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The map label for this gene is xdhA [H]

Identifier: 17546814

GI number: 17546814

Start: 2267318

End: 2268868

Strand: Direct

Name: xdhA [H]

Synonym: RSc2095

Alternate gene names: 17546814

Gene position: 2267318-2268868 (Clockwise)

Preceding gene: 17546812

Following gene: 17546815

Centisome position: 61.01

GC content: 70.02

Gene sequence:

>1551_bases
ATGGTTCAGTTACAGACACGAGACAGGCGCAAGATCCCCATGGAGACTCAGTCCATCCGCTTTTTCCATCGCGGGCAGGT
CCGCACCGTGACGCACGCCCCGATCACCCGGACGGTGCTGCAGTACCTGCGTGAAGACGCCCACTGCACAGGCACCAAAG
AAGGGTGCGCGGAGGGCGATTGCGGTGCATGCACGGTGGTGCTCGGCGAACTGCAGCCCGATGGCAGCATCGGGCTGAAG
GCCGTCAACGCGTGCATCCAGTTCCTGCCCACGCTGGACGGCAAGGCCCTGTTCACCGTCGAGGACGTGCGCGGCCAGAA
CGGCACGCTGCACCCGGTACAGCAGGCGCTGGTCGAGTGCCATGGCTCGCAGTGCGGCTTCTGCACGCCGGGCTTCGTGA
TGTCGCTGTACGCGCTGTACGAGAACACAGGGCATGCGCCGCCGCCCTCGCGCGAGGCGATCTGCGATGCGCTGACCGGC
AACCTGTGCCGCTGCACCGGCTACCGCCCCATCATCGACGCCGGCCAGCGCATGTACGCCCTGCCCGCGCCCGCCGGCAT
CGACCGCACGCAGCTGGCCGAAACGCTGCGCGCCATCCAGCGCACCGAGACCTTCTGCTACGCGCCAGCCGGCGTCGAAA
ACGCGCCGCGCTTCTACGCGCCGCGCACCGTCTCCGCCTTCGCCGCGCTGAAGGCGGCCCACCCGGACATCCGCGTCCTG
GCCGGCAGCACCGACCTCGGCCTGTGGGTCACCAAGCAGTTGCGCGAGCTGGGCGACCTCCTCTACGTGGGCCAGGTGGC
CGACCTGTGCGCACTGGACAAGCGCGACGGCTGGCTCGAGATCGGCGCCGCCGCGACGCTGGAGCAAGCGTATGCCTTCC
TCGCCGAGGACTACCCCGAACTCACCGAAATGTGGCGCCGCTTCGGCTCGCTGCCGATCCGCAATGCCGGCACGCTGGGC
GGCAACATCGCCAACGGCTCGCCGATCGGCGACTCGGCCCCGGCGCTGATCGCGCTGGGTGCGCGCGTCGTGCTGCAGCG
CGGTGACGCACACCGCGAGCTGCCGCTGGAAGACCTCTACCTGGCCTACATGAAGCACGCGATGGTGCCGGGCGAGTTCG
TCGCCAGCCTGCGCGTGCCGGCGCGCGCGGGCCGCGATGCGCTGCGCTTTCGCACGTACAAGCTGTCCAAGCGCTTCGAC
GAAGACATCTCCGCCGTGTGCGCGGCGCTGGCCATCGAGCTGGACGGCGGCATCGTGCGCAGCGCCCGCATCGCCTACGG
CGGCATGGCCGCCACCTCCAAGCGCGCCCCCGAGACCGAAGCCGCCATCACCGGCAAGCCGTGGGACGAAGCGACCGCGC
GGGCTGCCATGGCCGCCATGTCGCGCGACTACGCCCCGCTGACCGACATGCGCGCCACCGAGCACTACCGCCGCACCTCG
GCCGCCAACACGGTGTACCGCTTCTGGCTCGAAACCCGACCCGATGCCCCGCTGCCGGCGGCACAGATCAACGTGCGCGC
GGTCGAACCGGATATCCCGACCGTGGCCTGA

Upstream 100 bases:

>100_bases
GGGCGCGCCGCCAGATCGCGGCCGGTGGGTAAACCCCCGATTCTGGCGTTCCGATGCGGGTTATCACCTGGGCCGAATAT
TGCAGGAAGGGGGTGGTGCT

Downstream 100 bases:

>100_bases
GCGCAAGCGCGAACGAGACCTCGCATGAACAAGCAAACCGAATCCTTCCTGCTGGCGCAGGCCGACATCGCGGCAGCCGC
GCAGGCCGGGCGCGGCGCCG

Product: xanthine dehydrogenase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MVQLQTRDRRKIPMETQSIRFFHRGQVRTVTHAPITRTVLQYLREDAHCTGTKEGCAEGDCGACTVVLGELQPDGSIGLK
AVNACIQFLPTLDGKALFTVEDVRGQNGTLHPVQQALVECHGSQCGFCTPGFVMSLYALYENTGHAPPPSREAICDALTG
NLCRCTGYRPIIDAGQRMYALPAPAGIDRTQLAETLRAIQRTETFCYAPAGVENAPRFYAPRTVSAFAALKAAHPDIRVL
AGSTDLGLWVTKQLRELGDLLYVGQVADLCALDKRDGWLEIGAAATLEQAYAFLAEDYPELTEMWRRFGSLPIRNAGTLG
GNIANGSPIGDSAPALIALGARVVLQRGDAHRELPLEDLYLAYMKHAMVPGEFVASLRVPARAGRDALRFRTYKLSKRFD
EDISAVCAALAIELDGGIVRSARIAYGGMAATSKRAPETEAAITGKPWDEATARAAMAAMSRDYAPLTDMRATEHYRRTS
AANTVYRFWLETRPDAPLPAAQINVRAVEPDIPTVA

Sequences:

>Translated_516_residues
MVQLQTRDRRKIPMETQSIRFFHRGQVRTVTHAPITRTVLQYLREDAHCTGTKEGCAEGDCGACTVVLGELQPDGSIGLK
AVNACIQFLPTLDGKALFTVEDVRGQNGTLHPVQQALVECHGSQCGFCTPGFVMSLYALYENTGHAPPPSREAICDALTG
NLCRCTGYRPIIDAGQRMYALPAPAGIDRTQLAETLRAIQRTETFCYAPAGVENAPRFYAPRTVSAFAALKAAHPDIRVL
AGSTDLGLWVTKQLRELGDLLYVGQVADLCALDKRDGWLEIGAAATLEQAYAFLAEDYPELTEMWRRFGSLPIRNAGTLG
GNIANGSPIGDSAPALIALGARVVLQRGDAHRELPLEDLYLAYMKHAMVPGEFVASLRVPARAGRDALRFRTYKLSKRFD
EDISAVCAALAIELDGGIVRSARIAYGGMAATSKRAPETEAAITGKPWDEATARAAMAAMSRDYAPLTDMRATEHYRRTS
AANTVYRFWLETRPDAPLPAAQINVRAVEPDIPTVA
>Mature_516_residues
MVQLQTRDRRKIPMETQSIRFFHRGQVRTVTHAPITRTVLQYLREDAHCTGTKEGCAEGDCGACTVVLGELQPDGSIGLK
AVNACIQFLPTLDGKALFTVEDVRGQNGTLHPVQQALVECHGSQCGFCTPGFVMSLYALYENTGHAPPPSREAICDALTG
NLCRCTGYRPIIDAGQRMYALPAPAGIDRTQLAETLRAIQRTETFCYAPAGVENAPRFYAPRTVSAFAALKAAHPDIRVL
AGSTDLGLWVTKQLRELGDLLYVGQVADLCALDKRDGWLEIGAAATLEQAYAFLAEDYPELTEMWRRFGSLPIRNAGTLG
GNIANGSPIGDSAPALIALGARVVLQRGDAHRELPLEDLYLAYMKHAMVPGEFVASLRVPARAGRDALRFRTYKLSKRFD
EDISAVCAALAIELDGGIVRSARIAYGGMAATSKRAPETEAAITGKPWDEATARAAMAAMSRDYAPLTDMRATEHYRRTS
AANTVYRFWLETRPDAPLPAAQINVRAVEPDIPTVA

