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The map label for this gene is argH [H]

Identifier: 17547082

GI number: 17547082

Start: 2566073

End: 2567488

Strand: Direct

Name: argH [H]

Synonym: RSc2363

Alternate gene names: 17547082

Gene position: 2566073-2567488 (Clockwise)

Preceding gene: 17547081

Following gene: 17547099

Centisome position: 69.05

GC content: 68.36

Gene sequence:

>1416_bases
ATGACCTCCCAACTCGCCAAGAAGGCCGAAGCGTGGTCCGCCCGCTTTAACGAGCCGATGTCCGACCTCGTCAAGCGCTA
TACCGCCTCGGTGTTCTTCGACAAGCGCCTCGCGCTGTTCGACATCCAGGGCTCGCTCGCGCACGCGGCCATGCTCGCCA
AGCAGGGCATCATCGCGGAGGCCGATCGCGCTGCCATCGAGCAAGGCATGGCGCAGATCCGCCAGGAGATCGAAGCCGGC
ACGTTCGAGTGGAAGCTGGACCTGGAAGACGTGCACCTGAACATCGAAGCGCGCCTGACCGCCATGGCGGGCGACGCCGG
CAAGCGCCTGCACACCGGCCGCTCGCGCAACGACCAGGTCGCCACCGACATCCGCCTGTGGCTGCGCAGCGAGATCGACA
ATATCGTCGGCTTGCTCCGCGCCCTGCGCGGCGCCCTGCTGGACCTGGCCGAGCAGCACACCAACACCATCGTCCCCGGC
TTCACGCACCTGCAGGTCGCGCAACCGGTGGTGTTCGGCCACCACCTGCTGGCCTATGTCGAGATGTTCACGCGCGACAC
CGAGCGCATGCTCGACGCCCGCAAGCGGGTCAACCGCCTGCCGCTGGGCGCCGCCGCGCTGGCCGGCACGAGCTACCCGA
TCGACCGCGAATTCGTCGCGCAGCAGCTGGGCTTCGACGGCGTGTGCCGCAACTCGCTGGATGCGGTGTCGGACCGCGAC
TTCGCCATCGAATTCTGCGCCGCCGCCGCGCTGGTGATGACGCACATCTCGCGCTTCTCGGAAGAGCTGGTGCTGTGGAT
GAGCCCGCGCGTGGGCTTCATCGACATCGCCGACCGCTTCTGCACCGGCAGCTCGATCATGCCGCAGAAGAAGAACCCCG
ACGTGCCCGAACTGGCGCGCGGCAAGACCGGCCGCGTCAACGGCCACCTGATCGGCCTGCTCACGCTGATGAAGGGCCAG
CCGCTGGCCTACAACAAGGACAACCAGGAAGACAAGGAACCGCTGTTCGACACGGTCGACACGGTGGTCGACACGCTGCG
CATCTTCGCCGACATGGTGCCCGGCATCACGGTCAAGGCCGACGCCATGCGCGCCGCCGCCCTGCAGGGCTACGCCACCG
CCACCGACCTGGCCGACTACCTGGTCAAGCGCGGCCTGCCCTTCCGCGACGCGCACGAAGCCGTGGCCCACGCCGTGCGC
GCCTGCGACGACCTGCGCTGCGACCTGGCCGACCTGTCGGTGACGCAGCTGCGCGAGATCAGCGGCCTGGGTGACAAGGC
GAACCTGATCGGCGACGACGTGCACGCCGTGCTGACGCTGGAAGGCTCGGTTGCTTCGCGCAACCATATCGGCGGGACGG
CGCCGGAGCAGGTGAGGCTGGCGATTGTTGCGGCGCGGGCTGGGCTGGCGGGCTAA

Upstream 100 bases:

>100_bases
GGAGCGCCGGGCTGGCCATGGGCCGGCGGACGATATAATCGCGGTTTCCTGAATCCGCGGCCGGCCCATCCCGCCCGGCT
GCCCTCCTCCGCTGTCCACC

Downstream 100 bases:

