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The map label for this gene is pgi [H]

Identifier: 17546438

GI number: 17546438

Start: 1837991

End: 1839610

Strand: Reverse

Name: pgi [H]

Synonym: RSc1719

Alternate gene names: 17546438

Gene position: 1839610-1837991 (Counterclockwise)

Preceding gene: 17546439

Following gene: 17546436

Centisome position: 49.5

GC content: 68.7

Gene sequence:

>1620_bases
ATGCCCACCGCCCTTCCCGCCTGGCAGTCCCTGTCGCAACATGCCCAAGCGATCCGCGCCACCCACATGCGCGATTGGTT
TGCCGCACCGGACGCCGAGCAACGGGTGCACGCCTTCACCGTGGAAGCCGCCGGGCTCACGCTCGACTACGCCAAGAACC
GCATCACCCCCGAAACGCTCGCGCTGCTGCTCCAGCTCGCGGACGAAGCCGGCGTCCTCACGCTGCGCGATGCCATGCTG
CGCGGTGAGCGCATCAACAACACCGAGCACCGTTCCGTCCTGCATGCCGCCCTGCGCGGCCACGCTGAAGATGACTACCG
CGCCAACGGCGCCGCCGTGATGCCCGACGTGCTGCGCGTGCGCGCCCAGATGCGCGATTTCGCCCAGCGCGTGCACAGCG
GCACCTGGACCGGCCATGCCGGCCAGCGCATCACCGACGTGGTCAACATCGGCATCGGCGGCTCCGACCTCGGCCCCCGC
ATGGTGTGCCGCGCGCTGGCGCACCTCGCGGTGCCGCAGGTGCGCGTGCATTTCGTCTCCAACGTCGACGGCACTGACCT
GGCCGAGACCCTCGCGGGCCTCAACCCCGACACCACGCTCGCCATCGTCTGCTCCAAGACCTTCACCACGCTGGAGACCA
TGGCCAACGCGCACAGCATGCGCCGCTGGTTCATCGAGCACGGCGTGCCCGAGGCCCAGCTCAAGCAACACTTCGTCGCC
GTCTCGACCAACCGCGACGCCGTGGTCGCATTCGGCATCGATCCGGACAACATGTTCACCTTCTGGGACTGGGTCGGCGG
ACGCTTCTCGCTGTGGTCGGCCGTCGGCCTGTCGATCGTGCTGGCCATCGGGCCTGAGCAGTTCGAGACCATGCTCGACG
GCGCCCGCGCGATGGACCGGCACTTCGCCTCCGCGGCACCGCGCGAGAACATGCCGCTGATCCTCGGCCTGCTGTCGGTC
TGGTATCGCGGCTTCTTCGGCGCCGCCAGCGCCTGCACGGTGCCCTACTGCGCCCCGCTGGAGCTGCTCACCGACTTCAT
GCAGCAGTTGGAGATGGAGAGTAACGGCAAGTCCGTCCAGCGCAACGGCGCGGCCATCGGCACTGACACCGGCCCCATCG
TCTGGGGCACCGCCGGCACCAACGGCCAGCACGCCTATTTCCAGCTGATCCACCAGGGCTCGCAAATCGTGCCGGTGGAT
TTCATCACCACGCTCGAACCGGTGCGCAGCCTGCCGGGCCACCACACCAAGCTGCTGGCCAACTGCTTTGCCCAGGGCGA
AGCGCTGCTGCGCGGCCGCACGGCGGAAGAAGTGCGCGCAGACGGCATCACCGACGCGGCGCTGGTGCCGCACATGGTGT
TCGAAGGCAACCGGCCGAGCAACACGATCCTGATGCAGCGGCTGGACGCCGCATCGCTCGGCGCCCTGATCGCCTGCGCC
GAGCACCGCACCTTCGTGCAGGGCGCGGTCTGGAACATCAACTCGTTCGACCAATGGGGCGTCGAACTCGGCAAGAAGCT
CGCCAAGCCGATCCTCGAAGAACTGGAAGGCGCGCCGGCCTCGGTGGCGCACGACGCCTCGACGGCGGCGCTGATCCGCC
GCGCCAAGGCCGCGCGCTAA

Upstream 100 bases:

