Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 17546435

GI number: 17546435

Start: 1835805

End: 1836497

Strand: Reverse

Name: lepB [H]

Synonym: RSc1716

Alternate gene names: 17546435

Gene position: 1836497-1835805 (Counterclockwise)

Preceding gene: 17546436

Following gene: 17546426

Centisome position: 49.42

GC content: 67.97

Gene sequence:

>693_bases
ATGAAGCTGCTGGCGAAATCACTGAAAGCGGCACGGGACAACAAGCGGTTCCTGGTCGGCATGTCGCTGCTGCTCGCATT
CCGGGCCTGCGTCGCCGACTGGTCGGTCGTGCCGAGCGGCTCGATGAACCCGACGCTGATCGAAGGCGATTTCATCCTGG
TGAACCGCCTCGCCTATGGCATCCGGGTGCCGGCCACCACCGTCTGGCTCAAGCGCGGCAATGAACCGCGCCGCGGCGAC
GTCGTCGTGTTCTCATCGCCCGAGAACGGCACCAAGCTCGTCAAGCGCCTGATCGGGTTGCCGGGCGATGTGGTCGAGAT
GCGCGGCGAAGCGCTCTACATCAACCACCAGCGCCTGGCCTACACGCCGCTGCCCGATGTCGCGCCCGGCGCCCTGCCGC
AGGCAACGGCCGCCCAGCCCCACGACCTGTGGACCGAGGCCCTGCCCGACCACCCGCACCCGGTGATGGTGCTACCCAAG
GTGGCCGCGCTGCGCAGCTTCGGCCCCATCGTCGTGCCGGCCGATCAGTACCTGATGCTCGGCGACAACCGCGACAACAG
CCGGGATTCCCGCTACTTCGGCCTTGTGCCACGGCAGAACCTGATCGCGCGGGCATCGCACGTGGCGGTATCGTTCGATC
CCGATCACTGGTACCTGCCGCGCCTCGCGCGCATCGGCCGGCCGCTCGACTGA

Upstream 100 bases:

>100_bases
CTCAAGGGCCGGGTCGGAGGATGACCACCCTTTGCCCGCAGGCGTCCGATGCCCGGGCACCCGGGCTCAAACATCAATAT
GCATTACGGGGAGAAACACA

Downstream 100 bases:

>100_bases
GCGCCGATAACAAAAAGCCCCCTCATCGAGGGGGCTTTTTTCTTGTACCTGCCGAACCGCTCAGGAACCGTCGTCCGACG
AAGCCGCAGGCTTGGCGGCG

Product: signal peptidase I (SPase I) protein

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKLLAKSLKAARDNKRFLVGMSLLLAFRACVADWSVVPSGSMNPTLIEGDFILVNRLAYGIRVPATTVWLKRGNEPRRGD
VVVFSSPENGTKLVKRLIGLPGDVVEMRGEALYINHQRLAYTPLPDVAPGALPQATAAQPHDLWTEALPDHPHPVMVLPK
VAALRSFGPIVVPADQYLMLGDNRDNSRDSRYFGLVPRQNLIARASHVAVSFDPDHWYLPRLARIGRPLD

Sequences:

>Translated_230_residues
MKLLAKSLKAARDNKRFLVGMSLLLAFRACVADWSVVPSGSMNPTLIEGDFILVNRLAYGIRVPATTVWLKRGNEPRRGD
VVVFSSPENGTKLVKRLIGLPGDVVEMRGEALYINHQRLAYTPLPDVAPGALPQATAAQPHDLWTEALPDHPHPVMVLPK
VAALRSFGPIVVPADQYLMLGDNRDNSRDSRYFGLVPRQNLIARASHVAVSFDPDHWYLPRLARIGRPLD
>Mature_230_residues
MKLLAKSLKAARDNKRFLVGMSLLLAFRACVADWSVVPSGSMNPTLIEGDFILVNRLAYGIRVPATTVWLKRGNEPRRGD
VVVFSSPENGTKLVKRLIGLPGDVVEMRGEALYINHQRLAYTPLPDVAPGALPQATAAQPHDLWTEALPDHPHPVMVLPK
VAALRSFGPIVVPADQYLMLGDNRDNSRDSRYFGLVPRQNLIARASHVAVSFDPDHWYLPRLARIGRPLD

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=251, Percent_Identity=33.4661354581673, Blast_Score=116, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 25454; Mature: 25454

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLAKSLKAARDNKRFLVGMSLLLAFRACVADWSVVPSGSMNPTLIEGDFILVNRLAYG
CCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEHHHHC
IRVPATTVWLKRGNEPRRGDVVVFSSPENGTKLVKRLIGLPGDVVEMRGEALYINHQRLA
EECCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHCCCEEEEECCEEE
YTPLPDVAPGALPQATAAQPHDLWTEALPDHPHPVMVLPKVAALRSFGPIVVPADQYLML
ECCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEECCHHHHHHHCCCEEECCCCEEEE
GDNRDNSRDSRYFGLVPRQNLIARASHVAVSFDPDHWYLPRLARIGRPLD
ECCCCCCCCCEEEECCCCHHHHHHHHEEEEEECCCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MKLLAKSLKAARDNKRFLVGMSLLLAFRACVADWSVVPSGSMNPTLIEGDFILVNRLAYG
CCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEHHHHC
IRVPATTVWLKRGNEPRRGDVVVFSSPENGTKLVKRLIGLPGDVVEMRGEALYINHQRLA
EECCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHCCCEEEEECCEEE
YTPLPDVAPGALPQATAAQPHDLWTEALPDHPHPVMVLPKVAALRSFGPIVVPADQYLML
ECCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEECCHHHHHHHCCCEEECCCCEEEE
GDNRDNSRDSRYFGLVPRQNLIARASHVAVSFDPDHWYLPRLARIGRPLD
ECCCCCCCCCEEEECCCCHHHHHHHHEEEEEECCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]