Click here to switch to the map view.

The map label for this gene is moeA1 [H]

Identifier: 17545756

GI number: 17545756

Start: 1089768

End: 1091057

Strand: Reverse

Name: moeA1 [H]

Synonym: RSc1037

Alternate gene names: 17545756

Gene position: 1091057-1089768 (Counterclockwise)

Preceding gene: 17545757

Following gene: 17545755

Centisome position: 29.36

GC content: 71.32

Gene sequence:

>1290_bases
ATGACCACCCTAGCCTCTGTCGTCTCCTGTCTGTCCGACTATGATCCGAACGCGCTGCCCGTGGCGCAGGCTCAAGCCAT
CATGCGCGACTTCGTGCAGCCGGTGACGGGCGTGGCCCGCGTGCCGATCCGCAGCGCGCTGGACCGCGTGCTGGCCGAAG
ACGCGCTGTCCTCGATTGACGTGCCGGCGCACGACAACTCCGCGATGGACGGATTCGCCTTTGCCGGCGCGGAGCTGTCG
CGCGACGGCGGCAGCGGAGACGACCTCGCGCTGCGCGTGATCGGCACCGCCTACGCGGGCACCGCCTTCGACGGCGAGCC
CGGCCCGGGCGAAGCCGTGCGCGTGATGACCGGCGCCGTGATGCCGGCCGGCTGCAACACGGTCATCCCGCAGGAATTCA
CGCAGGGCGATGCCGCCACGGTGCGCTTTGCCCGCGATGCCGTCCGCGCCGGCGACAACCGCCGCCTGCGCGGCGAAGAC
CTCGCCAAGGGCAGCGCGGCGCTCACCGCCGGCCGCGTCCTGCGCCCGGCCGACATCGGCCTGCTGGCCTCGCTCGGCGT
CGCCGAGGTGCCGGTGCGCCGGCGGCTGCGCGTGGCCTTCTTCTCGACCGGGGACGAACTGCGCTCCATCGGCGAGCCGC
TGGACGCCGGCTGCGTGTACGACTCGAACCGCTACACGCTGCACGGCATGCTGTCGCACCTGGGCGTGGAGCTGATCGAC
ATGGGCGTGGTGCGCGACGACCCCGGTGCGATGGAAGCGACGTTCCGCAGCGCGGCCGAAAACGCGGATGCGATCATCAC
GTCCGGCGGGGTCTCGGTCGGGGAAGCGGATTTCACCAAGCAGATGATGGCGCAGCTGGGCGACGTGACCTTCTGGAAAA
TCGCCATGCGCCCGGGGCGGCCGATGGCCTTCGGCCGAATCGCCTCGAACGGCCGCAGCGCCGTCCTGTTCGGCCTGCCC
GGCAATCCGGTGGCGGTGATGGTGACGTTCTACCACTTCGTGCGCGGCGCGCTGCTGCGCATGATGGGCGCGGCCGAGAC
CGGCGCGCCGCTGGTGCCGGCCACCAGCGCGGCGCCGATCCGCAAGCGGCCCGGCCGCACCGAATACCAGCGTGGCATTG
CCGCACTCAACGGCAGCGGGCAACTGGAGGTGCGCCTGACCGGCCAGCAGGGCTCCGGCGTGCTGCGCTCGATGAGCGAG
GCCAACTGCTTTGTCGTGCTCGCCCACGAGCAAGGGCCGGTCAACGCGGGCGACACCGTCCAACTGCTGCTGTTCGACGG
GCTGATCTGA

Upstream 100 bases:

>100_bases
CGTCTTCGATGATGCCGCCGCCTTTGCCAACATCAACACGCTGGCCGAGTTGCGCCAGCTCGCCGAACGGCGTTAGCACC
GCTGGCGCCACCGCTCTCCC

Downstream 100 bases:

>100_bases
GCGACCGCCCGAACCCGGCCGCGCCGGCATGCGGATACCCGCCAGCCCAGCGCTGGCGGGCGTCCACGCGATCCTTACGC
TACCTGCAGCGGCGCCGGCT

Product: molybdopterin biosynthesis MOEA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTTLASVVSCLSDYDPNALPVAQAQAIMRDFVQPVTGVARVPIRSALDRVLAEDALSSIDVPAHDNSAMDGFAFAGAELS
RDGGSGDDLALRVIGTAYAGTAFDGEPGPGEAVRVMTGAVMPAGCNTVIPQEFTQGDAATVRFARDAVRAGDNRRLRGED
LAKGSAALTAGRVLRPADIGLLASLGVAEVPVRRRLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLSHLGVELID
MGVVRDDPGAMEATFRSAAENADAIITSGGVSVGEADFTKQMMAQLGDVTFWKIAMRPGRPMAFGRIASNGRSAVLFGLP
GNPVAVMVTFYHFVRGALLRMMGAAETGAPLVPATSAAPIRKRPGRTEYQRGIAALNGSGQLEVRLTGQQGSGVLRSMSE
ANCFVVLAHEQGPVNAGDTVQLLLFDGLI

Sequences:

>Translated_429_residues
MTTLASVVSCLSDYDPNALPVAQAQAIMRDFVQPVTGVARVPIRSALDRVLAEDALSSIDVPAHDNSAMDGFAFAGAELS
RDGGSGDDLALRVIGTAYAGTAFDGEPGPGEAVRVMTGAVMPAGCNTVIPQEFTQGDAATVRFARDAVRAGDNRRLRGED
LAKGSAALTAGRVLRPADIGLLASLGVAEVPVRRRLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLSHLGVELID
MGVVRDDPGAMEATFRSAAENADAIITSGGVSVGEADFTKQMMAQLGDVTFWKIAMRPGRPMAFGRIASNGRSAVLFGLP
GNPVAVMVTFYHFVRGALLRMMGAAETGAPLVPATSAAPIRKRPGRTEYQRGIAALNGSGQLEVRLTGQQGSGVLRSMSE
ANCFVVLAHEQGPVNAGDTVQLLLFDGLI
>Mature_428_residues
TTLASVVSCLSDYDPNALPVAQAQAIMRDFVQPVTGVARVPIRSALDRVLAEDALSSIDVPAHDNSAMDGFAFAGAELSR
DGGSGDDLALRVIGTAYAGTAFDGEPGPGEAVRVMTGAVMPAGCNTVIPQEFTQGDAATVRFARDAVRAGDNRRLRGEDL
AKGSAALTAGRVLRPADIGLLASLGVAEVPVRRRLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLSHLGVELIDM
GVVRDDPGAMEATFRSAAENADAIITSGGVSVGEADFTKQMMAQLGDVTFWKIAMRPGRPMAFGRIASNGRSAVLFGLPG
NPVAVMVTFYHFVRGALLRMMGAAETGAPLVPATSAAPIRKRPGRTEYQRGIAALNGSGQLEVRLTGQQGSGVLRSMSEA
NCFVVLAHEQGPVNAGDTVQLLLFDGLI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=385, Percent_Identity=34.2857142857143, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI66932975, Length=385, Percent_Identity=34.2857142857143, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1787049, Length=386, Percent_Identity=44.8186528497409, Blast_Score=333, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI25147659, Length=300, Percent_Identity=33, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=228, Percent_Identity=30.7017543859649, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17136978, Length=416, Percent_Identity=27.8846153846154, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24638841, Length=416, Percent_Identity=27.8846153846154, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44891; Mature: 44760

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLASVVSCLSDYDPNALPVAQAQAIMRDFVQPVTGVARVPIRSALDRVLAEDALSSID
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
VPAHDNSAMDGFAFAGAELSRDGGSGDDLALRVIGTAYAGTAFDGEPGPGEAVRVMTGAV
CCCCCCCCCCCCEECCCEECCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCEEEEEECCC
MPAGCNTVIPQEFTQGDAATVRFARDAVRAGDNRRLRGEDLAKGSAALTAGRVLRPADIG
CCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHCCEECCCCCH
LLASLGVAEVPVRRRLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLSHLGVELID
HHHHCCCHHCCHHHEEEEEEECCCHHHHHHCCCCCCCEEECCCCEEHHHHHHHCCHHHHH
MGVVRDDPGAMEATFRSAAENADAIITSGGVSVGEADFTKQMMAQLGDVTFWKIAMRPGR
CCCEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
PMAFGRIASNGRSAVLFGLPGNPVAVMVTFYHFVRGALLRMMGAAETGAPLVPATSAAPI
CCEEHHECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
RKRPGRTEYQRGIAALNGSGQLEVRLTGQQGSGVLRSMSEANCFVVLAHEQGPVNAGDTV
CCCCCCCHHHHCCEEECCCCEEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCEE
QLLLFDGLI
EEEEECCCC
>Mature Secondary Structure 
TTLASVVSCLSDYDPNALPVAQAQAIMRDFVQPVTGVARVPIRSALDRVLAEDALSSID
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
VPAHDNSAMDGFAFAGAELSRDGGSGDDLALRVIGTAYAGTAFDGEPGPGEAVRVMTGAV
CCCCCCCCCCCCEECCCEECCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCEEEEEECCC
MPAGCNTVIPQEFTQGDAATVRFARDAVRAGDNRRLRGEDLAKGSAALTAGRVLRPADIG
CCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHCCEECCCCCH
LLASLGVAEVPVRRRLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLSHLGVELID
HHHHCCCHHCCHHHEEEEEEECCCHHHHHHCCCCCCCEEECCCCEEHHHHHHHCCHHHHH
MGVVRDDPGAMEATFRSAAENADAIITSGGVSVGEADFTKQMMAQLGDVTFWKIAMRPGR
CCCEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
PMAFGRIASNGRSAVLFGLPGNPVAVMVTFYHFVRGALLRMMGAAETGAPLVPATSAAPI
CCEEHHECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
RKRPGRTEYQRGIAALNGSGQLEVRLTGQQGSGVLRSMSEANCFVVLAHEQGPVNAGDTV
CCCCCCCHHHHCCEEECCCCEEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCEE
QLLLFDGLI
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]