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The map label for this gene is hisI [H]

Identifier: 17547664

GI number: 17547664

Start: 3175325

End: 3175747

Strand: Reverse

Name: hisI [H]

Synonym: RSc2945

Alternate gene names: 17547664

Gene position: 3175747-3175325 (Counterclockwise)

Preceding gene: 17547665

Following gene: 17547663

Centisome position: 85.45

GC content: 61.7

Gene sequence:

>423_bases
ATGTCCAGGAAATGGCTCAACAAGGTGAAGTGGGACGATCACGGGCTGGTGCCGGTCATCGTGCAGGAGCAGGGCAGCAA
TGACGTCCTGATGTTTGCCTTCATGAACCGCGAAGCGCTGCAGAAGACGGTCGAGACCGGCGAGGCCGTGTTCTGGTCGC
GCTCGCGCAAACGCCTGTGGCACAAAGGCGAGGAGTCCGGCCACATCCAGCAGGTGCACGAGATTCGCCTCGACTGCGAT
GAAGACGTGGTCTTGCTCCGCGTCACGCAGGTCGGCGGCATCGCCTGCCATACTGGTCGCCACGCGTGCTTCTTCCAGAA
ATTCGAGGGCACCGCGGAGGACGGCGATTGGCATACCGTCGAACCCGTGCTCAAGAATCCTGACGACATCTACGCCGGCA
AGCCCGGCCACAACCATGAGTGA

Upstream 100 bases:

>100_bases
ACGCGGTGCTCGCCGCGAGCATCTTCCACTACGGCGAACACACGGTCGGCGAGGCCAAGCGGTTCATGGCGCAACAAGAT
ATTCCGGTGCGGATGTGATC

Downstream 100 bases:

>100_bases
CACCCTGCGCCGCCTGGGCGAGGTGCTCGAATCACGCAAGCTCGCCAACGGCGGTGACCCGGAGAAGAGCTACATCGCCC
GTCTGTTCCACAAGGGCGAC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MSRKWLNKVKWDDHGLVPVIVQEQGSNDVLMFAFMNREALQKTVETGEAVFWSRSRKRLWHKGEESGHIQQVHEIRLDCD
EDVVLLRVTQVGGIACHTGRHACFFQKFEGTAEDGDWHTVEPVLKNPDDIYAGKPGHNHE

Sequences:

>Translated_140_residues
MSRKWLNKVKWDDHGLVPVIVQEQGSNDVLMFAFMNREALQKTVETGEAVFWSRSRKRLWHKGEESGHIQQVHEIRLDCD
EDVVLLRVTQVGGIACHTGRHACFFQKFEGTAEDGDWHTVEPVLKNPDDIYAGKPGHNHE
>Mature_139_residues
SRKWLNKVKWDDHGLVPVIVQEQGSNDVLMFAFMNREALQKTVETGEAVFWSRSRKRLWHKGEESGHIQQVHEIRLDCDE
DVVLLRVTQVGGIACHTGRHACFFQKFEGTAEDGDWHTVEPVLKNPDDIYAGKPGHNHE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=90, Percent_Identity=48.8888888888889, Blast_Score=94, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319819, Length=105, Percent_Identity=31.4285714285714, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 16088; Mature: 15957

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKWLNKVKWDDHGLVPVIVQEQGSNDVLMFAFMNREALQKTVETGEAVFWSRSRKRLW
CCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHCCCEEEHHHHHHHHH
HKGEESGHIQQVHEIRLDCDEDVVLLRVTQVGGIACHTGRHACFFQKFEGTAEDGDWHTV
CCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCEEEEEECCCCCCCCCCEEE
EPVLKNPDDIYAGKPGHNHE
CHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRKWLNKVKWDDHGLVPVIVQEQGSNDVLMFAFMNREALQKTVETGEAVFWSRSRKRLW
CCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHCCCEEEHHHHHHHHH
HKGEESGHIQQVHEIRLDCDEDVVLLRVTQVGGIACHTGRHACFFQKFEGTAEDGDWHTV
CCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCEEEEEECCCCCCCCCCEEE
EPVLKNPDDIYAGKPGHNHE
CHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA