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The map label for this gene is ubiA

Identifier: 17547405

GI number: 17547405

Start: 2893954

End: 2894829

Strand: Reverse

Name: ubiA

Synonym: RSc2686

Alternate gene names: 17547405

Gene position: 2894829-2893954 (Counterclockwise)

Preceding gene: 17547406

Following gene: 17547401

Centisome position: 77.89

GC content: 68.04

Gene sequence:

>876_bases
ATGCAGTCCTCCACCGCCCACCCCAGCCGTCTCGCGCTCTACGCCCGCCTGGTGCGCATCGACAAGCCGATCGGCACGCT
GCTGCTGCTGTGGCCGACGCTGTGGGCCATGTGGATGGCGGCGGATGGGCACCCGCCGCCGGCGCTGGTGGCGATCTTCG
TGGTCGGCACCGTCCTGATGCGCTCGGCCGGCTGCGCGATCAACGACTGGGCCGACCGCGACTTCGACAAGCACGTCAAG
CGCACCAGGGAACGGCCGCTGACCGCCGGCCTGATTGCGCCCTGGGAGGCGCTGGCCGTGGCCGCCGTGCTGGCGCTCGT
CGCCTTCACGCTGATCCTGCCGCTCAACGCGCTGACCAAGTGGCTGTCGGTGGCGGCGGTGCTGATTGCCGGCACGTATC
CGTTCTTCAAGCGCTTCTTTGCGATTCCGCAGGCCTACCTGGGCATCGCGTTCGGCTTCGGCATTCCGATGGCGTATGCC
GCGGTGCAGGACCAGGTGCCGGCGCCGGCGTGGCTGATGCTGGCCGCCAACGTGCTGTGGGCCATTGCTTACGACACGGC
CTATGCGATGGTCGACCGCGATGACGACCTGCTGATCGGCATCCAGACCTCGGCCATCACCTTCGGCCGCTTCGATGTGG
CGGCGATCATGCTGTGCTATGCGGGCTTTTTCGGCATCATGGCCTGGGTCGGCCATGCGCTGGCGCTCGGCGCGGCGTAT
TGGATCGGACTGGCCGCGGCGGCGGCGCTGGCAGGCTACTACTACACATTGCTGCGCACGCGTGACCGCATGCAGTGCTT
CTTCGTGTTCCGCCACAACAACTGGTTCGGCGCCTGCGTGTTCGTGGGCGCGGCGCTTGCCTACGCGCTGCGCTAG

Upstream 100 bases:

>100_bases
TGGATGCTGCGCTCGCTGCTGGCGTAATCCGGCTTTCCGGAAGGACTAGAATGGCGCCTTGCCTCGTGCAGGCGCCATTT
TTCTTTTGTGCAGGCCGATC

Downstream 100 bases:

>100_bases
ATCAGCAGCTTCAGCGCCTTGTAGACCAGCGCGGTGCCGGCCGCGCAGCCCGCCGCGAAGGCGAGCATGCGCAGCGACTC
CCAGATGGCTTCGTCATATT

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MQSSTAHPSRLALYARLVRIDKPIGTLLLLWPTLWAMWMAADGHPPPALVAIFVVGTVLMRSAGCAINDWADRDFDKHVK
RTRERPLTAGLIAPWEALAVAAVLALVAFTLILPLNALTKWLSVAAVLIAGTYPFFKRFFAIPQAYLGIAFGFGIPMAYA
AVQDQVPAPAWLMLAANVLWAIAYDTAYAMVDRDDDLLIGIQTSAITFGRFDVAAIMLCYAGFFGIMAWVGHALALGAAY
WIGLAAAAALAGYYYTLLRTRDRMQCFFVFRHNNWFGACVFVGAALAYALR

Sequences:

