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The map label for this gene is trpE [H]

Identifier: 17547600

GI number: 17547600

Start: 3108946

End: 3110475

Strand: Direct

Name: trpE [H]

Synonym: RSc2881

Alternate gene names: 17547600

Gene position: 3108946-3110475 (Clockwise)

Preceding gene: 17547599

Following gene: 17547601

Centisome position: 83.65

GC content: 67.91

Gene sequence:

>1530_bases
ATGACCGAACTCGAATTCAAATCGCTGGCCGACCAGGGCTACAACCGCATCCCGCTGATCGCCGAGGCGCTGGCCGACCT
GGAGACGCCGCTCTCGCTGTACCTGAAGCTGGCGCAATCGCACGACCGCGGCACGCACACCTTCCTGCTGGAATCCGTGG
TGGGCGGCGAGCGCTTCGGGCGCTATTCCTTCATCGGCCTGCATGCGCGCACGCTGCTGCGCACCACCGGCCACCGCACC
GAGGTCGTCACCGACGGCCAGGTGGTCGAAACGCATGACGGCAATCCGCTGGAATTCATCGCCGCCTTCGAGCAACGCCA
CAAGATCGCGCTGCGCCCGGGCCTGCCGCGGTTCTGCGGCGGCCTGGCCGGCTATTTCGGCTACGACGCCGTGCGCTACA
TCGAGCCGCGCCTGACCGACACCGCGCCGCCCGATGACCTGCAGTTGCCCGACATCCAGCTGATGCTGTGCGAAGAGCTG
GCCGTGATCGACAACCTGTCGGGCAAGCTCTACCTGATCGTCTATGCCGATCCGTCCAAGCCCGAGGCTTATCCGCGCGC
CAGGCAGCGCCTGCGCGAACTGCGCGCCAAGCTGCGGCATCCGGTGGACGTGCCGGTGACCTCGCCGTCGGTGCGCACGG
ACATCGTGCGGGAATTCGACAAGGCGGACTACATCACCGCGGTGCTCAAGGCCAAGGAGTACATCGCGGCGGGCGATATG
ATGCAGGTGCAGGTCGGCCAGCGCCTGGTCAAGCCGTTCCGCGACGCGCCGCTGTCGCTGTACCGCGCGCTGCGCTCGCT
GAACCCGTCGCCCTATATGTACTTCTACAACTTCGGCGACATGCAGATCGTCGGGGCCTCGCCGGAGATCCTGGTGCGCC
AGGAAGAGCGCCGCGTGCCGGCCGGCGCGAACGGCAACGGCGCGGAGGAATCCGCCCGCATCGTGACGATCCGCCCGCTG
GCGGGCACCCGCCCGCGCGGCAGCACGCCCGAGCGCGACGCGGAACTGGCCACCGAGCTGCTCAACGACCCGAAGGAGAT
CGCCGAGCACGTCATGCTGATCGACCTGGCGCGCAATGACATCGGCCGCATCGCCGAGATCGGCTCGGTCAAGGTGACCG
ACCAGATGGTCATCGAGAAGTATTCGCACGTGCAGCACATCGTCAGCTCGGTCGAGGGGCGCCTGAAGCCCGGCATGACC
AATATGGACGTGCTGCGCGCCACCTTCCCCGCAGGCACGCTGTCGGGCGCGCCCAAGGTGCGGGCGATGGAGATCATCGA
CGAGCTGGAGCCGGTCAAGCGCGGCATCTACGGCGGCGCGGTGGGCTACCTGTCGTTCTCGGGCGAGATGGACCTGGCGA
TCGCCATCCGCACCGGCATCATCAAGGACGGCAACCTGTACGTGCAGGCCGCCGCCGGCGTGGTGGCCGATTCCGACCCG
GATGCCGAATGGCGCGAGACCGAACACAAGGCGCGCGCCGTGCTGCGCGCCGCCGAGCAGGTCCAGGACGGCCTGGACGC
CGATTTCTGA

Upstream 100 bases:

>100_bases
TGTTCTGCTAACGTTCCGTCGGCGCAACCGCGCTTGCCGTGGAGCGAAACGCATGCCGGCCGTGGCTTTCCGCCCGTCCG
GCGAACCGACCTGACCGCTC

Downstream 100 bases:

>100_bases
CAGGCAAGGAGCCCAACATGCTGCTGATGATCGACAACTACGACTCCTTCACCTACAACATCGTCCAGTACTTCGGCGAG
CTCGGCCAGGACGTGCGCAC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTELEFKSLADQGYNRIPLIAEALADLETPLSLYLKLAQSHDRGTHTFLLESVVGGERFGRYSFIGLHARTLLRTTGHRT
EVVTDGQVVETHDGNPLEFIAAFEQRHKIALRPGLPRFCGGLAGYFGYDAVRYIEPRLTDTAPPDDLQLPDIQLMLCEEL
AVIDNLSGKLYLIVYADPSKPEAYPRARQRLRELRAKLRHPVDVPVTSPSVRTDIVREFDKADYITAVLKAKEYIAAGDM
MQVQVGQRLVKPFRDAPLSLYRALRSLNPSPYMYFYNFGDMQIVGASPEILVRQEERRVPAGANGNGAEESARIVTIRPL
AGTRPRGSTPERDAELATELLNDPKEIAEHVMLIDLARNDIGRIAEIGSVKVTDQMVIEKYSHVQHIVSSVEGRLKPGMT
NMDVLRATFPAGTLSGAPKVRAMEIIDELEPVKRGIYGGAVGYLSFSGEMDLAIAIRTGIIKDGNLYVQAAAGVVADSDP
DAEWRETEHKARAVLRAAEQVQDGLDADF

Sequences:

