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The map label for this gene is nrdB [H]

Identifier: 17547523

GI number: 17547523

Start: 3014124

End: 3015326

Strand: Reverse

Name: nrdB [H]

Synonym: RSc2804

Alternate gene names: 17547523

Gene position: 3015326-3014124 (Counterclockwise)

Preceding gene: 17547524

Following gene: 17547522

Centisome position: 81.14

GC content: 63.51

Gene sequence:

>1203_bases
ATGCTGAGCTGGGACGACGACGTCAAACCTGCCGCACAACCGCAGGCTGCACCGCAGCCCGCCTACCAACCACAGCCGCC
GCTGCAATCGTTCACGCCCGACCAGGGCGGTGCGCTGCCGCCGTCGGCCACGCAGGCCGCGGGTATCCTGGGCAACAACC
CGAACGCCGCCGCCGCGCAGAGCAGCCGCCGCGTCAACGCCGCCGACAAGCGCGTCATCAACGGCGCCACCGACGTCAAC
CAGCTGGTGCCGTTCAAGTACAAGTGGGCCTGGGAAAAATACCTGGCCGGCTGCGCCAACCACTGGATGCCGCAAGAGAT
CAACATGTCGCGCGACATCGCCCTGTGGAAGGACCCGAACGGTCTGACCGAGGACGAGCGGCGTATCATCAAGCGCAACC
TGGGCTTCTTCGTGACGGCCGATTCGCTGGCCGCCAACAACATCGTGCTGGGCACGTACCGCCAGATCACCGCGCCGGAG
TGCCGCCAGTACCTGCTGCGCCAGGCGTTTGAAGAGGCGATCCACACGCACGCCTACCAGTACATCGTCGAATCGCTGGG
CCTGAACGAGGCCGAGATCTTCAACGCGTACCACGAGGTGCAGTCGATCCGCGACAAGGACGAGTTCCTGATCCCGTTCA
TCGACACGCTGACCGATCCGTCGTTCAAGACCGGCACGCCGGAGAATGACCAGAAGCTGCTGAAGTCGCTGATCGTGTTC
GCCTGCATCATGGAAGGGCTGTTCTTCTACGTGGGCTTCACGCAGATCCTGGCGATGGGCCGCCAGAACAAGATGACGGG
CGCCGCCGAGCAGTACCAGTACATCCTGCGCGACGAGTCGCTGCACTGCAATTTCGGCATCGACCTGATCAACCAGATCA
AGCTGGAGAACCCGCACCTGTGGACGGCCGAGTTCAAGGCCGAGATCACGGAGCTGTTCAAGAAGGCCGTCGACCTGGAA
TACCGCTACGCCGAGGACACCATGCCGCGCGGCGTGCTGGGCCTGAACGCGCCGATGTTCAAGGGTTACCTGCGCTTCAT
CTGCAACCGCCGCTGCCAGCAGATCGGCCTGGACGCGCTGTTCCCGAACGAAGACAACCCGTTCCCGTGGATGAGCGAGA
TGATCGACCTGAAGAAGGAGCGCAACTTCTTCGAGACGCGCGTGATCGAGTACCAGACCGGCGGCGCGCTGTCGTGGGAC
TGA

Upstream 100 bases:

>100_bases
CGGCCCGTTATTGCCAACGGCCACCGGCCGGATGGGCCGCGCATGTTCCGAAACATGCGCGCCGCCGGCGGGTCCAATTG
AGAGATTTCGGAGAAATTCC

Downstream 100 bases:

>100_bases
GCACCACAGTGAGCGCTCCACGCGCTTGACACGGAAATAGGCGACGCTGGCTGCGTCGCCTATTTTTTTGCGCGTGCCTT
CCCGGCGCGCGGTCCGGACA

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLSWDDDVKPAAQPQAAPQPAYQPQPPLQSFTPDQGGALPPSATQAAGILGNNPNAAAAQSSRRVNAADKRVINGATDVN
QLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITAPE
CRQYLLRQAFEEAIHTHAYQYIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLIVF
ACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENPHLWTAEFKAEITELFKKAVDLE
YRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLDALFPNEDNPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWD

Sequences:

>Translated_400_residues
MLSWDDDVKPAAQPQAAPQPAYQPQPPLQSFTPDQGGALPPSATQAAGILGNNPNAAAAQSSRRVNAADKRVINGATDVN
QLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITAPE
CRQYLLRQAFEEAIHTHAYQYIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLIVF
ACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENPHLWTAEFKAEITELFKKAVDLE
YRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLDALFPNEDNPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWD
>Mature_400_residues
MLSWDDDVKPAAQPQAAPQPAYQPQPPLQSFTPDQGGALPPSATQAAGILGNNPNAAAAQSSRRVNAADKRVINGATDVN
QLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITAPE
CRQYLLRQAFEEAIHTHAYQYIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLIVF
ACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENPHLWTAEFKAEITELFKKAVDLE
YRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLDALFPNEDNPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWD

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI42544136, Length=361, Percent_Identity=24.9307479224377, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI289177074, Length=320, Percent_Identity=26.5625, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI260064013, Length=320, Percent_Identity=26.875, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI4557845, Length=320, Percent_Identity=26.875, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI289177076, Length=300, Percent_Identity=28, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1788567, Length=292, Percent_Identity=26.3698630136986, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17551968, Length=319, Percent_Identity=26.9592476489028, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193206379, Length=401, Percent_Identity=21.6957605985037, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17567153, Length=224, Percent_Identity=25.4464285714286, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322434, Length=330, Percent_Identity=30.3030303030303, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=22.5, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18079279, Length=372, Percent_Identity=25.2688172043011, Blast_Score=138, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 45554; Mature: 45554

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSWDDDVKPAAQPQAAPQPAYQPQPPLQSFTPDQGGALPPSATQAAGILGNNPNAAAAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHH
SSRRVNAADKRVINGATDVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPN
HCCCCCHHHHHHHCCCCCHHHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
GLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITAPECRQYLLRQAFEEAIHTHAYQ
CCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHHH
YIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLIVF
HHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
ACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENPHL
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCE
WTAEFKAEITELFKKAVDLEYRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLDAL
EHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCC
FPNEDNPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWD
CCCCCCCCCHHHHHHHHHHHCCHHHHHEEEEECCCCCCCC
>Mature Secondary Structure
MLSWDDDVKPAAQPQAAPQPAYQPQPPLQSFTPDQGGALPPSATQAAGILGNNPNAAAAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHH
SSRRVNAADKRVINGATDVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPN
HCCCCCHHHHHHHCCCCCHHHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
GLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITAPECRQYLLRQAFEEAIHTHAYQ
CCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHHH
YIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLIVF
HHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
ACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENPHL
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCE
WTAEFKAEITELFKKAVDLEYRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLDAL
EHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCC
FPNEDNPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWD
CCCCCCCCCHHHHHHHHHHHCCHHHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]