Click here to switch to the map view.

The map label for this gene is dapE [H]

Identifier: 17546109

GI number: 17546109

Start: 1482385

End: 1483545

Strand: Reverse

Name: dapE [H]

Synonym: RSc1390

Alternate gene names: 17546109

Gene position: 1483545-1482385 (Counterclockwise)

Preceding gene: 17546110

Following gene: 17546108

Centisome position: 39.92

GC content: 68.91

Gene sequence:

>1161_bases
GTGACCGCCATGTCGCCCACGCTTGCCCTCACTGAAGACCTGATCCGCCGCCGCTCCGTCACGCCCGAAGACAAGGGCTG
CCAGGATGTGCTGATCGAACGCCTGTCCGCCGCCGGCTTCCAATGCGAAACCGTGGTCAGCGGGCCGGACCACTTCCGCG
TGACCAACCTGTGGGCCGTCAAGCGCGGCCGCGCGGGTACCGACGGCAAGCTGCTGGTCTTCGCCGGCCACACCGACGTG
GTGCCGACCGGCCCCGTGGAGCAGTGGCGCTCCGACCCGTTCGAGCCGACCCACCGCGACGGCAAGCTCTATGGCCGCGG
CGCCGCCGACATGAAAACCTCGATCGCCGGGTTCGTGGTAGCCGCCGAGGAATTCGTCGCCGTGCATCCGGACCACGCCG
GCTCGATCGGCTTCCTGATCACCAGTGACGAGGAAGGCCCGGCCCACGACGGCACCATCAAGGTCTGCGACCTGCTGCGC
ACGCGCGGCGAGCGGCTGGACTACTGCGTGGTGGGCGAGCCGACCTCGGTGTCCACGCTCGGCGACATGGTCAAGAACGG
GCGACGCGGCTCGCTGTCGGGCAAGCTGACCGTCAACGGCGTGCAGGGCCACATCGCCTATCCGCACCTGGCCAAGAACC
CGATCCACCTGGCCGTGCCGGCGCTGACCGCGCTGGCGGCCGAGCAGTGGGACGACGGCAACGCCTACTTCCCGCCGACC
ACCTGGCAGATGTCGAACATCCACGGCGGCACCGGCGCGACCAACGTGATTCCGGGCCACGTCATCATCGACTTCAACTT
CCGCTTCTCGACGGCGAGCACGCCGGAGGGCCTGAAGTCGCGCGTGCACGCCATCCTCGACGCGCACGGCCTGGACTACA
CGCTGGCCTGGACGCTGGGCGGCGAGCCCTTCCTGACCGAGCGCGGCGAGCTGTCGGAGGCGCTGTCGTCGGCCATCGGG
GCCGAGTGCGGCGTCGCCACTGAACTGTCGACCACCGGCGGCACGTCGGACGGCCGCTTCATCGCCAAGCTGTGCCCGCA
GGTGATCGAGTTCGGGCCGCCCAACGCCAGCATCCACAAGATCGACGAGCACGTCGATGTGGCCTTCATCGAGCCGCTCA
AGAACGTGTACCGGCGCGTGCTGGAAACACTGATCGCCTGA

Upstream 100 bases:

>100_bases
CTGATCAAGCGCCCGGTGCTGGTGCACGGCAAGGCCGTCAGCGTGGGCTTCTCGGCCGACCAGTACGCCAACCTGTTCTG
ACCTTACGCTCCCATTTACC

Downstream 100 bases:

>100_bases
GCGCCGCGCATGGCCCGCAACGTCGAGATCAAGGCCCGCGTGCGCGATGCGGCGGCGCTGAGCGCGCGCGCCGCCGCGCT
GACCGACGCCGGCCCCGAGC

Product: succinyl-diaminopimelate desuccinylase

Products: NA

Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTAMSPTLALTEDLIRRRSVTPEDKGCQDVLIERLSAAGFQCETVVSGPDHFRVTNLWAVKRGRAGTDGKLLVFAGHTDV
VPTGPVEQWRSDPFEPTHRDGKLYGRGAADMKTSIAGFVVAAEEFVAVHPDHAGSIGFLITSDEEGPAHDGTIKVCDLLR
TRGERLDYCVVGEPTSVSTLGDMVKNGRRGSLSGKLTVNGVQGHIAYPHLAKNPIHLAVPALTALAAEQWDDGNAYFPPT
TWQMSNIHGGTGATNVIPGHVIIDFNFRFSTASTPEGLKSRVHAILDAHGLDYTLAWTLGGEPFLTERGELSEALSSAIG
AECGVATELSTTGGTSDGRFIAKLCPQVIEFGPPNASIHKIDEHVDVAFIEPLKNVYRRVLETLIA

Sequences:

>Translated_386_residues
MTAMSPTLALTEDLIRRRSVTPEDKGCQDVLIERLSAAGFQCETVVSGPDHFRVTNLWAVKRGRAGTDGKLLVFAGHTDV
VPTGPVEQWRSDPFEPTHRDGKLYGRGAADMKTSIAGFVVAAEEFVAVHPDHAGSIGFLITSDEEGPAHDGTIKVCDLLR
TRGERLDYCVVGEPTSVSTLGDMVKNGRRGSLSGKLTVNGVQGHIAYPHLAKNPIHLAVPALTALAAEQWDDGNAYFPPT
TWQMSNIHGGTGATNVIPGHVIIDFNFRFSTASTPEGLKSRVHAILDAHGLDYTLAWTLGGEPFLTERGELSEALSSAIG
AECGVATELSTTGGTSDGRFIAKLCPQVIEFGPPNASIHKIDEHVDVAFIEPLKNVYRRVLETLIA
>Mature_385_residues
TAMSPTLALTEDLIRRRSVTPEDKGCQDVLIERLSAAGFQCETVVSGPDHFRVTNLWAVKRGRAGTDGKLLVFAGHTDVV
PTGPVEQWRSDPFEPTHRDGKLYGRGAADMKTSIAGFVVAAEEFVAVHPDHAGSIGFLITSDEEGPAHDGTIKVCDLLRT
RGERLDYCVVGEPTSVSTLGDMVKNGRRGSLSGKLTVNGVQGHIAYPHLAKNPIHLAVPALTALAAEQWDDGNAYFPPTT
WQMSNIHGGTGATNVIPGHVIIDFNFRFSTASTPEGLKSRVHAILDAHGLDYTLAWTLGGEPFLTERGELSEALSSAIGA
ECGVATELSTTGGTSDGRFIAKLCPQVIEFGPPNASIHKIDEHVDVAFIEPLKNVYRRVLETLIA

Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=401, Percent_Identity=23.6907730673317, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788816, Length=381, Percent_Identity=55.3805774278215, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1790395, Length=371, Percent_Identity=25.6064690026954, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17551016, Length=264, Percent_Identity=28.4090909090909, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005941
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 41397; Mature: 41266

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAMSPTLALTEDLIRRRSVTPEDKGCQDVLIERLSAAGFQCETVVSGPDHFRVTNLWAV
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEE
KRGRAGTDGKLLVFAGHTDVVPTGPVEQWRSDPFEPTHRDGKLYGRGAADMKTSIAGFVV
ECCCCCCCCEEEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHEE
AAEEFVAVHPDHAGSIGFLITSDEEGPAHDGTIKVCDLLRTRGERLDYCVVGEPTSVSTL
EEEHEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHH
GDMVKNGRRGSLSGKLTVNGVQGHIAYPHLAKNPIHLAVPALTALAAEQWDDGNAYFPPT
HHHHHCCCCCCCCCEEEEECCCCEEECCCCCCCCCEEEHHHHHHHHHHCCCCCCEECCCC
TWQMSNIHGGTGATNVIPGHVIIDFNFRFSTASTPEGLKSRVHAILDAHGLDYTLAWTLG
CEEECCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEC
GEPFLTERGELSEALSSAIGAECGVATELSTTGGTSDGRFIAKLCPQVIEFGPPNASIHK
CCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEHHHHHHHHHHCCCCCCHHEE
IDEHVDVAFIEPLKNVYRRVLETLIA
HHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAMSPTLALTEDLIRRRSVTPEDKGCQDVLIERLSAAGFQCETVVSGPDHFRVTNLWAV
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEE
KRGRAGTDGKLLVFAGHTDVVPTGPVEQWRSDPFEPTHRDGKLYGRGAADMKTSIAGFVV
ECCCCCCCCEEEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHEE
AAEEFVAVHPDHAGSIGFLITSDEEGPAHDGTIKVCDLLRTRGERLDYCVVGEPTSVSTL
EEEHEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHH
GDMVKNGRRGSLSGKLTVNGVQGHIAYPHLAKNPIHLAVPALTALAAEQWDDGNAYFPPT
HHHHHCCCCCCCCCEEEEECCCCEEECCCCCCCCCEEEHHHHHHHHHHCCCCCCEECCCC
TWQMSNIHGGTGATNVIPGHVIIDFNFRFSTASTPEGLKSRVHAILDAHGLDYTLAWTLG
CEEECCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEC
GEPFLTERGELSEALSSAIGAECGVATELSTTGGTSDGRFIAKLCPQVIEFGPPNASIHK
CCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEHHHHHHHHHHCCCCCCHHEE
IDEHVDVAFIEPLKNVYRRVLETLIA
HHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA