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The map label for this gene is dctS [H]

Identifier: 17546317

GI number: 17546317

Start: 1714420

End: 1716993

Strand: Reverse

Name: dctS [H]

Synonym: RSc1598

Alternate gene names: 17546317

Gene position: 1716993-1714420 (Counterclockwise)

Preceding gene: 17546318

Following gene: 17546316

Centisome position: 46.2

GC content: 68.22

Gene sequence:

>2574_bases
ATGTCCATCGACCCTCGTCCGCAGAATTCCGGCGTTCGCCCGCCCATCATGCTCTCCCCCTCCCACGCCACGCCGGAGCC
GGCCGACCCCGCGACGCAGCCGCCGGCCGCCGCGATGCCCGTTCCCGTACCGGCGCCCGAACTGCCGCCGGAAGACGGCG
TGCGCCCGAACGTGCCGCGCGGGCTGTGGATCATGCGCCTGGGCCGGCTATGGACCACCAACTGGTTCATGTTCATTCCG
CTGGTGGCCATCGTGCTGTTCGCCGGCGCGATGATCTTCATCCTCTACCAGCTGCATGCCACCGAGGTGCAGCAACAGCG
CGACGCTCTGTACCGCGACGCCGCCTGGGCCGAGCAGAAGGTGCGGCTGTCCCTGCAGAGCAACCAGGACCAGGTGGCGG
CGCTGGCGCGCGACATCGGCGCCGCGCAGCTGGACCCGAGCGCCTATCGCGATGCCGCGCGGCAACTGCTGCGCGAGAAC
CCCGAGGTGGTCTTCATCAACTGGCTGGATGCCACGCGCCGGCCGCGCTGGGCCTTTCCCGCCAATTCGGAATTCGCGCA
GCGCGTGCGCGAGACGCGCGACCATCCGCTCGAGGCCGAGATCCAGTCCGCCTATGATGCCGCGCGCGAGACCCAGCGCG
CGGTCTACTCCCGCCCCATCCAGAACGAGCGCGGCGAGAGCTTCATGCTGATGGAAGTGCCCATCGTCCGTGACAACGAG
TTCCTGGGCACGGTCGGCGCGATGTATTCCGTGACCGGCATCCTCACACAGCTGCTGCCGGGCGAGCTGACCGACCGCTA
CCGCTTCTCGCTGGTCGACAAGGACAATGTGGTGCGCGCCAGCACGTCGCTGCGGCCGGTGCCCAAGGCGGCCGCGTCGT
ACGAGGTGCTGCTGGACCCGCCGGGGCATTCGCTGTCGCTGCGGGCAGAGGCGTATCCGGCGCTGTCCAACCTGCCCAAC
AACATGCTGATGTGGCTGGTGGCGGGGCTGTCATGCTTCGTGATCTGGAGCCTGTGGAGCGTGTGGCGCCATACCAGCCG
GCGCTCCGAGGCCCAGCGGGCGCTGCTGGCCGAGACCTCCTTCCGGCGCGCCATGGAGAACTCCATGGTGATCGGCCTGC
GTTCGCTCGACCTCAACGGCCGCATCACCTATGTCAACCCGGCCTTCTGCCGCATGATCGGCTGGACCGAGCAGGAGCTG
GTCGGCCGCATGCCGCCCTTCCCGTACTGGCCGGCCAACGAGATCGGCGAGATGCAGAAGTACATCGAGTTGACGCTGCG
CGGCAAGGCGCCGGCCAACGGCATGGAGCTGCGCATGGTGCGCCGCGATGGCACCAGCTTCTATGCGCGGATGTACGTCT
CGCCGCTGATCGATGCGCGCGGCCGGCACACGGGCTGGATGAGCTCCATCACCGACATCACCGAGCCCAAGCGCGCGCGC
GAAGACCTGGCCGCCGCGCACGACCGCTTCACCACGGTGCTCGAGAGCCTGGATGCCGCCGTCTCGGTGCTATCGACCGA
CAAGGCGGAGCTGCTGTTCGCCAACCGCTATTACCGGCAGCTGTTCGGCTGGGAGGCCTCCGGCCACCTTCAGTTGTCGG
GCACCGATGTCAACACGGAGGATGTCTCCAGCGATGCGCTCGACCTGGTCGACGGCTTCGCCGGCCTGCCCGCCTCCGAG
CTCACGCCGCACGCCGCCGACGCGCGCGAGGTCTACCTGCCGTCGATGCAGAAATGGTTCGAGGTGCGCCGCCGCTATAT
CCAGTGGGTGGACGGCCACCTGGCGCAGATGCAGATCGCCACCGACATCACCGTGCGCAAGGCGGCCGAAGAGATGACAC
GCCAGCATGAAGAGCGCCTGCAGTTCACCAGCCGCCTGACCACCATGGGCGAGATGGCGTCGTCGCTCGCGCACGAGCTG
AACCAGCCGCTGGCGGCCATCAACAACTACTGCATGGGTGCGGTCGGGCGCCTGAAGAGCGGGCGCAGCACGCCGGAGGA
GCTGATCCCGGTGCTGGAGAAGACCTCCGCCCAGGCGGTGCGCGCCGGCACGATCATCCAGCGCATCCGCGGCTTCGTGA
AGCGCAGCCAGCCGCAGCGCCGCGAAGCCGACCTGCGCGAGATGGTGGCCGACGCGGTGGGCCTCGCCGAGCTGGAGGCC
ATCCGGCGCGGCGTGACCATCCTGACGCGGCTGCCGGCCGGCCTGCCGCACCTGTATGTCGACCCGGTGCTGATCGAGCA
GGTGCTGGTCAACCTGCTCAAGAACGCCGTCGAAGCCATGGCGGCCCATCCGCGCCTGCGCGCCGCCGCCGTGCTGCGCC
TGCACGCCAGCCTGGTCAGCGACCCGGAGAACTCCGTGCTGATCGAGGTCATCGACCAGGGCCCCGGCGTGGACGACAGC
ACCAAGGAGCGCCTGTTCGAGCCGTTCTTCAGCACCAAGTCCGACGGCATGGGCATGGGACTCAACATCTGCCGCTCCAT
CATAGAATCCCACCTCGGGCGGTTGTGGGTGGAAAACAATCCCGACGGCATCGGCTGTACGTTTAAAATCACCCTTCCGC
TGCATCCGGTCTAA

Upstream 100 bases:

>100_bases
ATGCAGCATCCGCACGGCCGCCATCCGCGCGCCACCAGCGGTTTCCCCAAGCGACCGGCCGATCGAATGCCGCTACACTT
GATTTTGCGCAGTTGCACAG

Downstream 100 bases:

>100_bases
CCGGCTTCAATCGTTTTCAGAACGTAGATTCAAAACGTAGAACGAGGACTCTCCATGAGTGCAACGCCCGCCGCGGTCGC
TCCGCGCAACGAAACCGTGT

Product: two-component transmembrane sensor histidine kinase transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 857; Mature: 856

Protein sequence:

>857_residues
MSIDPRPQNSGVRPPIMLSPSHATPEPADPATQPPAAAMPVPVPAPELPPEDGVRPNVPRGLWIMRLGRLWTTNWFMFIP
LVAIVLFAGAMIFILYQLHATEVQQQRDALYRDAAWAEQKVRLSLQSNQDQVAALARDIGAAQLDPSAYRDAARQLLREN
PEVVFINWLDATRRPRWAFPANSEFAQRVRETRDHPLEAEIQSAYDAARETQRAVYSRPIQNERGESFMLMEVPIVRDNE
FLGTVGAMYSVTGILTQLLPGELTDRYRFSLVDKDNVVRASTSLRPVPKAAASYEVLLDPPGHSLSLRAEAYPALSNLPN
NMLMWLVAGLSCFVIWSLWSVWRHTSRRSEAQRALLAETSFRRAMENSMVIGLRSLDLNGRITYVNPAFCRMIGWTEQEL
VGRMPPFPYWPANEIGEMQKYIELTLRGKAPANGMELRMVRRDGTSFYARMYVSPLIDARGRHTGWMSSITDITEPKRAR
EDLAAAHDRFTTVLESLDAAVSVLSTDKAELLFANRYYRQLFGWEASGHLQLSGTDVNTEDVSSDALDLVDGFAGLPASE
LTPHAADAREVYLPSMQKWFEVRRRYIQWVDGHLAQMQIATDITVRKAAEEMTRQHEERLQFTSRLTTMGEMASSLAHEL
NQPLAAINNYCMGAVGRLKSGRSTPEELIPVLEKTSAQAVRAGTIIQRIRGFVKRSQPQRREADLREMVADAVGLAELEA
IRRGVTILTRLPAGLPHLYVDPVLIEQVLVNLLKNAVEAMAAHPRLRAAAVLRLHASLVSDPENSVLIEVIDQGPGVDDS
TKERLFEPFFSTKSDGMGMGLNICRSIIESHLGRLWVENNPDGIGCTFKITLPLHPV

Sequences:

>Translated_857_residues
MSIDPRPQNSGVRPPIMLSPSHATPEPADPATQPPAAAMPVPVPAPELPPEDGVRPNVPRGLWIMRLGRLWTTNWFMFIP
LVAIVLFAGAMIFILYQLHATEVQQQRDALYRDAAWAEQKVRLSLQSNQDQVAALARDIGAAQLDPSAYRDAARQLLREN
PEVVFINWLDATRRPRWAFPANSEFAQRVRETRDHPLEAEIQSAYDAARETQRAVYSRPIQNERGESFMLMEVPIVRDNE
FLGTVGAMYSVTGILTQLLPGELTDRYRFSLVDKDNVVRASTSLRPVPKAAASYEVLLDPPGHSLSLRAEAYPALSNLPN
NMLMWLVAGLSCFVIWSLWSVWRHTSRRSEAQRALLAETSFRRAMENSMVIGLRSLDLNGRITYVNPAFCRMIGWTEQEL
VGRMPPFPYWPANEIGEMQKYIELTLRGKAPANGMELRMVRRDGTSFYARMYVSPLIDARGRHTGWMSSITDITEPKRAR
EDLAAAHDRFTTVLESLDAAVSVLSTDKAELLFANRYYRQLFGWEASGHLQLSGTDVNTEDVSSDALDLVDGFAGLPASE
LTPHAADAREVYLPSMQKWFEVRRRYIQWVDGHLAQMQIATDITVRKAAEEMTRQHEERLQFTSRLTTMGEMASSLAHEL
NQPLAAINNYCMGAVGRLKSGRSTPEELIPVLEKTSAQAVRAGTIIQRIRGFVKRSQPQRREADLREMVADAVGLAELEA
IRRGVTILTRLPAGLPHLYVDPVLIEQVLVNLLKNAVEAMAAHPRLRAAAVLRLHASLVSDPENSVLIEVIDQGPGVDDS
TKERLFEPFFSTKSDGMGMGLNICRSIIESHLGRLWVENNPDGIGCTFKITLPLHPV
>Mature_856_residues
SIDPRPQNSGVRPPIMLSPSHATPEPADPATQPPAAAMPVPVPAPELPPEDGVRPNVPRGLWIMRLGRLWTTNWFMFIPL
VAIVLFAGAMIFILYQLHATEVQQQRDALYRDAAWAEQKVRLSLQSNQDQVAALARDIGAAQLDPSAYRDAARQLLRENP
EVVFINWLDATRRPRWAFPANSEFAQRVRETRDHPLEAEIQSAYDAARETQRAVYSRPIQNERGESFMLMEVPIVRDNEF
LGTVGAMYSVTGILTQLLPGELTDRYRFSLVDKDNVVRASTSLRPVPKAAASYEVLLDPPGHSLSLRAEAYPALSNLPNN
MLMWLVAGLSCFVIWSLWSVWRHTSRRSEAQRALLAETSFRRAMENSMVIGLRSLDLNGRITYVNPAFCRMIGWTEQELV
GRMPPFPYWPANEIGEMQKYIELTLRGKAPANGMELRMVRRDGTSFYARMYVSPLIDARGRHTGWMSSITDITEPKRARE
DLAAAHDRFTTVLESLDAAVSVLSTDKAELLFANRYYRQLFGWEASGHLQLSGTDVNTEDVSSDALDLVDGFAGLPASEL
TPHAADAREVYLPSMQKWFEVRRRYIQWVDGHLAQMQIATDITVRKAAEEMTRQHEERLQFTSRLTTMGEMASSLAHELN
QPLAAINNYCMGAVGRLKSGRSTPEELIPVLEKTSAQAVRAGTIIQRIRGFVKRSQPQRREADLREMVADAVGLAELEAI
RRGVTILTRLPAGLPHLYVDPVLIEQVLVNLLKNAVEAMAAHPRLRAAAVLRLHASLVSDPENSVLIEVIDQGPGVDDST
KERLFEPFFSTKSDGMGMGLNICRSIIESHLGRLWVENNPDGIGCTFKITLPLHPV

Specific function: Member of the two-component regulatory system dctS/dctR involved in the transport of C4-dicarboxylates. DctS functions as a membrane-associated protein kinase that phosphorylates dctR in response to environmental signals [H]

COG id: COG2202

COG function: function code T; FOG: PAS/PAC domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=305, Percent_Identity=28.1967213114754, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=26.7782426778243, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790346, Length=242, Percent_Identity=26.8595041322314, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI1790300, Length=254, Percent_Identity=29.1338582677165, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786912, Length=127, Percent_Identity=34.6456692913386, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=238, Percent_Identity=25.2100840336134, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=25.0909090909091, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=269, Percent_Identity=25.2788104089219, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 95956; Mature: 95825

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDPRPQNSGVRPPIMLSPSHATPEPADPATQPPAAAMPVPVPAPELPPEDGVRPNVPR
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GLWIMRLGRLWTTNWFMFIPLVAIVLFAGAMIFILYQLHATEVQQQRDALYRDAAWAEQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRLSLQSNQDQVAALARDIGAAQLDPSAYRDAARQLLRENPEVVFINWLDATRRPRWAFP
HEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
ANSEFAQRVRETRDHPLEAEIQSAYDAARETQRAVYSRPIQNERGESFMLMEVPIVRDNE
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECEEECCC
FLGTVGAMYSVTGILTQLLPGELTDRYRFSLVDKDNVVRASTSLRPVPKAAASYEVLLDP
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEEECC
PGHSLSLRAEAYPALSNLPNNMLMWLVAGLSCFVIWSLWSVWRHTSRRSEAQRALLAETS
CCCCEEEEHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRRAMENSMVIGLRSLDLNGRITYVNPAFCRMIGWTEQELVGRMPPFPYWPANEIGEMQK
HHHHHHCCCEEEEEEECCCCEEEEECHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHH
YIELTLRGKAPANGMELRMVRRDGTSFYARMYVSPLIDARGRHTGWMSSITDITEPKRAR
HHHHEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHH
EDLAAAHDRFTTVLESLDAAVSVLSTDKAELLFANRYYRQLFGWEASGHLQLSGTDVNTE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHH
DVSSDALDLVDGFAGLPASELTPHAADAREVYLPSMQKWFEVRRRYIQWVDGHLAQMQIA
HCCHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDITVRKAAEEMTRQHEERLQFTSRLTTMGEMASSLAHELNQPLAAINNYCMGAVGRLKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
GRSTPEELIPVLEKTSAQAVRAGTIIQRIRGFVKRSQPQRREADLREMVADAVGLAELEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
IRRGVTILTRLPAGLPHLYVDPVLIEQVLVNLLKNAVEAMAAHPRLRAAAVLRLHASLVS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
DPENSVLIEVIDQGPGVDDSTKERLFEPFFSTKSDGMGMGLNICRSIIESHLGRLWVENN
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCEEEECCC
PDGIGCTFKITLPLHPV
CCCEEEEEEEEECCCCC
>Mature Secondary Structure 
SIDPRPQNSGVRPPIMLSPSHATPEPADPATQPPAAAMPVPVPAPELPPEDGVRPNVPR
CCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GLWIMRLGRLWTTNWFMFIPLVAIVLFAGAMIFILYQLHATEVQQQRDALYRDAAWAEQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRLSLQSNQDQVAALARDIGAAQLDPSAYRDAARQLLRENPEVVFINWLDATRRPRWAFP
HEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
ANSEFAQRVRETRDHPLEAEIQSAYDAARETQRAVYSRPIQNERGESFMLMEVPIVRDNE
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECEEECCC
FLGTVGAMYSVTGILTQLLPGELTDRYRFSLVDKDNVVRASTSLRPVPKAAASYEVLLDP
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEEECC
PGHSLSLRAEAYPALSNLPNNMLMWLVAGLSCFVIWSLWSVWRHTSRRSEAQRALLAETS
CCCCEEEEHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRRAMENSMVIGLRSLDLNGRITYVNPAFCRMIGWTEQELVGRMPPFPYWPANEIGEMQK
HHHHHHCCCEEEEEEECCCCEEEEECHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHH
YIELTLRGKAPANGMELRMVRRDGTSFYARMYVSPLIDARGRHTGWMSSITDITEPKRAR
HHHHEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHH
EDLAAAHDRFTTVLESLDAAVSVLSTDKAELLFANRYYRQLFGWEASGHLQLSGTDVNTE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHH
DVSSDALDLVDGFAGLPASELTPHAADAREVYLPSMQKWFEVRRRYIQWVDGHLAQMQIA
HCCHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDITVRKAAEEMTRQHEERLQFTSRLTTMGEMASSLAHELNQPLAAINNYCMGAVGRLKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
GRSTPEELIPVLEKTSAQAVRAGTIIQRIRGFVKRSQPQRREADLREMVADAVGLAELEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
IRRGVTILTRLPAGLPHLYVDPVLIEQVLVNLLKNAVEAMAAHPRLRAAAVLRLHASLVS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
DPENSVLIEVIDQGPGVDDSTKERLFEPFFSTKSDGMGMGLNICRSIIESHLGRLWVENN
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCEEEECCC
PDGIGCTFKITLPLHPV
CCCEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8455557 [H]