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The map label for this gene is prlC [H]

Identifier: 17546314

GI number: 17546314

Start: 1710531

End: 1712651

Strand: Reverse

Name: prlC [H]

Synonym: RSc1595

Alternate gene names: 17546314

Gene position: 1712651-1710531 (Counterclockwise)

Preceding gene: 17546315

Following gene: 17546312

Centisome position: 46.08

GC content: 68.55

Gene sequence:

>2121_bases
ATGACCGTCACCTCGCCTGAAGTCGCCACCCCGGCTGCCAACCCGCTTCTCGATTTCTCCGGTCTGCCGCGCTTTGCGGA
GATCCGCCCCGAGCACATCACGCCGGCGCTCGACGTGCTGCTGGAGCGCGCCACCGCCGCCGTGGTCCGCATCAAGGACC
CGGCCACGCCATCCACCTGGGACCATGTCGTCGCGGCACTGGAAGACGCCACCGAGCCGCTCGGCCGCGCCTGGGGCATC
GTCAGCCACCTGAGCTCGGTGGCCGATACGCCGGCGCTGCGCGAGGCCCACGCCGCCAACCTGCCCCGCGTGACCGAATT
CTGGTCGGCCCTCGGACAGGACCTGGAACTGTTCCAGAAGTACAAGGCGATCGCCGAAAGCGCCGAATACGCCACGCTGA
CGGCACCGCGCAAGCAGCTGCTCGACAACGAACTGCGCGGCTTCCGCCTGGGCGGCGCCGAGCTGCCGGAAGACCGCAAA
CCGCGCTTCGCCGCCATCCAGGAGCAGCAGGCGCAGCTGACCAAGGCGTTCAGCGACCACGTGCTGGACGCGACCAACGG
CTACGCGCTGCGGATCGACGACGAGGCGCGCCTGTCCGGCCTGCCCGAAGATGCCCGGCAAGCCGCGCACGAAGCCGCCC
GCCGCGACGATCCGGCCAGCACCGGCTGGAAGTTCACGCTGCACTTCCCGTCGTACTTCCCGGTGCTGCAGTACGCGAAC
GACCGCGCGCTGCGCCGCACGCTGTACGAGGCCAACGTCACGCGCGCCTCGGAGCTGGGGCCCCAGCACGGCAGCGGCAA
GCCCGAGTGGGACAACACCGCCAACATGGCCGAACAGCTGGCCTTGCGCACCGAAGAGGCGCACATGCTCGGCTACCGCA
ATTTCGGCGAGGTATCGCTGGTGCCCAAGATGGCCGACTCGCCCGAAGCGGTGCTGCGCTTCCTGGGCGAGCTGGCCGAC
CGCGCCCGCCCCTTCGCCGAGAAAGACTGGACCGAGCTGCAGGCGTTCGCCAAGACCACGCTGGGCATCGACAAACTCGA
GCCGTGGGACATGGCCTACGCCTCCGAAAAGCTGCGCGAAGCCCGCTATGCCTTCTCCGAGCAGGAGGTGAAGCAGTACT
TCCCGGAGCCGGCCGTGCTGGACGGCCTGTTCAACGTCGTGCAGACGCTGTTCTCCGTGCAGATCCGCCCGGAGCCGGCC
GAGGTGTGGCACCCCGACGTGCGCTTCTTCCGCGTCGAATCGGCGCAGGGCGAGCTGCTGGCGCAGTTCTACATCGACCT
GTACGCCCGTGACGGCAAGCGCGGCGGCGCCTGGATGGACGACGCCCGCGGCCGCAAGGTGCTGGCCGACGCCGGTGTGC
AAACCCCGGTGGCCTACCTCACCTGCAACTTCTCCGGCCCGGTCGGCGACAAGCCTGCGCTGTTCACGCACGACGAGGTC
ATCACCCTCTTCCACGAATTCGGCCACGGCCTGCACCACATGCTCACGCAGGTGGACGAACTGGGCGTGTCGGGCATCAA
CGGCGTGGAATGGGATGCGGTAGAGCTGCCCTCGCAGTTCATGGAGAACTTCTGCTGGGAGTGGGAAGTGCTCTCGCGCA
TGACCCGCCACGTCGAGTCCGGCGAGCCGCTGCCGCACGCGCTGTTCGACCGCATGCTGGCCGCCAAGAACTTCCAGAAC
GGCATGGCGACGCTGCGCCAGATCGTGTTCTCGACGTTCGACATGCACCTGCATACCGACTTCGATCCGAAGGGCGCGAC
CTCGGTGCTGGAGCTGTCGCGGCAGATCAACAATCGCTTCCATGTCGTGCCGCAGGCGGTGCTGTCGCGCTGGCCGAACA
CCTTCAGCCACATCTTCGCGGGCGGCTACGCGGCGGGCTACTACAGCTACAAGTGGGCTGAAGTGCTGTCGGCCGATGCC
TACGCGGCCTTCGAGGAAGCCGGCAAGCTGACCGGCTCGGTGCTCGATGCCGAGACCGGCGCGCGCTACCGCCGCGAGGT
GCTGGCCGTCGGCGGCAGCCGCCCGGCGATCGAGTCGTTCAAGGCCTTCCGCGGCCGCGCGCCAAGCATCGACGCGCTGC
TGCGCCATGGCGGCATGGTGGTGACGGCCGAACCCGCCTGA

Upstream 100 bases:

>100_bases
ATTGCGACCCGGTCGCAGCCATTGGAAACCGGAAAAGCGTCCCAACCTGCCTGACTGGACGCTTTTTCGATGTCCACTCC
TCCCGTTTTCCGAGCCCGCC

Downstream 100 bases:

>100_bases
GCCTGGGCCGGCTGACCGCCGCACAGCACGCCGCTTCGCGCCCCGCGCCGAAGCGGCGTTTGTCTTTCAGGCGAGCCGAA
AATCGACGCGTGGTGCTCGC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MTVTSPEVATPAANPLLDFSGLPRFAEIRPEHITPALDVLLERATAAVVRIKDPATPSTWDHVVAALEDATEPLGRAWGI
VSHLSSVADTPALREAHAANLPRVTEFWSALGQDLELFQKYKAIAESAEYATLTAPRKQLLDNELRGFRLGGAELPEDRK
PRFAAIQEQQAQLTKAFSDHVLDATNGYALRIDDEARLSGLPEDARQAAHEAARRDDPASTGWKFTLHFPSYFPVLQYAN
DRALRRTLYEANVTRASELGPQHGSGKPEWDNTANMAEQLALRTEEAHMLGYRNFGEVSLVPKMADSPEAVLRFLGELAD
RARPFAEKDWTELQAFAKTTLGIDKLEPWDMAYASEKLREARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVQIRPEPA
EVWHPDVRFFRVESAQGELLAQFYIDLYARDGKRGGAWMDDARGRKVLADAGVQTPVAYLTCNFSGPVGDKPALFTHDEV
ITLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVESGEPLPHALFDRMLAAKNFQN
GMATLRQIVFSTFDMHLHTDFDPKGATSVLELSRQINNRFHVVPQAVLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADA
YAAFEEAGKLTGSVLDAETGARYRREVLAVGGSRPAIESFKAFRGRAPSIDALLRHGGMVVTAEPA

Sequences:

>Translated_706_residues
MTVTSPEVATPAANPLLDFSGLPRFAEIRPEHITPALDVLLERATAAVVRIKDPATPSTWDHVVAALEDATEPLGRAWGI
VSHLSSVADTPALREAHAANLPRVTEFWSALGQDLELFQKYKAIAESAEYATLTAPRKQLLDNELRGFRLGGAELPEDRK
PRFAAIQEQQAQLTKAFSDHVLDATNGYALRIDDEARLSGLPEDARQAAHEAARRDDPASTGWKFTLHFPSYFPVLQYAN
DRALRRTLYEANVTRASELGPQHGSGKPEWDNTANMAEQLALRTEEAHMLGYRNFGEVSLVPKMADSPEAVLRFLGELAD
RARPFAEKDWTELQAFAKTTLGIDKLEPWDMAYASEKLREARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVQIRPEPA
EVWHPDVRFFRVESAQGELLAQFYIDLYARDGKRGGAWMDDARGRKVLADAGVQTPVAYLTCNFSGPVGDKPALFTHDEV
ITLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVESGEPLPHALFDRMLAAKNFQN
GMATLRQIVFSTFDMHLHTDFDPKGATSVLELSRQINNRFHVVPQAVLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADA
YAAFEEAGKLTGSVLDAETGARYRREVLAVGGSRPAIESFKAFRGRAPSIDALLRHGGMVVTAEPA
>Mature_705_residues
TVTSPEVATPAANPLLDFSGLPRFAEIRPEHITPALDVLLERATAAVVRIKDPATPSTWDHVVAALEDATEPLGRAWGIV
SHLSSVADTPALREAHAANLPRVTEFWSALGQDLELFQKYKAIAESAEYATLTAPRKQLLDNELRGFRLGGAELPEDRKP
RFAAIQEQQAQLTKAFSDHVLDATNGYALRIDDEARLSGLPEDARQAAHEAARRDDPASTGWKFTLHFPSYFPVLQYAND
RALRRTLYEANVTRASELGPQHGSGKPEWDNTANMAEQLALRTEEAHMLGYRNFGEVSLVPKMADSPEAVLRFLGELADR
ARPFAEKDWTELQAFAKTTLGIDKLEPWDMAYASEKLREARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVQIRPEPAE
VWHPDVRFFRVESAQGELLAQFYIDLYARDGKRGGAWMDDARGRKVLADAGVQTPVAYLTCNFSGPVGDKPALFTHDEVI
TLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVESGEPLPHALFDRMLAAKNFQNG
MATLRQIVFSTFDMHLHTDFDPKGATSVLELSRQINNRFHVVPQAVLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAY
AAFEEAGKLTGSVLDAETGARYRREVLAVGGSRPAIESFKAFRGRAPSIDALLRHGGMVVTAEPA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=652, Percent_Identity=30.2147239263804, Blast_Score=294, Evalue=2e-79,
Organism=Homo sapiens, GI14149738, Length=650, Percent_Identity=29.3846153846154, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI156105687, Length=659, Percent_Identity=25.1896813353566, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1789913, Length=687, Percent_Identity=47.8893740902475, Blast_Score=651, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=700, Percent_Identity=30.8571428571429, Blast_Score=271, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI71999758, Length=497, Percent_Identity=25.7545271629779, Blast_Score=132, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI32565901, Length=619, Percent_Identity=20.6785137318255, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319793, Length=688, Percent_Identity=27.1802325581395, Blast_Score=270, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6322715, Length=684, Percent_Identity=22.2222222222222, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21356111, Length=716, Percent_Identity=27.9329608938547, Blast_Score=245, Evalue=7e-65,
Organism=Drosophila melanogaster, GI20129717, Length=419, Percent_Identity=27.6849642004773, Blast_Score=168, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 78597; Mature: 78466

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTSPEVATPAANPLLDFSGLPRFAEIRPEHITPALDVLLERATAAVVRIKDPATPSTW
CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHCCHHHHHHHHHHHHEEEEECCCCCCCHH
DHVVAALEDATEPLGRAWGIVSHLSSVADTPALREAHAANLPRVTEFWSALGQDLELFQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YKAIAESAEYATLTAPRKQLLDNELRGFRLGGAELPEDRKPRFAAIQEQQAQLTKAFSDH
HHHHHHCCCHHEECCHHHHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLDATNGYALRIDDEARLSGLPEDARQAAHEAARRDDPASTGWKFTLHFPSYFPVLQYAN
HCCCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHCC
DRALRRTLYEANVTRASELGPQHGSGKPEWDNTANMAEQLALRTEEAHMLGYRNFGEVSL
HHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VPKMADSPEAVLRFLGELADRARPFAEKDWTELQAFAKTTLGIDKLEPWDMAYASEKLRE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
ARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVQIRPEPAEVWHPDVRFFRVESAQGELL
HHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCHHHHCCCCCEEEEEECCCHHHH
AQFYIDLYARDGKRGGAWMDDARGRKVLADAGVQTPVAYLTCNFSGPVGDKPALFTHDEV
HHHHHHHHHCCCCCCCCCCCCCCCCEEEHHCCCCCCEEEEEEECCCCCCCCCCEECHHHH
ITLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVES
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC
GEPLPHALFDRMLAAKNFQNGMATLRQIVFSTFDMHLHTDFDPKGATSVLELSRQINNRF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCE
HVVPQAVLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAGKLTGSVLDAETG
EEHHHHHHHHCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ARYRREVLAVGGSRPAIESFKAFRGRAPSIDALLRHGGMVVTAEPA
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEEECCC
>Mature Secondary Structure 
TVTSPEVATPAANPLLDFSGLPRFAEIRPEHITPALDVLLERATAAVVRIKDPATPSTW
CCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHCCHHHHHHHHHHHHEEEEECCCCCCCHH
DHVVAALEDATEPLGRAWGIVSHLSSVADTPALREAHAANLPRVTEFWSALGQDLELFQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YKAIAESAEYATLTAPRKQLLDNELRGFRLGGAELPEDRKPRFAAIQEQQAQLTKAFSDH
HHHHHHCCCHHEECCHHHHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLDATNGYALRIDDEARLSGLPEDARQAAHEAARRDDPASTGWKFTLHFPSYFPVLQYAN
HCCCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHCC
DRALRRTLYEANVTRASELGPQHGSGKPEWDNTANMAEQLALRTEEAHMLGYRNFGEVSL
HHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VPKMADSPEAVLRFLGELADRARPFAEKDWTELQAFAKTTLGIDKLEPWDMAYASEKLRE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
ARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVQIRPEPAEVWHPDVRFFRVESAQGELL
HHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCHHHHCCCCCEEEEEECCCHHHH
AQFYIDLYARDGKRGGAWMDDARGRKVLADAGVQTPVAYLTCNFSGPVGDKPALFTHDEV
HHHHHHHHHCCCCCCCCCCCCCCCCEEEHHCCCCCCEEEEEEECCCCCCCCCCEECHHHH
ITLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVES
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC
GEPLPHALFDRMLAAKNFQNGMATLRQIVFSTFDMHLHTDFDPKGATSVLELSRQINNRF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCE
HVVPQAVLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAGKLTGSVLDAETG
EEHHHHHHHHCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ARYRREVLAVGGSRPAIESFKAFRGRAPSIDALLRHGGMVVTAEPA
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]