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The map label for this gene is pcaR [H]

Identifier: 17546974

GI number: 17546974

Start: 2447482

End: 2448309

Strand: Direct

Name: pcaR [H]

Synonym: RSc2255

Alternate gene names: 17546974

Gene position: 2447482-2448309 (Clockwise)

Preceding gene: 17546963

Following gene: 17546975

Centisome position: 65.86

GC content: 66.79

Gene sequence:

>828_bases
ATGAAACCGGTTCCATTCATGTCTTTCCTTTTTTGCATGTCCGTCTCCGATCTGCCCGCCGAGAAGCCCAGCGATTCCTA
TGTGCAGTCGTTCGCACGCGGGCTCTCGGTCATCCGTGCCTTCAATGCCGAGCGCCCCGCGCAAACGCTGTCCGAAGTGG
CCGAGGCGACCGGCCTCACGCGCGCCGGCGCCCGCCGCATCCTGCTCACGCTGGTCAGCCTCGGCTACGTCAGCTTCGAG
GGGCGGCTGTTCCGCCTGACGCCCCGGATCCTCGACCTCGGCTTCGCGTATCTCACCTCGATGCCGTTCTGGAACCTGGC
CGAGCCGGTCATGGAAGAACTGGTGCAGACCGTCCACGAGAGCTGCTCGGCCTCGGTGCTGGACGGCACCGAGATCGTCT
ACGTGCTGCGCGTGCCCACGCAGAAGATCATCGCGCTGAACCTGTCGGTCGGCAGCCGGCTGCCGGCGTTCTGCACATCG
ATGGGGCGCGTGCTGCTGTCGGGGCTGCCAGAGGACCGGCTCGACATCGTGCTGCGCGAGTCGGACCGGCGCCCGCGCAC
GCAGCGCACCATCACCGAGGTCGACGCGCTCAAGGACGTGATTGCCGGCGTGCGCGCGCAGGGCTGGGCGCTGGTCGACC
AGGAACTGGAAGAAGGGCTGATCTCGCTGTCGACGCCGATCCGCAACCGGGCAGGCGATATCATCGCCGCCATGAACATC
AGCGGGCAGGCCAACCGCACCTCGGCCAGGCAGATGACCCGGCAGTTTCTCGGCCCGCTGCAGCAGGCGGCCGAACGGAT
TTCTTCCATGGTGCGGGTGCGAACCTGA

Upstream 100 bases:

>100_bases
ATCCAAGAACCAATCTACGGCAGCCCCCTCCCCCTGTCAAGGCGTACGCATGCCGACCAGCCGTTCGAGTGGCGAAGCAC
GGAGAAAGCCAGTAGGCTTG

Downstream 100 bases:

>100_bases
GCGCGCGCAAGCGTCGCGCATTCAGGTGCGCTCAACGCCTCGCATCCGGGAAGAATTTTCAATAGAATTGTGGCTCTGTG
GGCAAAGAGAAAGTACGTGA

Product: transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MKPVPFMSFLFCMSVSDLPAEKPSDSYVQSFARGLSVIRAFNAERPAQTLSEVAEATGLTRAGARRILLTLVSLGYVSFE
GRLFRLTPRILDLGFAYLTSMPFWNLAEPVMEELVQTVHESCSASVLDGTEIVYVLRVPTQKIIALNLSVGSRLPAFCTS
MGRVLLSGLPEDRLDIVLRESDRRPRTQRTITEVDALKDVIAGVRAQGWALVDQELEEGLISLSTPIRNRAGDIIAAMNI
SGQANRTSARQMTRQFLGPLQQAAERISSMVRVRT

Sequences:

>Translated_275_residues
MKPVPFMSFLFCMSVSDLPAEKPSDSYVQSFARGLSVIRAFNAERPAQTLSEVAEATGLTRAGARRILLTLVSLGYVSFE
GRLFRLTPRILDLGFAYLTSMPFWNLAEPVMEELVQTVHESCSASVLDGTEIVYVLRVPTQKIIALNLSVGSRLPAFCTS
MGRVLLSGLPEDRLDIVLRESDRRPRTQRTITEVDALKDVIAGVRAQGWALVDQELEEGLISLSTPIRNRAGDIIAAMNI
SGQANRTSARQMTRQFLGPLQQAAERISSMVRVRT
>Mature_275_residues
MKPVPFMSFLFCMSVSDLPAEKPSDSYVQSFARGLSVIRAFNAERPAQTLSEVAEATGLTRAGARRILLTLVSLGYVSFE
GRLFRLTPRILDLGFAYLTSMPFWNLAEPVMEELVQTVHESCSASVLDGTEIVYVLRVPTQKIIALNLSVGSRLPAFCTS
MGRVLLSGLPEDRLDIVLRESDRRPRTQRTITEVDALKDVIAGVRAQGWALVDQELEEGLISLSTPIRNRAGDIIAAMNI
SGQANRTSARQMTRQFLGPLQQAAERISSMVRVRT

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=261, Percent_Identity=29.5019157088123, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786468, Length=240, Percent_Identity=27.9166666666667, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1789999, Length=255, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082359, Length=253, Percent_Identity=24.5059288537549, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786715, Length=238, Percent_Identity=21.4285714285714, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30360; Mature: 30360

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVPFMSFLFCMSVSDLPAEKPSDSYVQSFARGLSVIRAFNAERPAQTLSEVAEATGLT
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCH
RAGARRILLTLVSLGYVSFEGRLFRLTPRILDLGFAYLTSMPFWNLAEPVMEELVQTVHE
HHHHHHHHHHHHHHHHHEECCEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SCSASVLDGTEIVYVLRVPTQKIIALNLSVGSRLPAFCTSMGRVLLSGLPEDRLDIVLRE
HHCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHEEEEC
SDRRPRTQRTITEVDALKDVIAGVRAQGWALVDQELEEGLISLSTPIRNRAGDIIAAMNI
CCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEEC
SGQANRTSARQMTRQFLGPLQQAAERISSMVRVRT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPVPFMSFLFCMSVSDLPAEKPSDSYVQSFARGLSVIRAFNAERPAQTLSEVAEATGLT
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCH
RAGARRILLTLVSLGYVSFEGRLFRLTPRILDLGFAYLTSMPFWNLAEPVMEELVQTVHE
HHHHHHHHHHHHHHHHHEECCEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SCSASVLDGTEIVYVLRVPTQKIIALNLSVGSRLPAFCTSMGRVLLSGLPEDRLDIVLRE
HHCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHEEEEC
SDRRPRTQRTITEVDALKDVIAGVRAQGWALVDQELEEGLISLSTPIRNRAGDIIAAMNI
CCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEEC
SGQANRTSARQMTRQFLGPLQQAAERISSMVRVRT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]