>100_bases
CCGCCGGACAGCCGGACCGTCGCCAGCCGCTCGAACCACGGCCCGTCCGGGGGCGTGCGGCTGGCGAAGAGCGACAGGCT
GTCGAACCGCATGGCCGCAC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTSQLAKKAEAWSARFNEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAAIEQGMAQIRQEIEAG
TFEWKLDLEDVHLNIEARLTAMAGDAGKRLHTGRSRNDQVATDIRLWLRSEIDNIVGLLRALRGALLDLAEQHTNTIVPG
FTHLQVAQPVVFGHHLLAYVEMFTRDTERMLDARKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDRD
FAIEFCAAAALVMTHISRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLIGLLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVKADAMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVR
ACDDLRCDLADLSVTQLREISGLGDKANLIGDDVHAVLTLEGSVASRNHIGGTAPEQVRLAIVAARAGLAG

Sequences:

>Translated_471_residues
MTSQLAKKAEAWSARFNEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAAIEQGMAQIRQEIEAG
TFEWKLDLEDVHLNIEARLTAMAGDAGKRLHTGRSRNDQVATDIRLWLRSEIDNIVGLLRALRGALLDLAEQHTNTIVPG
FTHLQVAQPVVFGHHLLAYVEMFTRDTERMLDARKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDRD
FAIEFCAAAALVMTHISRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLIGLLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVKADAMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVR
ACDDLRCDLADLSVTQLREISGLGDKANLIGDDVHAVLTLEGSVASRNHIGGTAPEQVRLAIVAARAGLAG
>Mature_470_residues
TSQLAKKAEAWSARFNEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAAIEQGMAQIRQEIEAGT
FEWKLDLEDVHLNIEARLTAMAGDAGKRLHTGRSRNDQVATDIRLWLRSEIDNIVGLLRALRGALLDLAEQHTNTIVPGF
THLQVAQPVVFGHHLLAYVEMFTRDTERMLDARKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDRDF
AIEFCAAAALVMTHISRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLIGLLTLMKGQP
LAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVKADAMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVRA
CDDLRCDLADLSVTQLREISGLGDKANLIGDDVHAVLTLEGSVASRNHIGGTAPEQVRLAIVAARAGLAG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=464, Percent_Identity=40.7327586206897, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI68303542, Length=464, Percent_Identity=40.7327586206897, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI68303547, Length=464, Percent_Identity=38.3620689655172, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI68303549, Length=462, Percent_Identity=37.6623376623377, Blast_Score=309, Evalue=4e-84,
Organism=Escherichia coli, GI1790398, Length=459, Percent_Identity=45.5337690631808, Blast_Score=401, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321806, Length=450, Percent_Identity=42.2222222222222, Blast_Score=343, Evalue=3e-95,
Organism=Drosophila melanogaster, GI221473854, Length=459, Percent_Identity=39.6514161220044, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI78706858, Length=459, Percent_Identity=39.6514161220044, Blast_Score=320, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51489; Mature: 51357

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQLAKKAEAWSARFNEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAE
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCHHH
ADRAAIEQGMAQIRQEIEAGTFEWKLDLEDVHLNIEARLTAMAGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHHHHHCCCEEEEEEHHHEEEEEEEEEEEECCCCCHHHCCCCCCCCHH
ATDIRLWLRSEIDNIVGLLRALRGALLDLAEQHTNTIVPGFTHLQVAQPVVFGHHLLAYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
EMFTRDTERMLDARKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHCCHHHCCCCH
FAIEFCAAAALVMTHISRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLIGLLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVKA
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEH
DAMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVRACDDLRCDLADLSVTQLREI
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHCHHHHHHHH
SGLGDKANLIGDDVHAVLTLEGSVASRNHIGGTAPEQVRLAIVAARAGLAG
HCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHEEHHCCCCC
>Mature Secondary Structure 
TSQLAKKAEAWSARFNEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAE
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCHHH
ADRAAIEQGMAQIRQEIEAGTFEWKLDLEDVHLNIEARLTAMAGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHHHHHCCCEEEEEEHHHEEEEEEEEEEEECCCCCHHHCCCCCCCCHH
ATDIRLWLRSEIDNIVGLLRALRGALLDLAEQHTNTIVPGFTHLQVAQPVVFGHHLLAYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
EMFTRDTERMLDARKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHCCHHHCCCCH
FAIEFCAAAALVMTHISRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLIGLLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVKA
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEH
DAMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVRACDDLRCDLADLSVTQLREI
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHCHHHHHHHH
SGLGDKANLIGDDVHAVLTLEGSVASRNHIGGTAPEQVRLAIVAARAGLAG
HCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA