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The map label for this gene is gltX [H]

Identifier: 17545898

GI number: 17545898

Start: 1239959

End: 1241461

Strand: Direct

Name: gltX [H]

Synonym: RSc1179

Alternate gene names: 17545898

Gene position: 1239959-1241461 (Clockwise)

Preceding gene: 17545896

Following gene: 17545908

Centisome position: 33.36

GC content: 65.93

Gene sequence:

>1503_bases
GTGCCAAAGTTCGGCGGCGGACCGGTCGGGCGCACAGGATGCGGTTGCTATAATTTCCGTTTTGACAGAGGCCGCCTTCG
CGGCCTTGTCCGTTCGGCCATTCCTATGACTCAGCGCGTCCGCACCCGTTTCGCTCCCAGCCCCACCGGTTTCATCCACC
TCGGCAACATCCGTTCGGCCCTGTATCCGTGGGCGTTCGCCCGCAAGATGAAGGGCGATTTCATCCTGCGCATCGAAGAT
ACCGACGTGGAGCGCTCGACCCAGGAGGCCGTCGATGTGATCCTGGAAGCGATGGATTGGCTGGGCCTGGATATCGACGA
AGGGCCGTTCTACCAGATGCAGCGCATGGACCGCTATCGCGAGGTCATCGCACAGATGGTCGCGCAAGACCTGGCCTACC
CGTGCTACATGAGCACCGAGGAACTCGACGCCCTGCGCGAAGCCCAGCGCGTGCGCGGCGAGAAGCCCCGGTACGACGGC
ACCTGGCGTCCCGAGCCAGGCAAAGTCCTGCCGACGCCGCCGGCCGGCGTGCAGCCGGTGATCCGCTTCAAGAACCCGAT
CGGCGGCAGCGTGGTGTGGGACGATGCGGTCAAGGGCCGCATCGAGATCTCCAACGACGAGCTCGACGATCTCGTCATCG
CGCGTCCGGATGGCACGCCCACCTACAACTTCTGCGTGGTGGTCGACGATATGGACATGCGTATCACCCATGTGATCCGC
GGCGACGATCACGTCAACAATACGCCGCGCCAGATCAATATCCTGCGCGCGCTGGGCGGCACGCCGCCCATCTATGCCCA
CCTGCCGACGGTGCTGAACGAGCAGGGCGAGAAGATGAGCAAGCGGCACGGCGCCATGAGCGTGACCGGCTACCGCGATG
CGGGCTACCTGCCCGAAGCCGTCGTCAACTACCTGGCCCGCTTGGGCTGGGCGCACGGCGACGCGGAAATCTTCTCGCGC
GAGCAGTTCGTCGAGTGGTTCGACCTGGAGCACCTGGGCAAGTCGCCGGCGCAGTACAACCCCGAGAAGCTCGCCTGGCT
GAACAACCACTACATCAAGCAGGCCGACAACGCGCGGCTGGCAGAGCTGGTGAAGCCGTTCATCGAAGCGCTGGGCGGCC
GCGTCGAGGGCGGTCCGCAGCTGGCCGACGTGATGGCCTTGGTGAAGGATCGCGCCAACACGCTGCAGGAAGTCGCGCAG
ACGGCGCTGCTGTTCTATCGCACCGAGATCTCGGTGGCGCCGGAGCTGGCTGCGCAGCATCTCACCGATGAGGTGCGCCC
GGGCATCATGGCCCTGGCCGACAAGCTGGGGACGTTGCCCGAGTGGAAGCGCGAGGCCATCGGCGCGGCCTTCAAGGAGG
TGTTGGGTGCCCACGGCTGGAAGATGCCGAAGCTGGCAATGCCGGTGCGGCTGCTGGTGGCCGGCCAGTTGCAGACGCCG
TCGATCGATGCGGTGCTGGAGCTGTTCGGCCGCGAGGTCGTGCTGCGCCGCCTGGCCGGGTGA

Upstream 100 bases:

>100_bases
CCGGCGGCGCCCAGGAAGAGACGGCGTTGCATGGACGGTTGGGGCAGTTCTGGGTGGGACGCGCGGAGCCATCATGGGCG
GACGCGGGCCGGTCGCCATT

Downstream 100 bases:

>100_bases
TCCGGGCGGCCTGAAAAAATTTGCGAAAGGGTATTGCCAGCCGCTGAACACTTCCCCTATACTCTTGTTTTCGCTGAAAC
ACGAAGCGAAAATGCAGTAA

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase; GluRS [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MPKFGGGPVGRTGCGCYNFRFDRGRLRGLVRSAIPMTQRVRTRFAPSPTGFIHLGNIRSALYPWAFARKMKGDFILRIED
TDVERSTQEAVDVILEAMDWLGLDIDEGPFYQMQRMDRYREVIAQMVAQDLAYPCYMSTEELDALREAQRVRGEKPRYDG
TWRPEPGKVLPTPPAGVQPVIRFKNPIGGSVVWDDAVKGRIEISNDELDDLVIARPDGTPTYNFCVVVDDMDMRITHVIR
GDDHVNNTPRQINILRALGGTPPIYAHLPTVLNEQGEKMSKRHGAMSVTGYRDAGYLPEAVVNYLARLGWAHGDAEIFSR
EQFVEWFDLEHLGKSPAQYNPEKLAWLNNHYIKQADNARLAELVKPFIEALGGRVEGGPQLADVMALVKDRANTLQEVAQ
TALLFYRTEISVAPELAAQHLTDEVRPGIMALADKLGTLPEWKREAIGAAFKEVLGAHGWKMPKLAMPVRLLVAGQLQTP
SIDAVLELFGREVVLRRLAG

Sequences:

>Translated_500_residues
MPKFGGGPVGRTGCGCYNFRFDRGRLRGLVRSAIPMTQRVRTRFAPSPTGFIHLGNIRSALYPWAFARKMKGDFILRIED
TDVERSTQEAVDVILEAMDWLGLDIDEGPFYQMQRMDRYREVIAQMVAQDLAYPCYMSTEELDALREAQRVRGEKPRYDG
TWRPEPGKVLPTPPAGVQPVIRFKNPIGGSVVWDDAVKGRIEISNDELDDLVIARPDGTPTYNFCVVVDDMDMRITHVIR
GDDHVNNTPRQINILRALGGTPPIYAHLPTVLNEQGEKMSKRHGAMSVTGYRDAGYLPEAVVNYLARLGWAHGDAEIFSR
EQFVEWFDLEHLGKSPAQYNPEKLAWLNNHYIKQADNARLAELVKPFIEALGGRVEGGPQLADVMALVKDRANTLQEVAQ
TALLFYRTEISVAPELAAQHLTDEVRPGIMALADKLGTLPEWKREAIGAAFKEVLGAHGWKMPKLAMPVRLLVAGQLQTP
SIDAVLELFGREVVLRRLAG
>Mature_499_residues
PKFGGGPVGRTGCGCYNFRFDRGRLRGLVRSAIPMTQRVRTRFAPSPTGFIHLGNIRSALYPWAFARKMKGDFILRIEDT
DVERSTQEAVDVILEAMDWLGLDIDEGPFYQMQRMDRYREVIAQMVAQDLAYPCYMSTEELDALREAQRVRGEKPRYDGT
WRPEPGKVLPTPPAGVQPVIRFKNPIGGSVVWDDAVKGRIEISNDELDDLVIARPDGTPTYNFCVVVDDMDMRITHVIRG
DDHVNNTPRQINILRALGGTPPIYAHLPTVLNEQGEKMSKRHGAMSVTGYRDAGYLPEAVVNYLARLGWAHGDAEIFSRE
QFVEWFDLEHLGKSPAQYNPEKLAWLNNHYIKQADNARLAELVKPFIEALGGRVEGGPQLADVMALVKDRANTLQEVAQT
ALLFYRTEISVAPELAAQHLTDEVRPGIMALADKLGTLPEWKREAIGAAFKEVLGAHGWKMPKLAMPVRLLVAGQLQTPS
IDAVLELFGREVVLRRLAG

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) [H]

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI134288884, Length=490, Percent_Identity=29.3877551020408, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1788743, Length=460, Percent_Identity=48.9130434782609, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI226510925, Length=245, Percent_Identity=35.5102040816327, Blast_Score=131, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71993394, Length=484, Percent_Identity=31.404958677686, Blast_Score=204, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324540, Length=484, Percent_Identity=29.7520661157025, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321192, Length=237, Percent_Identity=27.0042194092827, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24665321, Length=489, Percent_Identity=31.6973415132924, Blast_Score=228, Evalue=7e-60,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c [H]

EC number: =6.1.1.17 [H]

Molecular weight: Translated: 55981; Mature: 55850

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFGGGPVGRTGCGCYNFRFDRGRLRGLVRSAIPMTQRVRTRFAPSPTGFIHLGNIRSA
CCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEECCHHHH
LYPWAFARKMKGDFILRIEDTDVERSTQEAVDVILEAMDWLGLDIDEGPFYQMQRMDRYR
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
EVIAQMVAQDLAYPCYMSTEELDALREAQRVRGEKPRYDGTWRPEPGKVLPTPPAGVQPV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
IRFKNPIGGSVVWDDAVKGRIEISNDELDDLVIARPDGTPTYNFCVVVDDMDMRITHVIR
HEECCCCCCCEEECCCCCCEEEECCCCCCCEEEECCCCCCCEEEEEEEECCCCEEEEEEC
GDDHVNNTPRQINILRALGGTPPIYAHLPTVLNEQGEKMSKRHGAMSVTGYRDAGYLPEA
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHH
VVNYLARLGWAHGDAEIFSREQFVEWFDLEHLGKSPAQYNPEKLAWLNNHYIKQADNARL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHCCCCHHH
AELVKPFIEALGGRVEGGPQLADVMALVKDRANTLQEVAQTALLFYRTEISVAPELAAQH
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
LTDEVRPGIMALADKLGTLPEWKREAIGAAFKEVLGAHGWKMPKLAMPVRLLVAGQLQTP
HHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHEEECCCCCC
SIDAVLELFGREVVLRRLAG
CHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKFGGGPVGRTGCGCYNFRFDRGRLRGLVRSAIPMTQRVRTRFAPSPTGFIHLGNIRSA
CCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEECCHHHH
LYPWAFARKMKGDFILRIEDTDVERSTQEAVDVILEAMDWLGLDIDEGPFYQMQRMDRYR
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
EVIAQMVAQDLAYPCYMSTEELDALREAQRVRGEKPRYDGTWRPEPGKVLPTPPAGVQPV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
IRFKNPIGGSVVWDDAVKGRIEISNDELDDLVIARPDGTPTYNFCVVVDDMDMRITHVIR
HEECCCCCCCEEECCCCCCEEEECCCCCCCEEEECCCCCCCEEEEEEEECCCCEEEEEEC
GDDHVNNTPRQINILRALGGTPPIYAHLPTVLNEQGEKMSKRHGAMSVTGYRDAGYLPEA
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHH
VVNYLARLGWAHGDAEIFSREQFVEWFDLEHLGKSPAQYNPEKLAWLNNHYIKQADNARL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHCCCCHHH
AELVKPFIEALGGRVEGGPQLADVMALVKDRANTLQEVAQTALLFYRTEISVAPELAAQH
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
LTDEVRPGIMALADKLGTLPEWKREAIGAAFKEVLGAHGWKMPKLAMPVRLLVAGQLQTP
HHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHEEECCCCCC
SIDAVLELFGREVVLRRLAG
CHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA