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The map label for this gene is folE2

Identifier: 17546939

GI number: 17546939

Start: 2407469

End: 2408275

Strand: Reverse

Name: folE2

Synonym: RSc2220

Alternate gene names: 17546939

Gene position: 2408275-2407469 (Counterclockwise)

Preceding gene: 17546940

Following gene: 17546937

Centisome position: 64.8

GC content: 63.69

Gene sequence:

>807_bases
ATGAATGATATGAACCCGGGCTTCGTGATGCCGGACGTGCAGTCCAGCCACGATACCCGTCAGATTCCGATTCAGCGCGT
GGGCGTGCGCGGCGTGCGTTACCCGATGTCGCTGCAGACGCCGTCGGGCGTGCTGAGCACCGTGGGCACCTTCAACCTGG
ATGTGCACCTGCCGGCCGATCAGAAGGGCACGCACATGTCCCGCTTCGTCGCGCTGCTCGAAGAAGAGCGCGAGCCGCTG
AACCTGGCGCAATTCCAGCTGTTGCTGGAGAAGATGCTGGAGAAGCTCGAAGCCGACGCCGGCCGCATCGAAGTCAGCTT
CCCGTATTTCGTCAGCAAGACCGCGCCGGTGTCGGGCGTGCAGTCGCTGATGGACTACGAGGTGACGATGATCGGCGAAG
TGCGCGATGGCCACACCACCGTGCGCGTCAAGGCCCTGGTGCCGGTCACGAGCCTGTGCCCGTGCTCCAAGAAGATCTCG
CAGTACGGTGCGCACAACCAGCGCTCGCACATCACCATCGACGCGGAACTGGCGGCCGATACGCCGGTCGAGGCGCTGAT
CCGCATGGCCGAGGAAGAAGCCTCGTGCGAACTGTGGGGCCTGCTCAAGCGCCCGGACGAGAAGTTCGTCACCGAACGCG
CGTATGAGAACCCGAAGTTCGTCGAAGACCTGGTGCGCGACATCGCCATGCGCCTGAATGAAGACGACCGCATCGTGGCC
TACACGCTGGAAGCGGAGAACTTCGAGTCGATCCACAACCACAGCGCCTATGCCTTGATCGAGCGCGACAAGCGCCGCGC
CGGCTGA

Upstream 100 bases:

>100_bases
ATCACTTGAGGGGTGGTCGCCTTCAATCCGGTTCCGCGGTTTCACACTCGTTGCGCACCGGCCGACTGCGATGGCCGGGC
GACCGTAAAGGAAACCGACC

Downstream 100 bases:

>100_bases
TCGACGCCGACCCCCGGAAGAAGCCGCCCCATCGAGCGGCTTTTTTCATGCCTGCCGGATGCGGATGTCTTCCAGGTCCC
AGCGCGGCGTGACGCCGTAG

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MNDMNPGFVMPDVQSSHDTRQIPIQRVGVRGVRYPMSLQTPSGVLSTVGTFNLDVHLPADQKGTHMSRFVALLEEEREPL
NLAQFQLLLEKMLEKLEADAGRIEVSFPYFVSKTAPVSGVQSLMDYEVTMIGEVRDGHTTVRVKALVPVTSLCPCSKKIS
QYGAHNQRSHITIDAELAADTPVEALIRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNEDDRIVA
YTLEAENFESIHNHSAYALIERDKRRAG

Sequences:

>Translated_268_residues
MNDMNPGFVMPDVQSSHDTRQIPIQRVGVRGVRYPMSLQTPSGVLSTVGTFNLDVHLPADQKGTHMSRFVALLEEEREPL
NLAQFQLLLEKMLEKLEADAGRIEVSFPYFVSKTAPVSGVQSLMDYEVTMIGEVRDGHTTVRVKALVPVTSLCPCSKKIS
QYGAHNQRSHITIDAELAADTPVEALIRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNEDDRIVA
YTLEAENFESIHNHSAYALIERDKRRAG
>Mature_268_residues
MNDMNPGFVMPDVQSSHDTRQIPIQRVGVRGVRYPMSLQTPSGVLSTVGTFNLDVHLPADQKGTHMSRFVALLEEEREPL
NLAQFQLLLEKMLEKLEADAGRIEVSFPYFVSKTAPVSGVQSLMDYEVTMIGEVRDGHTTVRVKALVPVTSLCPCSKKIS
QYGAHNQRSHITIDAELAADTPVEALIRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNEDDRIVA
YTLEAENFESIHNHSAYALIERDKRRAG

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_RALSO (Q8XX96)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520341.1
- ProteinModelPortal:   Q8XX96
- SMR:   Q8XX96
- GeneID:   1221065
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2220
- NMPDR:   fig|267608.1.peg.2220
- HOGENOM:   HBG626871
- OMA:   SLMDYEV
- ProtClustDB:   PRK13674
- BioCyc:   RSOL267608:RSC2220-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10
- TIGRFAMs:   TIGR00294

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 30201; Mature: 30201

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDMNPGFVMPDVQSSHDTRQIPIQRVGVRGVRYPMSLQTPSGVLSTVGTFNLDVHLPAD
CCCCCCCEECCCCCCCCCCCCCCHHHHCCCCCCCCEECCCCCHHHHHCCEEEEEEEECCC
QKGTHMSRFVALLEEEREPLNLAQFQLLLEKMLEKLEADAGRIEVSFPYFVSKTAPVSGV
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCCCCHHHH
QSLMDYEVTMIGEVRDGHTTVRVKALVPVTSLCPCSKKISQYGAHNQRSHITIDAELAAD
HHHHHCCEEEEEEECCCCEEEEEEEECCCHHCCCCHHHHHHHCCCCCCCEEEEEECCCCC
TPVEALIRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNEDDRIVA
CCHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEE
YTLEAENFESIHNHSAYALIERDKRRAG
EEECCCCHHHHHCCCCEEEEECHHCCCC
>Mature Secondary Structure
MNDMNPGFVMPDVQSSHDTRQIPIQRVGVRGVRYPMSLQTPSGVLSTVGTFNLDVHLPAD
CCCCCCCEECCCCCCCCCCCCCCHHHHCCCCCCCCEECCCCCHHHHHCCEEEEEEEECCC
QKGTHMSRFVALLEEEREPLNLAQFQLLLEKMLEKLEADAGRIEVSFPYFVSKTAPVSGV
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCCCCHHHH
QSLMDYEVTMIGEVRDGHTTVRVKALVPVTSLCPCSKKISQYGAHNQRSHITIDAELAAD
HHHHHCCEEEEEEECCCCEEEEEEEECCCHHCCCCHHHHHHHCCCCCCCEEEEEECCCCC
TPVEALIRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNEDDRIVA
CCHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEE
YTLEAENFESIHNHSAYALIERDKRRAG
EEECCCCHHHHHCCCCEEEEECHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852