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The map label for this gene is adhA [H]

Identifier: 17546224

GI number: 17546224

Start: 1610507

End: 1611511

Strand: Reverse

Name: adhA [H]

Synonym: RSc1505

Alternate gene names: 17546224

Gene position: 1611511-1610507 (Counterclockwise)

Preceding gene: 17546225

Following gene: 17546223

Centisome position: 43.36

GC content: 71.84

Gene sequence:

>1005_bases
ATGCAAGCCATGGTCTGCTCGCGCGCCGGTGCGCCGCTGCAATGGCAGACCGTGCCGCGGCCCGAACCCGGTCCCGGTGA
AGTCCGGATCGCGGTGTCGGTGTGCGGCGTCTGCCGGACGGACCTGCATATCGTCGACGGCGAATTGCCCGATCCGAAGC
CGGCGCTGATTCCGGGGCACGAGATCGTCGGCACGGTCGATGCGTGCGGACCCGGCGTCAGCGGGCTCACCACGGGCGAG
CGCGTCGGCGTGCCCTGGCTGGGCTGGAGCTGCGGCACCTGCCCGTTCTGCCGGCGCGACCAGGAAAACCTGTGCGACCG
GCCGCGCTTCACCGGCTACACGCGTGACGGCGGCTACGCCGAATACACCGTTTGCGATGCCCGCTACTGCCTTCCCATCC
CGGCACGGTACGACGATGCCCACGCGGCGCCTCTGCTCTGCGCGGGGCTGATCGGCTACCGTACGCTGCGCATGGCGGGC
GACGCGCGCCGCCTTGGCATCTATGGCTTCGGCGCGGCGGCCCACCTGGTCACGCAGATTGCCGTGGCCGAGCAGCGCGA
AGTCTTTGCCTTCACCCGGGCGGGGGATACCGGCGCGCAGCAGCTCGCGCGCGACACCGGCGCCTGCTGGGCGGGCGCGA
GCGAAGCGCCGCCGCCCGCGCCGCTCGATGCCGCGCTGATCTTCGCCCCGGTGGGGGCGCTGGTGCCGCTCGCGCTGCAG
GCCGTCGTCAAGGGTGGCACGGTGGTCTGCGGCGGCATCCACATGAGCGACATCCCGGCGTTTCCCTATCGGCTGCTCTG
GGAAGAACGCAAGCTGATGTCGGTAGCGAACCTGACGCGCGCCGACGGCCTGGCGCTGATGCGCGTGGCGGCGACGGTGC
CGCTGCAATCGCACGTCACGCTCTACCCGCTCGCCGAAGCCAATGCCGCGCTCGATGATCTGCGCGCGGGACGGGTGACC
GGCGCGGCCGTCCTCCAGGTCCGGAGCCCGATCGACGGGCCTTGA

Upstream 100 bases:

>100_bases
CCGCTGTACGCCGTGCTCGGTATCCGGACCAGCCGGCCTGAGTAGCCACCGGCGGCCGTCTCGCCCCGGATCGGGCACCG
CATCCACCATGCCTGCCTCG

Downstream 100 bases:

>100_bases
TGCGTATCAAGGAGCGCGCCGCGCGAGCGGCTACGCTAAAAGCAGGCCACGCAGGGCGCGTGGCCGCATGCCCCGACACG
GAGACTGCCATGTATGAACG

Product: alcohol dehydrogenase-like oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MQAMVCSRAGAPLQWQTVPRPEPGPGEVRIAVSVCGVCRTDLHIVDGELPDPKPALIPGHEIVGTVDACGPGVSGLTTGE
RVGVPWLGWSCGTCPFCRRDQENLCDRPRFTGYTRDGGYAEYTVCDARYCLPIPARYDDAHAAPLLCAGLIGYRTLRMAG
DARRLGIYGFGAAAHLVTQIAVAEQREVFAFTRAGDTGAQQLARDTGACWAGASEAPPPAPLDAALIFAPVGALVPLALQ
AVVKGGTVVCGGIHMSDIPAFPYRLLWEERKLMSVANLTRADGLALMRVAATVPLQSHVTLYPLAEANAALDDLRAGRVT
GAAVLQVRSPIDGP

Sequences:

>Translated_334_residues
MQAMVCSRAGAPLQWQTVPRPEPGPGEVRIAVSVCGVCRTDLHIVDGELPDPKPALIPGHEIVGTVDACGPGVSGLTTGE
RVGVPWLGWSCGTCPFCRRDQENLCDRPRFTGYTRDGGYAEYTVCDARYCLPIPARYDDAHAAPLLCAGLIGYRTLRMAG
DARRLGIYGFGAAAHLVTQIAVAEQREVFAFTRAGDTGAQQLARDTGACWAGASEAPPPAPLDAALIFAPVGALVPLALQ
AVVKGGTVVCGGIHMSDIPAFPYRLLWEERKLMSVANLTRADGLALMRVAATVPLQSHVTLYPLAEANAALDDLRAGRVT
GAAVLQVRSPIDGP
>Mature_334_residues
MQAMVCSRAGAPLQWQTVPRPEPGPGEVRIAVSVCGVCRTDLHIVDGELPDPKPALIPGHEIVGTVDACGPGVSGLTTGE
RVGVPWLGWSCGTCPFCRRDQENLCDRPRFTGYTRDGGYAEYTVCDARYCLPIPARYDDAHAAPLLCAGLIGYRTLRMAG
DARRLGIYGFGAAAHLVTQIAVAEQREVFAFTRAGDTGAQQLARDTGACWAGASEAPPPAPLDAALIFAPVGALVPLALQ
AVVKGGTVVCGGIHMSDIPAFPYRLLWEERKLMSVANLTRADGLALMRVAATVPLQSHVTLYPLAEANAALDDLRAGRVT
GAAVLQVRSPIDGP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=174, Percent_Identity=28.1609195402299, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262073058, Length=174, Percent_Identity=28.1609195402299, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4501933, Length=174, Percent_Identity=30.4597701149425, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI71565154, Length=110, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI34577061, Length=172, Percent_Identity=29.6511627906977, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=32.5077399380805, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI87082401, Length=335, Percent_Identity=27.1641791044776, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1786518, Length=206, Percent_Identity=37.378640776699, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1787863, Length=226, Percent_Identity=30.0884955752212, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI226510992, Length=163, Percent_Identity=30.6748466257669, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790045, Length=147, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788407, Length=160, Percent_Identity=33.125, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786825, Length=99, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562582, Length=162, Percent_Identity=32.7160493827161, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=156, Percent_Identity=31.4102564102564, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=330, Percent_Identity=26.0606060606061, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=119, Percent_Identity=34.453781512605, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=126, Percent_Identity=32.5396825396825, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71997431, Length=121, Percent_Identity=33.8842975206612, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=159, Percent_Identity=38.3647798742138, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323729, Length=159, Percent_Identity=37.7358490566038, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324486, Length=212, Percent_Identity=34.4339622641509, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319621, Length=159, Percent_Identity=37.1069182389937, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323980, Length=142, Percent_Identity=39.4366197183099, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319949, Length=186, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=261, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737895, Length=110, Percent_Identity=32.7272727272727, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35205; Mature: 35205

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAMVCSRAGAPLQWQTVPRPEPGPGEVRIAVSVCGVCRTDLHIVDGELPDPKPALIPGH
CCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHCCCEEECCCCCCCCCCEECCH
EIVGTVDACGPGVSGLTTGERVGVPWLGWSCGTCPFCRRDQENLCDRPRFTGYTRDGGYA
HHEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEE
EYTVCDARYCLPIPARYDDAHAAPLLCAGLIGYRTLRMAGDARRLGIYGFGAAAHLVTQI
EEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHH
AVAEQREVFAFTRAGDTGAQQLARDTGACWAGASEAPPPAPLDAALIFAPVGALVPLALQ
HHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AVVKGGTVVCGGIHMSDIPAFPYRLLWEERKLMSVANLTRADGLALMRVAATVPLQSHVT
HHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHCCCCCCEE
LYPLAEANAALDDLRAGRVTGAAVLQVRSPIDGP
EEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MQAMVCSRAGAPLQWQTVPRPEPGPGEVRIAVSVCGVCRTDLHIVDGELPDPKPALIPGH
CCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHCCCEEECCCCCCCCCCEECCH
EIVGTVDACGPGVSGLTTGERVGVPWLGWSCGTCPFCRRDQENLCDRPRFTGYTRDGGYA
HHEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEE
EYTVCDARYCLPIPARYDDAHAAPLLCAGLIGYRTLRMAGDARRLGIYGFGAAAHLVTQI
EEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHH
AVAEQREVFAFTRAGDTGAQQLARDTGACWAGASEAPPPAPLDAALIFAPVGALVPLALQ
HHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AVVKGGTVVCGGIHMSDIPAFPYRLLWEERKLMSVANLTRADGLALMRVAATVPLQSHVT
HHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHCCCCCCEE
LYPLAEANAALDDLRAGRVTGAAVLQVRSPIDGP
EEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]