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=527, Percent_Identity=28.0834914611006, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI71773480, Length=464, Percent_Identity=26.0775862068966, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1786480, Length=149, Percent_Identity=34.2281879194631, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789232, Length=142, Percent_Identity=37.3239436619718, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789231, Length=255, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540638, Length=522, Percent_Identity=30.6513409961686, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI32566215, Length=150, Percent_Identity=44.6666666666667, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17539860, Length=140, Percent_Identity=48.5714285714286, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737937, Length=494, Percent_Identity=31.3765182186235, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24647201, Length=501, Percent_Identity=28.3433133732535, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24647197, Length=508, Percent_Identity=29.7244094488189, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24647199, Length=499, Percent_Identity=29.2585170340681, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24647193, Length=496, Percent_Identity=29.0322580645161, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24647195, Length=506, Percent_Identity=27.4703557312253, Blast_Score=148, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR017606
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 56067; Mature: 56067

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQLQTRDRRKIPMETQSIRFFHRGQVRTVTHAPITRTVLQYLREDAHCTGTKEGCAEGD
CCCCCCCCCCCCCCCHHHEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCC
CGACTVVLGELQPDGSIGLKAVNACIQFLPTLDGKALFTVEDVRGQNGTLHPVQQALVEC
CCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHH
HGSQCGFCTPGFVMSLYALYENTGHAPPPSREAICDALTGNLCRCTGYRPIIDAGQRMYA
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHCCCEEEE
LPAPAGIDRTQLAETLRAIQRTETFCYAPAGVENAPRFYAPRTVSAFAALKAAHPDIRVL
CCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEE
AGSTDLGLWVTKQLRELGDLLYVGQVADLCALDKRDGWLEIGAAATLEQAYAFLAEDYPE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHCCHH
LTEMWRRFGSLPIRNAGTLGGNIANGSPIGDSAPALIALGARVVLQRGDAHRELPLEDLY
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHH
LAYMKHAMVPGEFVASLRVPARAGRDALRFRTYKLSKRFDEDISAVCAALAIELDGGIVR
HHHHHHHCCCHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
SARIAYGGMAATSKRAPETEAAITGKPWDEATARAAMAAMSRDYAPLTDMRATEHYRRTS
HHHHHCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AANTVYRFWLETRPDAPLPAAQINVRAVEPDIPTVA
HHHHHHEEEECCCCCCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MVQLQTRDRRKIPMETQSIRFFHRGQVRTVTHAPITRTVLQYLREDAHCTGTKEGCAEGD
CCCCCCCCCCCCCCCHHHEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCC
CGACTVVLGELQPDGSIGLKAVNACIQFLPTLDGKALFTVEDVRGQNGTLHPVQQALVEC
CCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHH
HGSQCGFCTPGFVMSLYALYENTGHAPPPSREAICDALTGNLCRCTGYRPIIDAGQRMYA
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHCCCEEEE
LPAPAGIDRTQLAETLRAIQRTETFCYAPAGVENAPRFYAPRTVSAFAALKAAHPDIRVL
CCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEE
AGSTDLGLWVTKQLRELGDLLYVGQVADLCALDKRDGWLEIGAAATLEQAYAFLAEDYPE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHCCHH
LTEMWRRFGSLPIRNAGTLGGNIANGSPIGDSAPALIALGARVVLQRGDAHRELPLEDLY
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHH
LAYMKHAMVPGEFVASLRVPARAGRDALRFRTYKLSKRFDEDISAVCAALAIELDGGIVR
HHHHHHHCCCHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
SARIAYGGMAATSKRAPETEAAITGKPWDEATARAAMAAMSRDYAPLTDMRATEHYRRTS
HHHHHCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AANTVYRFWLETRPDAPLPAAQINVRAVEPDIPTVA
HHHHHHEEEECCCCCCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]