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The map label for this gene is clpA [H]

Identifier: 17547183

GI number: 17547183

Start: 2672247

End: 2674535

Strand: Reverse

Name: clpA [H]

Synonym: RSc2464

Alternate gene names: 17547183

Gene position: 2674535-2672247 (Counterclockwise)

Preceding gene: 17547184

Following gene: 17547179

Centisome position: 71.97

GC content: 65.49

Gene sequence:

>2289_bases
ATGATCGCGCAAGAACTGGAAGTCAGCCTGCACATGGCGTTTGTCGAAGCCCGCCAGGCTCGCCACGAATTCATTACGGT
GGAGCATCTGCTGCTTGCGCTGCTGGACAATCCGACGGCGGCGGAAGTGCTGCGCGCCTGCGCCGCCAACATCGAAGACC
TCCGCACGCACCTGAAGAACTTCATCGCCGACAACACGCCGGTGGTGCCGGGCACGGACGAGGTGGACACGCAGCCGACG
CTGGGCTTCCAGCGCGTGATCCAGCGCGCCATCATGCACGTGCAGTCGACCTCCAACGGCAAGAAGGAGGTGACGGGCGC
CAATGTGCTGGTGGCCATCTTCGGCGAGAAGGACTCCCACGCGGTCTACTACCTGCAGCAGCAGGGCGTGACGCGGCTGG
ACGTCGTCAACTTCATCAGCCACGGCATCCGCAAGGACCAGGCGGAGCCGGCCAAGCACGGCGACAGCAACCCGGAGGGC
GAAGCCGGCGACGGTAAGGAAAGCCCGCTGGAGCAGTTCACCCAGAACCTGAACGCGCTGGCCAAGGCCGGCAAGATCGA
TCCGCTGATCGGCCGCGAGCAGGAAGTCGAGCGCGTGGTGCAGGTGCTGTGCCGTCGCCGCAAGAACAATCCGCTGCTGG
TGGGCGAGGCGGGCGTCGGCAAGACGGCGATCGCCGAAGGGCTGGCATGGCGCATCACCAAGGGCGAGGTGCCGGACATC
CTGGCCCGGTCTGTGGTGTATTCGCTCGACATGGGCGCGCTGCTGGCCGGCACCAAGTATCGTGGCGACTTCGAGCAGCG
GCTCAAGGGCGTGCTGAAGTCGCTCAAGGACAACCCGAACGCGATCCTGTTCATCGACGAAATCCATACGCTGATCGGCG
CCGGCGCCGCATCGGGCGGCACGCTGGACGCGAGCAACCTGCTCAAGCCGGCGCTGTCGTCGGGCGCGCTCAAGTGCATC
GGCGCGACCACCTTCACCGAATACCGGGGCATCTTCGAGAAGGACGCGGCGCTGTCGCGGCGCTTCCAGAAGATCGACGT
GGTGGAGCCGTCCATTGACCAGACCGTGCAGATCCTGCGTGGGCTGAAGTCGCGGTTCGAGGAGCACCACGGCGTCAAGT
ACGCGGCGTCCGCCCTGACGGCGGCGGCTGAGCTGTCGGCGCGTTTCATTACTGACCGCCACCTGCCGGACAAGGCGATC
GACGTGATCGACGAGGCCGGCGCGGCGCAGCGCATCCTGCCGAAGTCGAAGCAGAAGAAGACCATCGGCAAGGGCGAGAT
TGAAGACATCGTGTCGCGCATCGCCCGTGTCCCGCCGCAAAGCGTGTCGCAGGACGACCGCAGCAAGCTGCAGACGCTGG
AGCGCGATCTGAAGTCGGTCGTGTTCGGGCAGGACCCGGCCATCGACGCGCTGGCTTCGGCCATCAAGATGTCGCGTGCC
GGGCTGGGCAAGACCGACAAGCCGATCGGCTCGTTCCTGTTCTCCGGCCCGACCGGCGTCGGCAAGACCGAGGTCGCCAA
GCAGCTGGCGTTCATCCTGGGCATCGAGCTGATCCGCTTCGACATGTCGGAGTACATGGAACGCCATGCGGTGAGCCGGC
TGATCGGCGCGCCTCCGGGCTACGTCGGGTTCGACCAGGGCGGCCTGCTGACCGAGGCCATCACCAAGAAGCCGCACTGC
GTGCTGCTGCTGGACGAAATCGAGAAGGCCCACCCGGACATCTTCAACATCCTGCTGCAAGTGATGGACCACGGCTCGCT
GACGGACAACAACGGCCGCAAGGCGGATTTCCGCAACGTGATCATCGTCATGACGACCAACGCGGGCGCCGAGACGATGA
ACAAGGCCACCATCGGCTTCACCACGACGCGCGAGCAGGGCGACGAGATGGCCGATATCAAGCGGATGTTCACGCCGGAG
TTCCGCAACCGCCTGGATGCGACCATCAGCTTCCGCTCGCTGGACGAGGACATCATCCTGCGCGTGGTCGACAAGTTCCT
GATGCAGCTGGAAGAGCAACTGCACGAGAAGAAGGTGGACGCCGTCTTCACCGAGAAGCTGCGCCGCTTCCTGGCGAAGA
AGGGCTTCGACCCGCTGATGGGCGCGCGGCCGATGCAGCGCCTGATCCAGGACATGATCCGCAAGGCGCTGGCCGACGAG
CTGCTGTTCGGCAAGCTGGTCAACGGCGGCAAGGTGGCGGTGGACCTGGACGATGCCGACGCGGTCAAGCTGGAGTTCTC
CGAGAACGAGGCGCCGCCCGCGCCCGCGCAGGAAGAGGCGGAAGCCTGA

Upstream 100 bases:

>100_bases
GCGGTATCTACACCCGGGATATCGCCGCGACGAAAGTGGAATTGGTATCAACCCATGCACGGCAGGCGGGCCACCCCCTG
CAGTGCGTGATGGAGGAAGC

Downstream 100 bases:

>100_bases
CGGTTCGGTGGTTCCCAAGCAAAACGGCCCGGAAATCCCGGGCCGTTTTTTTATGCATGGAGGCGGTGTTCAGTGCCGGC
CGGTGCTGCCGAAGCCGCCC

Product: ATP-dependent protease ATP-binding specificity subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 762; Mature: 762

Protein sequence:

>762_residues
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTHLKNFIADNTPVVPGTDEVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIRKDQAEPAKHGDSNPEG
EAGDGKESPLEQFTQNLNALAKAGKIDPLIGREQEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITKGEVPDI
LARSVVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGALKCI
GATTFTEYRGIFEKDAALSRRFQKIDVVEPSIDQTVQILRGLKSRFEEHHGVKYAASALTAAAELSARFITDRHLPDKAI
DVIDEAGAAQRILPKSKQKKTIGKGEIEDIVSRIARVPPQSVSQDDRSKLQTLERDLKSVVFGQDPAIDALASAIKMSRA
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFILGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAITKKPHC
VLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRKADFRNVIIVMTTNAGAETMNKATIGFTTTREQGDEMADIKRMFTPE
FRNRLDATISFRSLDEDIILRVVDKFLMQLEEQLHEKKVDAVFTEKLRRFLAKKGFDPLMGARPMQRLIQDMIRKALADE
LLFGKLVNGGKVAVDLDDADAVKLEFSENEAPPAPAQEEAEA

Sequences:

>Translated_762_residues
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTHLKNFIADNTPVVPGTDEVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIRKDQAEPAKHGDSNPEG
EAGDGKESPLEQFTQNLNALAKAGKIDPLIGREQEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITKGEVPDI
LARSVVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGALKCI
GATTFTEYRGIFEKDAALSRRFQKIDVVEPSIDQTVQILRGLKSRFEEHHGVKYAASALTAAAELSARFITDRHLPDKAI
DVIDEAGAAQRILPKSKQKKTIGKGEIEDIVSRIARVPPQSVSQDDRSKLQTLERDLKSVVFGQDPAIDALASAIKMSRA
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFILGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAITKKPHC
VLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRKADFRNVIIVMTTNAGAETMNKATIGFTTTREQGDEMADIKRMFTPE
FRNRLDATISFRSLDEDIILRVVDKFLMQLEEQLHEKKVDAVFTEKLRRFLAKKGFDPLMGARPMQRLIQDMIRKALADE
LLFGKLVNGGKVAVDLDDADAVKLEFSENEAPPAPAQEEAEA
>Mature_762_residues
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTHLKNFIADNTPVVPGTDEVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIRKDQAEPAKHGDSNPEG
EAGDGKESPLEQFTQNLNALAKAGKIDPLIGREQEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITKGEVPDI
LARSVVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGALKCI
GATTFTEYRGIFEKDAALSRRFQKIDVVEPSIDQTVQILRGLKSRFEEHHGVKYAASALTAAAELSARFITDRHLPDKAI
DVIDEAGAAQRILPKSKQKKTIGKGEIEDIVSRIARVPPQSVSQDDRSKLQTLERDLKSVVFGQDPAIDALASAIKMSRA
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFILGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAITKKPHC
VLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRKADFRNVIIVMTTNAGAETMNKATIGFTTTREQGDEMADIKRMFTPE
FRNRLDATISFRSLDEDIILRVVDKFLMQLEEQLHEKKVDAVFTEKLRRFLAKKGFDPLMGARPMQRLIQDMIRKALADE
LLFGKLVNGGKVAVDLDDADAVKLEFSENEAPPAPAQEEAEA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=340, Percent_Identity=29.4117647058824, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1787109, Length=738, Percent_Identity=64.0921409214092, Blast_Score=983, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=399, Percent_Identity=45.8646616541353, Blast_Score=307, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6320464, Length=253, Percent_Identity=57.3122529644269, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=259, Percent_Identity=51.7374517374517, Blast_Score=260, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83550; Mature: 83550

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTHLKN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIADNTPVVPGTDEVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIRKDQAEPAKHGDSNPEGEAGDGKESPLEQFTQNLNAL
EEEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AKAGKIDPLIGREQEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITKGEVPDI
HHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEECCCCCHHH
LARSVVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGG
HHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
TLDASNLLKPALSSGALKCIGATTFTEYRGIFEKDAALSRRFQKIDVVEPSIDQTVQILR
CCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSRFEEHHGVKYAASALTAAAELSARFITDRHLPDKAIDVIDEAGAAQRILPKSKQKK
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHHHH
TIGKGEIEDIVSRIARVPPQSVSQDDRSKLQTLERDLKSVVFGQDPAIDALASAIKMSRA
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFILGIELIRFDMSEYMERHAVSRLIGAPPG
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGFDQGGLLTEAITKKPHCVLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRKADFRNV
CCCCCCCCHHHHHHCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCE
IIVMTTNAGAETMNKATIGFTTTREQGDEMADIKRMFTPEFRNRLDATISFRSLDEDIIL
EEEEECCCCCHHHCCCEEEEEECHHCCHHHHHHHHHHCHHHHHHHHHEEEHHHCCHHHHH
RVVDKFLMQLEEQLHEKKVDAVFTEKLRRFLAKKGFDPLMGARPMQRLIQDMIRKALADE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLFGKLVNGGKVAVDLDDADAVKLEFSENEAPPAPAQEEAEA
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTHLKN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIADNTPVVPGTDEVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIRKDQAEPAKHGDSNPEGEAGDGKESPLEQFTQNLNAL
EEEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AKAGKIDPLIGREQEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITKGEVPDI
HHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEECCCCCHHH
LARSVVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGG
HHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
TLDASNLLKPALSSGALKCIGATTFTEYRGIFEKDAALSRRFQKIDVVEPSIDQTVQILR
CCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSRFEEHHGVKYAASALTAAAELSARFITDRHLPDKAIDVIDEAGAAQRILPKSKQKK
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHHHH
TIGKGEIEDIVSRIARVPPQSVSQDDRSKLQTLERDLKSVVFGQDPAIDALASAIKMSRA
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFILGIELIRFDMSEYMERHAVSRLIGAPPG
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGFDQGGLLTEAITKKPHCVLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRKADFRNV
CCCCCCCCHHHHHHCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCE
IIVMTTNAGAETMNKATIGFTTTREQGDEMADIKRMFTPEFRNRLDATISFRSLDEDIIL
EEEEECCCCCHHHCCCEEEEEECHHCCHHHHHHHHHHCHHHHHHHHHEEEHHHCCHHHHH
RVVDKFLMQLEEQLHEKKVDAVFTEKLRRFLAKKGFDPLMGARPMQRLIQDMIRKALADE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLFGKLVNGGKVAVDLDDADAVKLEFSENEAPPAPAQEEAEA
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]