>Translated_509_residues
MTELEFKSLADQGYNRIPLIAEALADLETPLSLYLKLAQSHDRGTHTFLLESVVGGERFGRYSFIGLHARTLLRTTGHRT
EVVTDGQVVETHDGNPLEFIAAFEQRHKIALRPGLPRFCGGLAGYFGYDAVRYIEPRLTDTAPPDDLQLPDIQLMLCEEL
AVIDNLSGKLYLIVYADPSKPEAYPRARQRLRELRAKLRHPVDVPVTSPSVRTDIVREFDKADYITAVLKAKEYIAAGDM
MQVQVGQRLVKPFRDAPLSLYRALRSLNPSPYMYFYNFGDMQIVGASPEILVRQEERRVPAGANGNGAEESARIVTIRPL
AGTRPRGSTPERDAELATELLNDPKEIAEHVMLIDLARNDIGRIAEIGSVKVTDQMVIEKYSHVQHIVSSVEGRLKPGMT
NMDVLRATFPAGTLSGAPKVRAMEIIDELEPVKRGIYGGAVGYLSFSGEMDLAIAIRTGIIKDGNLYVQAAAGVVADSDP
DAEWRETEHKARAVLRAAEQVQDGLDADF
>Mature_508_residues
TELEFKSLADQGYNRIPLIAEALADLETPLSLYLKLAQSHDRGTHTFLLESVVGGERFGRYSFIGLHARTLLRTTGHRTE
VVTDGQVVETHDGNPLEFIAAFEQRHKIALRPGLPRFCGGLAGYFGYDAVRYIEPRLTDTAPPDDLQLPDIQLMLCEELA
VIDNLSGKLYLIVYADPSKPEAYPRARQRLRELRAKLRHPVDVPVTSPSVRTDIVREFDKADYITAVLKAKEYIAAGDMM
QVQVGQRLVKPFRDAPLSLYRALRSLNPSPYMYFYNFGDMQIVGASPEILVRQEERRVPAGANGNGAEESARIVTIRPLA
GTRPRGSTPERDAELATELLNDPKEIAEHVMLIDLARNDIGRIAEIGSVKVTDQMVIEKYSHVQHIVSSVEGRLKPGMTN
MDVLRATFPAGTLSGAPKVRAMEIIDELEPVKRGIYGGAVGYLSFSGEMDLAIAIRTGIIKDGNLYVQAAAGVVADSDPD
AEWRETEHKARAVLRAAEQVQDGLDADF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=390, Percent_Identity=38.4615384615385, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788114, Length=460, Percent_Identity=32.1739130434783, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786809, Length=237, Percent_Identity=26.5822784810127, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87082077, Length=289, Percent_Identity=25.6055363321799, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=495, Percent_Identity=40.4040404040404, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6324361, Length=512, Percent_Identity=25.9765625, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56333; Mature: 56202

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELEFKSLADQGYNRIPLIAEALADLETPLSLYLKLAQSHDRGTHTFLLESVVGGERFG
CCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHCC
RYSFIGLHARTLLRTTGHRTEVVTDGQVVETHDGNPLEFIAAFEQRHKIALRPGLPRFCG
CEEEEHHHHHHHHHHCCCCEEEEECCEEEECCCCCHHHHHHHHHHCCEEEECCCCHHHHH
GLAGYFGYDAVRYIEPRLTDTAPPDDLQLPDIQLMLCEELAVIDNLSGKLYLIVYADPSK
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCC
PEAYPRARQRLRELRAKLRHPVDVPVTSPSVRTDIVREFDKADYITAVLKAKEYIAAGDM
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
MQVQVGQRLVKPFRDAPLSLYRALRSLNPSPYMYFYNFGDMQIVGASPEILVRQEERRVP
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEEHHCCCC
AGANGNGAEESARIVTIRPLAGTRPRGSTPERDAELATELLNDPKEIAEHVMLIDLARND
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
IGRIAEIGSVKVTDQMVIEKYSHVQHIVSSVEGRLKPGMTNMDVLRATFPAGTLSGAPKV
HHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCH
RAMEIIDELEPVKRGIYGGAVGYLSFSGEMDLAIAIRTGIIKDGNLYVQAAAGVVADSDP
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECEEECCCEEEEEECCEEECCCC
DAEWRETEHKARAVLRAAEQVQDGLDADF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TELEFKSLADQGYNRIPLIAEALADLETPLSLYLKLAQSHDRGTHTFLLESVVGGERFG
CCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHCC
RYSFIGLHARTLLRTTGHRTEVVTDGQVVETHDGNPLEFIAAFEQRHKIALRPGLPRFCG
CEEEEHHHHHHHHHHCCCCEEEEECCEEEECCCCCHHHHHHHHHHCCEEEECCCCHHHHH
GLAGYFGYDAVRYIEPRLTDTAPPDDLQLPDIQLMLCEELAVIDNLSGKLYLIVYADPSK
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCC
PEAYPRARQRLRELRAKLRHPVDVPVTSPSVRTDIVREFDKADYITAVLKAKEYIAAGDM
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
MQVQVGQRLVKPFRDAPLSLYRALRSLNPSPYMYFYNFGDMQIVGASPEILVRQEERRVP
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEEHHCCCC
AGANGNGAEESARIVTIRPLAGTRPRGSTPERDAELATELLNDPKEIAEHVMLIDLARND
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
IGRIAEIGSVKVTDQMVIEKYSHVQHIVSSVEGRLKPGMTNMDVLRATFPAGTLSGAPKV
HHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCH
RAMEIIDELEPVKRGIYGGAVGYLSFSGEMDLAIAIRTGIIKDGNLYVQAAAGVVADSDP
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECEEECCCEEEEEECCEEECCCC
DAEWRETEHKARAVLRAAEQVQDGLDADF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]