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The map label for this gene is alr

Identifier: 17546090

GI number: 17546090

Start: 1460580

End: 1461707

Strand: Direct

Name: alr

Synonym: RSc1371

Alternate gene names: 17546090

Gene position: 1460580-1461707 (Clockwise)

Preceding gene: 17546088

Following gene: 17546091

Centisome position: 39.3

GC content: 70.39

Gene sequence:

>1128_bases
ATGCCAAGACCCATTCAGGCCGTCATCCACGGCCCCGCACTCGTCAACAATCTCCAGGTGGTTCGCCGCCACGCCGCGGA
CTCGCGCGTCTGGGCGGTCATCAAGGCCAACGCATATGGCCACGGCATCGAGCGTGCCTATGAGGGGCTGCGCCAGGCCG
ACGGCTTCGGCCTGCTCGATCTGGACGAGGCCGTCCGGCTGCGCCAGCTGGGCTGGCAGGGGCCGATCCTGCTGCTCGAG
GGCTTCTTCAAGCCGGAAGACCTGGCGCTGGTCGAGCAATACCGACTGACCACCACCGTCCATTGCGAGGAGCAGTTGCG
CATGCTGGAGCTGGCGCGCCTGAAGGGGCCGGTGAGTATCCAGCTGAAGATCAACACGGGCATGAGCCGCCTGGGCTTCG
CGCCGGCCGCGTACCGTGCGGCCTGGGAGCATGCCCGCGCCATTTCCGGCATCGGCACCATCGTCCACATGACGCATTTT
TCCGATGCCGACGGCCCGCGCGGCATCGATCACCAGTTGGCCGCCTTCGAGCAAGCCACGCAGGGGCTGCCGGGCGAGGC
GAGCCTGTCCAACTCCGCCGCCACGCTGTGGCATCCGAGGGCGCACCGGGACTGGGTGCGCCCCGGCGTGATCCTGTACG
GTGCTTCGCCGACCGGCGTGGCCGCCGACATCGAAGGCACCGGCCTGATGCCGGCCATGACGCTCAAGAGCGAGCTGATC
GCCGTCCAGGACCTGCAGCCGGGCGCGACCGTCGGCTACGGCTCGCGCTTCGAGGCCGAGCAGCCGATGCGCATCGGCAT
CGTCGCGTGCGGCTATGCCGATGGCTATCCGCGCCATGCTCCCGGCTGGGACGGCAACTACACGCCGGTGCTGGTGGACG
GCGTGCGCACGCGCATGGTGGGCCGCGTGTCGATGGACATGATCACCGTGGACCTGGCCGAAGTGCCGGGCGCCCGCGTT
GGCGCACCCGTCACGCTGTGGGGGCAGGGCCTGCCGATCGACGAGGTGGCGCATGCCGCCGGCACGGTCGGCTACGAGCT
GATGTGCGCGCTGGCGCCGCGCGTGCCGGTGACGGTCGAGCCGGCCGGCGCGGCGGATGCCGGCGAGACGCTCGGCAAGG
CGGCCTGA

Upstream 100 bases:

>100_bases
GCGCACCATCTCGCACTGCCGGCTTCGCACGCTTATTGCGTCGCAGCATCGATGGCGTGCCATGCGCGTGCCGCCATCCT
CACTTTGCAGGTTTGTCGTC

Downstream 100 bases:

>100_bases
GCGCCGCGTTCCCATCACACTGAAAACAAAGCGATCAAGCGGCCGCCCCTGAATGCGGCGGCCGCGGGCAGGGGGTTGTT
TGGCCAAGAGCAAGACGGTC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MPRPIQAVIHGPALVNNLQVVRRHAADSRVWAVIKANAYGHGIERAYEGLRQADGFGLLDLDEAVRLRQLGWQGPILLLE
GFFKPEDLALVEQYRLTTTVHCEEQLRMLELARLKGPVSIQLKINTGMSRLGFAPAAYRAAWEHARAISGIGTIVHMTHF
SDADGPRGIDHQLAAFEQATQGLPGEASLSNSAATLWHPRAHRDWVRPGVILYGASPTGVAADIEGTGLMPAMTLKSELI
AVQDLQPGATVGYGSRFEAEQPMRIGIVACGYADGYPRHAPGWDGNYTPVLVDGVRTRMVGRVSMDMITVDLAEVPGARV
GAPVTLWGQGLPIDEVAHAAGTVGYELMCALAPRVPVTVEPAGAADAGETLGKAA

Sequences:

