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The map label for this gene is dnaX [H]

Identifier: 17545910

GI number: 17545910

Start: 1259777

End: 1261963

Strand: Direct

Name: dnaX [H]

Synonym: RSc1191

Alternate gene names: 17545910

Gene position: 1259777-1261963 (Clockwise)

Preceding gene: 17545909

Following gene: 17545911

Centisome position: 33.9

GC content: 72.61

Gene sequence:

>2187_bases
ATGAGTTATCAAGTGCTCGCCCGCAAGTGGCGCCCCCGCGATTTCACCACGCTGGTCGGTCAGGAACACGTGGTGAAGGC
GCTCACGCATGCGCTCGAACAGCAGCGCCTGCACCACGCATACCTGTTCACGGGCACGCGTGGTGTCGGCAAGACGACGC
TGTCGCGCATTCTCGCCAAATCGCTCAATTGCATCGGCACGGACGGGCAGGGCGGCATCACCGCGCAGCCGTGCGGCGTG
TGCCGCGCCTGCACCGAGATCGATGCCGGGCGCTTCGTCGATTACATCGAGATGGACGCCGCCTCCAACCGCGGCGTCGA
CGAGATGGCGCAGCTGCTCGATCGCGCGGTCTACGCACCCACGGCCGGCCGCTTCAAGGTCTACATGATCGACGAAGTGC
ACATGCTGACCAACCACGCCTTCAACGCGATGCTGAAGACGCTGGAGGAGCCGCCCGAGCACGTCAAGTTCATCCTCGCG
ACCACCGACCCGCAGAAGATTCCCGTCACGGTGCTGTCGCGCTGCCTGCAGTTCAACCTGAAGCAGATGCCGCCGGGACA
CATCGTGTCCCACCTGGACCGCATCCTCGGCGAGGAGGGCATCGCGCACGAGCCCAATGCGCTGCGCCTGCTGGCCTCGG
CCGCACAGGGGTCGATGCGCGATGCGCTGTCGCTGACCGATCAGGCCATCGCGTACAGCGCCGGCGAAGTCACCGAGGCG
GCCGTGCGCGGCATGCTGGGCGCGATCGACCAGAGCTACCTGGTGCGCCTGCTCGATGCGCTCGCCGACGAGAACGGCGC
GACACTGATCGGGATCGCCGACGAGATGGCCGGGCGCAGCCTGAGCTTCTCGGGGGCGCTGCAGGATCTGGCTTCGTTGC
TGCAGAAGATCGCGCTGGCACAGGTCGTGCCCGCCGCCGTGCAGGACGACTGGCCCGAGGCCGACGACATCCGCCGCCTG
GCCGAGCGCTTCGATGCGCAGTCGGTGCAACTGTTCTACCAGTTCGCCAACCTCGGTCGCAACGAACTGGCGCTGGCGCC
CGACGAATACGCCGGCTTCACGATGACGCTGCTGCGCATGCTGGCGTTCCAGCCCGGCCAGTCGGGCGGCGATGCGCCGC
CGCCGTCGGGTAGCGGCAAGCGTGCCGTGCCGTCGGCCGGCGTGCAGGGTGGATCGTCGCGGCCGGTTGTGGCGGCTGCT
GCCGCCGGGCCGGTCGCCCAGGCGGTGCCTGCTGTGCGTGCGGAACGGGTGGTCGATGCACCGCGCGCGACGTATCAAGC
CGATCCGCCGGCCGCCGCCGCACCGGCTGCAGCGCCTGCCCCAGCAACCCCGGCCCCGGCCAGTGCGCCGGCCCGCCGTT
CACCGGCGCTGGAAGCGCTGGCCGCGGCGCGCCAGGCGTCGAGCCGGGGGGCGCGCGGCGGTGCCGCGGCGCCGGCTTCC
GCGCCTGCCCCCGTGCCGGCGCCGGCCGCACGCCCGGCCGCGGCCGGTCCGCGCTCGAATCCGGCGGCTGCGCCTGCGTC
GCCGCCGGTGCGCCGTGAACCGGCTGCCGCGTCCGCGCCTGCCGACGACTTTGCCCCGCCGCCCTGGGAGGAGATGCCCG
ACGAGTTCGCTTCGCCGTCTCCCGATCAGATCGACGCCGCGTTTGCCGGCTGGGAGGCGGCTTCGACCACGCGCCCGGGC
GCGCAGGCTGCGGCCGCGCGCCCTGCGCAGAGTGAGCCGCCCGCCGCGGCGCCGGTGCCGGCCAGGGCTGCCGCACCGGA
GCCGGTGGTCGCCGCCACGCCGCCCGACCTGAGCGCCAGCGGTCTGACGGCCTTCGACGGCGACTGGCCCACGCTTGCGG
CACGTCTGCCGCTGCGCGGCTTGGCGCAGCAGCTGGCGCACCAGAGCGAGCTGGTCGCCGTGGAGGGCGCGACGGTACGC
TTGCGCGTCCCGCTGCCGGCACTGACCGAGGCAAGCGTGCTCGAACGGCTGGAGGCGGCGCTGACGGAGCACTTCGGCAC
GCCGGTCCGCGTGGTCTGCGACATCGGTGCCGTCCGGGCCACGGCCGCCGCCGCCGATGCCGAGCAGCGTGCCCAGCGCC
AGCGCGACGCCGAGGACGCCATCGCTGCCGATCCGTTCGTGCAGGCGCTGGTGCGGGACTTTGCCGCGACCGTCGTGCCC
GGCTCGATCCAGCCGCACGCGCACTGA

