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The map label for this gene is copA [H]

Identifier: 17545993

GI number: 17545993

Start: 1356598

End: 1359153

Strand: Direct

Name: copA [H]

Synonym: RSc1274

Alternate gene names: 17545993

Gene position: 1356598-1359153 (Clockwise)

Preceding gene: 17545991

Following gene: 17545994

Centisome position: 36.5

GC content: 71.44

Gene sequence:

>2556_bases
ATGTTCACCATAATGACAACGACGCTCGCCCCCATCCTTGCCGCCGCGCCCGGTGTCGGTTCGGTCTCATCCGGCCGGCC
GGATGATGCGCAGGCGTCACACGTCACGTGCTATCACTGCGGCGCATCATTGGATGGCGATGCCGCGTTGCATGCCGAGA
TGGCCGGCCAGTCCCGCGACTTCTGCTGTGCCGGCTGCCAGACCATCGCCATGACGCTGCACGCGTCGGGCATGGGCCAC
GTCTACGACGGGCCGATCGCCTTCGCACGGCCCATCGACGGCGAGGTACGCACCGAGGCCGAAGCCGCGTGGGCGACCTA
CGACTTGCCGGTCATGCGCGAGCGCTTCGTCCGCACGCGCAAGGATGGCGCCGAAGAGGTGTCGTTGACCCTGGCCGGCA
TGCGCTGCGCCGCCTGCGTGTGGCTCATCGAACGCGCGCTGGCGCGCGTGCCCGGTGTGCGCGAGGCCATCGTCAACTAC
GCGACGGAGCGCGTGCGCATCGTGTCCGATGCCGGTGCGGTCCGGCTCGCCGACCTGTTCGCCGCCATCGCCGACGTCGG
CTACGAGGCGTGGCCGGACCAGCCTTCCACGCGCCGCGCGGCCGAGGCGCGCGAGCGGCGCCAGTTGCTGATCCGTCTGG
GCATCGCCATGCTGGGCATGATGCAGGTGATGATGTATGCGTGGCCGGTCTACCTGCATGGCGGCAGCATCCCTGCGGAC
CAGGTCATGCTGATGCAGTGGGCCAGTCTCGCGCTGACCACACCGGTCGTCCTGTTCTCCGCCGGGCCTATCTTCCGCAA
TGCGTGGCGCCAGGTGCGGCACGCGCATGTCGGCATGGACGTGCCGGTGGCGCTCGGCGTCGGCGCGGCCTTTGCCGCGA
GCGTGGCCGCCATGGTGCGCGGCCACGGCGAAACCTACTTCGATTCGGTGACGATGTTCGTCGCTTTCCTGCTGGCGGCG
CGCTATCTGGAACTGCGCGCGCGGCAGAGCGCAACGTCCGGCACCGAGGCGCTGGTGCGGCAACTGCCGGCCACCTGCCG
GCGCATCGCCGATGGCGCCGAGGCGATGCAGACCGTTCCGGTCGCCGCGCTGCAGGTCGGCGATTGCGTGGAGGTCCGCG
CCGGCGAGATCCTGCCGGCGGATGGCGTGATCGAACGCGGCACGACCGAGATCGACGAATCCCTGCTGTCCGGCGAGAGC
GTGCCGCAGCCGCGCGGCATCGGCGCGATGGTGCTGGCAGGCAGCTACAACGCGGCCAGCGCGATTTGGCTGCGCGTGCA
TCGCGTGGGGGCGCAGACGCGGCTGGCGGCGATCGTCGAACTGCTCGAGCGCGCGCTGACCGACAAGCCGCGCATGGCCG
AGCTCGCCGATCGCGTGGCGGGGCGTTTCGTGATGGTGTTGCTCGGCTGGGCCGTGCTGACGGCGCTTGCGTGGTGGTGG
ATCGATCCGGACCGCATGTTCGCCGTGACGGTGGCCGTGCTGGTGGTCAGCTGCCCGTGCGCGCTGTCGCTGGCGACACC
GTCCGCGCTGGCGGCGGCAAGCGGCGCGCTGGCCAGGCGCGGCGTACTGATCACGCGCGGGCACGCCATTGAAAGCCTGG
CCGCCGTGACCGACGTGCTGCTCGACAAGACCGGCACGCTGACGCAGGGCCACCTGCGCCTGCTCAGCATCGAAACCTTC
GACGATCCCGACGCGCAGCAGTGTCTTGCGCTGGCCTGTGCGCTCGAGCAGGCAGAGAACCATCCGATCGCGCAATCGCT
GCGTGCCGCCGCCGCGCAGGGGCGGGTGCCGGCGGTGGCGGTGAGCGACGTGCTCAACGTGCCGGGGCAGGGCGTGCGTG
CCCGGCTGCAGATGCAGGACATCCGCCTGGGCACCCAGGCGTTCGCGGCCCAGGCGTTCGATGGGCAGCCGCCGCATGCC
ACCGCGCACGTCAGCGGCGAGCCGGCGGAGGACGTGCCGTCCGCCGCCTGCACGGCAATCTGGCTCGGCTGCGACGGCCA
CCCGCTGGCCCGCTTCGTTCTTGCCGATACGCCGCGTGCCGATGCGGCGGCTTGCCTGGATGCGCTGCGTGCGCAGGACC
TGCGGCTGCATCTCGTTTCCGGCGATGCGCCGCAGACCGTGCGCTGGTGGGCCGCGCGCCTGGGCATCGCGCATGCCGTG
GGCGGCGCCAGTCCCGAAGATAAGCGTGCCTATGTGCGCGCGTTGCAGGCCGGCGGCGCTCGCGTGCTGGCGGTGGGCGA
CGGCATCAACGATGCACCGCTGCTGGCGCAGGCGCAGGTCTCGATCGCCATCGGCACGGGCGCGCCGCTGGCGCAGGCCG
GTGCCGACGCCATCCTCACGGAGCCGCGCCTGCCCGCCATCGGCGAGGCCGTCTCGATCGGCCGCCGCACGCTGCGTGTG
GTGCGCCAGAACCTGGGCTGGGCCTTCGCCTACAACGCCGTCAGCATCCCGCTGGCGACGCTGGGCTGGCTGTCGCCGCT
GGAGGCCGGGATCGGCATGTCGGTGTCTTCGCTGCTGGTGGCGCTCAACGCGTGGCGGCTGTCGCGCGTCGCATAG

