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The map label for this gene is xdhB [H]

Identifier: 17546815

GI number: 17546815

Start: 2268893

End: 2271271

Strand: Direct

Name: xdhB [H]

Synonym: RSc2096

Alternate gene names: 17546815

Gene position: 2268893-2271271 (Clockwise)

Preceding gene: 17546814

Following gene: 17546816

Centisome position: 61.05

GC content: 70.28

Gene sequence:

>2379_bases
ATGAACAAGCAAACCGAATCCTTCCTGCTGGCGCAGGCCGACATCGCGGCAGCCGCGCAGGCCGGGCGCGGCGCCGTGGT
CGGCGTCTCCCGGCCGCACGAGTCGGCGCACCTGCACGTGGCCGGCACCGCCACCTATACCGACGACATTCCCGAACTGG
CGGGCACGCTGCATGCCGCGCTCGGCATGAGCACGCAGCCGCACGCGCGCATCGCGCACCTGGACCTGGCGCGCGTGAAG
CAGGCGCCGGGCGTGATCGCCGTGTTCACGGCGGCCGACATCCCGGGCACCAACGATTGCGGCCCGATCCTTCATGACGA
TCCGATCCTGGCCGCCGGCACGGTGCACTACGTCGGCCAGCCGGTTTTCCTGGTGGTGGCCACGTCGCACGACGCGGCGC
GGCGCGCGGCCCGCCTGGGCGCCATCGAATACGAAGCCCTGCCCCCGCTGCTGACGCCGGAAGACGCGCGCGCCGCCGGC
CGCGCCGTGCTGCCGCCGATGCACCTCAAGCGCGGCGACCCCGACGCGCGCATCGCCGCCGCGCCGCACGCGCAGGCCGG
CCGCCTGTCGCTGGGCGGGCAGGAGCAGTTCTACCTGGAGGGCCAGATCTCATATGCCGTGCCGAAGGAAGACAACGGCA
TGCACGTGTGGTGCTCGACGCAGCATCCGACCGAGATGCAGCACGCCGTGTCGCACATGCTGGGCTGGCATGCCAACCAG
GTGCTGGTGGAATGCCGGCGCATGGGCGGCGGCTTCGGCGGCAAGGAATCGCAGTCGGCGCTGTTCGCCTGCTGCGCCGC
GCTGGCCGCGTGGAAGCTGGCCTGCCCGGTGAAGCTGCGCCCCGACCGCGACGACGACATGATGATCACCGGCAAGCGGC
ACGACTTCCGCTTTGCGTACGAAGCCGGCTACGACGACGACGGCCGCATCCTCGGCGTGAAGGTCGACATGACCGCGCGC
GCGGGCTTCTCGGCCGACCTGTCCGGCCCGGTGATGACGCGCGCCATCTGCCACTTCGACAACGCCTACTGGCTGCCCGA
GGTGCAGATCGACGGCTTCTGCGCGCGCACCAACACGCAGTCGAACACTGCCTTCCGCGGCTTCGGCGGGCCGCAGGGCG
CGTTCGCCATCGAGACCATCCTGGACAACATCGCGCGCGCGCTCGGACGCGACCCGCTGGATGTGCGCCGCGCCAACCTG
TACGGCAAGGACAGGAACAACGTCACGCCGTACGGCCAGACCGTGGAAGACAACGTCATCCACGAACTGCTCGACGAACT
GGAAGCCTCGTCCGACTACCGCGCCCGCCGCGAGGCCGTGCGCGCCTTCAACGCGACCAGCCCGGTGCTCAAGCGCGGCC
TGGCGCTGACGCCGGTGAAGTTCGGCATCTCGTTCAACGTGCGGCACTTCAACCAGGCCGGCGCGCTGGTGCACGTGTAC
AACGACGGCTCCATCCTGGTGAACCACGGCGGCACCGAGATGGGCCAGGGCCTGAACACCAAGGTCGCGCAGGTGGTGGC
GCATGAGCTGGGCGTCGCCTTCGGCCGCGTGCGCGTGACGGCCACCGACACCAGCAAGGTCGCCAACACGTCCGCCACCG
CGGCCTCCACCGGCAGCGACCTGAACGGCAAGGCCGCGCAGGATGCCGCGCGCCAGATCCGCGAGCGCCTGACCGCCTTC
GCCGCGCAGCACTACGACGTGCCCATCGAGACCGTCGCCTTCGCCGACGACCACGCCGAGATCGGGGCCCAGCAGGGTCA
ACGCAGCGTGCCGTTCGACGAACTGGTGCGCCTGGCCTACATGGCGCGCGTGCAGCTGTGGTCCGACGGCTTCTACGCCA
CGCCCAAGCTGCACTGGGATCAGGCCAGGCTGCATGGCCGCCCGTTCTACTACTTCGCCTACGGCGCGGCGGTCTCGGAA
GTGGTGGTCGACACGCTGACCGGCGAATGGCGCCTGCTGCGCGCCGACGTGCTGCACGATGCCGGCCGCTCGATCAACCC
GGCCATCGACATCGGCCAGGTGGAAGGCGCGTTCATCCAGGGCATGGGCTGGCTGACCACCGAGGAGCTGTGGTGGGACC
CGTCGGGCAGGCTGATGACGCATGCGCCATCCACCTACAAGATCCCGACCGTCAACGACTGCCCGGCGGACTTCCGCGTG
CGCCTGTTCGACAACGCCAACGCCGAAGACAGCATCCACCGCTCCAAGGCGCTGGGCGAACCGCCGCTGCTGCTGCCGTT
CTCGGTGTTCTTCGCCATCCGCGATGCGGTGGCGGCGGTCGGCGACGGCCGCACCAGCCCGCCGCTGAATGCGCCAGCCA
CCTGCGAGGCAATCCTCAAGGCGGTGGACGCGCTGCGCAGCGCGCCGCTGTCCGCCTGA

Upstream 100 bases:

>100_bases
CCGACCCGATGCCCCGCTGCCGGCGGCACAGATCAACGTGCGCGCGGTCGAACCGGATATCCCGACCGTGGCCTGAGCGC
AAGCGCGAACGAGACCTCGC

Downstream 100 bases:

>100_bases
CCCGACGCACCGCGTCCGGAGACCGCCATGGACCACACGCAACTGCGCCCCTTCCGCTTCGCCGATGCGCTGGCCGCCGT
GCAGGCCGGGCAGCCTTGCG

Product: xanthine dehydrogenase subunit B

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 792; Mature: 792

Protein sequence:

>792_residues
MNKQTESFLLAQADIAAAAQAGRGAVVGVSRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSTQPHARIAHLDLARVK
QAPGVIAVFTAADIPGTNDCGPILHDDPILAAGTVHYVGQPVFLVVATSHDAARRAARLGAIEYEALPPLLTPEDARAAG
RAVLPPMHLKRGDPDARIAAAPHAQAGRLSLGGQEQFYLEGQISYAVPKEDNGMHVWCSTQHPTEMQHAVSHMLGWHANQ
VLVECRRMGGGFGGKESQSALFACCAALAAWKLACPVKLRPDRDDDMMITGKRHDFRFAYEAGYDDDGRILGVKVDMTAR
AGFSADLSGPVMTRAICHFDNAYWLPEVQIDGFCARTNTQSNTAFRGFGGPQGAFAIETILDNIARALGRDPLDVRRANL
YGKDRNNVTPYGQTVEDNVIHELLDELEASSDYRARREAVRAFNATSPVLKRGLALTPVKFGISFNVRHFNQAGALVHVY
NDGSILVNHGGTEMGQGLNTKVAQVVAHELGVAFGRVRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQIRERLTAF
AAQHYDVPIETVAFADDHAEIGAQQGQRSVPFDELVRLAYMARVQLWSDGFYATPKLHWDQARLHGRPFYYFAYGAAVSE
VVVDTLTGEWRLLRADVLHDAGRSINPAIDIGQVEGAFIQGMGWLTTEELWWDPSGRLMTHAPSTYKIPTVNDCPADFRV
RLFDNANAEDSIHRSKALGEPPLLLPFSVFFAIRDAVAAVGDGRTSPPLNAPATCEAILKAVDALRSAPLSA

Sequences:

