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The map label for this gene is fbp [H]

Identifier: 17546845

GI number: 17546845

Start: 2305211

End: 2306227

Strand: Direct

Name: fbp [H]

Synonym: RSc2126

Alternate gene names: 17546845

Gene position: 2305211-2306227 (Clockwise)

Preceding gene: 17546844

Following gene: 17546853

Centisome position: 62.03

GC content: 65.78

Gene sequence:

>1017_bases
ATGAAGCGCATCAACCTCACCCGCTACCTGATCGAAGAGCAGCGCGAGCACAACACCATCCCCGCCGAGCTGCGCCTGCT
GCTCGAAGTCGTGGCGCGCGCCTGCAAGGCGATCTCGCACAGCGTCAACAAGGGCGCGCTGGCCGGCGTGCTCGGCTCGG
CCGGCACAGGCAACGTGCAAGGCGAAACCCAGCAGAAGCTGGACGTGATCGCCAACGAAGTCCTGCTCGAAGCCAACGAG
TACGGCGGCAACCTGGCCGCGATGGCCTCGGAAGAGATGGAGTCGTTCTACGAGATCCCCCATCGCTATCCGAAGGGCGA
ATACCTGCTGCTGTTCGATCCGCTCGACGGCTCGTCCAACATCGACGTGAACGTGTCGATCGGCACCATCTTCTCGGTGC
TGCACATGCCCAAGCCGGGCCAGACCGTGACCGAAGCCGACTTCATGCAGCCGGGCGTCAGGCAGGTCGCCGCCGGCTAC
GCCGTCTACGGTCCGCAGACCACGCTGGTGCTCACCGTCGGCAACGGCGTGCACATGTTCACGCTCGACCGCGAAGTCGG
CAGCTTCATCCTGACCAACCGCGACGTGAAGATTCCGGCCGACACCAAGGAGTTCGCCATCAACATGTCGAACATGCGCC
ACTGGGCCCCGCCCGTGCGCCGCTACATCGACGAATGCCTGGCCGGCACCGAAGGCCCGCGCGGCAAGGACTTCAACATG
CGCTGGATCGCCTCGATGGTGGCCGACGTGCACCGCATCCTCACGCGCGGCGGCATCTTCATGTACCCGTGGGACAAGCG
CGAGCCGGGCAAGGCCGGCAAGCTGCGCCTGATGTACGAAGCCAACCCGATGGCCTTCCTGGTGGAGCAGGCCGGCGGCG
CCGCCACCAACGGCCATCAGCGCATCCTCGAGATCCAGCCGGAGAAGCTGCACCAGCGCGTGGCGGTGATCCTGGGCTCC
AAGAACGAGGTGGACCGCGTCACGCAGTACCACCGGGAAGCCCAGCAGACCGCCTGA

Upstream 100 bases:

>100_bases
CCGAGCCTGTCGCGCGACGTGCGCGAGATCGTCGGCAAGGCGCTGGCGTGACGACGCTCACACGGTCTGTCGTAAAATCG
CGCCCGTCCCAGGAGAACCC

Downstream 100 bases:

>100_bases
GACGGCCCTTGAACCGGTTGTTTCCGTGGTTCTTGCAGAGCGCCAAAAAGTTCTGCTAGAATCGCGGTTTCCGATGCCGG
TGTAGCTCAGTTGGTAGAGC

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLEANE
YGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSNIDVNVSIGTIFSVLHMPKPGQTVTEADFMQPGVRQVAAGY
AVYGPQTTLVLTVGNGVHMFTLDREVGSFILTNRDVKIPADTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNM
RWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGHQRILEIQPEKLHQRVAVILGS
KNEVDRVTQYHREAQQTA

Sequences:

>Translated_338_residues
MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLEANE
YGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSNIDVNVSIGTIFSVLHMPKPGQTVTEADFMQPGVRQVAAGY
AVYGPQTTLVLTVGNGVHMFTLDREVGSFILTNRDVKIPADTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNM
RWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGHQRILEIQPEKLHQRVAVILGS
KNEVDRVTQYHREAQQTA
>Mature_338_residues
MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLEANE
YGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSNIDVNVSIGTIFSVLHMPKPGQTVTEADFMQPGVRQVAAGY
AVYGPQTTLVLTVGNGVHMFTLDREVGSFILTNRDVKIPADTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNM
RWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGHQRILEIQPEKLHQRVAVILGS
KNEVDRVTQYHREAQQTA

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family [H]

Homologues:

Organism=Homo sapiens, GI189083692, Length=335, Percent_Identity=42.089552238806, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI16579888, Length=335, Percent_Identity=42.089552238806, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI22907028, Length=321, Percent_Identity=41.1214953271028, Blast_Score=231, Evalue=5e-61,
Organism=Escherichia coli, GI1790679, Length=332, Percent_Identity=45.4819277108434, Blast_Score=276, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17508131, Length=327, Percent_Identity=43.4250764525994, Blast_Score=264, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6323409, Length=333, Percent_Identity=39.9399399399399, Blast_Score=256, Evalue=3e-69,
Organism=Drosophila melanogaster, GI45550998, Length=329, Percent_Identity=42.5531914893617, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI19921562, Length=329, Percent_Identity=42.5531914893617, Blast_Score=252, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000146 [H]

Pfam domain/function: PF00316 FBPase [H]

EC number: =3.1.3.11 [H]

Molecular weight: Translated: 37545; Mature: 37545

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00659 GLYCOSYL_HYDROL_F5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQ
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
GETQQKLDVIANEVLLEANEYGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSN
CCHHHHHHHHHHHHHEECHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
IDVNVSIGTIFSVLHMPKPGQTVTEADFMQPGVRQVAAGYAVYGPQTTLVLTVGNGVHMF
EEEEEEHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHCCEEEECCCEEEEEEECCCEEEE
TLDREVGSFILTNRDVKIPADTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNM
EECHHHCCEEEECCCEECCCCCHHHEEEHHHCHHCCCHHHHHHHHHHCCCCCCCCCCCCH
RWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGHQ
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCC
RILEIQPEKLHQRVAVILGSKNEVDRVTQYHREAQQTA
EEEEECHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQ
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
GETQQKLDVIANEVLLEANEYGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSN
CCHHHHHHHHHHHHHEECHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
IDVNVSIGTIFSVLHMPKPGQTVTEADFMQPGVRQVAAGYAVYGPQTTLVLTVGNGVHMF
EEEEEEHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHCCEEEECCCEEEEEEECCCEEEE
TLDREVGSFILTNRDVKIPADTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNM
EECHHHCCEEEECCCEECCCCCHHHEEEHHHCHHCCCHHHHHHHHHHCCCCCCCCCCCCH
RWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGHQ
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCC
RILEIQPEKLHQRVAVILGSKNEVDRVTQYHREAQQTA
EEEEECHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA