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The map label for this gene is add [H]

Identifier: 17546817

GI number: 17546817

Start: 2272333

End: 2273370

Strand: Direct

Name: add [H]

Synonym: RSc2098

Alternate gene names: 17546817

Gene position: 2272333-2273370 (Clockwise)

Preceding gene: 17546816

Following gene: 17546818

Centisome position: 61.14

GC content: 68.11

Gene sequence:

>1038_bases
ATGCCGATCTCGCCCGCCCTCGCAGAACGCATCGCCACCAGCCCGAAAGCCGAGCTGCACATCCACATCGAAGGCTCGCT
CGAACCGGAACTGATGTTCGCGCTGGCCGAGCGCAACGGCGTCAAGCTGCCCTACGCCTCGGTCGACGAAGTGCGCGCCG
CCTATGCCTTCAACGATCTGCAGTCGTTCCTGGACCTGTACTACGCCGGCGCCAGCGTACTGCTGACCGAGCAGGACTTC
TACGACATGACCGCCGCCTATGTGGCGCGCGCCGTGGCCGACAACGTGCGCCACGCCGAGATCTTCTTCGACCCGCAGAC
GCACACCGCGCGCGACGTGCCGATGCACGTGGTGATCGGCGGCATCGTCCGCGCGCTGGACGACGCCGAGCGCGCGCACG
GCTTCTCCAGCCGCCTGATTCTCTGCTTCCTGCGCCACCTGAGCGAGGCCGACGCCTTCGACACGCTGGAAGCGGCCCTG
CCCTACATCCAGGACCCGGCCAACCGCATCATCGGCGTGGGGCTGGATTCGTCGGAGCGCGGCAATCCGCCCGAGAAGTT
CGCGCGCGTGTTCGCCCGCTGCAAGGCACTGGGCCTGCGCCTCGTGGCCCACGCCGGCGAGGAAGGCCCGGCGCAGTACG
TGATCGACGCGCTCGACATCCTCCAGGTGGAGCGCATCGACCACGGCGTGCGCGCCATCGACGATGCCGCCCTGGTCAAG
CGCCTGGCCGCCAGCCGCGTCGCCCTGACGGTGTGCCCGCTGTCGAACGAAAAGCTCAAGGTCTACCCCGACCTGCGCGA
CCACTCGCTCAAGCAGCTGCTGGACGCCGGCTGCGCGGTCACGCTGCATTCGGACGACCCCGCCTACTTCGGCGGCTACA
TGAACACCAACTGGCTCGCCACCTTCAACGCCCTCGGCCTGTCCGCCGCCGATGCGCACACGCTCGCGCGCAACAGCTTC
GAGGCGTCGTTCCTGCCCGAGCAGGACAAAGCCCTGTGGCTGAACGCCGTCGATATCCACTGGCGAGCCCATACCTGA

Upstream 100 bases:

>100_bases
CGCAGTTGCTGCAGGTCCGCGAGCTGCACCAGCACGCGCTGGCCAGCGCGAGCAGCGGCGCGGCGGCTCCCTATCGCGTC
CCCACCTCCGCTTAAGCACC

Downstream 100 bases:

>100_bases
ACCGCAAGAGACGACAGATGACCACCTTGCCGCCCGCGCCCGACGCCACCCTCCACGCCTACCGCGGCCGCGTGCTGCAT
TTCCTGCACGACCCGCAGTA

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MPISPALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVDEVRAAYAFNDLQSFLDLYYAGASVLLTEQDF
YDMTAAYVARAVADNVRHAEIFFDPQTHTARDVPMHVVIGGIVRALDDAERAHGFSSRLILCFLRHLSEADAFDTLEAAL
PYIQDPANRIIGVGLDSSERGNPPEKFARVFARCKALGLRLVAHAGEEGPAQYVIDALDILQVERIDHGVRAIDDAALVK
RLAASRVALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLATFNALGLSAADAHTLARNSF
EASFLPEQDKALWLNAVDIHWRAHT

Sequences:

>Translated_345_residues
MPISPALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVDEVRAAYAFNDLQSFLDLYYAGASVLLTEQDF
YDMTAAYVARAVADNVRHAEIFFDPQTHTARDVPMHVVIGGIVRALDDAERAHGFSSRLILCFLRHLSEADAFDTLEAAL
PYIQDPANRIIGVGLDSSERGNPPEKFARVFARCKALGLRLVAHAGEEGPAQYVIDALDILQVERIDHGVRAIDDAALVK
RLAASRVALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLATFNALGLSAADAHTLARNSF
EASFLPEQDKALWLNAVDIHWRAHT
>Mature_344_residues
PISPALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVDEVRAAYAFNDLQSFLDLYYAGASVLLTEQDFY
DMTAAYVARAVADNVRHAEIFFDPQTHTARDVPMHVVIGGIVRALDDAERAHGFSSRLILCFLRHLSEADAFDTLEAALP
YIQDPANRIIGVGLDSSERGNPPEKFARVFARCKALGLRLVAHAGEEGPAQYVIDALDILQVERIDHGVRAIDDAALVKR
LAASRVALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLATFNALGLSAADAHTLARNSFE
ASFLPEQDKALWLNAVDIHWRAHT

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=333, Percent_Identity=24.3243243243243, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI29029550, Length=147, Percent_Identity=32.6530612244898, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI29029552, Length=147, Percent_Identity=32.6530612244898, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787910, Length=323, Percent_Identity=26.9349845201238, Blast_Score=115, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17538512, Length=352, Percent_Identity=24.1477272727273, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI32565969, Length=340, Percent_Identity=24.4117647058824, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324188, Length=340, Percent_Identity=42.6470588235294, Blast_Score=272, Evalue=6e-74,
Organism=Drosophila melanogaster, GI24645260, Length=328, Percent_Identity=23.4756097560976, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 37929; Mature: 37798

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISPALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVDEVRAAYAFNDL
CCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHEEHHCCCCCCCCCCHHHHHHHHHHHHH
QSFLDLYYAGASVLLTEQDFYDMTAAYVARAVADNVRHAEIFFDPQTHTARDVPMHVVIG
HHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHH
GIVRALDDAERAHGFSSRLILCFLRHLSEADAFDTLEAALPYIQDPANRIIGVGLDSSER
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHEEEECCCCCCC
GNPPEKFARVFARCKALGLRLVAHAGEEGPAQYVIDALDILQVERIDHGVRAIDDAALVK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAASRVALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLA
HHHHCCEEEEEECCCCCCEEECCCCCHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCEE
TFNALGLSAADAHTLARNSFEASFLPEQDKALWLNAVDIHWRAHT
EHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEEECC
>Mature Secondary Structure 
PISPALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVDEVRAAYAFNDL
CCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHEEHHCCCCCCCCCCHHHHHHHHHHHHH
QSFLDLYYAGASVLLTEQDFYDMTAAYVARAVADNVRHAEIFFDPQTHTARDVPMHVVIG
HHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHH
GIVRALDDAERAHGFSSRLILCFLRHLSEADAFDTLEAALPYIQDPANRIIGVGLDSSER
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHEEEECCCCCCC
GNPPEKFARVFARCKALGLRLVAHAGEEGPAQYVIDALDILQVERIDHGVRAIDDAALVK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAASRVALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLA
HHHHCCEEEEEECCCCCCEEECCCCCHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCEE
TFNALGLSAADAHTLARNSFEASFLPEQDKALWLNAVDIHWRAHT
EHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA