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The map label for this gene is folP [H]

Identifier: 17546246

GI number: 17546246

Start: 1630846

End: 1631721

Strand: Direct

Name: folP [H]

Synonym: RSc1527

Alternate gene names: 17546246

Gene position: 1630846-1631721 (Clockwise)

Preceding gene: 17546245

Following gene: 17546247

Centisome position: 43.88

GC content: 68.15

Gene sequence:

>876_bases
TTGTCTGTTTCCATTCCCACCACGACGCATTTCCAGTGCGGACGCTTCCGCTACCCGCGTGACCGTCGCCCACTGGTCAT
GGGCATCCTCAACGTCACGCCCGATTCGTTTTCCGACGGTGGCCGGCATGCCACCCGCGATGCCGCGTTGCGCCACGCCG
AGCAGCTGATTGCCGAAGGGGCCGACCTCATCGACATCGGCGGCGAGTCGAGCCGGCCCGGGGCCGCGCCGCTCGGGCTG
CAGGAGGAGCTGGATCGGGTGATGCCGATCGTCGAGGCGCTGCGCGAATGCGGCAGGCCGCTGTCGATCGACACCTACAA
GCCGGACGTGATGCGCGCCACGCTCGATGCCGGCGCCGACCTGATCAACGATATCTGGGGCTTCCGCAAGCCGGGGGCGA
TCGAGGCTGTCGCGCAGGGCCATGCCGGGCTGTGCCTGATGCATATGCAGCGGGACCCCGAAACGATGCAGGAAGCCCCC
AGCTACACGGACCTGATGGCCGAAGTCGGGGCCTTCCTGCAAGCGCAGGCGCAAGTGCTGCTGGCTGCGGGCGTCGCGGC
CGAACGCATTGCGCTGGACCCTGGATTTGGCTTTGGAAAGACGCCGGACCACAATCTGATCATGCTCAACCGGCTGGAGC
ACTTCGAGCGGATGGGGCTGCCGTTGCTGGTGGGCCTGTCGCGTAAGTCGACGCTGGGCGCGGTGTTGGGCGGCAAGCCG
CCCGCCGAGCGCATCACGGCGAGCGTGGCGGCGGCGTTGCTGGCGGCGGAGCGGGGGGCCTTCATCGTGCGGGTGCACGA
TGTGCGGCCCACCGTCGAAGCCATCCAGCTCTGGTGGGCCATGCGGCACGAGCGGATCGATCCGCCGGTTGCATGA

Upstream 100 bases:

>100_bases
GTCCGCGAGGACGGCATAGGAGAGCCGGTGCGTGCGCACCGGCTTTTTTGTTGGCGCCGCTTTCCGCTTGCTTCGGGCGC
CGTGTTTTGAGTCACGTACC

Downstream 100 bases:

>100_bases
CCGCCAGGCCGGCCTCGCGCGATCGGGGTCGGGTGAACAGACGATTGTCCGGCCCAGTCCGGCGACTTACAAACAAAAGA
ACCTCTCTCTTCAGGAGTGA

Product: 7,8-dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSVSIPTTTHFQCGRFRYPRDRRPLVMGILNVTPDSFSDGGRHATRDAALRHAEQLIAEGADLIDIGGESSRPGAAPLGL
QEELDRVMPIVEALRECGRPLSIDTYKPDVMRATLDAGADLINDIWGFRKPGAIEAVAQGHAGLCLMHMQRDPETMQEAP
SYTDLMAEVGAFLQAQAQVLLAAGVAAERIALDPGFGFGKTPDHNLIMLNRLEHFERMGLPLLVGLSRKSTLGAVLGGKP
PAERITASVAAALLAAERGAFIVRVHDVRPTVEAIQLWWAMRHERIDPPVA

Sequences:

>Translated_291_residues
MSVSIPTTTHFQCGRFRYPRDRRPLVMGILNVTPDSFSDGGRHATRDAALRHAEQLIAEGADLIDIGGESSRPGAAPLGL
QEELDRVMPIVEALRECGRPLSIDTYKPDVMRATLDAGADLINDIWGFRKPGAIEAVAQGHAGLCLMHMQRDPETMQEAP
SYTDLMAEVGAFLQAQAQVLLAAGVAAERIALDPGFGFGKTPDHNLIMLNRLEHFERMGLPLLVGLSRKSTLGAVLGGKP
PAERITASVAAALLAAERGAFIVRVHDVRPTVEAIQLWWAMRHERIDPPVA
>Mature_290_residues
SVSIPTTTHFQCGRFRYPRDRRPLVMGILNVTPDSFSDGGRHATRDAALRHAEQLIAEGADLIDIGGESSRPGAAPLGLQ
EELDRVMPIVEALRECGRPLSIDTYKPDVMRATLDAGADLINDIWGFRKPGAIEAVAQGHAGLCLMHMQRDPETMQEAPS
YTDLMAEVGAFLQAQAQVLLAAGVAAERIALDPGFGFGKTPDHNLIMLNRLEHFERMGLPLLVGLSRKSTLGAVLGGKPP
AERITASVAAALLAAERGAFIVRVHDVRPTVEAIQLWWAMRHERIDPPVA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=259, Percent_Identity=51.7374517374517, Blast_Score=264, Evalue=6e-72,
Organism=Saccharomyces cerevisiae, GI6324073, Length=310, Percent_Identity=29.0322580645161, Blast_Score=112, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31559; Mature: 31428

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSIPTTTHFQCGRFRYPRDRRPLVMGILNVTPDSFSDGGRHATRDAALRHAEQLIAEG
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
ADLIDIGGESSRPGAAPLGLQEELDRVMPIVEALRECGRPLSIDTYKPDVMRATLDAGAD
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
LINDIWGFRKPGAIEAVAQGHAGLCLMHMQRDPETMQEAPSYTDLMAEVGAFLQAQAQVL
HHHHHHCCCCCCHHHHHHCCCCCEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LAAGVAAERIALDPGFGFGKTPDHNLIMLNRLEHFERMGLPLLVGLSRKSTLGAVLGGKP
HHHCCHHHHEEECCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCC
PAERITASVAAALLAAERGAFIVRVHDVRPTVEAIQLWWAMRHERIDPPVA
CHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SVSIPTTTHFQCGRFRYPRDRRPLVMGILNVTPDSFSDGGRHATRDAALRHAEQLIAEG
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
ADLIDIGGESSRPGAAPLGLQEELDRVMPIVEALRECGRPLSIDTYKPDVMRATLDAGAD
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
LINDIWGFRKPGAIEAVAQGHAGLCLMHMQRDPETMQEAPSYTDLMAEVGAFLQAQAQVL
HHHHHHCCCCCCHHHHHHCCCCCEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LAAGVAAERIALDPGFGFGKTPDHNLIMLNRLEHFERMGLPLLVGLSRKSTLGAVLGGKP
HHHCCHHHHEEECCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCC
PAERITASVAAALLAAERGAFIVRVHDVRPTVEAIQLWWAMRHERIDPPVA
CHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]