>Translated_375_residues
MPRPIQAVIHGPALVNNLQVVRRHAADSRVWAVIKANAYGHGIERAYEGLRQADGFGLLDLDEAVRLRQLGWQGPILLLE
GFFKPEDLALVEQYRLTTTVHCEEQLRMLELARLKGPVSIQLKINTGMSRLGFAPAAYRAAWEHARAISGIGTIVHMTHF
SDADGPRGIDHQLAAFEQATQGLPGEASLSNSAATLWHPRAHRDWVRPGVILYGASPTGVAADIEGTGLMPAMTLKSELI
AVQDLQPGATVGYGSRFEAEQPMRIGIVACGYADGYPRHAPGWDGNYTPVLVDGVRTRMVGRVSMDMITVDLAEVPGARV
GAPVTLWGQGLPIDEVAHAAGTVGYELMCALAPRVPVTVEPAGAADAGETLGKAA
>Mature_374_residues
PRPIQAVIHGPALVNNLQVVRRHAADSRVWAVIKANAYGHGIERAYEGLRQADGFGLLDLDEAVRLRQLGWQGPILLLEG
FFKPEDLALVEQYRLTTTVHCEEQLRMLELARLKGPVSIQLKINTGMSRLGFAPAAYRAAWEHARAISGIGTIVHMTHFS
DADGPRGIDHQLAAFEQATQGLPGEASLSNSAATLWHPRAHRDWVRPGVILYGASPTGVAADIEGTGLMPAMTLKSELIA
VQDLQPGATVGYGSRFEAEQPMRIGIVACGYADGYPRHAPGWDGNYTPVLVDGVRTRMVGRVSMDMITVDLAEVPGARVG
APVTLWGQGLPIDEVAHAAGTVGYELMCALAPRVPVTVEPAGAADAGETLGKAA

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=357, Percent_Identity=59.1036414565826, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1790487, Length=351, Percent_Identity=44.1595441595442, Blast_Score=272, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_RALSO (Q8XZM4)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519492.1
- ProteinModelPortal:   Q8XZM4
- SMR:   Q8XZM4
- GeneID:   1220195
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1371
- NMPDR:   fig|267608.1.peg.1371
- HOGENOM:   HBG712172
- OMA:   WGKQVLA
- ProtClustDB:   PRK00053
- BioCyc:   RSOL267608:RSC1371-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 40103; Mature: 39972

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 35-35 ACT_SITE 253-253

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPIQAVIHGPALVNNLQVVRRHAADSRVWAVIKANAYGHGIERAYEGLRQADGFGLLD
CCCCHHHEECCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEE
LDEAVRLRQLGWQGPILLLEGFFKPEDLALVEQYRLTTTVHCEEQLRMLELARLKGPVSI
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCEEEEEHHHHHHHHHHHHCCCCEEE
QLKINTGMSRLGFAPAAYRAAWEHARAISGIGTIVHMTHFSDADGPRGIDHQLAAFEQAT
EEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHH
QGLPGEASLSNSAATLWHPRAHRDWVRPGVILYGASPTGVAADIEGTGLMPAMTLKSELI
CCCCCCCCCCCCCEEEECCCHHCHHCCCCEEEECCCCCCEEEECCCCCCCHHHHHHHHHE
AVQDLQPGATVGYGSRFEAEQPMRIGIVACGYADGYPRHAPGWDGNYTPVLVDGVRTRMV
EEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHHH
GRVSMDMITVDLAEVPGARVGAPVTLWGQGLPIDEVAHAAGTVGYELMCALAPRVPVTVE
HHEEHEEEEEEHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PAGAADAGETLGKAA
CCCCCCHHHHHCCCC
>Mature Secondary Structure 
PRPIQAVIHGPALVNNLQVVRRHAADSRVWAVIKANAYGHGIERAYEGLRQADGFGLLD
CCCHHHEECCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEE
LDEAVRLRQLGWQGPILLLEGFFKPEDLALVEQYRLTTTVHCEEQLRMLELARLKGPVSI
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCEEEEEHHHHHHHHHHHHCCCCEEE
QLKINTGMSRLGFAPAAYRAAWEHARAISGIGTIVHMTHFSDADGPRGIDHQLAAFEQAT
EEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHH
QGLPGEASLSNSAATLWHPRAHRDWVRPGVILYGASPTGVAADIEGTGLMPAMTLKSELI
CCCCCCCCCCCCCEEEECCCHHCHHCCCCEEEECCCCCCEEEECCCCCCCHHHHHHHHHE
AVQDLQPGATVGYGSRFEAEQPMRIGIVACGYADGYPRHAPGWDGNYTPVLVDGVRTRMV
EEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHHH
GRVSMDMITVDLAEVPGARVGAPVTLWGQGLPIDEVAHAAGTVGYELMCALAPRVPVTVE
HHEEHEEEEEEHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PAGAADAGETLGKAA
CCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852