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The map label for this gene is xseA

Identifier: 17547246

GI number: 17547246

Start: 2734022

End: 2735344

Strand: Reverse

Name: xseA

Synonym: RSc2527

Alternate gene names: 17547246

Gene position: 2735344-2734022 (Counterclockwise)

Preceding gene: 17547254

Following gene: 17547245

Centisome position: 73.6

GC content: 72.71

Gene sequence:

>1323_bases
GTGCTGTCCGTCTCCGAGGTCAACCGGCGCATCGCCGGGCTGCTGGAGCGCCACTTTGCGCTCGGCTGGGTGCGCGGCGA
GATTTCGAACTTCACGCGCGCCGGCAGCGGGCACTGGTATTTCTCGCTCAAGGATGCCGGCGCGCAGATCCGCTGCGTGA
TGTTCAAGGGCCGCAACCAGTACGCCGATTTCACCCCGCGCGAGGGGGAGGCGATCGAGGTGCGCGCGCTGGTCACGCTG
TACGAGGCGCGCGGCGAGCTGCAGTTGAGCGTCGAGGCCATCCGCCGGGCCGGCCTGGGCAATCTGTACGAGGCCTTCCT
GCGGCTCAAGGCGGCGCTGGAGGCACAGGGGCTGTTCGACGCGGCGCGCAAGCGTCCGCTGCCGCGCCATCCGCATGCGA
TCGGCGTGGTGACCTCGCTGCAGGCGGCGGCATTGCGCGATGTGCTGACCACGCTGCATCGGCGCGCGCCGCATGTGCCG
GTGGTGGTCTATCCCGTACCGGTGCAGGGCGCCGGCGCGGCCGAGCGGATTGCGGCCATGCTCGATCTCGTCAACGCGCG
GGCCGAAGTCGATGTGATCATCCTGTGCCGGGGCGGCGGCAGCATCGAAGACCTGTGGGCCTTCAACGAAGAGCCGGTCG
CGCGCGCCGTGGCGGCCTCGGACATTCCCATCGTGGCCGGCGTCGGCCATGAGACCGACGTCACCATCGTCGATTTCGTC
GCCGACGTGCGCGCGCCCACGCCGACCGGGGCCGCCGAACTGGTCAGCCCCGACCGCGCCCGCATGCTGCGTGATGTGGC
GGGCTGCTGGGACGCGCTGTCCGCGACGCTGCGCCGGCAGCTGGACCGCCGCGCCCAGACGGTCGACTGGCTGGCCCGCC
GCCTGCGCAGCCCGCAGGCGCAGATGCGCGAACGGCGCGCCGGGCTGGCGCATCTGGAAGGCCGCCTGCGCTTCGCTCTG
CATGGCCGCGTGCAGCGCGCCGAGCATGGGCAGCGCCTGCTGGCGATGCGGCTGGACGCCGCCCGGCCGGACATCGCGCG
CGAACGCACCGCGCTGCAGGGCATCGAGGCCGCGCTGGCACGCGCCATGCGCGCCACGCTGGACCGTGCGCAGACCCGCC
TGTCGCATCATCAGGCCGGGCTGGAACTGCTGGCGCCGCAGCGCACGCTGGAGCGCGGCTACGCGGTGCTGCTCGATGCC
AAGGGGCAGGCCATCCGCGATCCGGCCGCGCTGCATGCGCGCGCGCGCATCGAGGCGCGGCTGGCGCGGGGCGCGGTCGA
TATCGAGATCGCCCAGGTCCAGCCCAAGCTGCCCGAGATGTGA

Upstream 100 bases:

>100_bases
TTTCTGGATGGATACTCCGGCCGCCGCGCCGGCATCGCCATCGGCCGTTCCGGCACCCCCGCCGCCCTCGCCGGTCGGGC
CGGGGCGGGGCGGGCAGGAG

Downstream 100 bases:

>100_bases
CCGGCGCATGAACACGTAGCGATGTCGTGCGATTCCGTACCTGTTTCGCGGGTATTCCGGTGATTCGGCGTGCGGTTTGC
GCCGGTTTTGCATCTCTCCT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MLSVSEVNRRIAGLLERHFALGWVRGEISNFTRAGSGHWYFSLKDAGAQIRCVMFKGRNQYADFTPREGEAIEVRALVTL
YEARGELQLSVEAIRRAGLGNLYEAFLRLKAALEAQGLFDAARKRPLPRHPHAIGVVTSLQAAALRDVLTTLHRRAPHVP
VVVYPVPVQGAGAAERIAAMLDLVNARAEVDVIILCRGGGSIEDLWAFNEEPVARAVAASDIPIVAGVGHETDVTIVDFV
ADVRAPTPTGAAELVSPDRARMLRDVAGCWDALSATLRRQLDRRAQTVDWLARRLRSPQAQMRERRAGLAHLEGRLRFAL
HGRVQRAEHGQRLLAMRLDAARPDIARERTALQGIEAALARAMRATLDRAQTRLSHHQAGLELLAPQRTLERGYAVLLDA
KGQAIRDPAALHARARIEARLARGAVDIEIAQVQPKLPEM

Sequences:

>Translated_440_residues
MLSVSEVNRRIAGLLERHFALGWVRGEISNFTRAGSGHWYFSLKDAGAQIRCVMFKGRNQYADFTPREGEAIEVRALVTL
YEARGELQLSVEAIRRAGLGNLYEAFLRLKAALEAQGLFDAARKRPLPRHPHAIGVVTSLQAAALRDVLTTLHRRAPHVP
VVVYPVPVQGAGAAERIAAMLDLVNARAEVDVIILCRGGGSIEDLWAFNEEPVARAVAASDIPIVAGVGHETDVTIVDFV
ADVRAPTPTGAAELVSPDRARMLRDVAGCWDALSATLRRQLDRRAQTVDWLARRLRSPQAQMRERRAGLAHLEGRLRFAL
HGRVQRAEHGQRLLAMRLDAARPDIARERTALQGIEAALARAMRATLDRAQTRLSHHQAGLELLAPQRTLERGYAVLLDA
KGQAIRDPAALHARARIEARLARGAVDIEIAQVQPKLPEM
>Mature_440_residues
MLSVSEVNRRIAGLLERHFALGWVRGEISNFTRAGSGHWYFSLKDAGAQIRCVMFKGRNQYADFTPREGEAIEVRALVTL
YEARGELQLSVEAIRRAGLGNLYEAFLRLKAALEAQGLFDAARKRPLPRHPHAIGVVTSLQAAALRDVLTTLHRRAPHVP
VVVYPVPVQGAGAAERIAAMLDLVNARAEVDVIILCRGGGSIEDLWAFNEEPVARAVAASDIPIVAGVGHETDVTIVDFV
ADVRAPTPTGAAELVSPDRARMLRDVAGCWDALSATLRRQLDRRAQTVDWLARRLRSPQAQMRERRAGLAHLEGRLRFAL
HGRVQRAEHGQRLLAMRLDAARPDIARERTALQGIEAALARAMRATLDRAQTRLSHHQAGLELLAPQRTLERGYAVLLDA
KGQAIRDPAALHARARIEARLARGAVDIEIAQVQPKLPEM

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=439, Percent_Identity=42.369020501139, Blast_Score=349, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_RALSO (Q8XWE7)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520648.1
- GeneID:   1221374
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2527
- NMPDR:   fig|267608.1.peg.2527
- HOGENOM:   HBG634411
- OMA:   EISNFTR
- ProtClustDB:   PRK00286
- BioCyc:   RSOL267608:RSC2527-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 48395; Mature: 48395

Theoretical pI: Translated: 10.79; Mature: 10.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVSEVNRRIAGLLERHFALGWVRGEISNFTRAGSGHWYFSLKDAGAQIRCVMFKGRNQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCC
YADFTPREGEAIEVRALVTLYEARGELQLSVEAIRRAGLGNLYEAFLRLKAALEAQGLFD
CCCCCCCCCCEEEHHHHHHHHHCCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AARKRPLPRHPHAIGVVTSLQAAALRDVLTTLHRRAPHVPVVVYPVPVQGAGAAERIAAM
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
LDLVNARAEVDVIILCRGGGSIEDLWAFNEEPVARAVAASDIPIVAGVGHETDVTIVDFV
HHHHHCCCCEEEEEEECCCCCHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHH
ADVRAPTPTGAAELVSPDRARMLRDVAGCWDALSATLRRQLDRRAQTVDWLARRLRSPQA
HHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QMRERRAGLAHLEGRLRFALHGRVQRAEHGQRLLAMRLDAARPDIARERTALQGIEAALA
HHHHHHCCHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
RAMRATLDRAQTRLSHHQAGLELLAPQRTLERGYAVLLDAKGQAIRDPAALHARARIEAR
HHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
LARGAVDIEIAQVQPKLPEM
HHCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MLSVSEVNRRIAGLLERHFALGWVRGEISNFTRAGSGHWYFSLKDAGAQIRCVMFKGRNQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCC
YADFTPREGEAIEVRALVTLYEARGELQLSVEAIRRAGLGNLYEAFLRLKAALEAQGLFD
CCCCCCCCCCEEEHHHHHHHHHCCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AARKRPLPRHPHAIGVVTSLQAAALRDVLTTLHRRAPHVPVVVYPVPVQGAGAAERIAAM
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
LDLVNARAEVDVIILCRGGGSIEDLWAFNEEPVARAVAASDIPIVAGVGHETDVTIVDFV
HHHHHCCCCEEEEEEECCCCCHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHH
ADVRAPTPTGAAELVSPDRARMLRDVAGCWDALSATLRRQLDRRAQTVDWLARRLRSPQA
HHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QMRERRAGLAHLEGRLRFALHGRVQRAEHGQRLLAMRLDAARPDIARERTALQGIEAALA
HHHHHHCCHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
RAMRATLDRAQTRLSHHQAGLELLAPQRTLERGYAVLLDAKGQAIRDPAALHARARIEAR
HHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
LARGAVDIEIAQVQPKLPEM
HHCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852