>Translated_291_residues
MQSSTAHPSRLALYARLVRIDKPIGTLLLLWPTLWAMWMAADGHPPPALVAIFVVGTVLMRSAGCAINDWADRDFDKHVK
RTRERPLTAGLIAPWEALAVAAVLALVAFTLILPLNALTKWLSVAAVLIAGTYPFFKRFFAIPQAYLGIAFGFGIPMAYA
AVQDQVPAPAWLMLAANVLWAIAYDTAYAMVDRDDDLLIGIQTSAITFGRFDVAAIMLCYAGFFGIMAWVGHALALGAAY
WIGLAAAAALAGYYYTLLRTRDRMQCFFVFRHNNWFGACVFVGAALAYALR
>Mature_291_residues
MQSSTAHPSRLALYARLVRIDKPIGTLLLLWPTLWAMWMAADGHPPPALVAIFVVGTVLMRSAGCAINDWADRDFDKHVK
RTRERPLTAGLIAPWEALAVAAVLALVAFTLILPLNALTKWLSVAAVLIAGTYPFFKRFFAIPQAYLGIAFGFGIPMAYA
AVQDQVPAPAWLMLAANVLWAIAYDTAYAMVDRDDDLLIGIQTSAITFGRFDVAAIMLCYAGFFGIMAWVGHALALGAAY
WIGLAAAAALAGYYYTLLRTRDRMQCFFVFRHNNWFGACVFVGAALAYALR

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=283, Percent_Identity=33.2155477031802, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1790473, Length=280, Percent_Identity=50.3571428571429, Blast_Score=270, Evalue=7e-74,
Organism=Escherichia coli, GI1786631, Length=186, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17553718, Length=295, Percent_Identity=34.9152542372881, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32565247, Length=294, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17553720, Length=192, Percent_Identity=38.5416666666667, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI32565245, Length=150, Percent_Identity=42.6666666666667, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI32565243, Length=146, Percent_Identity=42.4657534246575, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324370, Length=207, Percent_Identity=36.231884057971, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21355567, Length=283, Percent_Identity=33.5689045936396, Blast_Score=147, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_RALSO (Q8XVY9)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520807.1
- GeneID:   1221533
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2686
- NMPDR:   fig|267608.1.peg.2686
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- ProtClustDB:   PRK12848
- BioCyc:   RSOL267608:RSC2686-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 31846; Mature: 31846

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe8d46cc)-; HASH(0xf046d88)-; HASH(0xecd41a0)-; HASH(0xef780c4)-; HASH(0xe33dd5c)-; HASH(0xf04efcc)-; HASH(0xed016bc)-; HASH(0xf04e2a0)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSSTAHPSRLALYARLVRIDKPIGTLLLLWPTLWAMWMAADGHPPPALVAIFVVGTVLM
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RSAGCAINDWADRDFDKHVKRTRERPLTAGLIAPWEALAVAAVLALVAFTLILPLNALTK
HHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLSVAAVLIAGTYPFFKRFFAIPQAYLGIAFGFGIPMAYAAVQDQVPAPAWLMLAANVLW
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AIAYDTAYAMVDRDDDLLIGIQTSAITFGRFDVAAIMLCYAGFFGIMAWVGHALALGAAY
HHHHHHHHHEEECCCCEEEEEEECEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIGLAAAAALAGYYYTLLRTRDRMQCFFVFRHNNWFGACVFVGAALAYALR
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MQSSTAHPSRLALYARLVRIDKPIGTLLLLWPTLWAMWMAADGHPPPALVAIFVVGTVLM
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RSAGCAINDWADRDFDKHVKRTRERPLTAGLIAPWEALAVAAVLALVAFTLILPLNALTK
HHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLSVAAVLIAGTYPFFKRFFAIPQAYLGIAFGFGIPMAYAAVQDQVPAPAWLMLAANVLW
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AIAYDTAYAMVDRDDDLLIGIQTSAITFGRFDVAAIMLCYAGFFGIMAWVGHALALGAAY
HHHHHHHHHEEECCCCEEEEEEECEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIGLAAAAALAGYYYTLLRTRDRMQCFFVFRHNNWFGACVFVGAALAYALR
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852