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The map label for this gene is dut [H]

Identifier: 17547182

GI number: 17547182

Start: 2671731

End: 2672177

Strand: Direct

Name: dut [H]

Synonym: RSc2463

Alternate gene names: 17547182

Gene position: 2671731-2672177 (Clockwise)

Preceding gene: 17547181

Following gene: 17547185

Centisome position: 71.89

GC content: 69.8

Gene sequence:

>447_bases
ATGAAACTCGACGTCCAGATCCTCGACGCCCGCCTGCACGAACAGCTCCCGCAGTACGCCACGCCCGGCAGCGCCGGCCT
GGACCTGCGCGCCTGCCTCGATGCCCCGCTCACCCTCGAGCCCGGCAGCACGCACCTGATCCCGACCGGCATGGCCATCC
ACCTGGCCGACCCCGGCTATGCGGCGCTGATCCTGCCGCGCTCCGGCATGGGCCACAAGCACGGCATCGTGCTCGGCAAC
CTGGTCGGCCTGATCGATTCGGACTACCAGGGCCAGCTGATGATCAGCACCTGGAACCGCGGCGACACCGCCTTCGTGCT
GAATCCGATGGAGCGCCTGGCGCAGCTGGTGATCGTGCCGGTGGTGCAGGCCGAGCTGAACATCGTGGACGCCTTCGCGG
AAAGCGAGCGCGGCGCGGGCGGCTTCGGCAGCACCGGCCGGCACTGA

Upstream 100 bases:

>100_bases
CGCCGAGCTACCGGGCACGCATGCGCTCATACGAGCTGCTGGCCCAGGCGTTTGCGCTACCATCTCCGGCTTCCGCCACC
CAACCTTCGGCTTGTCCCGC

Downstream 100 bases:

>100_bases
ACACCGCCTCCATGCATAAAAAAACGGCCCGGGATTTCCGGGCCGTTTTGCTTGGGAACCACCGAACCGTCAGGCTTCCG
CCTCTTCCTGCGCGGGCGCG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKLDVQILDARLHEQLPQYATPGSAGLDLRACLDAPLTLEPGSTHLIPTGMAIHLADPGYAALILPRSGMGHKHGIVLGN
LVGLIDSDYQGQLMISTWNRGDTAFVLNPMERLAQLVIVPVVQAELNIVDAFAESERGAGGFGSTGRH

Sequences:

>Translated_148_residues
MKLDVQILDARLHEQLPQYATPGSAGLDLRACLDAPLTLEPGSTHLIPTGMAIHLADPGYAALILPRSGMGHKHGIVLGN
LVGLIDSDYQGQLMISTWNRGDTAFVLNPMERLAQLVIVPVVQAELNIVDAFAESERGAGGFGSTGRH
>Mature_148_residues
MKLDVQILDARLHEQLPQYATPGSAGLDLRACLDAPLTLEPGSTHLIPTGMAIHLADPGYAALILPRSGMGHKHGIVLGN
LVGLIDSDYQGQLMISTWNRGDTAFVLNPMERLAQLVIVPVVQAELNIVDAFAESERGAGGFGSTGRH

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=146, Percent_Identity=34.9315068493151, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4503423, Length=146, Percent_Identity=34.9315068493151, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI70906441, Length=146, Percent_Identity=34.9315068493151, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1790071, Length=149, Percent_Identity=65.7718120805369, Blast_Score=207, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71988561, Length=145, Percent_Identity=36.551724137931, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319729, Length=132, Percent_Identity=34.0909090909091, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583610, Length=149, Percent_Identity=31.5436241610738, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921126, Length=149, Percent_Identity=31.5436241610738, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15745; Mature: 15745

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDVQILDARLHEQLPQYATPGSAGLDLRACLDAPLTLEPGSTHLIPTGMAIHLADPGY
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEHHHCCCCEEECCCCCEEEECCEEEEECCCCE
AALILPRSGMGHKHGIVLGNLVGLIDSDYQGQLMISTWNRGDTAFVLNPMERLAQLVIVP
EEEEEECCCCCCCCCEEEEHEEECCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHH
VVQAELNIVDAFAESERGAGGFGSTGRH
HHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLDVQILDARLHEQLPQYATPGSAGLDLRACLDAPLTLEPGSTHLIPTGMAIHLADPGY
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEHHHCCCCEEECCCCCEEEECCEEEEECCCCE
AALILPRSGMGHKHGIVLGNLVGLIDSDYQGQLMISTWNRGDTAFVLNPMERLAQLVIVP
EEEEEECCCCCCCCCEEEEHEEECCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHH
VVQAELNIVDAFAESERGAGGFGSTGRH
HHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA