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The map label for this gene is hisC1

Identifier: 17547670

GI number: 17547670

Start: 3179325

End: 3180449

Strand: Reverse

Name: hisC1

Synonym: RSc2951

Alternate gene names: 17547670

Gene position: 3180449-3179325 (Counterclockwise)

Preceding gene: 17547671

Following gene: 17547669

Centisome position: 85.58

GC content: 68.0

Gene sequence:

>1125_bases
ATGAACGCCAACGCACCTGTCCAGCCCTCTCTCGATGACCTGCTCGGCCGCATCGTGCGCGACGATGTGCGCGCGATGGG
CGCGTACCACGTGCCCGACGCCTCCGGCATGGTCAAGCTGGACGCGATGGAGAACCCCTACCATCTGCCGGCCATGCTGC
GCGACGCGCTCGGCAAGCGGCTGGCCGAGGTGGCGCTGAACCGCTACCCGGTGCCCACCGCCGACGCGCTCAAGGCCCAG
CTCAAGCGCGTGATGCGCGTGCCGGCCGGCGCCGACGTGCTGCTGGGCAACGGCTCGGACGAGATCATCAGCCTGATCGC
TATCGCCGCGGCCAAGCCCGGCGCGACCGTGCTGGCGCCGGTGCCGGGCTTCGTGATGTATGCGATGTCGGCGCAGCTGA
TGGGGCTGAAGTTCGTGGGCGTGCCGCTCAGGGCCGATCTCACCCTCGACCGCGAAGCGATGCTGGCCGCCATGGCTGAG
CACCAGCCCGCCGTCATCTACCTGGCCTATCCGAACAACCCGACCGGCAACCTGTTCGACGCGGCCGACATGGATGCGCT
CCTCCGCGCCGCGCGCGGGCCGGTGTGCCAGAGCCTGGTGGTGGTCGACGAGGCCTATCAGCCGTTTGCCCAGCACAGCT
GGATGCCGCGCCTGCCCGAGTTCGACCACCTGCTGGTGATGCGCACTGTCTCCAAGCTGGGCCTGGCGGGCATCCGCCTG
GGCTACGTGGCCGGCCACCCGAAGTGGATCGCCGAGCTCGACAAGGTGCGCCCGCCGTACAACGTGAACGTGCTGACCGA
AGCCACCGCCGCGTTCGTGCTCGACCACGTGGACGTGCTCGATGCCCAGGCAGCGACCCTGCGTGCCGAGCGTACCCGGC
TGATCGATGCGCTGTCTGCCCAGCCGGGCGTGACGGTGTTCCCGAGCGCCGCCAATTTCCTGCTGCTGCGCGTGCCCGAT
GCCGCCGGCCTGTTCGAGCGCTTGCTCAAACGGCGGGTCCTGGTCAAAAACGTCAGTAAAATGCACCCGTTGCTGGCCAA
CTGTCTGCGCGTGACGGTCAGCAACCCCGAAGAAAACGCGCAATTTCTTGATGCCTTTGCCGCATCGCTGCAGGACACCC
CATGA

Upstream 100 bases:

>100_bases
GCCTCCGAACTGGCCTACGGCGAGGGGTTGCAGGCGCATGCCCGCAGCGCTGAATACCGCCTGCAGCGCACCACCACCGA
GTGATCCGATCCGCATGACC

Downstream 100 bases:

>100_bases
GCCGCCGCGCCGAGGTCACTCGCAACACCTCCGAAACGCAGATCCGCGTCGCCCTTGATCTGGACGGCACGGGCAAGCAG
ACGCTGAATACCGGCGTTCC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MNANAPVQPSLDDLLGRIVRDDVRAMGAYHVPDASGMVKLDAMENPYHLPAMLRDALGKRLAEVALNRYPVPTADALKAQ
LKRVMRVPAGADVLLGNGSDEIISLIAIAAAKPGATVLAPVPGFVMYAMSAQLMGLKFVGVPLRADLTLDREAMLAAMAE
HQPAVIYLAYPNNPTGNLFDAADMDALLRAARGPVCQSLVVVDEAYQPFAQHSWMPRLPEFDHLLVMRTVSKLGLAGIRL
GYVAGHPKWIAELDKVRPPYNVNVLTEATAAFVLDHVDVLDAQAATLRAERTRLIDALSAQPGVTVFPSAANFLLLRVPD
AAGLFERLLKRRVLVKNVSKMHPLLANCLRVTVSNPEENAQFLDAFAASLQDTP

Sequences:

>Translated_374_residues
MNANAPVQPSLDDLLGRIVRDDVRAMGAYHVPDASGMVKLDAMENPYHLPAMLRDALGKRLAEVALNRYPVPTADALKAQ
LKRVMRVPAGADVLLGNGSDEIISLIAIAAAKPGATVLAPVPGFVMYAMSAQLMGLKFVGVPLRADLTLDREAMLAAMAE
HQPAVIYLAYPNNPTGNLFDAADMDALLRAARGPVCQSLVVVDEAYQPFAQHSWMPRLPEFDHLLVMRTVSKLGLAGIRL
GYVAGHPKWIAELDKVRPPYNVNVLTEATAAFVLDHVDVLDAQAATLRAERTRLIDALSAQPGVTVFPSAANFLLLRVPD
AAGLFERLLKRRVLVKNVSKMHPLLANCLRVTVSNPEENAQFLDAFAASLQDTP
>Mature_374_residues
MNANAPVQPSLDDLLGRIVRDDVRAMGAYHVPDASGMVKLDAMENPYHLPAMLRDALGKRLAEVALNRYPVPTADALKAQ
LKRVMRVPAGADVLLGNGSDEIISLIAIAAAKPGATVLAPVPGFVMYAMSAQLMGLKFVGVPLRADLTLDREAMLAAMAE
HQPAVIYLAYPNNPTGNLFDAADMDALLRAARGPVCQSLVVVDEAYQPFAQHSWMPRLPEFDHLLVMRTVSKLGLAGIRL
GYVAGHPKWIAELDKVRPPYNVNVLTEATAAFVLDHVDVLDAQAATLRAERTRLIDALSAQPGVTVFPSAANFLLLRVPD
AAGLFERLLKRRVLVKNVSKMHPLLANCLRVTVSNPEENAQFLDAFAASLQDTP

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=361, Percent_Identity=32.1329639889197, Blast_Score=144, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6322075, Length=386, Percent_Identity=29.0155440414508, Blast_Score=115, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_RALSO (Q8XV80)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_521072.1
- ProteinModelPortal:   Q8XV80
- SMR:   Q8XV80
- GeneID:   1221805
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2951
- NMPDR:   fig|267608.1.peg.2951
- HOGENOM:   HBG646350
- OMA:   MDEAYQP
- ProtClustDB:   PRK04870
- BioCyc:   RSOL267608:RSC2951-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40442; Mature: 40442

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANAPVQPSLDDLLGRIVRDDVRAMGAYHVPDASGMVKLDAMENPYHLPAMLRDALGKR
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
LAEVALNRYPVPTADALKAQLKRVMRVPAGADVLLGNGSDEIISLIAIAAAKPGATVLAP
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEEEC
VPGFVMYAMSAQLMGLKFVGVPLRADLTLDREAMLAAMAEHQPAVIYLAYPNNPTGNLFD
CCHHHHHHHHHHHHCEEEECCCEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
AADMDALLRAARGPVCQSLVVVDEAYQPFAQHSWMPRLPEFDHLLVMRTVSKLGLAGIRL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHEEE
GYVAGHPKWIAELDKVRPPYNVNVLTEATAAFVLDHVDVLDAQAATLRAERTRLIDALSA
EEECCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPGVTVFPSAANFLLLRVPDAAGLFERLLKRRVLVKNVSKMHPLLANCLRVTVSNPEENA
CCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHH
QFLDAFAASLQDTP
HHHHHHHHHHCCCC
>Mature Secondary Structure
MNANAPVQPSLDDLLGRIVRDDVRAMGAYHVPDASGMVKLDAMENPYHLPAMLRDALGKR
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
LAEVALNRYPVPTADALKAQLKRVMRVPAGADVLLGNGSDEIISLIAIAAAKPGATVLAP
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEEEC
VPGFVMYAMSAQLMGLKFVGVPLRADLTLDREAMLAAMAEHQPAVIYLAYPNNPTGNLFD
CCHHHHHHHHHHHHCEEEECCCEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
AADMDALLRAARGPVCQSLVVVDEAYQPFAQHSWMPRLPEFDHLLVMRTVSKLGLAGIRL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHEEE
GYVAGHPKWIAELDKVRPPYNVNVLTEATAAFVLDHVDVLDAQAATLRAERTRLIDALSA
EEECCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPGVTVFPSAANFLLLRVPDAAGLFERLLKRRVLVKNVSKMHPLLANCLRVTVSNPEENA
CCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHH
QFLDAFAASLQDTP
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852