Upstream 100 bases:

>100_bases
AATATCCTTGCAAATCGCTCGGCGCGCCCGGGCCCATCCGGGGGCATCGTGCGCCGGAAAGCGCGTCGGAAATCCCCCCT
GCTTTGCTACAATCCGCGGC

Downstream 100 bases:

>100_bases
CAGGCCGGCACCCGCACAAAGGTTTTCCACACTGAACGCAACGGCGCGCCGTCCATCGGGCACGCCATGCATGACCCATT
CCAAGGAGCTACGACCATGA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 728; Mature: 727

Protein sequence:

>728_residues
MSYQVLARKWRPRDFTTLVGQEHVVKALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKSLNCIGTDGQGGITAQPCGV
CRACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDRAVYAPTAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILA
TTDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDRILGEEGIAHEPNALRLLASAAQGSMRDALSLTDQAIAYSAGEVTEA
AVRGMLGAIDQSYLVRLLDALADENGATLIGIADEMAGRSLSFSGALQDLASLLQKIALAQVVPAAVQDDWPEADDIRRL
AERFDAQSVQLFYQFANLGRNELALAPDEYAGFTMTLLRMLAFQPGQSGGDAPPPSGSGKRAVPSAGVQGGSSRPVVAAA
AAGPVAQAVPAVRAERVVDAPRATYQADPPAAAAPAAAPAPATPAPASAPARRSPALEALAAARQASSRGARGGAAAPAS
APAPVPAPAARPAAAGPRSNPAAAPASPPVRREPAAASAPADDFAPPPWEEMPDEFASPSPDQIDAAFAGWEAASTTRPG
AQAAAARPAQSEPPAAAPVPARAAAPEPVVAATPPDLSASGLTAFDGDWPTLAARLPLRGLAQQLAHQSELVAVEGATVR
LRVPLPALTEASVLERLEAALTEHFGTPVRVVCDIGAVRATAAAADAEQRAQRQRDAEDAIAADPFVQALVRDFAATVVP
GSIQPHAH

Sequences:

>Translated_728_residues
MSYQVLARKWRPRDFTTLVGQEHVVKALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKSLNCIGTDGQGGITAQPCGV
CRACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDRAVYAPTAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILA
TTDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDRILGEEGIAHEPNALRLLASAAQGSMRDALSLTDQAIAYSAGEVTEA
AVRGMLGAIDQSYLVRLLDALADENGATLIGIADEMAGRSLSFSGALQDLASLLQKIALAQVVPAAVQDDWPEADDIRRL
AERFDAQSVQLFYQFANLGRNELALAPDEYAGFTMTLLRMLAFQPGQSGGDAPPPSGSGKRAVPSAGVQGGSSRPVVAAA
AAGPVAQAVPAVRAERVVDAPRATYQADPPAAAAPAAAPAPATPAPASAPARRSPALEALAAARQASSRGARGGAAAPAS
APAPVPAPAARPAAAGPRSNPAAAPASPPVRREPAAASAPADDFAPPPWEEMPDEFASPSPDQIDAAFAGWEAASTTRPG
AQAAAARPAQSEPPAAAPVPARAAAPEPVVAATPPDLSASGLTAFDGDWPTLAARLPLRGLAQQLAHQSELVAVEGATVR
LRVPLPALTEASVLERLEAALTEHFGTPVRVVCDIGAVRATAAAADAEQRAQRQRDAEDAIAADPFVQALVRDFAATVVP
GSIQPHAH
>Mature_727_residues
SYQVLARKWRPRDFTTLVGQEHVVKALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKSLNCIGTDGQGGITAQPCGVC
RACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDRAVYAPTAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILAT
TDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDRILGEEGIAHEPNALRLLASAAQGSMRDALSLTDQAIAYSAGEVTEAA
VRGMLGAIDQSYLVRLLDALADENGATLIGIADEMAGRSLSFSGALQDLASLLQKIALAQVVPAAVQDDWPEADDIRRLA
ERFDAQSVQLFYQFANLGRNELALAPDEYAGFTMTLLRMLAFQPGQSGGDAPPPSGSGKRAVPSAGVQGGSSRPVVAAAA
AGPVAQAVPAVRAERVVDAPRATYQADPPAAAAPAAAPAPATPAPASAPARRSPALEALAAARQASSRGARGGAAAPASA
PAPVPAPAARPAAAGPRSNPAAAPASPPVRREPAAASAPADDFAPPPWEEMPDEFASPSPDQIDAAFAGWEAASTTRPGA
QAAAARPAQSEPPAAAPVPARAAAPEPVVAATPPDLSASGLTAFDGDWPTLAARLPLRGLAQQLAHQSELVAVEGATVRL
RVPLPALTEASVLERLEAALTEHFGTPVRVVCDIGAVRATAAAADAEQRAQRQRDAEDAIAADPFVQALVRDFAATVVPG
SIQPHAH

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=262, Percent_Identity=24.8091603053435, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194306571, Length=265, Percent_Identity=24.5283018867925, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI194306567, Length=265, Percent_Identity=24.5283018867925, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1786676, Length=366, Percent_Identity=56.0109289617486, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1787341, Length=192, Percent_Identity=31.25, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71986063, Length=254, Percent_Identity=25.5905511811024, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=219, Percent_Identity=25.5707762557078, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI18859927, Length=298, Percent_Identity=23.489932885906, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 75722; Mature: 75591

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPRDFTTLVGQEHVVKALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAK
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
SLNCIGTDGQGGITAQPCGVCRACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDRAVYAP
HHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
TAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNL
CCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCH
KQMPPGHIVSHLDRILGEEGIAHEPNALRLLASAAQGSMRDALSLTDQAIAYSAGEVTEA
HCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
AVRGMLGAIDQSYLVRLLDALADENGATLIGIADEMAGRSLSFSGALQDLASLLQKIALA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QVVPAAVQDDWPEADDIRRLAERFDAQSVQLFYQFANLGRNELALAPDEYAGFTMTLLRM
HHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEECCHHHCHHHHHHHHH
LAFQPGQSGGDAPPPSGSGKRAVPSAGVQGGSSRPVVAAAAAGPVAQAVPAVRAERVVDA
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCC
PRATYQADPPAAAAPAAAPAPATPAPASAPARRSPALEALAAARQASSRGARGGAAAPAS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
APAPVPAPAARPAAAGPRSNPAAAPASPPVRREPAAASAPADDFAPPPWEEMPDEFASPS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCC
PDQIDAAFAGWEAASTTRPGAQAAAARPAQSEPPAAAPVPARAAAPEPVVAATPPDLSAS
CCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCC
GLTAFDGDWPTLAARLPLRGLAQQLAHQSELVAVEGATVRLRVPLPALTEASVLERLEAA
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHCEEEECCCEEEEEECCCCCHHHHHHHHHHHH
LTEHFGTPVRVVCDIGAVRATAAAADAEQRAQRQRDAEDAIAADPFVQALVRDFAATVVP
HHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHCC
GSIQPHAH
CCCCCCCC
>Mature Secondary Structure 
SYQVLARKWRPRDFTTLVGQEHVVKALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAK
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
SLNCIGTDGQGGITAQPCGVCRACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDRAVYAP
HHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
TAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNL
CCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCH
KQMPPGHIVSHLDRILGEEGIAHEPNALRLLASAAQGSMRDALSLTDQAIAYSAGEVTEA
HCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
AVRGMLGAIDQSYLVRLLDALADENGATLIGIADEMAGRSLSFSGALQDLASLLQKIALA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QVVPAAVQDDWPEADDIRRLAERFDAQSVQLFYQFANLGRNELALAPDEYAGFTMTLLRM
HHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEECCHHHCHHHHHHHHH
LAFQPGQSGGDAPPPSGSGKRAVPSAGVQGGSSRPVVAAAAAGPVAQAVPAVRAERVVDA
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCC
PRATYQADPPAAAAPAAAPAPATPAPASAPARRSPALEALAAARQASSRGARGGAAAPAS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
APAPVPAPAARPAAAGPRSNPAAAPASPPVRREPAAASAPADDFAPPPWEEMPDEFASPS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCC
PDQIDAAFAGWEAASTTRPGAQAAAARPAQSEPPAAAPVPARAAAPEPVVAATPPDLSAS
CCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCC
GLTAFDGDWPTLAARLPLRGLAQQLAHQSELVAVEGATVRLRVPLPALTEASVLERLEAA
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHCEEEECCCEEEEEECCCCCHHHHHHHHHHHH
LTEHFGTPVRVVCDIGAVRATAAAADAEQRAQRQRDAEDAIAADPFVQALVRDFAATVVP
HHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHCC
GSIQPHAH
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]