Upstream 100 bases:

>100_bases
GCCGGCGGGATGGCGTGCCGCGGGCGCCGCATCTCTGCGTGGATTTTTGTGGGGTCGCTCTTGATGCGCATCAAAGGTTG
GGTGGGGCGCGCTGATTAGC

Downstream 100 bases:

>100_bases
AGCTTTGATATGGAAACCCTCTACCTGCTCGTGCCCCTGTCGCTGATGGCGGTGGCAGTGATCGTCAGCGCACTGTGGTG
GGCCGTCGGCACCGGCCAGT

Product: cation-transporting ATPase lipoprotein transmembrane

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 851; Mature: 851

Protein sequence:

>851_residues
MFTIMTTTLAPILAAAPGVGSVSSGRPDDAQASHVTCYHCGASLDGDAALHAEMAGQSRDFCCAGCQTIAMTLHASGMGH
VYDGPIAFARPIDGEVRTEAEAAWATYDLPVMRERFVRTRKDGAEEVSLTLAGMRCAACVWLIERALARVPGVREAIVNY
ATERVRIVSDAGAVRLADLFAAIADVGYEAWPDQPSTRRAAEARERRQLLIRLGIAMLGMMQVMMYAWPVYLHGGSIPAD
QVMLMQWASLALTTPVVLFSAGPIFRNAWRQVRHAHVGMDVPVALGVGAAFAASVAAMVRGHGETYFDSVTMFVAFLLAA
RYLELRARQSATSGTEALVRQLPATCRRIADGAEAMQTVPVAALQVGDCVEVRAGEILPADGVIERGTTEIDESLLSGES
VPQPRGIGAMVLAGSYNAASAIWLRVHRVGAQTRLAAIVELLERALTDKPRMAELADRVAGRFVMVLLGWAVLTALAWWW
IDPDRMFAVTVAVLVVSCPCALSLATPSALAAASGALARRGVLITRGHAIESLAAVTDVLLDKTGTLTQGHLRLLSIETF
DDPDAQQCLALACALEQAENHPIAQSLRAAAAQGRVPAVAVSDVLNVPGQGVRARLQMQDIRLGTQAFAAQAFDGQPPHA
TAHVSGEPAEDVPSAACTAIWLGCDGHPLARFVLADTPRADAAACLDALRAQDLRLHLVSGDAPQTVRWWAARLGIAHAV
GGASPEDKRAYVRALQAGGARVLAVGDGINDAPLLAQAQVSIAIGTGAPLAQAGADAILTEPRLPAIGEAVSIGRRTLRV
VRQNLGWAFAYNAVSIPLATLGWLSPLEAGIGMSVSSLLVALNAWRLSRVA

Sequences:

>Translated_851_residues
MFTIMTTTLAPILAAAPGVGSVSSGRPDDAQASHVTCYHCGASLDGDAALHAEMAGQSRDFCCAGCQTIAMTLHASGMGH
VYDGPIAFARPIDGEVRTEAEAAWATYDLPVMRERFVRTRKDGAEEVSLTLAGMRCAACVWLIERALARVPGVREAIVNY
ATERVRIVSDAGAVRLADLFAAIADVGYEAWPDQPSTRRAAEARERRQLLIRLGIAMLGMMQVMMYAWPVYLHGGSIPAD
QVMLMQWASLALTTPVVLFSAGPIFRNAWRQVRHAHVGMDVPVALGVGAAFAASVAAMVRGHGETYFDSVTMFVAFLLAA
RYLELRARQSATSGTEALVRQLPATCRRIADGAEAMQTVPVAALQVGDCVEVRAGEILPADGVIERGTTEIDESLLSGES
VPQPRGIGAMVLAGSYNAASAIWLRVHRVGAQTRLAAIVELLERALTDKPRMAELADRVAGRFVMVLLGWAVLTALAWWW
IDPDRMFAVTVAVLVVSCPCALSLATPSALAAASGALARRGVLITRGHAIESLAAVTDVLLDKTGTLTQGHLRLLSIETF
DDPDAQQCLALACALEQAENHPIAQSLRAAAAQGRVPAVAVSDVLNVPGQGVRARLQMQDIRLGTQAFAAQAFDGQPPHA
TAHVSGEPAEDVPSAACTAIWLGCDGHPLARFVLADTPRADAAACLDALRAQDLRLHLVSGDAPQTVRWWAARLGIAHAV
GGASPEDKRAYVRALQAGGARVLAVGDGINDAPLLAQAQVSIAIGTGAPLAQAGADAILTEPRLPAIGEAVSIGRRTLRV
VRQNLGWAFAYNAVSIPLATLGWLSPLEAGIGMSVSSLLVALNAWRLSRVA
>Mature_851_residues
MFTIMTTTLAPILAAAPGVGSVSSGRPDDAQASHVTCYHCGASLDGDAALHAEMAGQSRDFCCAGCQTIAMTLHASGMGH
VYDGPIAFARPIDGEVRTEAEAAWATYDLPVMRERFVRTRKDGAEEVSLTLAGMRCAACVWLIERALARVPGVREAIVNY
ATERVRIVSDAGAVRLADLFAAIADVGYEAWPDQPSTRRAAEARERRQLLIRLGIAMLGMMQVMMYAWPVYLHGGSIPAD
QVMLMQWASLALTTPVVLFSAGPIFRNAWRQVRHAHVGMDVPVALGVGAAFAASVAAMVRGHGETYFDSVTMFVAFLLAA
RYLELRARQSATSGTEALVRQLPATCRRIADGAEAMQTVPVAALQVGDCVEVRAGEILPADGVIERGTTEIDESLLSGES
VPQPRGIGAMVLAGSYNAASAIWLRVHRVGAQTRLAAIVELLERALTDKPRMAELADRVAGRFVMVLLGWAVLTALAWWW
IDPDRMFAVTVAVLVVSCPCALSLATPSALAAASGALARRGVLITRGHAIESLAAVTDVLLDKTGTLTQGHLRLLSIETF
DDPDAQQCLALACALEQAENHPIAQSLRAAAAQGRVPAVAVSDVLNVPGQGVRARLQMQDIRLGTQAFAAQAFDGQPPHA
TAHVSGEPAEDVPSAACTAIWLGCDGHPLARFVLADTPRADAAACLDALRAQDLRLHLVSGDAPQTVRWWAARLGIAHAV
GGASPEDKRAYVRALQAGGARVLAVGDGINDAPLLAQAQVSIAIGTGAPLAQAGADAILTEPRLPAIGEAVSIGRRTLRV
VRQNLGWAFAYNAVSIPLATLGWLSPLEAGIGMSVSSLLVALNAWRLSRVA

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=782, Percent_Identity=28.5166240409207, Blast_Score=284, Evalue=3e-76,
Organism=Homo sapiens, GI55743073, Length=503, Percent_Identity=29.8210735586481, Blast_Score=201, Evalue=3e-51,
Organism=Homo sapiens, GI115529486, Length=561, Percent_Identity=27.0944741532977, Blast_Score=189, Evalue=1e-47,
Organism=Escherichia coli, GI1786691, Length=799, Percent_Identity=32.7909887359199, Blast_Score=334, Evalue=1e-92,
Organism=Escherichia coli, GI1789879, Length=758, Percent_Identity=30.0791556728232, Blast_Score=209, Evalue=8e-55,
Organism=Escherichia coli, GI1786914, Length=464, Percent_Identity=27.1551724137931, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17556548, Length=670, Percent_Identity=26.7164179104478, Blast_Score=222, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6320475, Length=682, Percent_Identity=29.6187683284457, Blast_Score=273, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6319772, Length=679, Percent_Identity=27.2459499263623, Blast_Score=261, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6321430, Length=528, Percent_Identity=22.7272727272727, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325221, Length=248, Percent_Identity=25.8064516129032, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221329854, Length=596, Percent_Identity=27.6845637583893, Blast_Score=182, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 89806; Mature: 89806

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTIMTTTLAPILAAAPGVGSVSSGRPDDAQASHVTCYHCGASLDGDAALHAEMAGQSRD
CEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCC
FCCAGCQTIAMTLHASGMGHVYDGPIAFARPIDGEVRTEAEAAWATYDLPVMRERFVRTR
HHHHHHHHHHHHHCCCCCCCEECCCEEEECCCCCCHHCCHHHHHEECCCHHHHHHHHHHH
KDGAEEVSLTLAGMRCAACVWLIERALARVPGVREAIVNYATERVRIVSDAGAVRLADLF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCHHHHHHHH
AAIADVGYEAWPDQPSTRRAAEARERRQLLIRLGIAMLGMMQVMMYAWPVYLHGGSIPAD
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHH
QVMLMQWASLALTTPVVLFSAGPIFRNAWRQVRHAHVGMDVPVALGVGAAFAASVAAMVR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
GHGETYFDSVTMFVAFLLAARYLELRARQSATSGTEALVRQLPATCRRIADGAEAMQTVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
VAALQVGDCVEVRAGEILPADGVIERGTTEIDESLLSGESVPQPRGIGAMVLAGSYNAAS
HHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHH
AIWLRVHRVGAQTRLAAIVELLERALTDKPRMAELADRVAGRFVMVLLGWAVLTALAWWW
HHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IDPDRMFAVTVAVLVVSCPCALSLATPSALAAASGALARRGVLITRGHAIESLAAVTDVL
CCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHH
LDKTGTLTQGHLRLLSIETFDDPDAQQCLALACALEQAENHPIAQSLRAAAAQGRVPAVA
HCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEE
VSDVLNVPGQGVRARLQMQDIRLGTQAFAAQAFDGQPPHATAHVSGEPAEDVPSAACTAI
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHCCCHHHHEE
WLGCDGHPLARFVLADTPRADAAACLDALRAQDLRLHLVSGDAPQTVRWWAARLGIAHAV
EECCCCCHHHHHEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHC
GGASPEDKRAYVRALQAGGARVLAVGDGINDAPLLAQAQVSIAIGTGAPLAQAGADAILT
CCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCHHHCCCCCEEC
EPRLPAIGEAVSIGRRTLRVVRQNLGWAFAYNAVSIPLATLGWLSPLEAGIGMSVSSLLV
CCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHCCHHHHHHHHHHHHCCCCCHHHHHH
ALNAWRLSRVA
HHHHHHHHCCC
>Mature Secondary Structure
MFTIMTTTLAPILAAAPGVGSVSSGRPDDAQASHVTCYHCGASLDGDAALHAEMAGQSRD
CEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCC
FCCAGCQTIAMTLHASGMGHVYDGPIAFARPIDGEVRTEAEAAWATYDLPVMRERFVRTR
HHHHHHHHHHHHHCCCCCCCEECCCEEEECCCCCCHHCCHHHHHEECCCHHHHHHHHHHH
KDGAEEVSLTLAGMRCAACVWLIERALARVPGVREAIVNYATERVRIVSDAGAVRLADLF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCHHHHHHHH
AAIADVGYEAWPDQPSTRRAAEARERRQLLIRLGIAMLGMMQVMMYAWPVYLHGGSIPAD
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHH
QVMLMQWASLALTTPVVLFSAGPIFRNAWRQVRHAHVGMDVPVALGVGAAFAASVAAMVR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
GHGETYFDSVTMFVAFLLAARYLELRARQSATSGTEALVRQLPATCRRIADGAEAMQTVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
VAALQVGDCVEVRAGEILPADGVIERGTTEIDESLLSGESVPQPRGIGAMVLAGSYNAAS
HHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHH
AIWLRVHRVGAQTRLAAIVELLERALTDKPRMAELADRVAGRFVMVLLGWAVLTALAWWW
HHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IDPDRMFAVTVAVLVVSCPCALSLATPSALAAASGALARRGVLITRGHAIESLAAVTDVL
CCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHH
LDKTGTLTQGHLRLLSIETFDDPDAQQCLALACALEQAENHPIAQSLRAAAAQGRVPAVA
HCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEE
VSDVLNVPGQGVRARLQMQDIRLGTQAFAAQAFDGQPPHATAHVSGEPAEDVPSAACTAI
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHCCCHHHHEE
WLGCDGHPLARFVLADTPRADAAACLDALRAQDLRLHLVSGDAPQTVRWWAARLGIAHAV
EECCCCCHHHHHEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHC
GGASPEDKRAYVRALQAGGARVLAVGDGINDAPLLAQAQVSIAIGTGAPLAQAGADAILT
CCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCHHHCCCCCEEC
EPRLPAIGEAVSIGRRTLRVVRQNLGWAFAYNAVSIPLATLGWLSPLEAGIGMSVSSLLV
CCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHCCHHHHHHHHHHHHCCCCCHHHHHH
ALNAWRLSRVA
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA