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The map label for this gene is msrB

Identifier: 17546466

GI number: 17546466

Start: 1868416

End: 1868802

Strand: Reverse

Name: msrB

Synonym: RSc1747

Alternate gene names: 17546466

Gene position: 1868802-1868416 (Counterclockwise)

Preceding gene: 17546467

Following gene: 17546465

Centisome position: 50.29

GC content: 65.37

Gene sequence:

>387_bases
ATGACCATCGAGAAAACCGACGCCGAATGGCGCGACCAGCTCTCCGACATCGAATACCGCGTGACCCGCGAGGCCGCCAC
CGAGCGCCCCTTCACCGGCCGCTACTGGGACCACTGGGCGCGCGGCATCTATCACTGCGTCTGCTGCGGCACGCCGCTCT
TCGAATCGTCGACCAAGTTCGACGCCGGCTGCGGCTGGCCGAGCTATTTCGCCCCCATCAACGGCGAGGTCATCGCCGAG
AAGACCGACCATTCGCACGGCATGGTGCGCATCGAAGTGCAGTGCAAGCAGTGCGGCGCGCACCTGGGCCACGTCTTCGA
AGACGGCCCCGCGCCGACCGGCCTGCGGTATTGCATCAACTCGGCTGCGCTAAAATTCGGCGATTGA

Upstream 100 bases:

>100_bases
GCTCTAATCCCGGCCTGTCAGGATCGCCGCCGCCGCCCGACCAAACCACGTCGGCCGCCCATGCAGCGGCCGGCGGAACC
CGCAAGGAGCCTCTTCCATC

Downstream 100 bases:

>100_bases
TCTTTCGCGTGGCACACCCTGCATGAAATTCCTGTTCGATCTGTTCCCGGTCATCCTGTTCTTTGCCGCCTTCAAGGTGG
CGGGCATCTATGTGGCGACC

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 128; Mature: 127

Protein sequence:

>128_residues
MTIEKTDAEWRDQLSDIEYRVTREAATERPFTGRYWDHWARGIYHCVCCGTPLFESSTKFDAGCGWPSYFAPINGEVIAE
KTDHSHGMVRIEVQCKQCGAHLGHVFEDGPAPTGLRYCINSAALKFGD

Sequences:

>Translated_128_residues
MTIEKTDAEWRDQLSDIEYRVTREAATERPFTGRYWDHWARGIYHCVCCGTPLFESSTKFDAGCGWPSYFAPINGEVIAE
KTDHSHGMVRIEVQCKQCGAHLGHVFEDGPAPTGLRYCINSAALKFGD
>Mature_127_residues
TIEKTDAEWRDQLSDIEYRVTREAATERPFTGRYWDHWARGIYHCVCCGTPLFESSTKFDAGCGWPSYFAPINGEVIAEK
TDHSHGMVRIEVQCKQCGAHLGHVFEDGPAPTGLRYCINSAALKFGD

Specific function: Unknown

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=121, Percent_Identity=57.8512396694215, Blast_Score=152, Evalue=8e-38,
Organism=Homo sapiens, GI301336162, Length=121, Percent_Identity=57.8512396694215, Blast_Score=152, Evalue=8e-38,
Organism=Homo sapiens, GI73089054, Length=121, Percent_Identity=57.8512396694215, Blast_Score=152, Evalue=8e-38,
Organism=Homo sapiens, GI37620216, Length=121, Percent_Identity=57.8512396694215, Blast_Score=151, Evalue=1e-37,
Organism=Homo sapiens, GI117606353, Length=128, Percent_Identity=50, Blast_Score=129, Evalue=9e-31,
Organism=Homo sapiens, GI7706511, Length=93, Percent_Identity=35.4838709677419, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788077, Length=128, Percent_Identity=51.5625, Blast_Score=150, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17553450, Length=121, Percent_Identity=52.0661157024793, Blast_Score=128, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI115532676, Length=121, Percent_Identity=52.0661157024793, Blast_Score=128, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6319816, Length=132, Percent_Identity=40.9090909090909, Blast_Score=112, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221378664, Length=119, Percent_Identity=49.5798319327731, Blast_Score=135, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24645799, Length=119, Percent_Identity=49.5798319327731, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45553335, Length=119, Percent_Identity=49.5798319327731, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356369, Length=119, Percent_Identity=49.5798319327731, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221378662, Length=126, Percent_Identity=46.8253968253968, Blast_Score=131, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24645801, Length=130, Percent_Identity=46.1538461538462, Blast_Score=129, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24645804, Length=130, Percent_Identity=46.1538461538462, Blast_Score=129, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRB_RALSO (Q8XYL1)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519868.1
- ProteinModelPortal:   Q8XYL1
- SMR:   Q8XYL1
- GeneID:   1220585
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1747
- NMPDR:   fig|267608.1.peg.1747
- HOGENOM:   HBG715255
- OMA:   EVRCNHC
- ProtClustDB:   PRK00222
- BioCyc:   RSOL267608:RSC1747-MONOMER
- BRENDA:   1.8.4.12
- HAMAP:   MF_01400
- InterPro:   IPR002579
- InterPro:   IPR011057
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01641 SelR; SSF51316 Mss4_like

EC number: =1.8.4.12

Molecular weight: Translated: 14418; Mature: 14287

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: ACT_SITE 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
5.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEKTDAEWRDQLSDIEYRVTREAATERPFTGRYWDHWARGIYHCVCCGTPLFESSTKF
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
DAGCGWPSYFAPINGEVIAEKTDHSHGMVRIEVQCKQCGAHLGHVFEDGPAPTGLRYCIN
CCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEHHHHCHHHHHHHCCCCCCCHHHHHHH
SAALKFGD
HHHHCCCC
>Mature Secondary Structure 
TIEKTDAEWRDQLSDIEYRVTREAATERPFTGRYWDHWARGIYHCVCCGTPLFESSTKF
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
DAGCGWPSYFAPINGEVIAEKTDHSHGMVRIEVQCKQCGAHLGHVFEDGPAPTGLRYCIN
CCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEHHHHCHHHHHHHCCCCCCCHHHHHHH
SAALKFGD
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852