Click here to switch to the map view.

The map label for this gene is degS [H]

Identifier: 17547030

GI number: 17547030

Start: 2511607

End: 2512758

Strand: Direct

Name: degS [H]

Synonym: RSc2311

Alternate gene names: 17547030

Gene position: 2511607-2512758 (Clockwise)

Preceding gene: 17547009

Following gene: 17547034

Centisome position: 67.58

GC content: 64.93

Gene sequence:

>1152_bases
ATGAAAACCTCTTCGCAGCGCGACGGCCGGCACCTCCACCTGACGTGGCGTGACGTCATCGATGCTGTCCGCAAGCTGAC
CGCAACCGTTCAGCCCAACGAACAGAACTTCGACGCGGCGTCCGATGTCCGCGGCGCGGCGTTTTGCATCCTGTCTCCCG
ACGGACATTTCGTTTCCGCGAACGACAGCACCGGCGCCATCTTCGGCTACTCGGGCAACGAACTGATCGGCCATTCCCTG
GTGGACATGGCGGCGAACGGCGGACGGCAGGACATCATCGATGGGCTGTCGCGCTGTGCTTCGGGGACGTTCCATTCGTT
TCGTGCGCAGCTGTCCATGCGCGGTGGCCGCCATGCCTCGGTGCTGCTGCACCAGCATCCGATCTTCGACAGCGACGGCT
GCATCGGCGCATTGCTGACCATCTTCGAAGAGCCGTCCGCAAGCGAACCCGCTGCGCCGGACGCCGCCGCCAGCCCGCCA
TCGGCCGAACCGGATGCCAAGCGTCAATATGCCTTTCTGATGATCGGCCAGGAAAGGGAGCGCAAGCGGATCTCGGCTGA
GCTGCACGATGGGCTGGGCCAAGCGCTGACGCTCGTCAAGCTGACGGTCGAGGATGCCCTGATCCATATCCATCGCAACA
ACATCACCGAGGCCGCCGAGCTGCTCAATACCGCCGTGCTGCGCATCCGCGAATCGATCGGCGACCTGCGCCGCATCTGC
AGCGAACTGCGCCCCGCCCTGCTCGATCGCCTCGGCCTGGCCGCTTCGCTCGACGCCCTGTGCAAGCGTGTCGAACAGGA
AGCGGGGCACCTTGCCGTGCGCTTCGATAGCGGCGTCGAAGACGAGGAGGTCCCCGACAACCTGAAGGCCGACATCTTCC
GGATCACGCAGGAGGCCATGAACAACGCGATCAGGCATGGCGCGGCCACCGAAATCCGCCTGAGCCTGCGCCGCATCGAG
AGCGGCATCCTGCTGACGATTCAAGACAACGGCATCGGCTTCGACACGCAGCCCCTGTTTGCCGACCCGGTGTCGCAATC
CGGCCTCGGCCTGATCGGCATGCAACAGCGGGTCGAGCTCAACGGCGGCAGCTTCTTCATCCAGTCGAGCGTGGGCGACG
GCACGCTGGTCTCCGCGCTATGGCGCGCATGA

Upstream 100 bases:

>100_bases
TGGCCGAGCGCAGACACTGCGCATGCCGGCAATCGGCGCGTGCAGCAGCGGCGCGTATTGATGTCGCACCGCATCAACCG
GTCCCCCGTTCGGAGGCCAG

Downstream 100 bases:

>100_bases
CCACGGGCAGCCGCCCACGGTGACCTCAATACCGTCAAGCCGCCGCCCGTTCACCTCACCTCACGGCGATACGCCGGGGG
CTCGATATTGGTGTCGCTTT

Product: two-component sensor histidine kinase transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKTSSQRDGRHLHLTWRDVIDAVRKLTATVQPNEQNFDAASDVRGAAFCILSPDGHFVSANDSTGAIFGYSGNELIGHSL
VDMAANGGRQDIIDGLSRCASGTFHSFRAQLSMRGGRHASVLLHQHPIFDSDGCIGALLTIFEEPSASEPAAPDAAASPP
SAEPDAKRQYAFLMIGQERERKRISAELHDGLGQALTLVKLTVEDALIHIHRNNITEAAELLNTAVLRIRESIGDLRRIC
SELRPALLDRLGLAASLDALCKRVEQEAGHLAVRFDSGVEDEEVPDNLKADIFRITQEAMNNAIRHGAATEIRLSLRRIE
SGILLTIQDNGIGFDTQPLFADPVSQSGLGLIGMQQRVELNGGSFFIQSSVGDGTLVSALWRA