>Translated_792_residues
MNKQTESFLLAQADIAAAAQAGRGAVVGVSRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSTQPHARIAHLDLARVK
QAPGVIAVFTAADIPGTNDCGPILHDDPILAAGTVHYVGQPVFLVVATSHDAARRAARLGAIEYEALPPLLTPEDARAAG
RAVLPPMHLKRGDPDARIAAAPHAQAGRLSLGGQEQFYLEGQISYAVPKEDNGMHVWCSTQHPTEMQHAVSHMLGWHANQ
VLVECRRMGGGFGGKESQSALFACCAALAAWKLACPVKLRPDRDDDMMITGKRHDFRFAYEAGYDDDGRILGVKVDMTAR
AGFSADLSGPVMTRAICHFDNAYWLPEVQIDGFCARTNTQSNTAFRGFGGPQGAFAIETILDNIARALGRDPLDVRRANL
YGKDRNNVTPYGQTVEDNVIHELLDELEASSDYRARREAVRAFNATSPVLKRGLALTPVKFGISFNVRHFNQAGALVHVY
NDGSILVNHGGTEMGQGLNTKVAQVVAHELGVAFGRVRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQIRERLTAF
AAQHYDVPIETVAFADDHAEIGAQQGQRSVPFDELVRLAYMARVQLWSDGFYATPKLHWDQARLHGRPFYYFAYGAAVSE
VVVDTLTGEWRLLRADVLHDAGRSINPAIDIGQVEGAFIQGMGWLTTEELWWDPSGRLMTHAPSTYKIPTVNDCPADFRV
RLFDNANAEDSIHRSKALGEPPLLLPFSVFFAIRDAVAAVGDGRTSPPLNAPATCEAILKAVDALRSAPLSA
>Mature_792_residues
MNKQTESFLLAQADIAAAAQAGRGAVVGVSRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSTQPHARIAHLDLARVK
QAPGVIAVFTAADIPGTNDCGPILHDDPILAAGTVHYVGQPVFLVVATSHDAARRAARLGAIEYEALPPLLTPEDARAAG
RAVLPPMHLKRGDPDARIAAAPHAQAGRLSLGGQEQFYLEGQISYAVPKEDNGMHVWCSTQHPTEMQHAVSHMLGWHANQ
VLVECRRMGGGFGGKESQSALFACCAALAAWKLACPVKLRPDRDDDMMITGKRHDFRFAYEAGYDDDGRILGVKVDMTAR
AGFSADLSGPVMTRAICHFDNAYWLPEVQIDGFCARTNTQSNTAFRGFGGPQGAFAIETILDNIARALGRDPLDVRRANL
YGKDRNNVTPYGQTVEDNVIHELLDELEASSDYRARREAVRAFNATSPVLKRGLALTPVKFGISFNVRHFNQAGALVHVY
NDGSILVNHGGTEMGQGLNTKVAQVVAHELGVAFGRVRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQIRERLTAF
AAQHYDVPIETVAFADDHAEIGAQQGQRSVPFDELVRLAYMARVQLWSDGFYATPKLHWDQARLHGRPFYYFAYGAAVSE
VVVDTLTGEWRLLRADVLHDAGRSINPAIDIGQVEGAFIQGMGWLTTEELWWDPSGRLMTHAPSTYKIPTVNDCPADFRV
RLFDNANAEDSIHRSKALGEPPLLLPFSVFFAIRDAVAAVGDGRTSPPLNAPATCEAILKAVDALRSAPLSA

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=781, Percent_Identity=41.2291933418694, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI71773480, Length=756, Percent_Identity=38.0952380952381, Blast_Score=483, Evalue=1e-136,
Organism=Escherichia coli, GI1789246, Length=768, Percent_Identity=26.6927083333333, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1789230, Length=754, Percent_Identity=28.3819628647215, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1786478, Length=732, Percent_Identity=25.6830601092896, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17540638, Length=767, Percent_Identity=39.1134289439374, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI32566215, Length=714, Percent_Identity=31.0924369747899, Blast_Score=338, Evalue=7e-93,
Organism=Caenorhabditis elegans, GI17539860, Length=721, Percent_Identity=32.4549237170596, Blast_Score=333, Evalue=3e-91,
Organism=Drosophila melanogaster, GI17737937, Length=758, Percent_Identity=40.3693931398417, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24647199, Length=768, Percent_Identity=32.421875, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24647193, Length=785, Percent_Identity=31.2101910828025, Blast_Score=332, Evalue=9e-91,
Organism=Drosophila melanogaster, GI24647201, Length=768, Percent_Identity=32.2916666666667, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24647195, Length=762, Percent_Identity=30.9711286089239, Blast_Score=312, Evalue=7e-85,
Organism=Drosophila melanogaster, GI24647197, Length=762, Percent_Identity=30.9711286089239, Blast_Score=311, Evalue=9e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 85410; Mature: 85410

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQTESFLLAQADIAAAAQAGRGAVVGVSRPHESAHLHVAGTATYTDDIPELAGTLHAA
CCCCCCCEEEEHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
LGMSTQPHARIAHLDLARVKQAPGVIAVFTAADIPGTNDCGPILHDDPILAAGTVHYVGQ
HCCCCCCCCEEEHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCHHHCCC
PVFLVVATSHDAARRAARLGAIEYEALPPLLTPEDARAAGRAVLPPMHLKRGDPDARIAA
CEEEEEECCCHHHHHHHHHCCEEHHCCCCCCCCCCHHHCCCCCCCCHHHCCCCCCCEEEE
APHAQAGRLSLGGQEQFYLEGQISYAVPKEDNGMHVWCSTQHPTEMQHAVSHMLGWHANQ
CCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHH
VLVECRRMGGGFGGKESQSALFACCAALAAWKLACPVKLRPDRDDDMMITGKRHDFRFAY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEECCCCCEEEEE
EAGYDDDGRILGVKVDMTARAGFSADLSGPVMTRAICHFDNAYWLPEVQIDGFCARTNTQ
ECCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEECCCEEECCEEEECCCC
SNTAFRGFGGPQGAFAIETILDNIARALGRDPLDVRRANLYGKDRNNVTPYGQTVEDNVI
CCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHH
HELLDELEASSDYRARREAVRAFNATSPVLKRGLALTPVKFGISFNVRHFNQAGALVHVY
HHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHCCCEECEEEECEEEEEEEECCCCCEEEEE
NDGSILVNHGGTEMGQGLNTKVAQVVAHELGVAFGRVRVTATDTSKVANTSATAASTGSD
ECCEEEEECCCHHHCCCCCHHHHHHHHHHHHHEEEEEEEEECCCHHHCCCCCCCCCCCCC
LNGKAAQDAARQIRERLTAFAAQHYDVPIETVAFADDHAEIGAQQGQRSVPFDELVRLAY
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHH
MARVQLWSDGFYATPKLHWDQARLHGRPFYYFAYGAAVSEVVVDTLTGEWRLLRADVLHD
HHHHHEECCCEEECCCCCCCHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEHHHHHH
AGRSINPAIDIGQVEGAFIQGMGWLTTEELWWDPSGRLMTHAPSTYKIPTVNDCPADFRV
CCCCCCCCEECCCCCCHHCCCCCCCEEHHEEECCCCCEEEECCCCEECCCCCCCCCCCEE
RLFDNANAEDSIHRSKALGEPPLLLPFSVFFAIRDAVAAVGDGRTSPPLNAPATCEAILK
EEECCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
AVDALRSAPLSA
HHHHHHCCCCCC
>Mature Secondary Structure
MNKQTESFLLAQADIAAAAQAGRGAVVGVSRPHESAHLHVAGTATYTDDIPELAGTLHAA
CCCCCCCEEEEHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
LGMSTQPHARIAHLDLARVKQAPGVIAVFTAADIPGTNDCGPILHDDPILAAGTVHYVGQ
HCCCCCCCCEEEHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCHHHCCC
PVFLVVATSHDAARRAARLGAIEYEALPPLLTPEDARAAGRAVLPPMHLKRGDPDARIAA
CEEEEEECCCHHHHHHHHHCCEEHHCCCCCCCCCCHHHCCCCCCCCHHHCCCCCCCEEEE
APHAQAGRLSLGGQEQFYLEGQISYAVPKEDNGMHVWCSTQHPTEMQHAVSHMLGWHANQ
CCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHH
VLVECRRMGGGFGGKESQSALFACCAALAAWKLACPVKLRPDRDDDMMITGKRHDFRFAY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEECCCCCEEEEE
EAGYDDDGRILGVKVDMTARAGFSADLSGPVMTRAICHFDNAYWLPEVQIDGFCARTNTQ
ECCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEECCCEEECCEEEECCCC
SNTAFRGFGGPQGAFAIETILDNIARALGRDPLDVRRANLYGKDRNNVTPYGQTVEDNVI
CCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHH
HELLDELEASSDYRARREAVRAFNATSPVLKRGLALTPVKFGISFNVRHFNQAGALVHVY
HHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHCCCEECEEEECEEEEEEEECCCCCEEEEE
NDGSILVNHGGTEMGQGLNTKVAQVVAHELGVAFGRVRVTATDTSKVANTSATAASTGSD
ECCEEEEECCCHHHCCCCCHHHHHHHHHHHHHEEEEEEEEECCCHHHCCCCCCCCCCCCC
LNGKAAQDAARQIRERLTAFAAQHYDVPIETVAFADDHAEIGAQQGQRSVPFDELVRLAY
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHH
MARVQLWSDGFYATPKLHWDQARLHGRPFYYFAYGAAVSEVVVDTLTGEWRLLRADVLHD
HHHHHEECCCEEECCCCCCCHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEHHHHHH
AGRSINPAIDIGQVEGAFIQGMGWLTTEELWWDPSGRLMTHAPSTYKIPTVNDCPADFRV
CCCCCCCCEECCCCCCHHCCCCCCCEEHHEEECCCCCEEEECCCCEECCCCCCCCCCCEE
RLFDNANAEDSIHRSKALGEPPLLLPFSVFFAIRDAVAAVGDGRTSPPLNAPATCEAILK
EEECCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
AVDALRSAPLSA
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]