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The map label for this gene is map [H]

Identifier: 17546122

GI number: 17546122

Start: 1502501

End: 1503328

Strand: Reverse

Name: map [H]

Synonym: RSc1403

Alternate gene names: 17546122

Gene position: 1503328-1502501 (Counterclockwise)

Preceding gene: 17546139

Following gene: 17546121

Centisome position: 40.45

GC content: 65.7

Gene sequence:

>828_bases
ATGGCCGTTACCCTCAAGACCGCCGAAGACATTGCGCACATGCGCGTGGCCTGCCGGCTTGCGTCGGAAGTACTCGACTA
CATCACGCCGTTCGTCAAGGCCGGCGTTTCCACCGGTGAACTGGACCGCCTGTGCCACGCCTACATGCGTGACGTGCAAG
GCACCGTGCCCGCGCCGCTGAATTACGCGCCGCCGGGCTACCCGCCCTTCCCCGGCGCGATCTGCACATCGGTCAACGAT
GTGATCTGCCACGGTATTCCGGACGACAAAAAGATTCTCAAGAACGGCGACGCCATCAACCTGGACATCACCGTGATCAC
GCCCGAGGGCTATTACGGCGATACCAGCCGCATGTTCATCGTCGGCGAGGGCTCGATCCTGGCCAAGCGGCTGGCGCAGG
TGACGTACGAATGCATGTGGAAGGGCATCGCCGTGGTGCGGCCTGGCGCGCGCCTGGGCGACATCGGCCACGTGATCCAG
CAGCACGCCGAAGCCGCCGGCTACAGCGTGGTGCGCGAGTATTGCGGGCACGGCATCGGCCAGGTCTTCCACGAAGATCC
GCAGATCCTGCACTACGGCCGCCCGGGTACGGGCCTGGAGCTGAAGGCCGGCATGATTTTCACCATCGAACCGATGATCA
ACGCGGGCAAGCGCGACATCCGCACCATGCCCGACCAGTGGACGGTCAAGACGCGCGACCGCAGCCTGTCGGCCCAGTGG
GAGCACACGATCCTGGTGACGGAAGCCGGCTACGACGTGCTGACCGTGTCGGCGCATACGCCGGCGCCGCCGGCGTTCGT
GAGCGACGGTACGCCGGCCACGGCCTGA

Upstream 100 bases:

>100_bases
CGCCTCGCCCGCGACGCCCGGCAGGACGGCTTTGGTGCGATAATCCATGCTTTGGACACCACGCCGCACAATCGCTGTTG
CGTGCAGAAAGAGTCACAAC

Downstream 100 bases:

>100_bases
TCGGGCCCGGCCGCTCGTCGCCCCAGGTGCGCCGCAGCGGTCGCGCCGGCCCATGTTTTTCCGCAACGACCGGACCGCTC
CGGTCGTTGTTCCATTGACG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MAVTLKTAEDIAHMRVACRLASEVLDYITPFVKAGVSTGELDRLCHAYMRDVQGTVPAPLNYAPPGYPPFPGAICTSVND
VICHGIPDDKKILKNGDAINLDITVITPEGYYGDTSRMFIVGEGSILAKRLAQVTYECMWKGIAVVRPGARLGDIGHVIQ
QHAEAAGYSVVREYCGHGIGQVFHEDPQILHYGRPGTGLELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQW
EHTILVTEAGYDVLTVSAHTPAPPAFVSDGTPATA

Sequences:

>Translated_275_residues
MAVTLKTAEDIAHMRVACRLASEVLDYITPFVKAGVSTGELDRLCHAYMRDVQGTVPAPLNYAPPGYPPFPGAICTSVND
VICHGIPDDKKILKNGDAINLDITVITPEGYYGDTSRMFIVGEGSILAKRLAQVTYECMWKGIAVVRPGARLGDIGHVIQ
QHAEAAGYSVVREYCGHGIGQVFHEDPQILHYGRPGTGLELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQW
EHTILVTEAGYDVLTVSAHTPAPPAFVSDGTPATA
>Mature_274_residues
AVTLKTAEDIAHMRVACRLASEVLDYITPFVKAGVSTGELDRLCHAYMRDVQGTVPAPLNYAPPGYPPFPGAICTSVNDV
ICHGIPDDKKILKNGDAINLDITVITPEGYYGDTSRMFIVGEGSILAKRLAQVTYECMWKGIAVVRPGARLGDIGHVIQQ
HAEAAGYSVVREYCGHGIGQVFHEDPQILHYGRPGTGLELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HTILVTEAGYDVLTVSAHTPAPPAFVSDGTPATA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=266, Percent_Identity=46.6165413533835, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI40385867, Length=260, Percent_Identity=39.2307692307692, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1786364, Length=269, Percent_Identity=55.3903345724907, Blast_Score=312, Evalue=1e-86,
Organism=Escherichia coli, GI1788728, Length=256, Percent_Identity=28.125, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71996291, Length=256, Percent_Identity=45.703125, Blast_Score=218, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=44.758064516129, Blast_Score=210, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21355531, Length=259, Percent_Identity=45.5598455598456, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24583427, Length=251, Percent_Identity=37.8486055776892, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29816; Mature: 29684

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTLKTAEDIAHMRVACRLASEVLDYITPFVKAGVSTGELDRLCHAYMRDVQGTVPAPL
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
NYAPPGYPPFPGAICTSVNDVICHGIPDDKKILKNGDAINLDITVITPEGYYGDTSRMFI
CCCCCCCCCCCCHHHHCCHHHEECCCCCHHHHHHCCCEEEEEEEEECCCCCCCCCCEEEE
VGEGSILAKRLAQVTYECMWKGIAVVRPGARLGDIGHVIQQHAEAAGYSVVREYCGHGIG
EECCHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QVFHEDPQILHYGRPGTGLELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQW
HHHCCCCCEEEECCCCCCCEEECCEEEEECCCCCCCCHHHHCCCCCEEEEECCCCCCCCC
EHTILVTEAGYDVLTVSAHTPAPPAFVSDGTPATA
CEEEEEEECCCEEEEEECCCCCCCCEECCCCCCCC
>Mature Secondary Structure 
AVTLKTAEDIAHMRVACRLASEVLDYITPFVKAGVSTGELDRLCHAYMRDVQGTVPAPL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
NYAPPGYPPFPGAICTSVNDVICHGIPDDKKILKNGDAINLDITVITPEGYYGDTSRMFI
CCCCCCCCCCCCHHHHCCHHHEECCCCCHHHHHHCCCEEEEEEEEECCCCCCCCCCEEEE
VGEGSILAKRLAQVTYECMWKGIAVVRPGARLGDIGHVIQQHAEAAGYSVVREYCGHGIG
EECCHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QVFHEDPQILHYGRPGTGLELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQW
HHHCCCCCEEEECCCCCCCEEECCEEEEECCCCCCCCHHHHCCCCCEEEEECCCCCCCCC
EHTILVTEAGYDVLTVSAHTPAPPAFVSDGTPATA
CEEEEEEECCCEEEEEECCCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]