245 BINDING 267-267 BINDING 270-270 BINDING 336-336 BINDING 369-369 BINDING 423-423 BINDING 428-428

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTLRKLDSADAGFAAQLRQVLAFEASEDEAIDRAAAQILADVKVRGDAAVLETTLRFD
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RVEADSVAALELSPVVLQAALDGLEPTRRAALEAAAARVRAYHEKQKIECGTHSWEYAEA
CCCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECC
DGTVLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAGVKEIIMVVPTPGGVRNELV
CCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHH
LAAACIAGVDRVFTIGGAQAVGALAYGTETVPAVDKIVGPGNAYVAAAKRRVFGTVGIDM
HHHHHHHCCHHEEEECCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDAGFIAQVEASIRRQLDDM
ECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHHHC
PRKEVIAASLSGRGALIQVRDMDEACEIANDIAPEHLEISAENPRQWAERIRHAGAIFLG
CHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCEEEEE
KYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSEAGAQMLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YGEGLQAHARSAEYRLQRTTTE
HCCCHHHHHCCHHHEEECCCCC
>Mature Secondary Structure 
SLTLRKLDSADAGFAAQLRQVLAFEASEDEAIDRAAAQILADVKVRGDAAVLETTLRFD
CCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RVEADSVAALELSPVVLQAALDGLEPTRRAALEAAAARVRAYHEKQKIECGTHSWEYAEA
CCCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECC
DGTVLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAGVKEIIMVVPTPGGVRNELV
CCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHH
LAAACIAGVDRVFTIGGAQAVGALAYGTETVPAVDKIVGPGNAYVAAAKRRVFGTVGIDM
HHHHHHHCCHHEEEECCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDAGFIAQVEASIRRQLDDM
ECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHHHC
PRKEVIAASLSGRGALIQVRDMDEACEIANDIAPEHLEISAENPRQWAERIRHAGAIFLG
CHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCEEEEE
KYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSEAGAQMLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YGEGLQAHARSAEYRLQRTTTE
HCCCHHHHHCCHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852