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The map label for this gene is mutT [H]

Identifier: 17547550

GI number: 17547550

Start: 3044163

End: 3044624

Strand: Reverse

Name: mutT [H]

Synonym: RSc2831

Alternate gene names: 17547550

Gene position: 3044624-3044163 (Counterclockwise)

Preceding gene: 17547551

Following gene: 17547541

Centisome position: 81.92

GC content: 68.18

Gene sequence:

>462_bases
ATGGGCGGCAGCATGTCGGCTGACACGATCACGCAAGCATCGGCCACACACACGCCGGACGGCCGCAAGATCACCGAAGT
GGCCGTCGGCGTGCTGGTGCAGCCGGATGGCCGCTTCCTGCTGGCGCAGCGCCCCGAGGGCAAGCCGTACGCCGGCTACT
GGGAGTTTCCCGGCGGCAAGCTGGAGTCGGGCGAATCGGTGGAGGCGGCGCTCACGCGCGAGCTGAAGGAAGAGCTCGAC
ATCACGCTGCGCGCCTGCGAGCGGTGGCACACCATCGAGCACGACTATCCGCACGCTTACGTGCGGCTGCACTTCTGCAA
GGTGACGGCGTGGGACGGTGCGTTGCGCGCGCTGGAGGGCCAGGATTTTGCCTGGCAGACGCTGCCCATCAGCGTCGATC
CGGTGCTGCCGGCGACGCTGCCGGTCTTCGAGTGGATGCGCGTTGAGGCCGGGGCTAGTTGA

Upstream 100 bases:

>100_bases
ATCGCCGCCGCCCGGGGCGATGCGCTGGTATGGGCGCTGGAGCGCGGTTCCCGCTCGGGCCGGGTGGCCTGGCAGTTCGC
GCGTGACTGGGGGGGCAAGC

Downstream 100 bases:

>100_bases
GCCTGCCGCTGGCGCCGCCCGATTCCCCACCCGGAGCATCCGGCGGCAGGTCGTCGTCTTCCACCACGGGAATCGTGTAC
TGCTCGGCGGCCCAGGCGCC

Product: 7,8-dihydro-8-oxoguanine-triphosphatase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MGGSMSADTITQASATHTPDGRKITEVAVGVLVQPDGRFLLAQRPEGKPYAGYWEFPGGKLESGESVEAALTRELKEELD
ITLRACERWHTIEHDYPHAYVRLHFCKVTAWDGALRALEGQDFAWQTLPISVDPVLPATLPVFEWMRVEAGAS

Sequences:

>Translated_153_residues
MGGSMSADTITQASATHTPDGRKITEVAVGVLVQPDGRFLLAQRPEGKPYAGYWEFPGGKLESGESVEAALTRELKEELD
ITLRACERWHTIEHDYPHAYVRLHFCKVTAWDGALRALEGQDFAWQTLPISVDPVLPATLPVFEWMRVEAGAS
>Mature_152_residues
GGSMSADTITQASATHTPDGRKITEVAVGVLVQPDGRFLLAQRPEGKPYAGYWEFPGGKLESGESVEAALTRELKEELDI
TLRACERWHTIEHDYPHAYVRLHFCKVTAWDGALRALEGQDFAWQTLPISVDPVLPATLPVFEWMRVEAGAS

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=123, Percent_Identity=38.2113821138211, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1786288, Length=122, Percent_Identity=33.6065573770492, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 16922; Mature: 16791

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGSMSADTITQASATHTPDGRKITEVAVGVLVQPDGRFLLAQRPEGKPYAGYWEFPGGK
CCCCCCCCCEECCCCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCEEECCCCC
LESGESVEAALTRELKEELDITLRACERWHTIEHDYPHAYVRLHFCKVTAWDGALRALEG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECCCHHHHCCC
QDFAWQTLPISVDPVLPATLPVFEWMRVEAGAS
CCCEEEEECEEECCCCCCHHHHHHHHEECCCCC
>Mature Secondary Structure 
GGSMSADTITQASATHTPDGRKITEVAVGVLVQPDGRFLLAQRPEGKPYAGYWEFPGGK
CCCCCCCCEECCCCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCEEECCCCC
LESGESVEAALTRELKEELDITLRACERWHTIEHDYPHAYVRLHFCKVTAWDGALRALEG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECCCHHHHCCC
QDFAWQTLPISVDPVLPATLPVFEWMRVEAGAS
CCCEEEEECEEECCCCCCHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8244038 [H]