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The map label for this gene is hisE [H]

Identifier: 17547663

GI number: 17547663

Start: 3174958

End: 3175332

Strand: Reverse

Name: hisE [H]

Synonym: RSc2944

Alternate gene names: 17547663

Gene position: 3175332-3174958 (Counterclockwise)

Preceding gene: 17547664

Following gene: 17547662

Centisome position: 85.44

GC content: 67.47

Gene sequence:

>375_bases
ATGAGTGACACCCTGCGCCGCCTGGGCGAGGTGCTCGAATCACGCAAGCTCGCCAACGGCGGTGACCCGGAGAAGAGCTA
CATCGCCCGTCTGTTCCACAAGGGCGACGACGCCATCCTCAAGAAGATCGGCGAAGAGGCCACCGAGACCGTGATGGCCG
CCAAGGACGCCCGCGCCGCCGGCATGACCGACGAGGCGCGCGGCAAGGTCGTCTACGAGGTGGCCGACCTGTGGTTCCAC
ACCATGGTGCTGCTGTCGCACTTCGACCTGACGCCCGACGACGTGGTTAACGAACTGGCGCGCCGCGAAGGGCTCTCGGG
CCTGGAGGAGAAGGCGCTGCGCAAGTCGCAGGCGCGCGATGCGGCCGGTGACTGA

Upstream 100 bases:

>100_bases
CAGAAATTCGAGGGCACCGCGGAGGACGGCGATTGGCATACCGTCGAACCCGTGCTCAAGAATCCTGACGACATCTACGC
CGGCAAGCCCGGCCACAACC

Downstream 100 bases:

>100_bases
GGCCGCGGGTGACTGACACGGCGGCCGATCGCCGCAGGGAGGCAGCGTGGACAAATACGGATCGGCGATGGCGCTGACGG
ACGATGCGGAACGGCTGGCC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH [H]

Number of amino acids: Translated: 124; Mature: 123

Protein sequence:

>124_residues
MSDTLRRLGEVLESRKLANGGDPEKSYIARLFHKGDDAILKKIGEEATETVMAAKDARAAGMTDEARGKVVYEVADLWFH
TMVLLSHFDLTPDDVVNELARREGLSGLEEKALRKSQARDAAGD

Sequences:

>Translated_124_residues
MSDTLRRLGEVLESRKLANGGDPEKSYIARLFHKGDDAILKKIGEEATETVMAAKDARAAGMTDEARGKVVYEVADLWFH
TMVLLSHFDLTPDDVVNELARREGLSGLEEKALRKSQARDAAGD
>Mature_123_residues
SDTLRRLGEVLESRKLANGGDPEKSYIARLFHKGDDAILKKIGEEATETVMAAKDARAAGMTDEARGKVVYEVADLWFHT
MVLLSHFDLTPDDVVNELARREGLSGLEEKALRKSQARDAAGD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008179
- InterPro:   IPR021130 [H]

Pfam domain/function: PF01503 PRA-PH [H]

EC number: =3.6.1.31 [H]

Molecular weight: Translated: 13659; Mature: 13527

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTLRRLGEVLESRKLANGGDPEKSYIARLFHKGDDAILKKIGEEATETVMAAKDARAA
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
GMTDEARGKVVYEVADLWFHTMVLLSHFDLTPDDVVNELARREGLSGLEEKALRKSQARD
CCCCHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
AAGD
CCCC
>Mature Secondary Structure 
SDTLRRLGEVLESRKLANGGDPEKSYIARLFHKGDDAILKKIGEEATETVMAAKDARAA
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
GMTDEARGKVVYEVADLWFHTMVLLSHFDLTPDDVVNELARREGLSGLEEKALRKSQARD
CCCCHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
AAGD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA