Click here to switch to the map view.

The map label for this gene is moaA [H]

Identifier: 17545758

GI number: 17545758

Start: 1091718

End: 1092839

Strand: Reverse

Name: moaA [H]

Synonym: RSc1039

Alternate gene names: 17545758

Gene position: 1092839-1091718 (Counterclockwise)

Preceding gene: 17545759

Following gene: 17545757

Centisome position: 29.41

GC content: 66.49

Gene sequence:

>1122_bases
ATGACCGAAACCGTCATCCCCCTTTACGACCTGCGCGACGGCCAGCACCATCGCGCCACGGTGCCTGCCGTACCGGACAC
GCTCGTGCCCGCGCAAGGCTGGCTGGCCGATACGTACGGTCGCCGCCTGCACGACCTGCGCATCTCCGTCACCGACCGCT
GCAACTTCCGCTGCATCTACTGCATGCCGAAGGACGTATTCGACAAGGACTACCGCTTCCTGCAGCACAGCGAACTGCTG
TCGTTCGAGGAAATCGAGCGAATGGTCCGCCTGTTCATCGAGCACGGTGTCGAAAAGATCCGCCTGACCGGCGGCGAGCC
GCTGCTGCGCAAGGACATCGAGCGACTCGTCGAGATGCTCGCGCGCCTGAACACCCGCGACGGCAAGCCGCTGGACCTGA
CCCTGACGACCAACGGCGCCCTGCTCGCCCGCAAGGCCCAGGCGCTCAAGGACGCCGGCCTGACGCGGGTGACGGTGAGC
CTGGATGCCATCGACGATGCGACTTTCCGACGCATGAACGATGTCGACTTTGCCGTCGCCGAAGTGCTGCACGGCATCGA
AGTCGCGCAGCGCGTCGGGCTGGCGCCGCTGAAGATCAACATGGTGGTCAAGAAAGGCGACAACGACGACCAGATCGTTC
CGCTGGCGAGGCATTTCCGGAACAGCGGCATCATCCTGCGCTTCATCGAATACATGGACGTGGGCGTGACCAACCACTGG
GAGATGGCCTCGGTGGTGCCGTCGGCCGAAGTCATCCGGCGGCTGTCGGCAGCGTTCGCGCTGGAACCGCTGTCGGCCAA
CTACGCAGGCGAGACGGCCGAGCGCTGGCGCTATGCGGACGGCGCGGGCGAGATCGGCGTGATCTCCAGCGTCACCCAGG
CGTTCTGCCACGACTGCACACGTGCGCGGCTGTCGACGGAAGGCAAGCTCTACCTGTGCCTGTTCGCCACCCAGGGCTTC
GACCTGCGCGCCCTGCTGCGCGGCGGGGCGTCCGACCTGGAGGTGTCCAACGCCATCCGCACCGTCTGGCAGGCCCGCAC
GGACCGCTATTCCGAACTGCGCGCGAGCGGCACCGCCCCGCCGACCGGCCGGCGCATCGAAATGTCCTATATCGGCGGCT
GA

Upstream 100 bases:

>100_bases
GGGTTGGCGACCCCCGCGCAAAACGAGGGGGTGCGCTACACTCGGAGTTGTCTACGCGCGTGGCCGCCGCATCAGCCGGC
CCACTGCGCTGCATCACGTC

Downstream 100 bases:

>100_bases
ACGTTGCCGGCATCCCTCCACATGATTCCGACTTCCGACATCACCGGCCTGATCCTGGCCGGCGGCCGGGGCAGCCGCAT
GGGCGGCGTCGACAAGGGCC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTETVIPLYDLRDGQHHRATVPAVPDTLVPAQGWLADTYGRRLHDLRISVTDRCNFRCIYCMPKDVFDKDYRFLQHSELL
SFEEIERMVRLFIEHGVEKIRLTGGEPLLRKDIERLVEMLARLNTRDGKPLDLTLTTNGALLARKAQALKDAGLTRVTVS
LDAIDDATFRRMNDVDFAVAEVLHGIEVAQRVGLAPLKINMVVKKGDNDDQIVPLARHFRNSGIILRFIEYMDVGVTNHW
EMASVVPSAEVIRRLSAAFALEPLSANYAGETAERWRYADGAGEIGVISSVTQAFCHDCTRARLSTEGKLYLCLFATQGF
DLRALLRGGASDLEVSNAIRTVWQARTDRYSELRASGTAPPTGRRIEMSYIGG

Sequences:

>Translated_373_residues
MTETVIPLYDLRDGQHHRATVPAVPDTLVPAQGWLADTYGRRLHDLRISVTDRCNFRCIYCMPKDVFDKDYRFLQHSELL
SFEEIERMVRLFIEHGVEKIRLTGGEPLLRKDIERLVEMLARLNTRDGKPLDLTLTTNGALLARKAQALKDAGLTRVTVS
LDAIDDATFRRMNDVDFAVAEVLHGIEVAQRVGLAPLKINMVVKKGDNDDQIVPLARHFRNSGIILRFIEYMDVGVTNHW
EMASVVPSAEVIRRLSAAFALEPLSANYAGETAERWRYADGAGEIGVISSVTQAFCHDCTRARLSTEGKLYLCLFATQGF
DLRALLRGGASDLEVSNAIRTVWQARTDRYSELRASGTAPPTGRRIEMSYIGG
>Mature_372_residues
TETVIPLYDLRDGQHHRATVPAVPDTLVPAQGWLADTYGRRLHDLRISVTDRCNFRCIYCMPKDVFDKDYRFLQHSELLS
FEEIERMVRLFIEHGVEKIRLTGGEPLLRKDIERLVEMLARLNTRDGKPLDLTLTTNGALLARKAQALKDAGLTRVTVSL
DAIDDATFRRMNDVDFAVAEVLHGIEVAQRVGLAPLKINMVVKKGDNDDQIVPLARHFRNSGIILRFIEYMDVGVTNHWE
MASVVPSAEVIRRLSAAFALEPLSANYAGETAERWRYADGAGEIGVISSVTQAFCHDCTRARLSTEGKLYLCLFATQGFD
LRALLRGGASDLEVSNAIRTVWQARTDRYSELRASGTAPPTGRRIEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=311, Percent_Identity=35.048231511254, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI22027536, Length=311, Percent_Identity=35.048231511254, Blast_Score=182, Evalue=4e-46,
Organism=Escherichia coli, GI1786999, Length=347, Percent_Identity=33.4293948126801, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17561210, Length=334, Percent_Identity=33.2335329341317, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI32566329, Length=332, Percent_Identity=32.2289156626506, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI32566331, Length=333, Percent_Identity=32.1321321321321, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI28574490, Length=296, Percent_Identity=35.1351351351351, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28574488, Length=296, Percent_Identity=35.1351351351351, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41792; Mature: 41661

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETVIPLYDLRDGQHHRATVPAVPDTLVPAQGWLADTYGRRLHDLRISVTDRCNFRCIY
CCCCEEEEEECCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHEEEEEEEEECCCCEEEEE
CMPKDVFDKDYRFLQHSELLSFEEIERMVRLFIEHGVEKIRLTGGEPLLRKDIERLVEML
ECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
ARLNTRDGKPLDLTLTTNGALLARKAQALKDAGLTRVTVSLDAIDDATFRRMNDVDFAVA
HHHCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHCCCHHHHHH
EVLHGIEVAQRVGLAPLKINMVVKKGDNDDQIVPLARHFRNSGIILRFIEYMDVGVTNHW
HHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEEHHHHHHCCCCHHEEEHHHHHCCCCCCC
EMASVVPSAEVIRRLSAAFALEPLSANYAGETAERWRYADGAGEIGVISSVTQAFCHDCT
HHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCEECCCCCCCHHHHHHHHHHHHHHH
RARLSTEGKLYLCLFATQGFDLRALLRGGASDLEVSNAIRTVWQARTDRYSELRASGTAP
HHHCCCCCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTGRRIEMSYIGG
CCCCEEEEEECCC
>Mature Secondary Structure 
TETVIPLYDLRDGQHHRATVPAVPDTLVPAQGWLADTYGRRLHDLRISVTDRCNFRCIY
CCCEEEEEECCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHEEEEEEEEECCCCEEEEE
CMPKDVFDKDYRFLQHSELLSFEEIERMVRLFIEHGVEKIRLTGGEPLLRKDIERLVEML
ECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
ARLNTRDGKPLDLTLTTNGALLARKAQALKDAGLTRVTVSLDAIDDATFRRMNDVDFAVA
HHHCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHCCCHHHHHH
EVLHGIEVAQRVGLAPLKINMVVKKGDNDDQIVPLARHFRNSGIILRFIEYMDVGVTNHW
HHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEEHHHHHHCCCCHHEEEHHHHHCCCCCCC
EMASVVPSAEVIRRLSAAFALEPLSANYAGETAERWRYADGAGEIGVISSVTQAFCHDCT
HHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCEECCCCCCCHHHHHHHHHHHHHHH
RARLSTEGKLYLCLFATQGFDLRALLRGGASDLEVSNAIRTVWQARTDRYSELRASGTAP
HHHCCCCCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTGRRIEMSYIGG
CCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]