Sequences:

>Translated_383_residues
MKTSSQRDGRHLHLTWRDVIDAVRKLTATVQPNEQNFDAASDVRGAAFCILSPDGHFVSANDSTGAIFGYSGNELIGHSL
VDMAANGGRQDIIDGLSRCASGTFHSFRAQLSMRGGRHASVLLHQHPIFDSDGCIGALLTIFEEPSASEPAAPDAAASPP
SAEPDAKRQYAFLMIGQERERKRISAELHDGLGQALTLVKLTVEDALIHIHRNNITEAAELLNTAVLRIRESIGDLRRIC
SELRPALLDRLGLAASLDALCKRVEQEAGHLAVRFDSGVEDEEVPDNLKADIFRITQEAMNNAIRHGAATEIRLSLRRIE
SGILLTIQDNGIGFDTQPLFADPVSQSGLGLIGMQQRVELNGGSFFIQSSVGDGTLVSALWRA
>Mature_383_residues
MKTSSQRDGRHLHLTWRDVIDAVRKLTATVQPNEQNFDAASDVRGAAFCILSPDGHFVSANDSTGAIFGYSGNELIGHSL
VDMAANGGRQDIIDGLSRCASGTFHSFRAQLSMRGGRHASVLLHQHPIFDSDGCIGALLTIFEEPSASEPAAPDAAASPP
SAEPDAKRQYAFLMIGQERERKRISAELHDGLGQALTLVKLTVEDALIHIHRNNITEAAELLNTAVLRIRESIGDLRRIC
SELRPALLDRLGLAASLDALCKRVEQEAGHLAVRFDSGVEDEEVPDNLKADIFRITQEAMNNAIRHGAATEIRLSLRRIE
SGILLTIQDNGIGFDTQPLFADPVSQSGLGLIGMQQRVELNGGSFFIQSSVGDGTLVSALWRA

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=206, Percent_Identity=27.1844660194175, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082311, Length=210, Percent_Identity=26.1904761904762, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41443; Mature: 41443

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSSQRDGRHLHLTWRDVIDAVRKLTATVQPNEQNFDAASDVRGAAFCILSPDGHFVSA
CCCCCCCCCCEEEEEHHHHHHHHHHHHEECCCCCCCCCCHHCCCCEEEEEECCCCCEEEC
NDSTGAIFGYSGNELIGHSLVDMAANGGRQDIIDGLSRCASGTFHSFRAQLSMRGGRHAS
CCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
VLLHQHPIFDSDGCIGALLTIFEEPSASEPAAPDAAASPPSAEPDAKRQYAFLMIGQERE
EEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEECCHHH
RKRISAELHDGLGQALTLVKLTVEDALIHIHRNNITEAAELLNTAVLRIRESIGDLRRIC
HHHHHHHHHHHHHHHHHHHEEEHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SELRPALLDRLGLAASLDALCKRVEQEAGHLAVRFDSGVEDEEVPDNLKADIFRITQEAM
HHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
NNAIRHGAATEIRLSLRRIESGILLTIQDNGIGFDTQPLFADPVSQSGLGLIGMQQRVEL
HHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCEEEEE
NGGSFFIQSSVGDGTLVSALWRA
CCCEEEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MKTSSQRDGRHLHLTWRDVIDAVRKLTATVQPNEQNFDAASDVRGAAFCILSPDGHFVSA
CCCCCCCCCCEEEEEHHHHHHHHHHHHEECCCCCCCCCCHHCCCCEEEEEECCCCCEEEC
NDSTGAIFGYSGNELIGHSLVDMAANGGRQDIIDGLSRCASGTFHSFRAQLSMRGGRHAS
CCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
VLLHQHPIFDSDGCIGALLTIFEEPSASEPAAPDAAASPPSAEPDAKRQYAFLMIGQERE
EEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEECCHHH
RKRISAELHDGLGQALTLVKLTVEDALIHIHRNNITEAAELLNTAVLRIRESIGDLRRIC
HHHHHHHHHHHHHHHHHHHEEEHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SELRPALLDRLGLAASLDALCKRVEQEAGHLAVRFDSGVEDEEVPDNLKADIFRITQEAM
HHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
NNAIRHGAATEIRLSLRRIESGILLTIQDNGIGFDTQPLFADPVSQSGLGLIGMQQRVEL
HHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCEEEEE
NGGSFFIQSSVGDGTLVSALWRA
CCCEEEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]