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The map label for this gene is nudF [H]

Identifier: 17546766

GI number: 17546766

Start: 2220213

End: 2220830

Strand: Reverse

Name: nudF [H]

Synonym: RSc2047

Alternate gene names: 17546766

Gene position: 2220830-2220213 (Counterclockwise)

Preceding gene: 17546767

Following gene: 17546765

Centisome position: 59.76

GC content: 65.53

Gene sequence:

>618_bases
ATGAAACCCGATCCTGCCCGCCTGTCCGCCGATTCCAATGAGGCCGTGTCCGATCCGGATGCCGGCCTGCGCGAAACGCA
GCTGGCTTCGGCGCTGGTGCACCAGGGCAAGTTCCTGACGCTCAAGCAGGATGTCGTCCGCCTGCCGGATGGCCGCAACG
CCAGCCGTGAATACCTGATCCATCCGGGCGCGGTGATGATGATCCCGCTGTTCGACGATGGCACCGTGCTGATGGAGCGC
CAGTTCCGCTATCCGGTGGGCAAGGTGATGATCGAATTCCCGGCGGGCAAGCTCGATCCGCGCGAGGGCGCGCTGGCCTG
CGGCAAGCGCGAGCTGCGCGAGGAGACGGGCTACGTGGCGCAGCGCTGGGATTTCCTGACGCGCATCCACCCGGTCATCT
CGTATTCCACCGAGTTCATCGATCTCTATCTCGCCCGCGACCTGCAGCCGGGCGAAAGCGCGCTGGACGAGGGCGAGTTC
CTCGAGACCTTCATCGCGCCGGCCGGCCAGTTGATCGACTGGGTGCGCACCGGCAGGATCTCCGACGTCAAGACCATCAT
CGGCGTATTCTGGCTGGAGAAAATCCTGTCGGGCACGTGGACGCCGGGCGACGCCTGA

Upstream 100 bases:

>100_bases
GGTGTTCGCCTTTCCCGGGTTCACCTGGCAGTATCTGGTGCGCCGCCAACGTCATTGATTTCCAGCCGGGCACGCCAATG
GTCCGGCGTTCGAGGTTCCC

Downstream 100 bases:

>100_bases
ACCGCTTGGATGGCCTGCTCCGGCGGCTTGACGTGCCGCCGGGTGCCCTCATCTGACAACGCTTCGCCACCCGGACGGAC
GGCCGTGCGGAAAAATTAGC

Product: hypothetical protein

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MKPDPARLSADSNEAVSDPDAGLRETQLASALVHQGKFLTLKQDVVRLPDGRNASREYLIHPGAVMMIPLFDDGTVLMER
QFRYPVGKVMIEFPAGKLDPREGALACGKRELREETGYVAQRWDFLTRIHPVISYSTEFIDLYLARDLQPGESALDEGEF
LETFIAPAGQLIDWVRTGRISDVKTIIGVFWLEKILSGTWTPGDA

Sequences:

>Translated_205_residues
MKPDPARLSADSNEAVSDPDAGLRETQLASALVHQGKFLTLKQDVVRLPDGRNASREYLIHPGAVMMIPLFDDGTVLMER
QFRYPVGKVMIEFPAGKLDPREGALACGKRELREETGYVAQRWDFLTRIHPVISYSTEFIDLYLARDLQPGESALDEGEF
LETFIAPAGQLIDWVRTGRISDVKTIIGVFWLEKILSGTWTPGDA
>Mature_205_residues
MKPDPARLSADSNEAVSDPDAGLRETQLASALVHQGKFLTLKQDVVRLPDGRNASREYLIHPGAVMMIPLFDDGTVLMER
QFRYPVGKVMIEFPAGKLDPREGALACGKRELREETGYVAQRWDFLTRIHPVISYSTEFIDLYLARDLQPGESALDEGEF
LETFIAPAGQLIDWVRTGRISDVKTIIGVFWLEKILSGTWTPGDA

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789800, Length=137, Percent_Identity=29.1970802919708, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 22905; Mature: 22905

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDPARLSADSNEAVSDPDAGLRETQLASALVHQGKFLTLKQDVVRLPDGRNASREYLI
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCCCCCEEE
HPGAVMMIPLFDDGTVLMERQFRYPVGKVMIEFPAGKLDPREGALACGKRELREETGYVA
CCCEEEEEEEECCCEEEEHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCHHH
QRWDFLTRIHPVISYSTEFIDLYLARDLQPGESALDEGEFLETFIAPAGQLIDWVRTGRI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCHHHHHHHHHCCCC
SDVKTIIGVFWLEKILSGTWTPGDA
HHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKPDPARLSADSNEAVSDPDAGLRETQLASALVHQGKFLTLKQDVVRLPDGRNASREYLI
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCCCCCEEE
HPGAVMMIPLFDDGTVLMERQFRYPVGKVMIEFPAGKLDPREGALACGKRELREETGYVA
CCCEEEEEEEECCCEEEEHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCHHH
QRWDFLTRIHPVISYSTEFIDLYLARDLQPGESALDEGEFLETFIAPAGQLIDWVRTGRI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCHHHHHHHHHCCCC
SDVKTIIGVFWLEKILSGTWTPGDA
HHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]