>100_bases
CGCGCCCTCAACGGGCTGCTGAAATCAGACGCCTACCCATAGAGCACCCGCGCGGTGCGCCGTTATACTGCACATTCGTT
TTCCCACGCCGACCCGCCGT

Downstream 100 bases:

>100_bases
GGCGCCACAGGCTCAGAGTTCGGTAACGGTCTCATCGCCAACCAGGTGGCCGGCCTCGATGGTCAGGATGCGACTGCATC
GCGCCGCGACCGAGCGGTCG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MPTALPAWQSLSQHAQAIRATHMRDWFAAPDAEQRVHAFTVEAAGLTLDYAKNRITPETLALLLQLADEAGVLTLRDAML
RGERINNTEHRSVLHAALRGHAEDDYRANGAAVMPDVLRVRAQMRDFAQRVHSGTWTGHAGQRITDVVNIGIGGSDLGPR
MVCRALAHLAVPQVRVHFVSNVDGTDLAETLAGLNPDTTLAIVCSKTFTTLETMANAHSMRRWFIEHGVPEAQLKQHFVA
VSTNRDAVVAFGIDPDNMFTFWDWVGGRFSLWSAVGLSIVLAIGPEQFETMLDGARAMDRHFASAAPRENMPLILGLLSV
WYRGFFGAASACTVPYCAPLELLTDFMQQLEMESNGKSVQRNGAAIGTDTGPIVWGTAGTNGQHAYFQLIHQGSQIVPVD
FITTLEPVRSLPGHHTKLLANCFAQGEALLRGRTAEEVRADGITDAALVPHMVFEGNRPSNTILMQRLDAASLGALIACA
EHRTFVQGAVWNINSFDQWGVELGKKLAKPILEELEGAPASVAHDASTAALIRRAKAAR

Sequences:

>Translated_539_residues
MPTALPAWQSLSQHAQAIRATHMRDWFAAPDAEQRVHAFTVEAAGLTLDYAKNRITPETLALLLQLADEAGVLTLRDAML
RGERINNTEHRSVLHAALRGHAEDDYRANGAAVMPDVLRVRAQMRDFAQRVHSGTWTGHAGQRITDVVNIGIGGSDLGPR
MVCRALAHLAVPQVRVHFVSNVDGTDLAETLAGLNPDTTLAIVCSKTFTTLETMANAHSMRRWFIEHGVPEAQLKQHFVA
VSTNRDAVVAFGIDPDNMFTFWDWVGGRFSLWSAVGLSIVLAIGPEQFETMLDGARAMDRHFASAAPRENMPLILGLLSV
WYRGFFGAASACTVPYCAPLELLTDFMQQLEMESNGKSVQRNGAAIGTDTGPIVWGTAGTNGQHAYFQLIHQGSQIVPVD
FITTLEPVRSLPGHHTKLLANCFAQGEALLRGRTAEEVRADGITDAALVPHMVFEGNRPSNTILMQRLDAASLGALIACA
EHRTFVQGAVWNINSFDQWGVELGKKLAKPILEELEGAPASVAHDASTAALIRRAKAAR
>Mature_538_residues
PTALPAWQSLSQHAQAIRATHMRDWFAAPDAEQRVHAFTVEAAGLTLDYAKNRITPETLALLLQLADEAGVLTLRDAMLR
GERINNTEHRSVLHAALRGHAEDDYRANGAAVMPDVLRVRAQMRDFAQRVHSGTWTGHAGQRITDVVNIGIGGSDLGPRM
VCRALAHLAVPQVRVHFVSNVDGTDLAETLAGLNPDTTLAIVCSKTFTTLETMANAHSMRRWFIEHGVPEAQLKQHFVAV
STNRDAVVAFGIDPDNMFTFWDWVGGRFSLWSAVGLSIVLAIGPEQFETMLDGARAMDRHFASAAPRENMPLILGLLSVW
YRGFFGAASACTVPYCAPLELLTDFMQQLEMESNGKSVQRNGAAIGTDTGPIVWGTAGTNGQHAYFQLIHQGSQIVPVDF
ITTLEPVRSLPGHHTKLLANCFAQGEALLRGRTAEEVRADGITDAALVPHMVFEGNRPSNTILMQRLDAASLGALIACAE
HRTFVQGAVWNINSFDQWGVELGKKLAKPILEELEGAPASVAHDASTAALIRRAKAAR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=551, Percent_Identity=47.5499092558984, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI296080693, Length=551, Percent_Identity=43.9201451905626, Blast_Score=453, Evalue=1e-127,
Organism=Escherichia coli, GI1790457, Length=545, Percent_Identity=50.2752293577982, Blast_Score=531, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI71996703, Length=514, Percent_Identity=49.2217898832685, Blast_Score=503, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71996708, Length=514, Percent_Identity=49.2217898832685, Blast_Score=503, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319673, Length=546, Percent_Identity=48.1684981684982, Blast_Score=515, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24651916, Length=544, Percent_Identity=48.7132352941176, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24651914, Length=544, Percent_Identity=48.7132352941176, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI17737445, Length=544, Percent_Identity=48.7132352941176, Blast_Score=506, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 58631; Mature: 58500

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTALPAWQSLSQHAQAIRATHMRDWFAAPDAEQRVHAFTVEAAGLTLDYAKNRITPETL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCEEEEEEEECCEEHHHHHCCCCHHHH
ALLLQLADEAGVLTLRDAMLRGERINNTEHRSVLHAALRGHAEDDYRANGAAVMPDVLRV
HHHHHHHHCCCEEHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
RAQMRDFAQRVHSGTWTGHAGQRITDVVNIGIGGSDLGPRMVCRALAHLAVPQVRVHFVS
HHHHHHHHHHHHCCCCCCCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEC
NVDGTDLAETLAGLNPDTTLAIVCSKTFTTLETMANAHSMRRWFIEHGVPEAQLKQHFVA
CCCCCHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEEE
VSTNRDAVVAFGIDPDNMFTFWDWVGGRFSLWSAVGLSIVLAIGPEQFETMLDGARAMDR
EECCCCEEEEEECCCCCCEEHHHHCCCHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHH
HFASAAPRENMPLILGLLSVWYRGFFGAASACTVPYCAPLELLTDFMQQLEMESNGKSVQ
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH
RNGAAIGTDTGPIVWGTAGTNGQHAYFQLIHQGSQIVPVDFITTLEPVRSLPGHHTKLLA
CCCCEECCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCHHHHHHH
NCFAQGEALLRGRTAEEVRADGITDAALVPHMVFEGNRPSNTILMQRLDAASLGALIACA
HHHHCCHHHHCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHH
EHRTFVQGAVWNINSFDQWGVELGKKLAKPILEELEGAPASVAHDASTAALIRRAKAAR
HHHHHHHCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTALPAWQSLSQHAQAIRATHMRDWFAAPDAEQRVHAFTVEAAGLTLDYAKNRITPETL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCEEEEEEEECCEEHHHHHCCCCHHHH
ALLLQLADEAGVLTLRDAMLRGERINNTEHRSVLHAALRGHAEDDYRANGAAVMPDVLRV
HHHHHHHHCCCEEHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
RAQMRDFAQRVHSGTWTGHAGQRITDVVNIGIGGSDLGPRMVCRALAHLAVPQVRVHFVS
HHHHHHHHHHHHCCCCCCCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEC
NVDGTDLAETLAGLNPDTTLAIVCSKTFTTLETMANAHSMRRWFIEHGVPEAQLKQHFVA
CCCCCHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEEE
VSTNRDAVVAFGIDPDNMFTFWDWVGGRFSLWSAVGLSIVLAIGPEQFETMLDGARAMDR
EECCCCEEEEEECCCCCCEEHHHHCCCHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHH
HFASAAPRENMPLILGLLSVWYRGFFGAASACTVPYCAPLELLTDFMQQLEMESNGKSVQ
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH
RNGAAIGTDTGPIVWGTAGTNGQHAYFQLIHQGSQIVPVDFITTLEPVRSLPGHHTKLLA
CCCCEECCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCHHHHHHH
NCFAQGEALLRGRTAEEVRADGITDAALVPHMVFEGNRPSNTILMQRLDAASLGALIACA
HHHHCCHHHHCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHH
EHRTFVQGAVWNINSFDQWGVELGKKLAKPILEELEGAPASVAHDASTAALIRRAKAAR
HHHHHHHCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA